Impairments in set-shifting but not reversal learning in the neonatal ventral hippocampal lesion model of schizophrenia: further evidence for medial prefrontal deficits
Abstract
The executive function processes of set-shifting and reversal learning in rodents are mediated by the medial prefrontal cortex and the orbitofrontal cortex, respectively. Here, we investigated both set-shifting and reversal learning in a developmental animal model of schizophrenia, the neonatal ventral hippocampal lesion (NVHL) model. The NVHL manipulation is known to disrupt development of the medial prefrontal cortex, and to impair behaviors dependent on this area, but potential orbitofrontal abnormalities and reversal learning deficits are less well studied. Animals received excitotoxic lesions of the ventral hippocampus (NVHL) or a sham treatment during the first postnatal week, and all animals were subsequently tested in adulthood on either an operant set-shifting or an operant reversal task. Results indicated that NVHL animals were able to acquire a simple discrimination rule and exhibited normal reversal learning, but were impaired on a prefrontal-dependent set-shifting task. Furthermore, this set-shifting deficit was due to an increase in perseverative errors, which indicate difficulty suppressing a previously learned strategy and result from medial prefrontal insult. Together, these results confirm and extend the idea that cognitive impairments in the NVHL animal are primarily driven by medial prefrontal abnormalities, while the orbitofrontal cortex may remain relatively unaffected.
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Reversal learning depends on an intact orbitofrontal cortex to inhibit the previously learned response.
“Such reversal is known to depend on an intact orbitofrontal cortex to inhibit the prior learned response (Placek et al., 2013; Rolls, 2016).”
From The effects of early life stress on reward processing (2018) · cites this paper as Placek et al., 2013
Cites
Abstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003 · see citing works
van Os, J., & Kapur, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60995-8 · Cited by 1,971 · see citing works
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636 · see citing works
Medial Frontal Cortex Mediates Perceptual Attentional Set Shifting in the Rat
Birrell, J. M., & Brown, V. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04320.2000 · Cited by 1,421 · see citing works
Identification of separable cognitive factors in schizophrenia
Nuechterlein, K. H., Barch, D. M., Gold, J. M., Goldberg, T. E., Green, M. F., & Heaton, R. K. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.09.007 · Cited by 1,304 · see citing works
Jay, T. M., & Witter, M. P. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903130404 · Cited by 841 · see citing works
Lipska, B. K., Jaskiw, G. E., & Weinberger, D. R. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.44 · Cited by 697 · see citing works
To Model a Psychiatric Disorder in Animals Schizophrenia As a Reality Test
Lipska, B. K. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00137-8 · Cited by 650 · see citing works
Fellows, L. K. (2003) · Brain · doi:10.1093/brain/awg180 · Cited by 631 · see citing works
Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat
McAlonan, K., & Brown, V. J. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.019 · Cited by 618 · see citing works
Hornak, J., O'Doherty, J., Bramham, J., Rolls, E. T., Morris, R. G., Bullock, P. R., & Polkey, C. E. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/089892904322926791 · Cited by 603 · see citing works
Dias, R., Robbins, T. W., & Roberts, A. C. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09285.1997 · Cited by 555 · see citing works
Ragozzino, M. E., Detrick, S., & Kesner, R. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04585.1999 · Cited by 553 · see citing works
RAGOZZINO, M. E. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.013 · Cited by 482 · see citing works
Frontal-striatal cognitive deficits in patients with chronic schizophrenia
Pantelis, C. (1997) · Brain · doi:10.1093/brain/120.10.1823 · Cited by 430 · see citing works
Tunbridge, E. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1124-04.2004 · Cited by 418 · see citing works
Floresco, S. B., Block, A. E., & Tse, M. T. L. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.008 · Cited by 405 · see citing works
Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting
Floresco, S. B., Magyar, O., Ghods-Sharifi, S., Vexelman, C., & Tse, M. T. L. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300825 · Cited by 395 · see citing works
PRICE, J. L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.008 · Cited by 395 · see citing works
Using fMRI to decompose the neural processes underlying the Wisconsin Card Sorting Test
