Anatomical and Functional Connectivity of Cytoarchitectonic Areas within the Human Parietal Operculum
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In monkeys, the somatosensory cortex on the parietal operculum can be differentiated into several distinct cortical fields. Potential human homologues for these areas have already been defined by cytoarchitectonic mapping and functional imaging experiments. Differences between the two most widely studied areas [operculum parietale (OP) 1 and OP 4] within this region particularly pertain to their connection with either the perceptive parietal network or the frontal motor areas. In the present study, we investigated differences in anatomical connection patterns probed by probabilistic tractography on diffusion tensor imaging data. Functional connectivity was then mapped by coordinate-based meta-analysis of imaging studies. Comparison between these two aspects of connectivity showed a good congruency and hence converging evidence for an involvement of these areas in matching brain networks. There were, however, also several instances in which anatomical and functional connectivity diverged, underlining the independence of these measures and the need for multimodal characterization of brain connectivity. The connectivity analyses performed showed that the two largest areas within the human parietal operculum region display considerable differences in their connectivity to frontoparietal brain regions. In particular, relative to OP 1, area OP 4 is more closely integrated with areas responsible for basic sensorimotor processing and action control, while OP 1 is more closely connected to the parietal networks for higher order somatosensory processing. These results are largely congruent with data on nonhuman primates. Differences between anatomical and functional connectivity as well as between species, however, highlight the need for an integrative view on connectivity, including comparison and cross-validation of results from different approaches.
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Joint anatomical and functional MRI evidence suggests that OP4 is densely connected with frontal premotor regions and may subserve aspects of sensorimotor integration.
“Joint anatomical and functional MRI evidence suggests that OP4 is densely connected with frontal premotor regions and may subserve aspects of sensorimotor integration (Eickhoff et al. 2010).”
From Neuroanatomical correlates of peripersonal space: bridging the gap between perception, action, emotion and social cognition (2024) · cites this paper as Eickhoff et al. 2010
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Tonic somatosensory responses and deficits of tactile awareness converge in the parietal operculum
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van ‘t Veer, A. E., Thijssen, S., Witteman, J., van IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz018 · Cited by 25 · see citing works
Basile, G. A., Tatti, E., Bertino, S., Milardi, D., Genovese, G., Bruno, A., Muscatello, M. R. A., Ciurleo, R., Cerasa, A., Quartarone, A., et al. (2024) · Brain Structure and Function · doi:10.1007/s00429-024-02781-9 · Cited by 24 · see citing works
“…as well as their spatial position (such as PoCG, SII, LOC, or cerebellar lobule VI) (lriki et al. 1996; Disbrow et al. 2000; Grodd et al. 2001 ; Eickhoff et al. 2010; Ber-nasconi et al. 2018; Sonobe et al. 2023), visual and auditory space representation and movement detection (such as PT, STS,…”
BackgroundInfluential
- Authors
- Eickhoff, S. B., Jbabdi, S., Caspers, S., Laird, A. R., Fox, P. T., Zilles, K., & Behrens, T. E. J.
- Affiliations
- RWTH Aachen University (DE)
- Forschungszentrum Jülich (DE)
- The University of Texas at San Antonio Health Science Center (US)
- John Radcliffe Hospital (GB)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-05-05
- Volume
- 30
- Issue
- 18
- Pages
- 6409-6421
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4791040
- OpenAlex
- W1968770448
- Cited by
- 352
- References
- 7
- Citations by year
- 2026: 15 · 2025: 9 · 2024: 13 · 2023: 7 · 2022: 15 · 2021: 19 · 2020: 28 · 2019: 19 · 2018: 26 · 2017: 21 · 2016: 32 · 2015: 37 · 2014: 29 · 2013: 34 · 2012: 22
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH074457, MH074457-01A1, MH074457)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- parietal operculum, somatosensory cortex, cytoarchitecture, structural connectivity, functional connectivity, probabilistic tractography, coordinate-based meta-analysis, frontoparietal network, action control, sensorimotor processing
- MeSH terms
- Adult, Brain Mapping, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Male, Neural Pathways, Parietal Lobe, Databases, Factual
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