Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

Cognitive reserve in ageing and Alzheimer's disease

Stern, Y. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70191-6 · Cited by 3,557 · cited 1× · see citing works

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459 · see citing works

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · see citing works

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works

Structural basis of long-term potentiation in single dendritic spines

Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

Jansen, I. E., Savage, J. E., Watanabe, K., Bryois, J., Williams, D. M., Steinberg, S., Sealock, J., Karlsson, I. K., Hägg, S., Athanasiu, L., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0311-9 · Cited by 2,277 · see citing works

Experience-dependent structural synaptic plasticity in the mammalian brain

Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934 · see citing works

Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

Trachtenberg, J. T., Chen, B. E., Knott, G. W., Feng, G., Sanes, J. R., Welker, E., & Svoboda, K. (2002) · Nature · doi:10.1038/nature01273 · Cited by 1,927 · see citing works

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892 · see citing works

Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons

Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · see citing works

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

Karch, C. M., & Goate, A. M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.006 · Cited by 1,357 · see citing works

Neuropathology of older persons without cognitive impairment from two community-based studies

Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000219668.47116.e6 · Cited by 1,336 · see citing works

Long-term dendritic spine stability in the adult cortex

Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198 · see citing works

Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

Lacor, P. N., Buniel, M. C., Furlow, P. W., Sanz Clemente, A., Velasco, P. T., Wood, M., Viola, K. L., & Klein, W. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3501-06.2007 · Cited by 1,188 · see citing works

Transient and persistent dendritic spines in the neocortex in vivo

Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131 · see citing works

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

Giannakopoulos, P., Herrmann, F. R., Bussière, T., Bouras, C., Kövari, E., Perl, D. P., Morrison, J. H., Gold, G., & Hof, P. R. (2003) · Neurology · doi:10.1212/01.wnl.0000063311.58879.01 · Cited by 1,118 · see citing works

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

Hoover, B. R., Reed, M. N., Su, J., Penrod, R. D., Kotilinek, L. A., Grant, M. K., Pitstick, R., Carlson, G. A., Lanier, L. M., Yuan, L.-L., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.030 · Cited by 1,118 · see citing works

Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses

Zhou, Q., Homma, K. J., & Poo, M.-M. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.011 · Cited by 1,025 · see citing works

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

Scheff, S. W., Price, D. A., Schmitt, F. A., & Mufson, E. J. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.012 · Cited by 1,017 · see citing works

Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence

Hamer, M., & Chida, Y. (2009) · Psychological Medicine · doi:10.1017/s0033291708003681 · Cited by 988 · see citing works

The ageing cortical synapse: hallmarks and implications for cognitive decline

Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965 · see citing works

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.002 · Cited by 938 · see citing works

Age, Neuropathology, and Dementia

Savva, G. M., Wharton, S. B., Ince, P. G., Forster, G., Matthews, F. E., & Brayne, C. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0806142 · Cited by 900 · see citing works

Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation

Ziv, N. E., & Smith, S. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80283-4 · Cited by 863 · see citing works

Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity

Okamoto, K.-I., Nagai, T., Miyawaki, A., & Hayashi, Y. (2004) · Nature Neuroscience · doi:10.1038/nn1311 · Cited by 854 · see citing works

Structure-stability-function relationships of dendritic spines

Kasai, H., Matsuzaki, M., Noguchi, J., Yasumatsu, N., & Nakahara, H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00162-0 · Cited by 847 · see citing works

Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment

Scheff, S. W., Price, D. A., Schmitt, F. A., DeKosky, S. T., & Mufson, E. J. (2007) · Neurology · doi:10.1212/01.wnl.0000260698.46517.8f · Cited by 824 · see citing works

Repeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex

Radley, J. J., Rocher, A. B., Miller, M., Janssen, W. G. M., Liston, C., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi104 · Cited by 820 · see citing works

Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

Roberson, E. D., Halabisky, B., Yoo, J. W., Yao, J., Chin, J., Yan, F., Wu, T., Hamto, P., Devidze, N., Yu, G.-Q., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4152-10.2011 · Cited by 654 · see citing works

Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity

Jaworski, J., Kapitein, L. C., Gouveia, S. M., Dortland, B. R., Wulf, P. S., Grigoriev, I., Camera, P., Spangler, S. A., Di Stefano, P., Demmers, J., et al. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.013 · Cited by 643 · see citing works

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

Bosch, M., Castro, J., Saneyoshi, T., Matsuno, H., Sur, M., & Hayashi, Y. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.021 · Cited by 637 · see citing works