Lie, C., Specht, K., Marshall, J. C., & Fink, G. R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.10.031 · Cited by 388 · see citing works
Moore, H. M., Jentsch, J. D., Ghajarnia, M., Geyer, M. A., & Grace, A. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.003 · Cited by 359 · see citing works
Bissonette, G. B., Martins, G. J., Franz, T. M., Harper, E. S., Schoenbaum, G., & Powell, E. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2820-08.2008 · Cited by 353 · see citing works
Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damage
Pantelis, C., Barber, F. Z., Barnes, T. R. E., Nelson, H. E., Owen, A. M., & Robbins, T. W. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00156-x · Cited by 347 · see citing works
Sams-Dodd, F., Lipska, B. K., & Weinberger, D. R. (1997) · Psychopharmacology · doi:10.1007/s002130050349 · Cited by 346 · see citing works
The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia
Tseng, K. Y., Chambers, R. A., & Lipska, B. K. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.039 · Cited by 336 · see citing works
Waltz, J. A., & Gold, J. M. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.03.010 · Cited by 331 · see citing works
Neural circuits subserving behavioral flexibility and their relevance to schizophrenia
Floresco, S. B., Zhang, Y., & Enomoto, T. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.001 · Cited by 298 · see citing works
Flores, G., Alquicer, G., Gómez, A. B. S., Zaldivar, G. A., Stewart, J., Quirion, R., & Srivastava, L. K. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.021 · Cited by 220 · see citing works
Leeson, V. C., Robbins, T. W., Matheson, E., Hutton, S. B., Ron, M. A., Barnes, T. R. E., & Joyce, E. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.016 · Cited by 219 · see citing works
Block, A. E., Dhanji, H., Thompson-Tardif, S. F., & Floresco, S. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl073 · Cited by 215 · see citing works
Dissociable Roles for the Nucleus Accumbens Core and Shell in Regulating Set Shifting
Floresco, S., Ghods-Sharifi, S., Vexelman, C., & Magyar, O. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4431-05.2006 · Cited by 214 · see citing works
Neonatal Damage of the Ventral Hippocampus Impairs Working Memory in the Rat
Lipska, B. K. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00282-8 · Cited by 211 · see citing works
Cognitive Effects of Neonatal Hippocampal Lesions in a Rat Model of Schizophrenia
Chambers, R. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00132-7 · Cited by 210 · see citing works
Ventral Striatal Dopamine Modulation of Different Forms of Behavioral Flexibility
Haluk, D. M., & Floresco, S. B. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.21 · Cited by 195 · see citing works
Enomoto, T., Tse, M. T., & Floresco, S. B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.038 · Cited by 179 · see citing works
Ghods-Sharifi, S., Haluk, D. M., & Floresco, S. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.10.007 · Cited by 178 · see citing works
Ragozzino, M. E. (2002) · Learning & Memory · doi:10.1101/lm.45802 · Cited by 174 · see citing works
O'Donnell, P. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.9.975 · Cited by 172 · see citing works
Glutamate receptors in the rat medial prefrontal cortex regulate set-shifting ability
Stefani, M. R., Groth, K., & Moghaddam, B. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.4.728 · Cited by 164 · see citing works
More Is Less: A Disinhibited Prefrontal Cortex Impairs Cognitive Flexibility
Gruber, A. J., Calhoon, G. G., Shusterman, I., Schoenbaum, G., Roesch, M. R., & O'Donnell, P. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4623-10.2010 · Cited by 160 · see citing works
Reinforcement and Reversal Learning in First-Episode Psychosis
Murray, G. K., Cheng, F., Clark, L., Barnett, J. H., Blackwell, A. D., Fletcher, P. C., Robbins, T. W., Bullmore, E. T., & Jones, P. B. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn078 · Cited by 159 · see citing works
Smith, A. B., Taylor, E., Brammer, M., & Rubia, K. (2004) · Human Brain Mapping · doi:10.1002/hbm.20007 · Cited by 152 · see citing works
Tseng, K. Y., Lewis, B. L., Hashimoto, T., Sesack, S. R., Kloc, M., Lewis, D. A., & O'Donnell, P. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4166-08.2008 · Cited by 144 · see citing works
Stefani, M. R., & Moghaddam, B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1656-06.2006 · Cited by 142 · see citing works
Genetic variation in vulnerability to the behavioral effects of neonatal hippocampal damage in rats.
Lipska, B., & Weinberger, D. R. (1995) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.92.19.8906 · Cited by 138 · see citing works
Tseng, K.-Y., Lewis, B. L., Lipska, B. K., & O’Donnell, P. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.012 · Cited by 132 · see citing works
Performance of patients with schizophrenia on the Wisconsin Card Sorting Test (WCST).
