Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells

Uhl, M; Kepp, O; Jusforgues-Saklani, H; Vicencio, J-M; Kroemer, G; Albert, M L

doi:10.1038/cdd.2009.8

Cited by 196Immunotherapy and Immune ResponsesAutophagy in Disease and TherapyT-cell and B-cell Immunology

Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells

Uhl, M, Kepp, O, Jusforgues-Saklani, H, Vicencio, J-M, Kroemer, G, Albert, M L·2009·Cell Death & Differentiation

DOI 10.1038/cdd.2009.8

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Abstract

Cross-presentation of cell-associated antigen is important in the priming of CD8(+) T-cell responses to proteins that are not expressed by antigen-presenting cells (APCs). In vivo, dendritic cells are the main cross-presenting APC, and much is known regarding their ability to capture and process cell-associated antigen. In contrast, little is known about the way death effector pathways influence the efficiency of cross-priming. Here, we compared two important mechanisms of programmed cell death: classical apoptosis, as it occurs in wild-type (WT) fibroblasts, and caspase-independent cell death, which occurs with increased features of autophagy in Bax/Bak(-/-) fibroblasts. We assessed virally infected WT and Bax/Bak(-/-) fibroblasts as a source of cell-associated antigen. We found that immunization with cells undergoing autophagy before cell death was superior in facilitating the cross-priming of antigen-specific CD8(+) T cells. Strikingly, silencing of Atg5 expression inhibited priming. We interpret this to be a novel form of 'immunogenic death' with the enhanced priming efficiency being a result of persistent MHC I cross-presentation and the induction of type I interferons. These results offer the first molecular evidence that catabolic pathways, including autophagy, influence the efficiency of cross-priming. We predict that targeting the autophagy cascade may provide a therapeutic strategy for achieving robust cross-priming of viral and tumor-specific CD8(+) T cells.

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Antigens associated with apoptotic cells engulfed by DC can be cross-presented by MHC class I to CD8+ T cells to prime CTL.
“Antigens associated with apoptotic cells and engulfed by DC can be cross-presented by MHC class I molecules to CD8+ T cells to prime CTL. 67”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [67]

Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069 · see citing works
Self-citation
Caspases: Enemies Within
Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857 · see citing works
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605 · see citing works
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Wei, M. C., Zong, W.-X., Cheng, E. H.-Y., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., & Korsmeyer, S. J. (2001) · Science · doi:10.1126/science.1059108 · Cited by 3,988 · see citing works
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888 · see citing works
Self-eating and self-killing: crosstalk between autophagy and apoptosis
Maiuri, M. C., Zalckvar, E., Kimchi, A., & Kroemer, G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2239 · Cited by 3,560 · see citing works
Self-citation
Calreticulin exposure dictates the immunogenicity of cancer cell death
Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216 · see citing works
Self-citation
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056 · see citing works
Self-citation
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
Albert, M. L., Sauter, B., & Bhardwaj, N. (1998) · Nature · doi:10.1038/32183 · Cited by 2,350 · see citing works
Self-citation
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy · doi:10.4161/auto.5338 · Cited by 2,230 · see citing works
Immunosuppressive effects of apoptotic cells
Voll, R. E., Herrmann, M., Roth, E. A., Stach, C., Kalden, J. R., & Girkontaite, I. (1997) · Nature · doi:10.1038/37022 · Cited by 1,787 · see citing works
A protein conjugation system essential for autophagy
Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M. D., Klionsky, D. J., Ohsumi, M., & Ohsumi, Y. (1998) · Nature · doi:10.1038/26506 · Cited by 1,701 · see citing works
Natural adjuvants: Endogenous activators of dendritic cells
Gallucci, S., Lolkema, M. P., & Matzinger, P. (1999) · Nature Medicine · doi:10.1038/15200 · Cited by 1,601 · see citing works
A blast from the past: clearance of apoptotic cells regulates immune responses
Savill, J., Dransfield, I., Gregory, C. D., & Haslett, C. (2002) · Nature reviews. Immunology · doi:10.1038/nri957 · Cited by 1,574 · see citing works
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
Casares, N., Pequignot, M. O., Tesniere, A., Ghiringhelli, F., Roux, S., Chaput, N., Schmitt, E., Hamai, A., Hervas-Stubbs, S., Obeid, M., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050915 · Cited by 1,512 · see citing works
Self-citation
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
Shimizu, S., Kanaseki, T., Mizushima, N., Mizuta, T., Arakawa-Kobayashi, S., Thompson, C. B., & Tsujimoto, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1192 · Cited by 1,358 · see citing works
Consequences of Cell Death
Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357 · see citing works
Self-citation
Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway
Basu, S., Binder, R. J., Suto, R., Anderson, K. M., & Srivastava, P. K. (2000) · International Immunology · doi:10.1093/intimm/12.11.1539 · Cited by 1,305 · see citing works
Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes
Albert, M. L., Pearce, S. F. A., Francisco, L. M., Sauter, B., Roy, P., Silverstein, R. L., & Bhardwaj, N. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.7.1359 · Cited by 1,234 · see citing works
Self-citation
Autophagy and signaling: their role in cell survival and cell death
Codogno, P., & Meijer, A. J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401751 · Cited by 1,092 · see citing works
Autophagy Defends Cells Against Invading Group A Streptococcus
Nakagawa, I., Amano, A., Mizushima, N., Yamamoto, A., Yamaguchi, H., Kamimoto, T., Nara, A., Funao, J., Nakata, M., Tsuda, K., et al. (2004) · Science · doi:10.1126/science.1103966 · Cited by 1,091 · see citing works
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
Kanzawa, T., Germano, I. M., Komata, T., Ito, H., Kondo, Y., & Kondo, S. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401359 · Cited by 986 · see citing works
A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes
Cuervo, A. M., & Dice, J. F. (1996) · Science · doi:10.1126/science.273.5274.501 · Cited by 979 · see citing works
Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.
Bevan, M. J. (1976) · The Journal of Experimental Medicine · doi:10.1084/jem.143.5.1283 · Cited by 962 · see citing works
Toll-like receptor 3 promotes cross-priming to virus-infected cells
Schulz, O., Diebold, S. S., Chen, M., Näslund, T. I., Nolte, M. A., Alexopoulou, L., Azuma, Y., Flavell, R. A., Liljeström, P., & Sousa, C. R. E. (2005) · Nature · doi:10.1038/nature03326 · Cited by 919 · see citing works
Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells
Lee, H. K., Lund, J. M., Ramanathan, B., Mizushima, N., & Iwasaki, A. (2007) · Science · doi:10.1126/science.1136880 · Cited by 865 · see citing works
Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
Paludan, C., Schmid, D., Landthaler, M., Vockerodt, M., Kube, D., Tuschl, T., & Münz, C. (2005) · Science · doi:10.1126/science.1104904 · Cited by 860 · cited 1× · see citing works
“Although this study represents the first demonstration that antigen may be efficiently cross-presented following the phagocytosis of cells dying with enhanced autophagy, this pathway is not new for the field of antigen presentation.(48,49) Indeed, there is strong evidence that viral, tumor and self-antigens may gain a…”
Subversion of Cellular Autophagosomal Machinery by RNA Viruses
Jackson, W. T., Giddings, T. H., Taylor, M. P., Mulinyawe, S. B., Rabinovitch, M., Kopito, R. R., & Kirkegaard, K. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030156 · Cited by 820 · see citing works
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon
Bon, A. L., Etchart, N., Rossmann, C., Ashton, M., Hou, S., Gewert, D. R., Borrow, P., & Tough, D. F. (2003) · Nature Immunology · doi:10.1038/ni978 · Cited by 816 · see citing works
Helping the CD8+ T-cell response
Bevan, M. J. (2004) · Nature reviews. Immunology · doi:10.1038/nri1413 · Cited by 790 · see citing works
Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway
Tallóczy, Z., Jiang, W., Virgin, H. W., Leib, D. A., Scheuner, D. L., Kaufman, R. J., Eskelinen, E., & Levine, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012485299 · Cited by 741 · see citing works
Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
Gutierrez, M. G., Munafó, D. B., Berón, W., & Colombo, M. I. (2004) · Journal of Cell Science · doi:10.1242/jcs.01114 · Cited by 680 · see citing works
Autophagy Controls Salmonella Infection in Response to Damage to the Salmonella-containing Vacuole
Birmingham, C. L., Smith, A. C., Bakowski, M. A., Yoshimori, T., & Brumell, J. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509157200 · Cited by 658 · see citing works
The role of BH3-only proteins in the immune system
Strasser, A. (2005) · Nature reviews. Immunology · doi:10.1038/nri1568 · Cited by 624 · see citing works
The Atg5–Atg12 conjugate associates with innate antiviral immune responses
Jounai, N., Takeshita, F., Kobiyama, K., Sakaue-Sawano, A., Miyawaki, A., Xin, K.-Q., Ishii, K. J., Kawai, T., Akira, S., Suzuki, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704014104 · Cited by 562 · see citing works