The Postsynaptic Organization of Synapses

Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603 · see citing works

Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight

Shi, Y., & Holtzman, D. M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0051-1 · Cited by 595 · see citing works

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Dejanovic, B., Huntley, M. A., De Mazière, A., Meilandt, W. J., Wu, T., Srinivasan, K., Jiang, Z., Gandham, V., Friedman, B. A., Ngu, H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.014 · Cited by 575 · see citing works

Spine growth precedes synapse formation in the adult neocortex in vivo

Knott, G. W., Holtmaat, A., Wilbrecht, L., Welker, E., & Svoboda, K. (2006) · Nature Neuroscience · doi:10.1038/nn1747 · Cited by 563 · see citing works

Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy

Spires, T. L., Meyer-Luehmann, M., Stern, E. A., McLean, P. J., Skoch, J., Nguyen, P. T., Bacskai, B. J., & Hyman, B. T. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1879-05.2005 · Cited by 550 · see citing works

Physical activity predicts gray matter volume in late adulthood: The Cardiovascular Health Study

Erickson, K. I., Raji, C. A., Lopez, O. L., Becker, J. T., Rosano, C., Newman, A. B., Gach, H. M., Thompson, P. M., Ho, A. J., & Kuller, L. H. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f88359 · Cited by 508 · see citing works

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

Wu, T., Dejanovic, B., Gandham, V. D., Gogineni, A., Edmonds, R., Schauer, S., Srinivasan, K., Huntley, M. A., Wang, Y., Wang, T.-M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.060 · Cited by 466 · see citing works

Changes in the structural complexity of the aged brain

Dickstein, D. L., Kabaso, D., Rocher, A. B., Luebke, J. I., Wearne, S. L., & Hof, P. R. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00289.x · Cited by 460 · see citing works

The small pyramidal neuron of the rat cerebral cortex: The synapses upon dendritic spines

Peters, A., & Kaiserman-Abramof, I. R. (1969) · Zeitschrift f�r Zellforschung und Mikroskopische Anatomie · doi:10.1007/bf00344370 · Cited by 441 · see citing works

Selective Changes in Thin Spine Density and Morphology in Monkey Prefrontal Cortex Correlate with Aging-Related Cognitive Impairment

Dumitriu, D., Hao, J., Hara, Y., Kaufmann, J., Janssen, W. G. M., Lou, W., Rapp, P. R., & Morrison, J. H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6410-09.2010 · Cited by 439 · see citing works

Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex

Zuo, Y., Yang, G., Kwon, E., & Gan, W.-B. (2005) · Nature · doi:10.1038/nature03715 · Cited by 436 · see citing works

Synaptic loss in Alzheimer's disease and other dementias

Hamos, J. E., DeGennaro, L. J., & Drachman, D. A. (1989) · Neurology · doi:10.1212/wnl.39.3.355 · Cited by 432 · see citing works

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging

Chen, M.-K., Mecca, A. P., Naganawa, M., Finnema, S. J., Toyonaga, T., Lin, S.-F., Najafzadeh, S., Ropchan, J., Lu, Y., McDonald, J. W., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.1836 · Cited by 431 · see citing works

Regional Dendritic and Spine Variation in Human Cerebral Cortex: a Quantitative Golgi Study

Jacobs, B. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.6.558 · Cited by 423 · see citing works

Spine-Neck Geometry Determines NMDA Receptor-Dependent Ca2+ Signaling in Dendrites

Noguchi, J., Matsuzaki, M., Ellis-Davies, G. C. R., & Kasai, H. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.015 · Cited by 419 · see citing works

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

Busche, M. A., Wegmann, S., Dujardin, S., Commins, C., Schiantarelli, J., Klickstein, N., Kamath, T. V., Carlson, G. A., Nelken, I., & Hyman, B. T. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0289-8 · Cited by 413 · see citing works

High actin concentrations in brain dendritic spines and postsynaptic densities.

