SYD-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains, specifies axon identity in C. elegans
Abstract
Axons are defined by the presence of presynaptic specializations at specific locations. We show here that loss-of-function mutations in the C. elegans gene syd-1 cause presynaptic specializations to form in the dendritic processes of GABA-expressing motor neurons during initial differentiation. At a later developmental stage, however, syd-1 is not required for the polarity respecification of a subset of these neurons. The SYD-1 protein contains PDZ, C2 and rho-GTPase activating protein (GAP)-like domains, and is localized to presynaptic terminals in mature neurons. A truncated SYD-1 that lacks the rhoGAP domain interferes with neurite outgrowth and guidance. Our data indicate that syd-1 may be involved in specifying axon identity during initial polarity acquisition.
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Proteins related to C. elegans SYD-1 are important for the assembly of active zones in invertebrates.
“In addition to these five core active zone proteins, piccolo and bassoon (two large homologous proteins) are associated in vertebrates with active zones (tom Dieck et al., 1998; Wang et al., 1999; Fenster et al., 2000; Limbach et al., 2011), and proteins related to C. elegans SYD-1 are important for the assembly of active zones in invertebrates (Hallam et al., 2002; Patel et al., 2006; Owald et al”
From The Presynaptic Active Zone (2012) · cites this paper as Hallam et al., 2002
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- Authors
- Hallam, S. J., Goncharov, A., McEwen, J., Baran, R., & Jin, Y.
- Affiliations
- University of California, Santa Cruz (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jin, Yishi
- Venue
- Nature Neuroscience
- Published
- 2002-10-15
- Volume
- 5
- Issue
- 11
- Pages
- 1137-1146
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2095289526
- Cited by
- 118
- References
- 46
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 5
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- presynaptic specialization, motor neurons, dendritic processes, PDZ domain, C2 domain, neurite outgrowth, axon guidance, Caenorhabditis elegans
- MeSH terms
- Animals, Axons, Larva, Molecular Sequence Data, Neurons, Spinal Cord, Neurites, Caenorhabditis elegans, Sequence Homology, Amino Acid, Protein Structure, Tertiary, Presynaptic Terminals, Gene Expression Regulation, Developmental, Mutation, Missense, GTPase-Activating Proteins, Caenorhabditis elegans Proteins
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