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
Nedjic, J., Aichinger, M., Emmerich, J., Mizushima, N., & Klein, L. (2008) · Nature · doi:10.1038/nature07208 · Cited by 533 · see citing works
GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation
Colell, A., Ricci, J.-E., Tait, S., Milasta, S., Maurer, U., Bouchier-Hayes, L., Fitzgerald, P., Guio-Carrion, A., Waterhouse, N. J., Li, C. W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.045 · Cited by 516 · see citing works
Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC light-induced apoptosis
Obeid, M., Panaretakis, T., Joza, N., Tufi, R., Tesniere, A., van Endert, P., Zitvogel, L., & Kroemer, G. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402201 · Cited by 474 · see citing works
Self-citation
Innate and Adaptive Immunity through Autophagy
Schmid, D., & Münz, C. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.004 · Cited by 461 · see citing works
The Evolutionarily Conserved Domain of Beclin 1 is Required for Vps34 Binding, Autophagy, and Tumor Suppressor Function
Furuya, N., Yu, J., Byfield, M. P., Pattingre, S., & Levine, B. (2005) · Autophagy · doi:10.4161/auto.1.1.1542 · Cited by 430 · see citing works
Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens
Zhao, Z., Fux, B., Goodwin, M., Dunay, I. R., Strong, D. W., Miller, B. C., Cadwell, K., Delgado, M. A., Ponpuak, M., Green, K. G., et al. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.10.003 · Cited by 413 · see citing works
Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection
Badovinac, V. P., Haring, J. S., & Harty, J. T. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.013 · Cited by 406 · see citing works
Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells
Albert, M. L., Jegathesan, M., & Darnell, R. B. (2001) · Nature Immunology · doi:10.1038/ni722 · Cited by 402 · see citing works
Self-citation
Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells
Binder, R. J., & Srivastava, P. K. (2005) · Nature Immunology · doi:10.1038/ni1201 · Cited by 295 · see citing works
CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine
Curtsinger, J., Johnson, C. M., & Mescher, M. F. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5165 · Cited by 287 · see citing works
Transcriptional Suppression of Interleukin-12 Gene Expression following Phagocytosis of Apoptotic Cells
Kim, S. J., Elkon, K. B., & Ma, X. (2004) · Immunity · doi:10.1016/j.immuni.2004.09.009 · Cited by 277 · see citing works
Inhibitory Effects of Apoptotic Cell Ingestion upon Endotoxin-Driven Myeloid Dendritic Cell Maturation
Stuart, L. M., Lucas, M., Simpson, C., Lamb, J. R., Savill, J., & Lacy‐Hulbert, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1627 · Cited by 275 · see citing works
CD8(+) T cell-mediated spontaneous diabetes in neonatal mice
Morgan, D. J., Liblau, R., Scott, B., Fleck, S., McDevitt, H. O., Sarvetnick, N., Lo, D. D., & Sherman, L. A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.3.978 · Cited by 267 · see citing works
Death-defying immunity: do apoptotic cells influence antigen processing and presentation?
Albert, M. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri11308 · Cited by 257 · see citing works
Self-citation
Pharmacological manipulation of cell death: clinical applications in sight?
Green, D. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26321 · Cited by 239 · see citing works
Apoptotic, but not necrotic, tumor cell vaccines induce a potent immune response in vivo
Scheffer, S., Nave, H., Korangy, F., Schlote, K., Pabst, R., Jaffee, E. M., Manns, M. P., & Greten, T. F. (2002) · International Journal of Cancer · doi:10.1002/ijc.10777 · Cited by 201 · see citing works
Apoptotic Cells Deliver Processed Antigen to Dendritic Cells for Cross-Presentation
Blachère, N. E., Darnell, R. B., & Albert, M. L. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030185 · Cited by 153 · see citing works
Self-citation
Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity
Feng, H., Zeng, Y., Whitesell, L. J., & Katsanis, E. (2001) · Blood · doi:10.1182/blood.v97.11.3505 · Cited by 152 · see citing works
Immune Response Against Dying Tumor Cells
Zitvogel, L., Casares, N., Péquignot, M. O., Chaput, N., Albert, M. L., & Kroemer, G. (2004) · Advances in immunology · doi:10.1016/s0065-2776(04)84004-5 · Cited by 129 · see citing works
Self-citation
Cut and trim: generating MHC class I peptide ligands
Yewdell, J. W., & Bennink, J. R. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00175-8 · Cited by 114 · see citing works
Proapoptotic BAX and BAK control multiple initiator caspases
Ruiz‐Vela, A., Opferman, J. T., Cheng, E. H. Y., & Korsmeyer, S. J. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400375 · Cited by 112 · see citing works
Autophagy: Is It Cancer's Friend or Foe?
Marx, J. L. (2006) · Science · doi:10.1126/science.312.5777.1160 · Cited by 93 · see citing works
Efficient T Cell Activation via a Toll-Interleukin 1 Receptor-Independent Pathway
Janssen, E. M., Tabeta, K., Barnes, M. J., Rutschmann, S., McBride, S. W., Bahjat, K. S., Schoenberger, S. P., Theofilopoulos, A. N., Beutler, B., & Hoebe, K. H. N. (2006) · Immunity · doi:10.1016/j.immuni.2006.03.024 · Cited by 91 · see citing works
Autophagy and antigen presentation
Münz, C. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00714.x · Cited by 90 · see citing works
Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes
Petrovski, G., Zahuczky, G., Katona, K., Vereb, G., Martinet, W., Nemes, Z., Bursch, W., & Fésüs, L. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402112 · Cited by 77 · see citing works
Caspase activation is not death
Perfettini, J., & Kroemer, G. (2003) · Nature Immunology · doi:10.1038/ni0403-308 · Cited by 76 · see citing works
Self-citation
Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-α/β on antigen cross-presentation
Longman, R., Braun, D., Pellegrini, S., Rice, C. M., Darnell, R. B., & Albert, M. L. (2006) · Blood · doi:10.1182/blood-2006-05-023465 · Cited by 66 · see citing works
Self-citation
Bak and Bax are non‐redundant during infection‐ and DNA damage‐induced apoptosis
Kepp, O., Rajalingam, K., Kimmig, S., & Rudel, T. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601533 · Cited by 63 · see citing works
Self-citation
Cell death in the absence of Bax and Bak
Lindsten, T., & Thompson, C. B. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401953 · Cited by 62 · see citing works
Caspase-dependent Inactivation of Proteasome Function during Programmed Cell Death in Drosophila and Man
Adrain, C., Creagh, E. M., Cullen, S. P., & Martin, S. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402638200 · Cited by 61 · see citing works
Antigen Persistence Is Required for Dendritic Cell Licensing and CD8+ T Cell Cross-Priming
Jusforgues-Saklani, H., Uhl, M., Blachère, N. E., Lemaı̂tre, F., Lantz, O. J., Bousso, P., Braun, D., Moon, J. J., & Albert, M. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3067 · Cited by 45 · see citing works
Self-citation
Untitled work
(2001) · doi:10.1002/1521-4141(200112)31:12