Matus, A., Ackermann, M., Pehling, G., Byers, H. R., & Fujiwara, K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.23.7590 · Cited by 401 · see citing works

Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology

Perez-Nievas, B. G., Stein, T. D., Tai, H.-C., Dols-Icardo, O., Scotton, T. C., Barroeta-Espar, I., Fernandez-Carballo, L., de Munain, E. L., Perez, J., Marquie, M., et al. (2013) · Brain · doi:10.1093/brain/awt171 · Cited by 387 · see citing works

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

DeMattos, R. B., O'dell, M. A., Parsadanian, M., Taylor, J. W., Harmony, J. A. K., Bales, K. R., Paul, S. M., Aronow, B. J., & Holtzman, D. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162228299 · Cited by 359 · see citing works

Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning

Brigman, J. L., Wright, T., Talani, G., Prasad-Mulcare, S., Jinde, S., Seabold, G. K., Mathur, P., Davis, M. I., Bock, R., Gustin, R. M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0640-10.2010 · Cited by 339 · see citing works

Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery

Goldwater, D. S., Pavlides, C., Hunter, R. G., Bloss, E. B., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.053 · Cited by 333 · see citing works

Life Extension Factor Klotho Enhances Cognition

Dubal, D. B., Yokoyama, J. S., Zhu, L., Broestl, L., Worden, K., Wang, D., Sturm, V. E., Kim, D., Klein, E., Yu, G.-Q., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.076 · Cited by 322 · see citing works

Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease

Šišková, Z., Justus, D., Kaneko, H., Friedrichs, D., Henneberg, N., Beutel, T., Pitsch, J., Schoch, S., Becker, A., von der Kammer, H., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.024 · Cited by 320 · see citing works

Principles of Long-Term Dynamics of Dendritic Spines

Yasumatsu, N., Matsuzaki, M., Miyazaki, T., Noguchi, J., & Kasai, H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0603-08.2008 · Cited by 314 · see citing works

Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology

Kim, Y., Sung, J. Y., Ceglia, I., Lee, K.-W., Ahn, J.-H., Halford, J. M., Kim, A. M., Kwak, S. P., Park, J. B., Ho Ryu, S., et al. (2006) · Nature · doi:10.1038/nature04976 · Cited by 307 · see citing works

Synaptic Loss in the Inferior Temporal Gyrus in Mild Cognitive Impairment and Alzheimer's Disease

Scheff, S. W., PRICE, D. A., Schmitt, F. A., Scheff, M. A., & Mufson, E. J. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101782 · Cited by 301 · see citing works

Dendritic spines: from structure to in vivo function

Rochefort, N. L., & Konnerth, A. (2012) · The EMBO Reports · doi:10.1038/embor.2012.102 · Cited by 299 · see citing works

Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.

Masliah, E., Terry, R. D., Alford, M. F., DeTeresa, R. M., & Hansen, L. A. (1991) · PubMed Central · Cited by 296 · see citing works

Different Rho GTPase–dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation

Rex, C. S., Chen, L. Y., Sharma, A., Liu, J., Babayan, A. H., Gall, C. M., & Lynch, G. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200901084 · Cited by 293 · see citing works

Activity-Dependent Dynamic Microtubule Invasion of Dendritic Spines

Hu, X., Viesselmann, C., Nam, S., Merriam, E. B., & Dent, E. W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3074-08.2008 · Cited by 291 · see citing works

Three-Dimensional analysis of dendritic spines

Špaček, J., & Hartmann, M. (1983) · Anatomy and Embryology · doi:10.1007/bf00298517 · Cited by 267 · see citing works

Synapse loss in the temporal lobe in Alzheimer's disease

Scheff, S. W., & PRICE, D. A. (1993) · Annals of Neurology · doi:10.1002/ana.410330209 · Cited by 263 · see citing works

Remodeling of Synaptic Structure in Sensory Cortical AreasIn Vivo

Majewska, A. K., Newton, J. R., & Sur, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4454-05.2006 · Cited by 246 · see citing works

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

Chung, W.-S., Verghese, P. B., Chakraborty, C., Joung, J., Hyman, B. T., Ulrich, J. D., Holtzman, D. M., & Barres, B. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609896113 · Cited by 242 · see citing works

Dendritic spine geometry: functional implication and regulation

Hayashi, Y., & Majewska, A. K. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.006 · Cited by 237 · see citing works

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

Pooler, A. M., Polydoro, M., Maury, E. A., Nicholls, S. B., Reddy, S. M., Wegmann, S., William, C., Saqran, L., Cagsal-Getkin, O., Pitstick, R., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0199-x · Cited by 236 · see citing works

stathmin, a Gene Enriched in the Amygdala, Controls Both Learned and Innate Fear

Shumyatsky, G. P., Malleret, G., Shin, R.-M., Takizawa, S., Tully, K., Tsvetkov, E., Zakharenko, S. S., Joseph, J., Vronskaya, S., Yin, D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.038 · Cited by 235 · see citing works

