The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Diagnosing breast cancer by using Raman spectroscopy
Open accessAbstract
We employ Raman spectroscopy to diagnose benign and malignant lesions in human breast tissue based on chemical composition. In this study, 130 Raman spectra are acquired from ex vivo samples of human breast tissue (normal, fibrocystic change, fibroadenoma, and infiltrating carcinoma) from 58 patients. Data are fit by using a linear combination model in which nine basis spectra represent the morphologic and chemical features of breast tissue. The resulting fit coefficients provide insight into the chemical/morphological makeup of the tissue and are used to develop diagnostic algorithms. The fit coefficients for fat and collagen are the key parameters in the resulting diagnostic algorithm, which classifies samples according to their specific pathological diagnoses, attaining 94% sensitivity and 96% specificity for distinguishing cancerous tissues from normal and benign tissues. The excellent results demonstrate that Raman spectroscopy has the potential to be applied in vivo to accurately classify breast lesions, thereby reducing the number of excisional breast biopsies that are performed.
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Prospects for in vivo Raman spectroscopy
Hanlon, E. B., Manoharan, R., Koo, T.-W., Shafer, K. E., Motz, J. T., Fitzmaurice, M., Kramer, J. R., Itzkan, I., Dasari, R. R., & Feld, M. S. (2000) · Physics in Medicine and Biology · doi:10.1088/0031-9155/45/2/201 · Cited by 894
Self-citationConcurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement
Ntziachristos, V., Yodh, A. G., Schnall, M., & Chance, B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040570597 · Cited by 793
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Raman Spectroscopy of Normal and Diseased Human Breast Tissues
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Applied Multivariate Techniques
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Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
Huang, X., Neretina, S., & El‐Sayed, M. A. (2009) · Advanced Materials · doi:10.1002/adma.200802789 · Cited by 1,921
Raman Techniques: Fundamentals and Frontiers
Jones, R. R., Hooper, D. C., Zhang, L., Wolverson, D., & Valev, V. K. (2019) · Nanoscale Research Letters · doi:10.1186/s11671-019-3039-2 · Cited by 804
Review of multidimensional data processing approaches for Raman and infrared spectroscopy
Gautam, R., Vanga, S., Ariese, F., & Umapathy, S. (2015) · EPJ Techniques and Instrumentation · doi:10.1140/epjti/s40485-015-0018-6 · Cited by 696
Chemically sensitive bioimaging with coherent Raman scattering
Camp Jr, C. H., & Cicerone, M. T. (2015) · Nature Photonics · doi:10.1038/nphoton.2015.60 · Cited by 472
High-speed coherent Raman fingerprint imaging of biological tissues
Camp Jr, C. H., Lee, Y. J., Heddleston, J. M., Hartshorn, C. M., Walker, A. R. H., Rich, J. N., Lathia, J. D., & Cicerone, M. T. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.145 · Cited by 469
Metadata
- Authors
- Haka, A. S., Shafer-Peltier, K. E., Fitzmaurice, M., Crowe, J., Dasari, R. R., & Feld, M. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-08-22
- Volume
- 102
- Issue
- 35
- Pages
- 12371-12376
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2039897852
- Cited by
- 630
- References
- 22
- FWCI
- 12.95
- Type
- journal article
- Language
- en
- Open access
- green
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