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Matsuzawa, Y., Hwang, S., & Cadwell, K. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053253 · Cited by 378 · see citing works
Type I interferon response and innate immune sensing of cancer
Fuertes, M. B., Woo, S.-R., Burnett, B., Fu, Y.-X., & Gajewski, T. F. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.10.004 · Cited by 375 · see citing works
Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response
Li, H., Li, Y., Jiao, J., & Hu, H. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.153 · Cited by 347 · see citing works
Autophagy and the Immune System
Kuballa, P., Nolte, W. M., Castoreno, A. B., & Xavier, R. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074948 · Cited by 326 · see citing works
Oncolytic viruses as therapeutic cancer vaccines
Bartlett, D. L., Liu, Z., Sathaiah, M., Ravindranathan, R., Guo, Z., He, Y., & Guo, Z. S. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-103 · Cited by 326 · see citing works
Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses
Blanchet, F. P., Moris, A., Nikolic, D. S., Lehmann, M., Cardinaud, S., Stalder, R., Garcia, E., Dinkins, C., Leuba, F., Wu, L. J., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.011 · Cited by 291 · see citing works
Oncolytic Immunotherapy: Dying the Right Way is a Key to Eliciting Potent Antitumor Immunity
Guo, Z. S., Liu, Z., & Bartlett, D. L. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00074 · Cited by 285 · see citing works
Autophagy: shaping the tumor microenvironment and therapeutic response
Maes, H., Rubio, N., Garg, A. D., & Agostinis, P. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.04.005 · Cited by 266 · see citing works
Presentation of Phagocytosed Antigens by MHC Class I and II
Mantegazza, A. R., Magalhaes, J. G., Amigorena, S., & Marks, M. S. (2012) · Traffic · doi:10.1111/tra.12026 · Cited by 254 · see citing works
Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation
Ravindran, R., Khan, N., Nakaya, H. I., Li, S., Loebbermann, J., Maddur, M. S., Park, Y. H., Jones, D. P., Chappert, P., Davoust, J. M., et al. (2013) · Science · doi:10.1126/science.1246829 · Cited by 222 · see citing works
Heme oxygenase-1–mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice
Carchman, E. H., Rao, J., Loughran, P., Rosengart, M. R., & Zuckerbraun, B. S. (2011) · Hepatology · doi:10.1002/hep.24324 · Cited by 214 · see citing works
Chikungunya virus–induced autophagy delays caspase-dependent cell death
Joubert, P.-E., Werneke, S. W., de la Calle, C., Guivel‐Benhassine, F., Giodini, A., Peduto, L., Levine, B., Schwartz, O., Lenschow, D. J., & Albert, M. L. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20110996 · Cited by 209 · see citing works
Self-citation
Immunogenic cell death modalities and their impact on cancer treatment
Kepp, O., Tesnière, A., Schlemmer, F., Michaud, M., Senovilla, L., Zitvogel, L., & Kroemer, G. (2009) · APOPTOSIS · doi:10.1007/s10495-008-0303-9 · Cited by 203 · see citing works
Self-citation
IL-21 and T follicular helper cells
Spolski, R. J., & Leonard, W. J. (2009) · International Immunology · doi:10.1093/intimm/dxp112 · Cited by 182 · see citing works
Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers
Lefort, S., Joffre, C., Kieffer, Y., Givel, A.-M., Bourachot, B., Zago, G., Bièche, I., Dubois, T., Meseure, D., Vincent‐Salomon, A., et al. (2014) · Autophagy · doi:10.4161/15548627.2014.981788 · Cited by 174 · see citing works
Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8+ T Cell Responses
Loi, M., Mueller, A., Steinbach, K., Niven, J., da Silva, R. B., Paul, P., Ligeon, L., Caruso, A., Albrecht, R. A., Becker, A. C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.002 · Cited by 173 · see citing works
Autophagy in dendritic cells
Ghislat, G., & Lawrence, T. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2018.2 · Cited by 169 · see citing works
Autophagy Beyond Intracellular MHC Class II Antigen Presentation
Münz, C. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.08.017 · Cited by 150 · see citing works
Autophagy and adaptive immunity
Crotzer, V. L., & Blum, J. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03321.x · Cited by 145 · see citing works
Extracellular nucleosides and nucleotides as immunomodulators
Kepp, O., Loos, F., Liu, P., & Kroemer, G. (2017) · Immunological Reviews · doi:10.1111/imr.12571 · Cited by 144 · see citing works
Self-citation
Cell-Mediated Autophagy Promotes Cancer Cell Survival
Buchser, W., Laskow, T. C., Pavlik, P. J., Lin, H., & Lotze, M. T. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3396 · Cited by 143 · see citing works
ATP Release from Dying Autophagic Cells and Their Phagocytosis Are Crucial for Inflammasome Activation in Macrophages
Duran, G. A., Krysko, D. V., Kaczmarek, A., Petrovski, G., Vandenabeele, P., & Fésüs, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040069 · Cited by 132 · see citing works
High ambient temperature dampens adaptive immune responses to influenza A virus infection
Moriyama, M., & Ichinohe, T. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815029116 · Cited by 134 · see citing works
Delta-24-RGD Oncolytic Adenovirus Elicits Anti-Glioma Immunity in an Immunocompetent Mouse Model
Jiang, H., Clise-Dwyer, K., Ruisaard, K. E., Fan, X., Tian, W., Gumin, J., Lamfers, M. L. M., Kleijn, A., Lang, F. F., Yung, W.-K. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097407 · Cited by 127 · see citing works
Adaptive immunity after cell death
Zelenay, S., & Sousa, C. R. E. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.03.005 · Cited by 124 · see citing works
Autophagy in T‐cell development, activation and differentiation
Bronietzki, A. W., Schuster, M., & Schmitz, I. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.81 · Cited by 121 · see citing works
Oncolytic parvoviruses as cancer therapeutics
Rommelaere, J., Geletneky, K., Angelova, A. L., Daeffler, L., Dinsart, C., Kiprianova, I., Schlehofer, J. R., & Raykov, Z. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.02.011 · Cited by 118 · see citing works
Autophagy and Mammalian Viruses
Paul, P., & Münz, C. (2016) · Advances in virus research · doi:10.1016/bs.aivir.2016.02.002 · Cited by 117 · see citing works
Autophagy in the regulation of pathogen replication and adaptive immunity
Randow, F., & Münz, C. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.06.003 · Cited by 115 · see citing works