N-WASP and the Arp2/3 Complex Are Critical Regulators of Actin in the Development of Dendritic Spines and Synapses

Wegner, A. M., Nebhan, C. A., Hu, L., Majumdar, D., Meier, K. M., Weaver, A. M., & Webb, D. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801555200 · Cited by 232 · see citing works

ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons<i>In Vivo</i>

Dumanis, S. B., Tesoriero, J. A., Babus, L. W., Nguyen, M. T., Trotter, J. H., Ladu, M. J., Weeber, E. J., Turner, R. S., Xu, B., Rebeck, G. W., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4026-09.2009 · Cited by 220 · see citing works

Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex

Bloss, E. B., Janssen, W. G., Ohm, D. T., Yuk, F. J., Wadsworth, S., Saardi, K. M., McEwen, B. S., & Morrison, J. H. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0839-11.2011 · Cited by 219 · see citing works

A half century of experimental neuroanatomical tracing

Lanciego, J. L., & Wouterlood, F. G. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.07.001 · Cited by 215 · see citing works

Diffuse plaques do not accentuate synapse loss in Alzheimer's disease.

(1990) · Europe PMC (PubMed Central) · Cited by 209 · see citing works

Immunocytochemical localization of actin and microtubule-associated protein MAP2 in dendritic spines.

Cáceres, A., Payne, M. R., Binder, L. I., & Steward, O. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.6.1738 · Cited by 204 · see citing works

Untitled work

Iacono (2009) · doi:10.1212/wnl.0b013e3181b01077 · Cited by 203 · see citing works

Neuronal Morphology Goes Digital: A Research Hub for Cellular and System Neuroscience

Parekh, R., & Ascoli, G. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.008 · Cited by 202 · see citing works

Regulation of Spine Calcium Dynamics by Rapid Spine Motility

Majewska, A. K., Tashiro, A., & Yuste, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08262.2000 · Cited by 201 · see citing works

Dendritic spines provide cognitive resilience against <scp>A</scp> lzheimer's disease

Boros, B. D., Greathouse, K. M., Gentry, E. G., Curtis, K. A., Birchall, E. L., Gearing, M., & Herskowitz, J. H. (2017) · Annals of Neurology · doi:10.1002/ana.25049 · Cited by 198 · see citing works

Brain Lesions at Autopsy in Older Japanese-American Men as Related to Cognitive Impairment and Dementia in the Final Years of Life: A Summary Report from the Honolulu-Asia Aging Study

White, L. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1178 · Cited by 193 · see citing works

Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo

Pfeiffer, T., Poll, S., Bancelin, S., Angibaud, J., Inavalli, V. K., Keppler, K., Mittag, M., Fuhrmann, M., & Nägerl, U. V. (2018) · eLife · doi:10.7554/elife.34700 · Cited by 192 · see citing works

Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

Dubal, D. B., Zhu, L., Sanchez, P. E., Worden, K., Broestl, L., Johnson, E. C. B., Ho, K., Yu, G.-Q., Kim, D., Bétourné, A., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5791-12.2015 · Cited by 192 · see citing works

Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients

Ji, Y., Gong, Y., Gan, W., Beach, T., Holtzman, D. M., & Wisniewski, T. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.007 · Cited by 189 · see citing works

Synaptic Regulation of Microtubule Dynamics in Dendritic Spines by Calcium, F-Actin, and Drebrin

Merriam, E. B., Millette, M. M., Lumbard, D., Saengsawang, W., Fothergill, T., Hu, X., Ferhat, L., & Dent, E. W. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0661-13.2013 · Cited by 177 · see citing works

In vivo two‐photon uncaging of glutamate revealing the structure–function relationships of dendritic spines in the neocortex of adult mice

Noguchi, J., Nagaoka, A., Watanabe, S., Ellis‐Davies, G. C. R., Kitamura, K., Kano, M., Matsuzaki, M., & Kasai, H. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.207100 · Cited by 173 · see citing works

High-throughput, detailed, cell-specific neuroanatomy of dendritic spines using microinjection and confocal microscopy

Dumitriu, D., Rodriguez, A., & Morrison, J. H. (2011) · Nature Protocols · doi:10.1038/nprot.2011.389 · Cited by 153 · see citing works

Synaptic proteins, neuropathology and cognitive status in the oldest-old

Head, E., Corrada, M. M., Kahle-Wrobleski, K., Kim, R. C., Sarsoza, F., Goodus, M., & Kawas, C. H. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.10.001 · Cited by 145 · see citing works

