The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Studying synapses in human brain with array tomography and electron microscopy
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Array tomography allows a 70nm axial resolution, which enables the identification of single synaptic terminals in three dimensions.
“Array tomography allows us to reach a 70nm axial resolution, which enables the identification of single synaptic terminals in three dimensions [31].”
From Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease (2024) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
de Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.033 · Cited by 1,427
Self-citationMicheva, K. D., & Smith, S. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.014 · Cited by 787
Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β
Koffie, R. M., Hashimoto, T., Tai, H.-C., Kay, K. R., Serrano-Pozo, A., Joyner, D., Hou, S., Kopeikina, K. J., Frosch, M. P., Lee, V. M., et al. (2012) · Brain · doi:10.1093/brain/aws127 · Cited by 327
Self-citationPseudoreplication is (still) a problem.
Freeberg, T. M., & Lucas, J. R. (2009) · Journal of Comparative Psychology · doi:10.1037/a0017031 · Cited by 37
Flagged first, then by citations
Research works printed but not linked: 32
- Morrison, J.H. & Baxter, M.G. The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat. Rev. Neurosci. 13, 240–250 (2012). · DOI · Paper page
- Koffie, R.M., Hyman, B.T. & Spires-Jones, T.L. Alzheimer′s disease: synapses gone cold. Mol. Neurodegener. 6, 63 (2011). · DOI
- Mayhew, T.M. How to count synapses unbiasedly and efficiently at the ultrastructural level: proposal for a standard sampling and counting protocol. J. Neurocytol. 25, 793–804 (1996). · DOI
- Mayhew, T.M., Muhlfeld, C., Vanhecke, D. & Ochs, M. A review of recent methods for efficiently quantifying immunogold and other nanoparticles using TEM sections through cells, tissues and organs. Ann. Anat. 191, 153–170 (2009). · DOI
- Scheff, S.W., Price, D.A. & Sparks, D.L. Quantitative assessment of possible age-related change in synaptic numbers in the human frontal cortex. Neurobiol. Aging 22, 355–365 (2001). · DOI
- Pawley, J.B. Handbook of Biological Confocal Microscopy (Springer, 2006). · DOI
- Holtmaat, A. et al. Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nat. Protoc. 4, 1128–1144 (2009). · DOI
- Kuchibhotla, K.V. et al. Aβ plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron 59, 214–225 (2008). · DOI · Paper page
- Wakabayashi, K., Honer, W. & Masliah, E. Synapse alterations in the hippocampal-entorhinal formation in Alzheimer′s disease with and without Lewy body disease. Brain Res. 667, 24–32 (1994). · DOI
- Moore, D. et al. Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment. AIDS 20, 879–887 (2006). · DOI
- DeKosky, S., Scheff, S. & Styren, S. Structural correlates of cognition in dementia: quantification and assessment of synapse change. Neurodegeneration 5, 417–421 (1996). · DOI · Paper page
- Masliah, E., Terry, R., Alford, M., DeTeresa, R. & Hansen, L. Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer′s disease. Am. J. Pathol. 138, 235–246 (1991).
- Clare, R., King, V., Wirenfeldt, M. & Vinters, H. Synapse loss in dementias. J. Neurosci. Res. 88, 2083–2090 (2010). · DOI · Paper page
- Tai, H.-C. et al. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am. J. Pathol. 181, 1426–1435 (2012). · DOI · Paper page
- Micheva, K.D., Busse, B., Weiler, N.C., O′Rourke, N. & Smith, S.J. Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers. Neuron 68, 639–653 (2010). · DOI
- Koffie, R.M. et al. Oligomeric amyloid-β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc. Natl. Acad. Sci. USA 106, 4012–4017 (2009). · DOI · Paper page
- Kopeikina, K.J. et al. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human AD brain. Am. J. Pathol. 179, 2071–2082 (2011). · DOI
- Soiza-Reilly, M. & Commons, K.G. Quantitative analysis of glutamatergic innervation of the mouse dorsal raphe nucleus using array tomography. J. Comp. Neurol. 519, 3802–3814 (2011). · DOI
- Nanguneri, S., Flottmann, B., Horstmann, H., Heilemann, M. & Kuner, T. Three-dimensional, tomographic super-resolution fluorescence imaging of serially sectioned thick samples. PLoS ONE 7, e38098 (2012). · DOI
- Kopeikina, K.J. et al. Synaptic alterations in the rTg4510 mouse model of tauopathy. J. Comp. Neurol. 521, 1334–1353 (2013). · DOI
- Lacey, C.J., Bryant, A., Brill, J. & Huguenard, J.R. Enhanced NMDA receptor-dependent thalamic excitation and network oscillations in stargazer mice. J. Neurosci. 32, 11067–11081 (2012). · DOI
- Oberti, D., Kirschmann, M.A. & Hahnloser, R.H. Projection neuron circuits resolved using correlative array tomography. Front Neurosci. 5, 50 (2011). · DOI
- Oberti, D., Kirschmann, M.A. & Hahnloser, R.H. Correlative microscopy of densely labeled projection neurons using neural tracers. Front Neuroanat. 4, 24 (2010).