Everett, J. L., Lavoie, K., Gagnon, J., & Gosselin, N. (2001) · PubMed Central · Cited by 125 · see citing works
McLean, S. L., Grayson, B., Harris, M., Protheroe, C., Woolley, M. L., & Neill, J. C. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108093842 · Cited by 118 · see citing works
Featherstone, R. E., Rizos, Z., Nóbrega, J. N., Kapur, S., & Fletcher, P. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301223 · Cited by 111 · see citing works
Adolescent Maturation of Cortical Dopamine
O’Donnell, P. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9157-3 · Cited by 107 · see citing works
Schobel, S., Kelly, M. A., Corcoran, C. M., Heertum, K. V., Seckinger, R. A., Goetz, R. R., Harkavy‐Friedman, J., & Malaspina, D. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.07.016 · Cited by 102 · see citing works
Gastambide, F., Côtel, M.-C., Gilmour, G., O’Neill, M. J., Robbins, T. W., & Tricklebank, M. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.298 · Cited by 101 · see citing works
Neurocognitive deficits and prefrontal cortical atrophy in patients with schizophrenia
Bonilha, L., Molnar, C., Horner, M. D., Anderson, B. S., Forster, L., George, M. S., & Nahas, Z. H. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.11.023 · Cited by 94 · see citing works
Delayed Mesolimbic System Alteration in a Developmental Animal Model of Schizophrenia
Goto, Y., & O’Donnell, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09070.2002 · Cited by 92 · see citing works
Pen, G. L., Grottick, A. J., Higgins, G. A., Martin, J. R., Jenck, F., & Moreau, J. (2000) · Behavioural Pharmacology · doi:10.1097/00008877-200006000-00009 · Cited by 84 · see citing works
Set shifting and reversal learning in patients with bipolar disorder or schizophrenia
McKirdy, J. W., Sussmann, J. E., Hall, J., Lawrie, S. M., Johnstone, E. C., & McIntosh, A. M. (2008) · Psychological Medicine · doi:10.1017/s0033291708004935 · Cited by 81 · see citing works
Lillrank, S., Lipska, B., Kolachana, B., & Weinberger, D. R. (1999) · Journal of neural transmission · doi:10.1007/s007020050150 · Cited by 75 · see citing works
Adolescent rats show cognitive rigidity in a test of attentional set shifting
Newman, L. A., & McGaughy, J. A. (2011) · Developmental Psychobiology · doi:10.1002/dev.20537 · Cited by 68 · see citing works
Broberg, B. V., Dias, R., Glenthoj, B. Y., & Olsen, C. K. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.020 · Cited by 65 · see citing works
Neural correlates of set-shifting: decomposing executive functions in schizophrenia
Wilmsmeier, A., Ohrmann, P., Suslow, T., Siegmund, A., Koelkebeck, K., Rothermundt, M., Kugel, H., Arolt, V., Bauer, J., & Pedersen, A. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.090181 · Cited by 63 · see citing works
Marquis, J., Goulet, S., & Doré, F. Y. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.04.005 · Cited by 57 · see citing works
O’Donnell, P. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.07.005 · Cited by 52 · see citing works
Brady, A. M., Saul, R. D., & Wiest, M. K. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.08.012 · Cited by 50 · see citing works
Self-citationTseng, K. Y., Amin, F., Lewis, B. L., & O’Donnell, P. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.030 · Cited by 43 · see citing works
Chambers, R. A., Sentir, A. M., Conroy, S. K., Truitt, W. A., & Shekhar, A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.006 · Cited by 36 · see citing works
Neonatal ventral hippocampal lesions disrupt set-shifting ability in adult rats
Brady, A. M. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.025 · Cited by 34 · see citing works
Self-citationRyan, R. T., Bhardwaj, S. K., Tse, Y. C., Srivastava, L. K., & Wong, T. P. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs111 · Cited by 24 · see citing works
Chambers, R., Sentir, A. M., & Engleman, E. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1929-1 · Cited by 23 · see citing works
Corda, M. G., Piras, G., & Giorgi, O. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.047 · Cited by 16 · see citing works
Flores, C., Bhardwaj, S. K., Labelle‐Dumais, C., & Srivastava, L. K. (2008) · Synapse · doi:10.1002/syn.20584 · Cited by 10 · see citing works
Marquis, J., Goulet, S., & Doré, F. Y. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.3.629 · Cited by 10 · see citing works
Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways.
Lavenex (2000) · Pure Amsterdam UMC · doi:10.1002/1098-1063(2000)10:4 · Cited by 1 · see citing works
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Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works
“Such reversal is known to depend on an intact orbitofrontal cortex to inhibit the prior learned response (Placek et al., 2013; Rolls, 2016).”
