Cited by 118Axon Guidance and Neuronal SignalingNeuroscience and Neuropharmacology ResearchNeurobiology and Insect Physiology Research

SYD-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains, specifies axon identity in C. elegans

Hallam, Steven J., Goncharov, Alexandr, McEwen, Jason, Baran, Renee, Jin, Yishi·2002·Nature Neuroscience

Abstract

Axons are defined by the presence of presynaptic specializations at specific locations. We show here that loss-of-function mutations in the C. elegans gene syd-1 cause presynaptic specializations to form in the dendritic processes of GABA-expressing motor neurons during initial differentiation. At a later developmental stage, however, syd-1 is not required for the polarity respecification of a subset of these neurons. The SYD-1 protein contains PDZ, C2 and rho-GTPase activating protein (GAP)-like domains, and is localized to presynaptic terminals in mature neurons. A truncated SYD-1 that lacks the rhoGAP domain interferes with neurite outgrowth and guidance. Our data indicate that syd-1 may be involved in specifying axon identity during initial polarity acquisition.

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Crossref · 10.1038/nn959

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  • Proteins related to C. elegans SYD-1 are important for the assembly of active zones in invertebrates.

    “In addition to these five core active zone proteins, piccolo and bassoon (two large homologous proteins) are associated in vertebrates with active zones (tom Dieck et al., 1998; Wang et al., 1999; Fenster et al., 2000; Limbach et al., 2011), and proteins related to C. elegans SYD-1 are important for the assembly of active zones in invertebrates (Hallam et al., 2002; Patel et al., 2006; Owald et al”

    From The Presynaptic Active Zone (2012) · cites this paper as Hallam et al., 2002

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Authors
Hallam, S. J., Goncharov, A., McEwen, J., Baran, R., & Jin, Y.
Affiliations
  • University of California, Santa Cruz (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Jin, Yishi
Venue
Nature Neuroscience
Published
2002-10-15
Volume
5
Issue
11
Pages
1137-1146
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2095289526
Cited by
118
References
46
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 5
FWCI
1.39
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
presynaptic specialization, motor neurons, dendritic processes, PDZ domain, C2 domain, neurite outgrowth, axon guidance, Caenorhabditis elegans
MeSH terms
Animals, Axons, Larva, Molecular Sequence Data, Neurons, Spinal Cord, Neurites, Caenorhabditis elegans, Sequence Homology, Amino Acid, Protein Structure, Tertiary, Presynaptic Terminals, Gene Expression Regulation, Developmental, Mutation, Missense, GTPase-Activating Proteins, Caenorhabditis elegans Proteins

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