Ventral Striatal Dopamine Modulation of Different Forms of Behavioral Flexibility
Abstract
Different forms of behavioral flexibility are facilitated by interactions between separate regions of the prefrontal cortex and their striatal outputs. However, the contribution of ventral striatal dopamine (DA) to these functions is unclear. The present study assessed the involvement of DA receptors in the nucleus accumbens (NAc) core on either between- or within-strategy shifts using operant chamber-based tasks. Strategy set-shifting required rats initially to learn a visual-cue discrimination and, on the following day, shift to using an egocentric spatial response strategy to obtain reward. For reversal learning, rats were initially trained on a response discrimination and then required to select the opposite lever to receive food reward. Intra-NAc microinfusions of D(1) (SCH23390) but not D(2) (eticlopride) receptor antagonists impaired set-shifting, disrupting the maintenance of a new strategy. Conversely, supranormal activation of D(2) (quinpirole) but not D(1) (SKF81297) receptors also impaired set-shifting, inducing perseverative deficits. However, only infusions of the D(2) agonist impaired reversal learning, but did so without disrupting initial response learning. Thus, mesoaccumbens DA, acting on D(1) receptors, selectively facilitates complex forms of flexibility requiring shifts between different strategies, but does not appear to contribute to simpler forms of flexibility entailing shifts of specific stimulus-reward associations. In contrast, abnormal increases…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lesions to the nucleus accumbens can produce perseverative responding, impair reversal learning, and reduce behavioural switching.
“Lesions to the nucleus accumbens can produce perseverative responding, impair reversal learning, and reduce behavioural switching [69–71].”
Cites
Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
Goto, Y., & Grace, A. A. (2005) · Nature Neuroscience · doi:10.1038/nn1471 · Cited by 576 · see citing works
Boulougouris, V., Dalley, J. W., & Robbins, T. W. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.005 · Cited by 297 · see citing works
Ragozzino, M. E. (2002) · Learning & Memory · doi:10.1101/lm.45802 · Cited by 174 · see citing works
Collins, P., Wilkinson, L. S., Everitt, B. J., Robbins, T. W., & Roberts, A. C. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.1.3 · Cited by 129 · see citing works
Rodefer, J. S., Nguyen, T. N., Karlsson, J.-J., & Arnt, J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301654 · Cited by 126 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control
Cools, R., & D'Esposito, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.028 · Cited by 1,673 · see citing works
The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action
Floresco, S. B. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115159 · Cited by 938 · see citing works
Self-citationDissecting impulsivity and its relationships to drug addictions
Jentsch, J. D., Ashenhurst, J. R., Cervantes, M. C., Groman, S. M., James, A. S., & Pennington, Z. T. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12388 · Cited by 281 · see citing works
Dopaminergic control of cognitive flexibility in humans and animals
Klanker, M., Feenstra, M., & Denys, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00201 · Cited by 209 · see citing works
Gass, J. T., Glen, W. B., McGonigal, J. T., Trantham-Davidson, H., Lopez, M. F., Randall, P. K., Yaxley, R., Floresco, S. B., & Chandler, L. J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.109 · Cited by 197 · see citing works
Self-citationEnomoto, T., Tse, M. T., & Floresco, S. B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.038 · Cited by 179 · see citing works
Self-citationPrefrontal cortex executive processes affected by stress in health and disease
Girotti, M., Adler, S. M., Bulin, S. E., Fucich, E. A., Paredes, D., & Morilak, D. A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.004 · Cited by 176 · see citing works
Hahn, T., Heinzel, S., Dresler, T., Plichta, M. M., Renner, T. J., Markulin, F., Jakob, P. M., Lesch, K., & Fallgatter, A. J. (2011) · Human Brain Mapping · doi:10.1002/hbm.21127 · Cited by 78 · see citing works
Acute stress impairs set-shifting but not reversal learning
Butts, K. A., Floresco, S. B., & Phillips, A. G. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.06.007 · Cited by 77 · see citing works
Self-citationBlum, K., Thompson, B., Demotrovics, Z., Femino, J., Giordano, J., Oscar-Berman, M., Teitelbaum, S., Smith, D. E., Roy, A. K., Agan, G., et al. (2015) · Journal of Reward Deficiency Syndrome · doi:10.17756/jrds.2015-008 · Cited by 73 · see citing works
Klanker, M., Sandberg, T., Joosten, R., Willuhn, I., Feenstra, M., & Denys, D. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.08.011 · Cited by 37 · see citing works
Placek, K., Dippel, W. C., Jones, S., & Brady, A. M. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.034 · Cited by 25 · see citing works
Haddon, J. E., Titherage, D., Heckenast, J. R., Carter, J., Owen, M. J., Hall, J., Wilkinson, L. S., & Jones, M. W. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02969-x · Cited by 6 · see citing works
- Authors
- Haluk, D. M., & Floresco, S. B.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Floresco, Stan B
- ORCID
- Floresco, Stan B
- Venue
- Neuropsychopharmacology
- Published
- 2009-03-04
- Volume
- 34
- Issue
- 8
- Pages
- 2041-2052
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W1994892862
- Cited by
- 195
- References
- 5
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 11 · 2018: 17 · 2017: 10 · 2016: 12 · 2015: 13 · 2014: 17 · 2013: 17 · 2012: 15
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ventral striatum, dopamine, behavioral flexibility, set-shifting, reversal learning, nucleus accumbens, dopamine D1 receptor, dopamine D2 receptor, perseveration, executive function
- MeSH terms
- Animals, Behavior, Animal, Cognition, Conditioning, Operant, Cues, Discrimination Learning, Dopamine, Learning, Neural Pathways, Neuropsychological Tests, Nucleus Accumbens, Photic Stimulation, Receptors, Dopamine, Reward, Thinking, Receptors, Dopamine D1, Receptors, Dopamine D2, Ventral Tegmental Area, Dopamine Agonists, Dopamine Antagonists, Rats, Long-Evans, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
