The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
A spatially localized architecture for fast and modular DNA computing
Open accessAbstract
Cells use spatial constraints to control and accelerate the flow of information in enzyme cascades and signalling networks. Synthetic silicon-based circuitry similarly relies on spatial constraints to process information. Here, we show that spatial organization can be a similarly powerful design principle for overcoming limitations of speed and modularity in engineered molecular circuits. We create logic gates and signal transmission lines by spatially arranging reactive DNA hairpins on a DNA origami. Signal propagation is demonstrated across transmission lines of different lengths and orientations and logic gates are modularly combined into circuits that establish the universality of our approach. Because reactions preferentially occur between neighbours, identical DNA hairpins can be reused across circuits. Co-localization of circuit elements decreases computation time from hours to minutes compared to circuits with diffusible components. Detailed computational models enable predictive circuit design. We anticipate our approach will motivate using spatial constraints for future molecular control circuit designs.
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Cites
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Self-citationNUPACK: Analysis and design of nucleic acid systems
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Cited by
Principles and Applications of Nucleic Acid Strand Displacement Reactions
Simmel, F. C., Yurke, B., & Singh, H. R. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00580 · Cited by 792
Fractal assembly of micrometre-scale DNA origami arrays with arbitrary patterns
Tikhomirov, G., Petersen, P., & Qian, L. (2017) · Nature · doi:10.1038/nature24655 · Cited by 507
DNA-based communication in populations of synthetic protocells
Joesaar, A., Yang, S., Bögels, B., van der Linden, A., Pieters, P., Kumar, B. V. V. S. P., Dalchau, N., Phillips, A., Mann, S., & de Greef, T. F. A. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0399-9 · Cited by 331
Self-citationSolving mazes with single-molecule DNA navigators
Chao, J., Wang, J., Wang, F., Ouyang, X., Kopperger, E., Liu, H., Li, Q., Shi, J., Wang, L., Hu, J., et al. (2019) · Nature Materials · doi:10.1038/s41563-018-0205-3 · Cited by 258
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Metadata
- Authors
- Chatterjee, G., Dalchau, N., Muscat, R. A., Phillips, A., & Seelig, G.
- Venue
- Nature Nanotechnology
- Published
- 2017-07-24
- Volume
- 12
- Issue
- 9
- Pages
- 920-927
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2738534387
- Cited by
- 353
- References
- 46
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Chatterjee, G., Dalchau, N., Muscat, R. A., Phillips, A., & Seelig, G. (2017). A spatially localized architecture for fast and modular DNA computing. Nature Nanotechnology. https://doi.org/10.1038/nnano.2017.127
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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