Evidence for thalamocortical circuit abnormalities and associated cognitive dysfunctions in underweight individuals with anorexia nervosa
Open accessAbstract
Anorexia nervosa (AN) is characterized by extremely low body weight resulting from pathological food restriction, and carries a mortality rate among the highest of any psychiatric illness. AN, particularly during the acute, underweight state of the illness, has been associated with abnormalities across a range of brain regions, including the frontal cortex and basal ganglia. Few studies of AN have investigated the thalamus, a key mediator of information flow through frontal-basal ganglia circuit loops. We examined both thalamic surface morphology using anatomical MRI and thalamo-frontal functional connectivity using resting-state functional MRI. Individuals with AN (n=28) showed localized inward deformations of the thalamus relative to healthy controls (HC, n=22), and abnormal functional connectivity between the thalamus and the dorsolateral and anterior prefrontal cortices. Alterations in thalamo-frontal connectivity were associated with deficits in performance on tasks probing cognitive control (Stroop task) and working memory (Letter-Number Sequencing (LNS) task). Our findings suggest that abnormalities in thalamo-frontal circuits may have a role in mediating aspects of cognitive dysfunction in underweight individuals with AN.
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AN patients show reduced fractional anisotropy in the medial dorsal thalamic radiations.
“and reduced fractional anisotrophy in the medial dorsal thalamic radiations (Biezonski et al., 2015; Hayes et al., 2015).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Biezonski et al., 2015
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“On DTI, AN patients show abnormal thalamic connectivity to the dlPFC and anterior PFC (Frieling et al., 2012; Hayes et al., 2015), and reduced fractional anisotrophy in the medial dorsal thalamic radiations (Biezonski et al., 2015; Hayes et al., 2015).”
BackgroundResting‐state connectivity within and across neural circuits in anorexia nervosa
Uniacke, B., Wang, Y., Biezonski, D., Sussman, T., Lee, S., Posner, J., & Steinglass, J. (2019) · Brain and Behavior · doi:10.1002/brb3.1205 · Cited by 31 · see citing works
Self-citation
- Authors
- Biezonski, D., Cha, J., Steinglass, J., & Posner, J.
- Affiliations
- New York State Psychiatric Institute (US)
- Corresponding author
- Biezonski, Dominik
- Venue
- Neuropsychopharmacology
- Published
- 2015-10-14
- Volume
- 41
- Issue
- 6
- Pages
- 1560-1568
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC4832017
- OpenAlex
- W2332561913
- Cited by
- 58
- References
- 56
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 4
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Klarman Family Foundation
- National Institute of Mental Health (K23MH076195, K23 MH76195, MH091249, R21MH099388, MH099388, K23MH091249)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- anorexia nervosa, thalamus, cognitive impairment, cognitive control, working memory, dorsolateral prefrontal cortex, anterior prefrontal cortex, underweight, resting-state functional connectivity, Stroop task, letter-number sequencing
- MeSH terms
- Adolescent, Adult, Anorexia Nervosa, Cerebral Cortex, Cognition Disorders, Female, Humans, Magnetic Resonance Imaging, Neural Pathways, Neuropsychological Tests, Thalamus, Thinness, Case-Control Studies, Young Adult, Functional Neuroimaging
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