Cognitive and social lifestyle: links with neuropathology and cognition in late life

Bennett, D. A., Arnold, S. E., Valenzuela, M., Brayne, C., & Schneider, J. A. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1226-2 · Cited by 141 · see citing works

Clinical Correlates of Cortical and Nucleus Basalis Pathology in Alzheimer Dementia

Samuel, W., Terry, R. D., DeTeresa, R. M., Butters, N., & Masliah, E. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540200048015 · Cited by 140 · see citing works

Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)

O'Brien, R. J., Resnick, S. M., Zonderman, A. B., Ferrucci, L., Crain, B. J., Pletnikova, O., Rudow, G., Iacono, D., Riudavets, M. A., Driscoll, I., et al. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1179 · Cited by 137 · see citing works

Of microtubules and memory: implications for microtubule dynamics in dendrites and spines

Dent, E. W. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-11-0769 · Cited by 136 · see citing works

Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer‐induced <scp>AMPA</scp> glutamate receptor signaling deficits

Miller, E. C., Teravskis, P. J., Dummer, B. W., Zhao, X., Huganir, R. L., & Liao, D. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12507 · Cited by 131 · see citing works

Asymptomatic Alzheimers Disease: A Prodrome or a State of Resilience?

Driscoll, I., & Troncoso, J. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745348 · Cited by 130 · see citing works

Interfering with the Actin Network and Its Effect on Long-Term Potentiation and Synaptic Tagging in Hippocampal CA1 Neurons in SlicesIn Vitro

Ramachandran, B., & Frey, J. U. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2045-09.2009 · Cited by 130 · see citing works

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis

Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · see citing works

Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer’s disease

Arnold, S. E., Louneva, N., Cao, K., Wang, L.-S., Han, L.-Y., Wolk, D. A., Negash, S., Leurgans, S. E., Schneider, J. A., Buchman, A. S., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.03.004 · Cited by 123 · see citing works

Studying synapses in human brain with array tomography and electron microscopy

Kay, K. R., Smith, C., Wright, A. K., Serrano‐Pozo, A., Pooler, A. M., Koffie, R. M., Bastin, M. E., Bak, T. H., Abrahams, S., Kopeikina, K. J., et al. (2013) · Nature Protocols · doi:10.1038/nprot.2013.078 · Cited by 114 · see citing works

Association of<i>Klotho</i>-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry<i>APOE4</i>

Belloy, M. E., Napolioni, V., Han, S. S., Le Guen, Y., Greicius, M. D., & Initiative, F. T. A. D. N. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.0414 · Cited by 110 · see citing works

Synaptotoxicity in Alzheimer's Disease Involved a Dysregulation of Actin Cytoskeleton Dynamics through Cofilin 1 Phosphorylation

Rush, T., Hernández, J. M., Dollmeyer, M., Frandemiche, M., Borel, E., Boisseau, S., Jacquier‐Sarlin, M. R., & Buisson, A. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1409-18.2018 · Cited by 110 · see citing works

Human tau increases amyloid β plaque size but not amyloid β‐mediated synapse loss in a novel mouse model of Alzheimer's disease

Jackson, R. J., Rudinskiy, N., Herrmann, A. G., Croft, S., Kim, J. M., Petrova, V., Ramos‐Rodríguez, J. J., Pitstick, R., Wegmann, S., Garcı́a-Alloza, M., et al. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13442 · Cited by 109 · see citing works

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data

White, C. C., Yang, H., Yu, L., Chibnik, L. B., Dawe, R. J., Yang, J., Klein, H., Felsky, D., Ramos‐Miguel, A., Arfanakis, K., et al. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002287 · Cited by 108 · see citing works

Amyloid β synaptotoxicity is Wnt‐PCP dependent and blocked by fasudil

Sellers, K. J., Elliott, C., Jackson, J. D., Ghosh, A., Ribé, E. M., Rojo, A. I., Jarosz-Griffiths, H., Watson, I. A., Xia, W., Semënov, M. V., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.09.008 · Cited by 104 · see citing works

Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer’s disease pathology

Scheff, S. W., Ansari, M. A., & Mufson, E. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.030 · Cited by 100 · see citing works

Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

Chabrier, M. A., Cheng, D., Castello, N. A., Green, K. N., & LaFerla, F. M. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.01.007 · Cited by 97 · see citing works

ENC-1 : A Novel Mammalian Kelch -Related Gene Specifically Expressed in the Nervous System Encodes an Actin-Binding Protein