Autophagy proteins in antigen processing for presentation on MHC molecules
Münz, C. (2016) · Immunological Reviews · doi:10.1111/imr.12422 · Cited by 112 · see citing works
Antigen processing via autophagy – not only for MHC class II presentation anymore?
Münz, C. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.016 · Cited by 118 · see citing works
Noncanonical autophagy: one small step for LC3, one giant leap for immunity
Mehta, P., Hénault, J., Kolbeck, R., & Sanjuán, M. A. F. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.10.012 · Cited by 107 · see citing works
Therapeutic Cancer Vaccines
Schlom, J., Hodge, J. W., Palena, C., Tsang, K.-Y., Jochéms, C., Greiner, J. W., Farsaci, B., Madan, R. A., Heery, C. R., & Gulley, J. L. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-800249-0.00002-0 · Cited by 102 · see citing works
Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent
Morgan, M. J., Gamez, G., Menke, C., Hernandez, A. L., Thorburn, J., Gidan, F., Staskiewicz, L., Morgan, S. C., Cummings, C. T., Maycotte, P., et al. (2014) · Autophagy · doi:10.4161/auto.32135 · Cited by 102 · see citing works
Autophagy: An adaptive metabolic response to stress shaping the antitumor immunity
Viry, E., Paggetti, J., Bagińska, J., Mgrditchian, T., Berchem, G., Moussay, E., & Janji, B. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.07.006 · Cited by 95 · see citing works
Autophagy-Mediated Dendritic Cell Activation Is Essential for Innate Cytokine Production and APC Function with Respiratory Syncytial Virus Responses
Morris, S. B., Swanson, M. S., Lieberman, A. P., Reed, M., Yue, Z., Lindell, D. M., & Lukacs, N. W. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100524 · Cited by 96 · see citing works
Oncolytic viruses as immunotherapy: progress and remaining challenges
Aurelian, L. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s63049 · Cited by 95 · see citing works
HDLs inhibit endoplasmic reticulum stress and autophagic response induced by oxidized LDLs
Muller, C., Salvayre, R., Nègre‐Salvayre, A., & Vindis, C. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.149 · Cited by 94 · see citing works
The role of the mitochondria and the endoplasmic reticulum contact sites in the development of the immune responses
Martinvalet, D. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0237-7 · Cited by 91 · see citing works
The beneficial role of autophagy in multiple sclerosis: Yes or No?
Al-Kuraishy, H. M., Jabir, M. S., Al-Gareeb, A. I., Saad, ‏. M., Batiha, G. E., & Klionsky, D. J. (2023) · Autophagy · doi:10.1080/15548627.2023.2259281 · Cited by 86 · see citing works
Interactions between Autophagy and Inhibitory Cytokines
Wu, T., Li, W., & Yao, Y.-M. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.15194 · Cited by 82 · see citing works
CD4+ T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease
Luca, A. D., Iannitti, R. G., Bozza, S., Beau, R., Casagrande, A., D’Angelo, C., Moretti, S., Cunha, C., Giovannini, G., Massi-Benedetti, C., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60862 · Cited by 77 · see citing works
Antitumor immune responses mediated by dendritic cells: How signals derived from dying cancer cells drive antigen cross-presentation
Spel, L., Boelens, J. J., Nierkens, S., & Boes, M. L. (2013) · OncoImmunology · doi:10.4161/onci.26403 · Cited by 74 · see citing works
Human natural killer cells promote cross‐presentation of tumor cell‐derived antigens by dendritic cells
Deauvieau, F., Ollion, V., Doffin, A., Achard, C., Fonteneau, J., Verronèse, E., Durand, I., Ghittoni, R., Marvel, J., Dezutter‐Dambuyant, C., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29087 · Cited by 74 · see citing works
Viral interactions with macroautophagy: A double-edged sword
Lin, L., Dawson, P. W. H., & Richardson, C. D. (2010) · Virology · doi:10.1016/j.virol.2010.03.026 · Cited by 74 · see citing works
Alternative pathways for MHC class I presentation: a new function for autophagy
Chemali, M., Radtke, K., Desjardins, M., & English, L. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0660-3 · Cited by 70 · see citing works
Autophagy: The multi‐purpose bridge in viral infections and host cells
Abdoli, A., Alirezaei, M., Mehrbod, P., & Forouzanfar, F. (2018) · Reviews in Medical Virology · doi:10.1002/rmv.1973 · Cited by 67 · see citing works
Autophagy Shapes Inflammation
Fésüs, L., Demény, M. Á., & Petrovski, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3485 · Cited by 68 · see citing works
Autophagy and Autoimmunity Crosstalks
Bhattacharya, A., & Eissa, N. T. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00088 · Cited by 67 · see citing works
IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion
Herhaus, L., Mato, U. G., Eapen, V. V., Mačinković, I., Bailey, H., Prieto‐Garcia, C., Misra, M., Jacomin, A., Ammanath, A. V., Bagarić, I., et al. (2024) · Cell · doi:10.1016/j.cell.2024.09.048 · Cited by 66 · see citing works
Viral subversion of immunogenic cell death
Kepp, O., Senovilla, L., Galluzzi, L., Panaretakis, T., Schlemmer, F., Madeo, F., Zitvogel, L., & Kroemer, G. (2009) · Cell Cycle · doi:10.4161/cc.8.6.7939 · Cited by 65 · see citing works
Self-citation
Immunogenicity of necrotic cell death
Gamrekelashvili, J., Greten, T. F., & Korangy, F. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1741-x · Cited by 62 · see citing works
Dying to Replicate: The Orchestration of the Viral Life Cycle, Cell Death Pathways, and Immunity
Yatim, N., & Albert, M. L. (2011) · Immunity · doi:10.1016/j.immuni.2011.10.010 · Cited by 60 · see citing works
Self-citation
An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice
Khan, A., Bakhru, P., Saikolappan, S., Das, K., Soudani, E., Singh, C. R., Estrella, J. L., Zhang, D., Pasare, C., Ma, Y., et al. (2019) · npj Vaccines · doi:10.1038/s41541-019-0122-8 · Cited by 61 · see citing works
Autophagy and the regulation of the immune response
Valdor, R., & Macián, F. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.003 · Cited by 62 · see citing works
Cross-presentation by dendritic cells from live cells induces protective immune responses in vivo
Matheoud, D., Perié, L., Hoeffel, G., Vimeux, L., Parent, I., Marañón, C., Bourdoncle, P., Rénia, L., Prévost‐Blondel, A., Lucas, B., et al. (2010) · Blood · doi:10.1182/blood-2009-11-255935 · Cited by 61 · see citing works
Adeno-associated virus capsid antigen presentation is dependent on endosomal escape
