The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
Open accessAbstract
Dysfunctional endothelium contributes to more disease than any other tissue in the body. Small interfering RNAs (siRNAs) have the potential to help study and treat endothelial cells in vivo by durably silencing multiple genes simultaneously, but efficient siRNA delivery has so far remained challenging. Here we show that polymeric nanoparticles made of low molecular weight polyamines and lipids can deliver siRNA to endothelial cells with high efficiency, thereby facilitating the simultaneous silencing of multiple endothelial genes in vivo. Unlike lipid or lipid-like nanoparticles, this formulation does not significantly reduce gene expression in hepatocytes or immune cells even at the dosage necessary for endothelial gene silencing. It mediates the most durable non-liver silencing reported to date, and facilitates the delivery of siRNAs that modify endothelial function in mouse models of vascular permeability, emphysema, primary tumour growth, and metastasis. We believe these nanoparticles improve the ability to study endothelial gene function in vivo, and may be used to treat diseases caused by vascular dysfunction.
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Cites
Knocking down barriers: advances in siRNA delivery
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Rational design of cationic lipids for siRNA delivery
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Self-citationDelivery materials for siRNA therapeutics
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Self-citationMaximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
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Self-citationTargeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
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Platt, R. J., Chen, S., Zhou, Y., Yim, M. J., Swiech, L., Kempton, H. R., Dahlman, J. E., Parnas, O., Eisenhaure, T. M., Jovanovic, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.014 · Cited by 2,001
Self-citationThe current state and future directions of RNAi-based therapeutics
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Metadata
- Authors
- Dahlman, J. E., Barnes, C., Khan, O. F., Thiriot, A., Jhunjunwala, S., Shaw, T. E., Xing, Y., Sager, H. B., Sahay, G., Speciner, L., Bader, A., Bogorad, R. L., Yin, H., Racie, T., Dong, Y., Jiang, S., Seedorf, D., Dave, A., Singh Sandhu, K., Webber, M. J., Novobrantseva, T., Ruda, V. M., Lytton-Jean, A. K. R., Levins, C. G., Kalish, B., Mudge, D. K., Perez, M., Abezgauz, L., Dutta, P., Smith, L., Charisse, K., Kieran, M. W., Fitzgerald, K., Nahrendorf, M., Danino, D., Tuder, R. M., von Andrian, U. H., Akinc, A., Panigrahy, D., Schroeder, A., Koteliansky, V., Langer, R., & Anderson, D. G.
- Venue
- Nature Nanotechnology
- Published
- 2014-05-11
- Volume
- 9
- Issue
- 8
- Pages
- 648-655
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2002050544
- Cited by
- 592
- References
- 9
- FWCI
- 21.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Dahlman, J. E., Barnes, C., Khan, O. F., Thiriot, A., Jhunjunwala, S., Shaw, T. E., Xing, Y., Sager, H. B., Sahay, G., Speciner, L., Bader, A., Bogorad, R. L., Yin, H., Racie, T., Dong, Y., Jiang, S., Seedorf, D., Dave, A., Singh Sandhu, K., . . . Anderson, D. G. (2014). In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nature Nanotechnology. https://doi.org/10.1038/nnano.2014.84
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