Hernandez, M., Andrés-Barquin, P. J., Martı́nez, S., Bulfone, A., Rubenstein, J. L. R., & Israel, M. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03038.1997 · Cited by 97 · see citing works

Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau

Dickstein, D. L., Brautigam, H., Stockton, S. D., Schmeidler, J., & Hof, P. R. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0245-1 · Cited by 94 · see citing works

Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid

Henderson, B. W., Greathouse, K. M., Ramdas, R., Walker, C. K., Rao, T. C., Bach, S. V., Curtis, K. A., Day, J. J., Mattheyses, A. L., & Herskowitz, J. H. (2019) · Science Signaling · doi:10.1126/scisignal.aaw9318 · Cited by 92 · see citing works

Absolute 10-year risk of dementia by age, sex and <i>APOE</i> genotype: a population-based cohort study

Rasmussen, K. L., Tybjærg-Hansen, A., Nordestgaard, B. G., & Frikke-Schmidt, R. (2018) · Canadian Medical Association Journal · doi:10.1503/cmaj.180066 · Cited by 91 · see citing works

Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging

Boros, B. D., Greathouse, K. M., Gearing, M., & Herskowitz, J. H. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.003 · Cited by 90 · see citing works

Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: a meta-analysis

Yin, Y.-W., Li, J.-C., Wang, J.-Z., Li, B.-H., Pi, Y., Yang, Q.-W., Fang, C.-Q., Gao, C.-Y., & Zhang, L.-L. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.02.031 · Cited by 84 · see citing works

Synaptic Proteins in the Hippocampus Indicative of Increased Neuronal Activity in CA3 in Schizophrenia

Li, W., Ghose, S., Gleason, K., Begović, A., Perez, J. M., Bartko, J. J., Russo, S. J., Wagner, A. D., Selemon, L. D., & Tamminga, C. A. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010123 · Cited by 84 · see citing works

Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

Initiative, F. T. A. D. N., Ridge, P. G., Karch, C. M., Hsu, S., Arano, I., Teerlink, C. C., Ebbert, M. T. W., Gonzalez Murcia, J. D., Farnham, J. M., Damato, A. R., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0486-1 · Cited by 83 · see citing works

Decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke

Skoog, I. G., Börjesson‐Hanson, A., Kern, S., Johansson, L. H., Falk, H., Sigström, R., & Östling, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-05022-8 · Cited by 83 · see citing works

Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination

Ng, L. H. L., Huang, Y., Han, L., Chang, R. C.-C., Chan, Y. S., & Lai, C. S. W. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0321-5 · Cited by 82 · see citing works

Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease

Scheff, S. W., Sparks, D. L., & PRICE, D. A. (1993) · Annals of Neurology · doi:10.1002/ana.410340309 · Cited by 82 · see citing works

Effects of APOE on cognitive aging in community-dwelling older adults.

Reas, E. T., Laughlin, G. A., Bergstrom, J., Kritz‐Silverstein, D. C., Barrett-Connor, E. L., & McEvoy, L. K. (2019) · Neuropsychology · doi:10.1037/neu0000501 · Cited by 82 · see citing works

Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices

Shahani, N., Subramaniam, S., Wolf, T., Tackenberg, C., & Brandt, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4245-05.2006 · Cited by 81 · see citing works

Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients

Domínguez-Álvaro, M., Montero-Crespo, M., Blazquez-Llorca, L., Insausti, R., DeFelipe, J., & Alonso-Nanclares, L. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0520-6 · Cited by 79 · see citing works

The Ca2+ and Rho GTPase signaling pathways underlying activity‐dependent actin remodeling at dendritic spines

Saneyoshi, T., & Hayashi, Y. (2012) · Cytoskeleton · doi:10.1002/cm.21037 · Cited by 78 · see citing works

Chapter 10 Spine distribution in cortical pyramidal cells: a common organizational principle across species

Elson, G. N., & DeFelipe, J. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36012-6 · Cited by 78 · see citing works

The discovery of dendritic spines by Cajal in 1888 and its relevance in the present neuroscience

García-López, P., García‐Marín, V., & Freire, M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.06.002 · Cited by 77 · see citing works

Vascular risk factors and dementia in the general population aged >85 years

Rastas, S., Pirttilä, T., Mattila, K. J., Verkkoniemi, A., Juva, K., Niinistö, L., Länsimies, E., & Sulkava, R. O. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.02.020 · Cited by 76 · see citing works