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Girotti, M., Bulin, S. E., & Carreno, F. R. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100670 · Cited by 142 · see citing works
Effects of stress on behavioral flexibility in rodents
Hurtubise, J. L., & Howland, J. G. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.007 · Cited by 79 · see citing works
Operant Procedures for Assessing Behavioral Flexibility in Rats
Brady, A. M., & Floresco, S. (2015) · Journal of Visualized Experiments · doi:10.3791/52387 · Cited by 69 · see citing works
Self-citationPrefrontal cortical GABAergic signaling and impaired behavioral flexibility in aged F344 rats
Beas, B. S., McQuail, J. A., Bañuelos, C., Setlow, B., & Bizon, J. L. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.014 · Cited by 56 · see citing works
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Kätzel, D., Wolff, A. R., Bygrave, A. M., & Bannerman, D. M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.486811 · Cited by 50 · see citing works
Grimm, C., Aksamaz, S., Schulz, S., Teutsch, J., Siciński, P., Liss, B., & Kätzel, D. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0268-6 · Cited by 34 · see citing works
Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior
Chou, A., Morganti, J. M., & Rosi, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151418 · Cited by 31 · see citing works
Sex differences in cognitive flexibility are driven by the estrous cycle and stress-dependent
Gargiulo, A. T., Hu, J., Ravaglia, I. C., Hawks, A., Li, X., Sweasy, K., & Grafe, L. A. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.958301 · Cited by 31 · see citing works
Horváth, G., Liszli, P., Kékesi, G., Büki, A., & Benedek, G. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.039 · Cited by 26 · see citing works
Young, J. W., Winstanley, C. A., Brady, A. M., & Hall, F. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.029 · Cited by 24 · see citing works
Self-citationRao, K. N., Sentir, A. M., Engleman, E. A., Bell, R. L., Hulvershorn, L. A., Breier, A. F., & Chambers, R. A. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4421-8 · Cited by 19 · see citing works
The Neonatal Ventral Hippocampal Lesion (NVHL) Rodent Model of Schizophrenia
Brady, A. M. (2016) · Current Protocols in Neuroscience · doi:10.1002/cpns.15 · Cited by 19 · see citing works
Self-citationQvist, P., Rajkumar, A. P., Redrobe, J. P., Nyegaard, M., Christensen, J., Mors, O. N., Wegener, G., Didriksen, M., & Børglum, A. D. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.03.009 · Cited by 19 · see citing works
Sentir, A. M., Bell, R. L., Engleman, E. A., & Chambers, R. A. (2018) · Addiction Biology · doi:10.1111/adb.12704 · Cited by 19 · see citing works
Beas, B. S., Setlow, B., & Bizon, J. L. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4321-y · Cited by 18 · see citing works
Maas, D. A., Eijsink, V. D., van Hulten, J. A., Panic, R., Weerd, P. D., Homberg, J. R., Vallès, A., Nait‐Oumesmar, B., & Martens, G. J. M. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-00964-0 · Cited by 16 · see citing works
Černotová, D., Stuchlı́k, A., & Svoboda, J. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107477 · Cited by 16 · see citing works
Cole, R. D., Zimmerman, M., Matchanova, A., Kutlu, M. G., Gould, T. J., & Parikh, V. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0574-6 · Cited by 15 · see citing works
Effects of orbitofrontal cortex and ventral hippocampus disconnection on spatial reversal learning
Thonnard, D., Callaerts‐Vegh, Z., & D’Hooge, R. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135711 · Cited by 10 · see citing works
Desai, S. J., Allman, B. L., & Rajakumar, N. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx159 · Cited by 4 · see citing works
Sirotin, B. Z., & Жмеренецкий, К. В. (2003) · PubMed · Cited by 1 · see citing works
Sullivan, E. D. K., Locke, L. N., Wallin, D. J., Khokhar, J. Y., Bragg, E. M., Henricks, A. M., & Doucette, W. T. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.760791 · Cited by 1 · see citing works
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- Authors
- Placek, K., Dippel, W. C., Jones, S., & Brady, A. M.
- Affiliations
- St. Mary's College of Maryland (US)
- Corresponding author
- Brady, Anne Marie
- ORCID
- Placek, Katerina
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 256
- Pages
- 405-413
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W1969309428
- Cited by
- 25
- References
- 72
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 8 · 2015: 1
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- set-shifting, reversal learning, animal models of schizophrenia, medial prefrontal cortex, orbitofrontal cortex, executive function, perseverative errors, excitotoxic lesions, cognitive impairment
- MeSH terms
- Animals, Attention, Disease Models, Animal, Hippocampus, Ibotenic Acid, Reversal Learning, Schizophrenia, Set, Psychology, Rats, Sprague-Dawley, Prefrontal Cortex, Maze Learning, Rats
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