The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response
Open accessAbstract
Therapeutic cancer vaccination is an attractive immune therapy strategy to actively induce T cells that specifically recognize and kill tumour cells in cancer patients. However, it remains difficult to generate a large number antigen-specific T cells using conventional vaccine carrier systems1,2. Here we show that α-Al2O3 nanoparticles can act as an antigen carrier to reduce the amount of antigen required by dendritic cells to activate T cells in vitro and in vivo. We found that α- Al2O3 nanoparticles delivered antigens to autophagosomes in dendritic cells (DCs), which then presented the antigens to T cells through autophagy – the normal degradation process of cell components in cells. Immunization of mice with α-Al2O3 nanoparticles that are conjugated to either a model tumour antigen or autophagosomes derived from tumour cells resulted in tumour regression. These results suggest that α-Al2O3 nanoparticles may be a promising adjuvant in the development of therapeutic cancer vaccines.
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Cites
Towards an understanding of the adjuvant action of aluminium
Marrack, P., McKee, A. S., & Munks, M. W. (2009) · Nature Reviews Immunology · doi:10.1038/nri2510 · Cited by 887
Cross-Presentation, Dendritic Cells, Tolerance and Immunity
Heath, W. R., & Carbone, F. R. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.47 · Cited by 882
Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
Flach, T. L., Ng, G., Hari, A., Desrosiers, M. D., Zhang, P., Ward, S. M., Seamone, M. E., Vilaysane, A., Mucsi, A. D., Fong, Y., et al. (2011) · Nature Medicine · doi:10.1038/nm.2306 · Cited by 405
Uhl, M., Kepp, O., Jusforgues-Saklani, H., Vicencio, J.-M., Kroemer, G., & Albert, M. L. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.8 · Cited by 196
Cited by
Consensus guidelines for the detection of immunogenic cell death
Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., et al. (2014) · OncoImmunology · doi:10.4161/21624011.2014.955691 · Cited by 832
Self-citationAutophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity
Stern, S. T., Adiseshaiah, P. P., & Crist, R. M. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-20 · Cited by 836
Dying cells actively regulate adaptive immune responses
Yatim, N., Cullen, S., & Albert, M. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.9 · Cited by 442
Liang, C., Xu, L., Song, G., & Liu, Z. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00458j · Cited by 435
Bridging Bio–Nano Science and Cancer Nanomedicine
Björnmalm, M., Thurecht, K. J., Michael, M., Scott, A. M., & Caruso, F. (2017) · ACS Nano · doi:10.1021/acsnano.7b04855 · Cited by 382
Metadata
- Authors
- Li, H., Li, Y., Jiao, J., & Hu, H.-M.
- Venue
- Nature Nanotechnology
- Published
- 2011-09-18
- Volume
- 6
- Issue
- 10
- Pages
- 645-650
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2154265087
- Cited by
- 347
- References
- 4
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- green
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