Physical activity for brain health in older adults

Liu-Ambrose, T. Y. L., Barha, C. K., & Best, J. R. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0260 · Cited by 75 · see citing works

Treadmill exercise suppressed stress-induced dendritic spine elimination in mouse barrel cortex and improved working memory via BDNF/TrkB pathway

Chen, K., Zhang, L., Tan, M., Lai, C. S. W., Li, A., Ren, C., & So, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.41 · Cited by 75 · see citing works

Lifestyle Factors and Dementia in the Oldest-old

Paganini‐Hill, A., Kawas, C. H., & Corrada, M. M. (2015) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000087 · Cited by 71 · see citing works

Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old

Mengel‐From, J., Christensen, K., McGue, M. K., & Christiansen, L. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.07.016 · Cited by 71 · see citing works

<i>KLOTHO</i> heterozygosity attenuates <i>APOE4</i> -related amyloid burden in preclinical AD

Erickson, C. M., Schultz, S. A., Oh, J. M., Darst, B. F., Ma, Y., Norton, D., Betthauser, T., Gallagher, C. L., Carlsson, C. M., Bendlin, B. B., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000007323 · Cited by 70 · see citing works

Effects of dark rearing on dendritic spines in layer IV of the mouse visual cortex. A quantitative electron microscopical study.

Freire, M. (1978) · Europe PMC (PubMed Central) · Cited by 69 · see citing works

Neocortical Synapse Density and Braak Stage in the Lewy Body Variant of Alzheimer Disease: A Comparison with Classic Alzheimer Disease and Normal Aging

Brown, D. F., Risser, R. C., Bigio, E. H., Tripp, P., Stiegler, A., Welch, E., Eagan, K. P., Hladik, C. L., & White, C. L. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199810000-00007 · Cited by 69 · see citing works

Regional differences in dendritic spine density confer resilience to chronic social defeat stress

Qu, Y., Yang, C., Ren, Q., Ma, M., Dong, C., & Hashimoto, K. (2018) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.16 · Cited by 68 · see citing works

Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease

Borin, M., Saraceno, C., Catania, M., Lorenzetto, E., Pontelli, V., Paterlini, A., Fostinelli, S., Avesani, A., Di Fede, G., Zanusso, G., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0567-4 · Cited by 68 · see citing works

Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey

Young, M. E., Ohm, D. T., Dumitriu, D., Rapp, P. R., & Morrison, J. H. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.008 · Cited by 67 · see citing works

Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer’s disease

Wu, W., Du, S., Shi, W., Liu, Y., Hu, Y., Xie, Z., Yao, X., Liu, Z., Ma, W., Xu, L., et al. (2019) · Protein & Cell · doi:10.1007/s13238-019-0641-0 · Cited by 67 · see citing works

Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens ΔFosB

Mul, J. D., Soto, M., Cahill, M. E., Ryan, R. E., Takahashi, H., So, K., Zheng, J., Croote, D. E., Hirshman, M. F., la Fleur, S. E., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0103-z · Cited by 66 · see citing works

Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice

Hoffmann, N. A., Dorostkar, M. M., Blumenstock, S., Goedert, M., & Herms, J. W. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-82 · Cited by 64 · see citing works

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early A lzheimer's disease

Pickett, E. K., Henstridge, C. M., Allison, E. K., Pitstick, R., Pooler, A. M., Wegmann, S., Carlson, G. A., Hyman, B. T., & Spires‐Jones, T. L. (2017) · Synapse · doi:10.1002/syn.21965 · Cited by 64 · see citing works

The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old

Soerensen, M., Christensen, K., Stevnsner, T., & Christiansen, L. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.01.005 · Cited by 63 · see citing works

Association of the Alzheimer's Disease Clusterin Risk Allele with Plasma Clusterin Concentration

Schürmann, B., Wiese, B., Bickel, H., Weyerer, S. B., Riedel-Heller, S. G., Pentzek, M., Bachmann, C., Williams, J. H., van den Bussche, H., Maier, W., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110251 · Cited by 63 · see citing works

Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers

Jackson, R. J., Rose, J. L., Tulloch, J., Henstridge, C. M., Smith, C., & Spires‐Jones, T. L. (2019) · Brain Communications · doi:10.1093/braincomms/fcz003 · Cited by 62 · see citing works

The Selective RhoA Inhibitor Rhosin Promotes Stress Resiliency Through Enhancing D1-Medium Spiny Neuron Plasticity and Reducing Hyperexcitability