- Robles, E., Smith, S.J. & Baier, H. Characterization of genetically targeted neuron types in the zebrafish optic tectum. Front Neural Circuits 5, 1 (2011). · DOI · Paper page
- Saatchi, S. et al. Three-dimensional microstructural changes in murine abdominal aortic aneurysms quantified using immunofluorescent array tomography. J. Histochem. Cytochem. 60, 97–109 (2012). · DOI
- Winkler, M. et al. High resolution three-dimensional reconstruction of the collagenous matrix of the human optic nerve head. Brain Res. Bull. 81, 339–348 (2010). · DOI
- Vonsattel, J. et al. An improved approach to prepare human brains for research. J. Neuropathol. Exp. Neurol. 54, 42–56 (1995). · DOI
- Wright, A.K., Wishart, T.M., Ingham, C.A. & Gillingwater, T.H. Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose. PLoS ONE 5, e15108 (2010). · DOI
- Rudinskiy, N. et al. Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer′s disease. Nat. Neurosci. 15, 1422–1429 (2012). · DOI · Paper page
- Thevenaz, P., Ruttimann, U.E. & Unser, M. A pyramid approach to subpixel registration based on intensity. IEEE Trans Image Process 7, 27–41 (1998). · DOI
- Koch, S. et al. Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis. J. Neuropathol. Exp. Neurol. 70, 1089–1096 (2011). · DOI
- Gillingwater, T. et al. Delayed synaptic degeneration in the CNS of WldS mice after cortical lesion. Brain 129, 1546–1556 (2006). · DOI
Cited by
Sorted by citations
Wang, D., Cao, L., Zhou, X., Wang, G., Ma, Y., Hao, X., & Fan, H. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129381 · Cited by 186
Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease
Walker, C. K., & Herskowitz, J. H. (2021) · The Neuroscientist · doi:10.1177/1073858420945964 · Cited by 86
Imaging Synaptic Density: The Next Holy Grail of Neuroscience?
Serrano, M. E., Kim, E., Petrinovic, M. M., Turkheimer, F., & Cash, D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.796129 · Cited by 67
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
Colom-Cadena, M., Toombs, J., Simzer, E., Holt, K., McGeachan, R., Tulloch, J., Jackson, R. J., Catterson, J. H., Spires-Jones, M. P., Rose, J., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-023-02679-6 · Cited by 44
Self-citationOpposing Roles of apolipoprotein E in aging and neurodegeneration
Hudry, E., Klickstein, J., Cannavo, C., Jackson, R., Muzikansky, A., Gandhi, S., Urick, D., Sargent, T., Wrobleski, L., Roe, A. D., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201900325 · Cited by 30
Self-citation
Metadata
- Authors
- Kay, K. R., Smith, C., Wright, A. K., Serrano-Pozo, A., Pooler, A. M., Koffie, R., Bastin, M. E., Bak, T. H., Abrahams, S., Kopeikina, K. J., McGuone, D., Frosch, M. P., Gillingwater, T. H., Hyman, B. T., & Spires-Jones, T. L.
- Venue
- Nature Protocols
- Published
- 2013-06-20
- Volume
- 8
- Issue
- 7
- Pages
- 1366-1380
- ISSN
- 1754-2189
- 1750-2799
- PMC
- PMC3712649
- Cited by
- 116
- References
- 4
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review