Cited by 218Neuroscience and Neuropharmacology ResearchCellular transport and secretionNeurobiology and Insect Physiology Research

SYD-2 Liprin-α organizes presynaptic active zone formation through ELKS

Dai, Ya, Taru, Hidenori, Deken, Scott L, Grill, Brock, Ackley, Brian, Nonet, Michael L, Jin, Yishi·2006·Nature Neuroscience

Abstract

A central event in synapse development is formation of the presynaptic active zone in response to positional cues. Three active zone proteins, RIM, ELKS (also known as ERC or CAST) and Liprin-alpha, bind each other and are implicated in linking active zone formation to synaptic vesicle release. Loss of function in Caenorhabditis elegans syd-2 Liprin-alpha alters the size of presynaptic specializations and disrupts synaptic vesicle accumulation. Here we report that a missense mutation in the coiled-coil domain of SYD-2 causes a gain of function. In HSN synapses, the syd-2(gf) mutation promotes synapse formation in the absence of syd-1, which is essential for HSN synapse formation. syd-2(gf) also partially suppresses the synaptogenesis defects in syg-1 and syg-2 mutants. The activity of syd-2(gf) requires elks-1, an ELKS homolog; but not unc-10, a RIM homolog. The mutant SYD-2 shows increased association with ELKS. These results establish a functional dependency for assembly of the presynaptic active zone in which SYD-2 plays a key role.

Integrity signals

Registry

Crossref · 10.1038/nn1808

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • α-Liprin is required for active zone formation with recruitment of synaptic vesicles and of LAR-type receptor phosphotyrosine phosphatases.

    “Together, these data established that active zone formation with recruitment of synaptic vesicles and of LAR-type receptor phosphotyrosine phosphatases requires α-liprin, possibly by simultaneous binding of α-liprin to the receptor phosphotyrosine phosphatase, RIM, ELKS, Syd-1, and itself.”

    From The Presynaptic Active Zone (2012) · cites this paper as Dai et al., 2006

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Dai, Y., Taru, H., Deken, S. L., Grill, B., Ackley, B., Nonet, M. L., & Jin, Y.
Affiliations
  • University of California, Santa Cruz (US)
  • Washington University in St. Louis (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Jin, Yishi
Venue
Nature Neuroscience
Published
2006-11-19
Volume
9
Issue
12
Pages
1479-1487
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1999369847
Cited by
218
References
41
Citations by year
2026: 6 · 2025: 8 · 2024: 15 · 2023: 14 · 2022: 8 · 2021: 7 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 8 · 2016: 14 · 2015: 12 · 2014: 14 · 2013: 16 · 2012: 10
FWCI
3.79
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
Liprin-α, active zone, elk, RIM, synaptogenesis, Caenorhabditis elegans, coiled-coil domain, gain-of-function mutations
MeSH terms
Animals, Carrier Proteins, Cytoskeleton, Gene Expression Regulation, Motor Neurons, Mutation, Synaptic Transmission, Phosphoproteins, Synaptic Vesicles, Caenorhabditis elegans, Presynaptic Terminals, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Intercellular Signaling Peptides and Proteins, Intracellular Signaling Peptides and Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review