Li, C., He, Y., Nicolson, S., Hirsch, M., Weinberg, M. S., Zhang, P., Kafri, T., & Samulski, R. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66611 · Cited by 61 · see citing works
Disruption of Immune Homeostasis in Human Dendritic Cells via Regulation of Autophagy and Apoptosis by Porphyromonas gingivalis
Meghil, M. M., Tawfik, O. K., Elashiry, M., Rajendran, M., Arce, R. M., Fulton, D. J., Schoenlein, P. V., & Cutler, C. W. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02286 · Cited by 60 · see citing works
Exploration of graphene oxide as an intelligent platform for cancer vaccines
Yue, H., Wei, W., Gu, Z., Ni, D., Luo, N., Yang, Z., Zhao, L., Gárate, J. A., Zhou, R., Su, Z., et al. (2015) · Nanoscale · doi:10.1039/c5nr04986e · Cited by 59 · see citing works
Pharmacological regulators of autophagy and their link with modulators of lupus disease
Gros, F., & Muller, S. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12792 · Cited by 57 · see citing works
MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock
Kader, M., Alaoui-El-Azher, M., Vorhauer, J., Kode, B. B., Wells, J. Z., Stolz, D. B., Michalopoulos, G. K., Wells, A. H., Scott, M. J., & Ismail, N. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006644 · Cited by 56 · see citing works
The inducible role of autophagy in cell death: emerging evidence and future perspectives
Huang, X., Yan, H., Xu, Z., Yang, B., Luo, P., & He, Q. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02135-w · Cited by 57 · see citing works
Modulation of the immune microenvironment by tumor-intrinsic oncogenic signaling
Nguyen, K. B., & Spranger, S. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201908224 · Cited by 54 · see citing works
Beclin-1 Targeting for Viral Immune Escape
Münz, C. (2011) · Viruses · doi:10.3390/v3071166 · Cited by 54 · see citing works
Role of autophagy in MHC class I-restricted antigen presentation
Kaer, L. V., Parekh, V. V., Postoak, J. L., & Wu, L. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.10.021 · Cited by 53 · see citing works
Orchestration of the immune response by dendritic cells
Buckwalter, M. R., & Albert, M. L. (2009) · Current Biology · doi:10.1016/j.cub.2009.03.012 · Cited by 51 · see citing works
Self-citation
The Autophagic Machinery in Viral Exocytosis
Münz, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00269 · Cited by 50 · see citing works
Tumor-intrinsic determinants of immunogenic cell death modalities
Workenhe, S. T., Pol, J. G., & Kroemer, G. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1893466 · Cited by 51 · see citing works
Self-citation
Role of autophagy in the host response to microbial infection and potential for therapy
Fabri, M., Realegeno, S. E., Jo, E., & Modlin, R. L. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.10.010 · Cited by 47 · see citing works
Autophagy is involved in regulating the immune response of dendritic cells to influenza A (H1N1) pdm09 infection
Zang, F., Chen, Y., Lin, Z., Cai, Z., Yu, L., Xu, F., Wang, J., Zhu, W., & Lu, H. (2016) · Immunology · doi:10.1111/imm.12587 · Cited by 47 · see citing works
Lysosomotropic agents including azithromycin, chloroquine and hydroxychloroquine activate the integrated stress response
Tian, A.-L., Wu, Q., Liu, P., Zhao, L., Martins, I., Kepp, O., Leduc, M., & Kroemer, G. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03324-w · Cited by 45 · see citing works
Self-citation
Autophagy and selective deployment of Atg proteins in antiviral defense
Yordy, B., Tal, M. C., Hayashi, K., Arojo, O., & Iwasaki, A. (2012) · International Immunology · doi:10.1093/intimm/dxs101 · Cited by 44 · see citing works
Nanopulse Stimulation (NPS) Induces Tumor Ablation and Immunity in Orthotopic 4T1 Mouse Breast Cancer: A Review
Beebe, S. J., Lassiter, B. P., & Guo, S. (2018) · Cancers · doi:10.3390/cancers10040097 · Cited by 43 · see citing works
Current challenges in designing GBM trials for immunotherapy
Weathers, S.-P. S., & Gilbert, M. R. (2015) · Journal of Neuro-Oncology · doi:10.1007/s11060-015-1716-2 · Cited by 42 · see citing works
Checking the garbage bin for problems in the house, or how autophagy assists in antigen presentation to the immune system.
Romão, S., Gannagé, M., & Münz, C. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.03.001 · Cited by 40 · see citing works
The role of autophagy in the pathogenesis of systemic lupus erythematosus.
Liu, X., Qin, H.-H., & Xu, J. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.09.017 · Cited by 37 · see citing works
Autophagy regulation as a promising approach for improving cancer immunotherapy
Ishimwe, N., Zhang, W., Qian, J., Zhang, Y., & Wen, L. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.01.034 · Cited by 37 · see citing works
Concanavalin A/IFN-Gamma Triggers Autophagy-Related Necrotic Hepatocyte Death through IRGM1-Mediated Lysosomal Membrane Disruption
Chang, C., Yang, M.-C., & Lei, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028323 · Cited by 36 · see citing works
Autophagy, autophagy-associated adaptive immune responses and its role in hematologic malignancies
You, L., Jin, S., Zhu, L., & Qian, W. (2016) · Oncotarget · doi:10.18632/oncotarget.13583 · Cited by 35 · see citing works
Nano-Pulse Stimulation Ablates Orthotopic Rat Hepatocellular Carcinoma and Induces Innate and Adaptive Memory Immune Mechanisms that Prevent Recurrence
Lassiter, B. P., Guo, S., & Beebe, S. J. (2018) · Cancers · doi:10.3390/cancers10030069 · Cited by 35 · see citing works
Involvement of autophagy in MHC class I antigen presentation
Øynebråten, I. (2020) · Scandinavian Journal of Immunology · doi:10.1111/sji.12978 · Cited by 34 · see citing works
The Macroautophagy Machinery in MHC Restricted Antigen Presentation
Münz, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628429 · Cited by 35 · see citing works
Primary sterile necrotic cells fail to cross-prime CD8+T cells
Gamrekelashvili, J., Ormandy, L. A., Heimesaat, M. M., Kirschning, C. J., Manns, M. P., Korangy, F., & Greten, T. F. (2012) · OncoImmunology · doi:10.4161/onci.21098 · Cited by 34 · see citing works
Enhancing therapeutic efficacy of oncolytic vaccinia virus armed with Beclin-1, an autophagic Gene in leukemia and myeloma
Lei, W., Wang, S., Xu, N., Chen, Y., Wu, G., Zhang, A., Chen, X., Tong, Y., & Qian, W. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110030 · Cited by 34 · see citing works

