Association between reward‐related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype
Open accessAbstract
The impact of individual differences on human reward processing has been a focus of research in recent years, particularly, as they are associated with a variety of neuropsychiatric diseases including addiction and attention‐deficit/hyperactivity disorder. Studies exploring the neural basis of individual differences in reward sensitivity have consistently implicated the ventral striatum (VS) as a core component of the human reward system. However, the mechanisms of dopaminergic neurotransmission underlying ventral striatal activation as well as trait reward sensitivity remain speculative. We addressed this issue by investigating the triadic interplay between VS reactivity during reward anticipation using functional magnetic resonance imaging, trait reward sensitivity, and dopamine (DA) transporter genotype (40‐bp 3′VNTR of DAT, SLC6A3) affecting synaptic DA neurotransmission. Our results show that DAT variation moderates the association between VS‐reactivity and trait reward sensitivity. Specifically, homozygote carriers of the DAT 10‐repeat allele exhibit a strong positive correlation between reward sensitivity and reward‐related VS activity whereas this relationship is absent in the DAT 9‐repeat allele carriers. We discuss the possibility that this moderation of VS‐trait relation might arise from DAT‐dependent differences in DA availability affecting synaptic plasticity within the VS. Generally, studying the impact of dopaminergic gene variations on the relation between reward‐related brain activity and trait reward sensitivity might facilitate the investigation of complex mechanisms underlying disorders linked to dysregulation of DA neurotransmission. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
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Children with ADHD have reduced NAc activity when anticipating monetary rewards, seen particularly in drug-naive children, carriers of the DAT nine-repeat allele, and in response to seeking gains rather than avoiding losses.
“Children with ADHD have reduced NAc activity when anticipating monetary rewards [18,486,487], which is seen particularly in drug-naive children [490], in carriers of the DAT nine-repeat allele [491], and in response to seeking gains rather than avoiding losses [492].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [491]
This finding confirms previous evidence that genetic variation in DAT1 modulates striatal reward-related activation.
“This finding confirms previous evidence from healthy volunteers that genetic variation in DAT1 modulates striatal reward-related activation.26,49,50”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [50]
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- Authors
- Hahn, T., Heinzel, S., Dresler, T., Plichta, M. M., Renner, T. J., Markulin, F., Jakob, P. M., Lesch, K., & Fallgatter, A. J.
- Affiliations
- University of Würzburg (DE)
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2010-09-15
- Volume
- 32
- Issue
- 10
- Pages
- 1557-1565
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6870133
- OpenAlex
- W2085932859
- Cited by
- 78
- References
- 52
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 9 · 2013: 13 · 2012: 12
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- German Excellence Initiative to the Graduate School of Life Sciences, University of Wuerzburg
- Deutsche Forschungsgemeinschaft (KFO 125/1-2)
- Transregio-SFB (TRR58-C4)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- ventral striatum, dopamine transporter gene, dopamine transporter, reward anticipation, dopamine signaling, synaptic plasticity, addiction, attention deficit hyperactivity disorder
- MeSH terms
- Adolescent, Adult, Basal Ganglia, Brain Mapping, Female, Genotype, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen, Psychometrics, Reward, Sensitivity and Specificity, Minisatellite Repeats, Dopamine Plasma Membrane Transport Proteins, Young Adult
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