Greater insula white matter fiber connectivity in women recovered from anorexia nervosa
Open accessAbstract
Anorexia nervosa is a severe psychiatric disorder associated with reduced drive to eat. Altered taste-reward circuit white matter fiber organization in anorexia nervosa after recovery could indicate a biological marker that alters the normal motivation to eat. Women recovered from restricting-type anorexia (Recovered AN, n = 24, age = 30.3 ± 8.1 years) and healthy controls (n = 24, age = 27.4 ± 6.3 years) underwent diffusion weighted imaging of the brain. Probabilistic tractography analyses calculated brain white matter connectivity (streamlines) as an estimate of fiber connections in taste-reward-related white matter tracts, and microstructural integrity (fractional anisotropy, FA) was assessed using tract-based spatial statistics. Recovered AN showed significantly (range P<0.05-0.001, Bonferroni corrected) greater white matter connectivity between bilateral insula regions and ventral striatum, left insula and middle orbitofrontal cortex (OFC), and right insula projecting to gyrus rectus and medial OFC. Duration of illness predicted connectivity of tracts projecting from the insula to ventral striatum and OFC. Microstructural integrity was lower in Recovered AN in most insula white matter tracts, as was whole-brain FA in parts of the anterior corona radiata, external capsule, and cerebellum (P<0.05, family-wise error-corrected). This study indicates higher structural white matter connectivity, an estimate of fibers connections, in anorexia after recovery in tracts that connect taste-reward processing regions. Greater connectivity together with less-fiber integrity could indicate altered neural activity between those regions, which could interfere with normal food-reward circuit function. Correlations between connectivity and illness duration suggest that connectivity could be a marker for illness severity. Whether greater connectivity can predict prognosis of the disorder requires further study.
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Increased structural connectivity between the insula and striatum is observed in eating disorders.
“Further, increased structural connectivity between the insula and striatum is observed in ED (Frank et al., 2016; Shott et al., 2016).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Shott et al., 2016
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- Authors
- Shott, M. E., Pryor, T. L., Yang, T. T., & Frank, G. K. W.
- Affiliations
- University of Colorado Anschutz (US)
- University of California, San Francisco (US)
- Venue
- Neuropsychopharmacology
- Published
- 2015-06-16
- Volume
- 41
- Issue
- 2
- Pages
- 498-507
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5130125
- OpenAlex
- W911261592
- Cited by
- 62
- References
- 55
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 11 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 2
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH085734, R01MH096777, R01MH103436, K23MH080135)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- anorexia nervosa, recovery from anorexia, insula, white matter connectivity, ventral striatum, orbitofrontal cortex, gyrus rectus, fractional anisotropy, microstructural integrity, disease duration, women, eating motivation, biomarkers
- MeSH terms
- Adult, Anorexia Nervosa, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Neural Pathways, Reward, Time Factors, Anisotropy, Diffusion Magnetic Resonance Imaging, Taste Perception, White Matter
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