Antigen Cross-Priming of Cell-Associated Proteins is Enhanced by Macroautophagy within the Antigen Donor Cell
Joubert, P.-E., & Albert, M. L. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00061 · Cited by 15 · see citing works
Self-citation
Dendritic cells efficiently cross-prime HLA class I-restricted cytolytic T lymphocytes when pulsed with both apoptotic and necrotic cells but not with soluble cell-derived lysates
Ferlazzo, G., Semino, C., Spaggiari, G. M., Meta, M., Mingari, M. C., & Melioli, G. (2000) · International Immunology · doi:10.1093/intimm/12.12.1741 · Cited by 57 · see citing works
Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo
den Haan, J. M. M., Lehar, S. M., & Bevan, M. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1685 · Cited by 1,319 · see citing works
Dying cells actively regulate adaptive immune responses
Yatim, N., Cullen, S., & Albert, M. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.9 · Cited by 442 · see citing works
Self-citation
Type I IFNs Control Antigen Retention and Survival of CD8α+ Dendritic Cells after Uptake of Tumor Apoptotic Cells Leading to Cross-Priming
Lorenzi, S., Mattei, F., Sistigu, A., Bracci, L., Spadaro, F., Sanchez, M., Spada, M., Belardelli, F., Gabriele, L., & Schiavoni, G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004163 · Cited by 134 · see citing works

Authors: Uhl, M., Kepp, O., Jusforgues-Saklani, H., Vicencio, J.-M., Kroemer, G., & Albert, M. L.
Affiliations: Institut Pasteur (FR)
Université Paris-Sud (FR)
Inserm (FR)
Corresponding author: Albert, M L
ORCID: Kepp, O
Kroemer, G
Albert, M L
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2009-02-20
Volume: 16
Issue: 7
Pages: 991-1005
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/cdd.2009.8
OpenAlex: W2093172507
Cited by: 196
References: 67
Citations by year: 2026: 4 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 12 · 2020: 8 · 2019: 12 · 2018: 13 · 2017: 10 · 2016: 16 · 2015: 7 · 2014: 15 · 2013: 18 · 2012: 19
FWCI: 8.19
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Death and Differentiation (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: European Science Foundation
Agence Nationale de la Recherche
Deutsche Krebshilfe
Institut National Du Cancer
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: autophagy, CD8+ T cells, cross-presentation, immunogenic cell death, apoptosis, caspase-independent cell death, ATG5, MHC class I, type I interferon, viral infection, dendritic cells, cancer immunotherapy
MeSH terms: Autophagy-Related Protein 5, Animals, Autophagy, Dendritic Cells, Fibroblasts, Humans, Interferon Type I, Lymphocyte Activation, Major Histocompatibility Complex, Mice, Inbred BALB C, Mice, Inbred C57BL, Microtubule-Associated Proteins, Orthomyxoviridae Infections, Influenza A virus, Apoptosis, Antigen Presentation, Mice, Knockout, CD8-Positive T-Lymphocytes, RNA, Small Interfering, Calreticulin, Cross-Priming, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein, Mice, Gene Knockdown Techniques

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Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells

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