Francis, T. C., Gaynor, A., Chandra, R., Fox, M. E., & Lobo, M. K. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.007 · Cited by 61 · see citing works

Memory deficits correlate with tau and spine pathology in P 301 S MAPT transgenic mice

Xu, H. W., Rösler, T. W., Carlsson, T., de Andrade, A., Bruch, J., Höllerhage, M., Oertel, W. H., & Höglinger, G. U. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12160 · Cited by 57 · see citing works

Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline

Berchtold, N. C., Prieto, G. A., Phelan, M. J., Gillen, D. L., Baldi, P., Bennett, D. A., Buchman, A. S., & Cotman, C. W. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.02.012 · Cited by 53 · see citing works

The ROCK Inhibitor Fasudil Prevents Chronic Restraint Stress-Induced Depressive-Like Behaviors and Dendritic Spine Loss in Rat Hippocampus

García‐Rojo, G., Fresno, C., Vilches, N., Díaz‐Véliz, G., Mora, S., Aguayo, F. I., Pacheco, A., Parra-Fiedler, N. A., Parra, C. S., Rojas, P. S., et al. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw108 · Cited by 50 · see citing works

Early Improved and Late Defective Cognition Is Reflected by Dendritic Spines in Tau.P301L Mice

Kremer, A., Maurin, H., Demedts, D., Devijver, H., Borghgraef, P., & LEUVEN, F. V. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4859-11.2011 · Cited by 50 · see citing works

Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy

Kopeikina, K. J., Wegmann, S., Pitstick, R., Carlson, G. A., Bacskai, B. J., Betensky, R. A., Hyman, B. T., & Spires‐Jones, T. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080834 · Cited by 48 · see citing works

Deconstructing and targeting the genomic architecture of human neurodegeneration

Jager, P. L. D., Yang, H., & Bennett, D. A. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0240-z · Cited by 46 · see citing works

Structural dynamics of dendritic spines: Molecular composition, geometry and functional regulation

Ebrahimi, S., & Okabe, S. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.06.002 · Cited by 46 · see citing works

Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study

Legdeur, N., Badissi, M., Carter, S. F., de Crom, S., van de Kreeke, A., Vreeswijk, R., Trappenburg, M. C., Oudega, M. L., Koek, H. L., van Campen, J. P., et al. (2018) · BMC Geriatrics · doi:10.1186/s12877-018-0984-z · Cited by 45 · see citing works

Intensity and Types of Physical Exercise in Relation to Dementia Risk Reduction in Community-Living Older Adults

Lee, A. T. C., Richards, M., Chan, W. C., Chiu, H. F. K., Lee, R. S. Y., & LAM, L. C. W. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.07.012 · Cited by 39 · see citing works

Stable Mossy Fiber Long-Term Potentiation Requires Calcium Influx at the Granule Cell Soma, Protein Synthesis, and Microtubule-Dependent Axonal Transport

Barnes, S. J., Opitz, T., Merkens, M., Kelly, T., von der Brelie, C., Krueppel, R., & Beck, H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1847-10.2010 · Cited by 39 · see citing works

Progression of Alzheimer histopathological changes.

Duyckaerts, C. J., Colle, M.-A., Dessi, F., Piette, F., & Hauw, J. (1998) · PubMed · Cited by 38 · see citing works

Relative Contributions of Specific Activity Histories and Spontaneous Processes to Size Remodeling of Glutamatergic Synapses

Dvorkin, R., & Ziv, N. E. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002572 · Cited by 38 · see citing works

Redistribution of microtubules in dendrites of hippocampal CA1 neurons after tetanic stimulation during long-term potentiation.

Mitsuyama, F., Niimi, G., Katō, K., Hirosawa, K., Mikoshiba, K., Okuya, M., Karagiozov, K. L., Kato, Y., Kanno, T., Sanoe, H., et al. (2008) · PubMed · Cited by 35 · see citing works

New waves in dendritic spine actin cytoskeleton: From branches and bundles to rings, from actin binding proteins to post-translational modifications

Bertling, E., & Hotulainen, P. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.05.002 · Cited by 28 · see citing works

Dynamic Microtubules in Alzheimer’s Disease: Association with Dendritic Spine Pathology

Pchitskaya, E. I., Zhemkov, V., & Борисович, Б. И. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918090080 · Cited by 26 · see citing works

Modeling the Shape of Synaptic Spines by Their Actin Dynamics

Bonilla-Quintana, M., Wörgötter, F., Tetzlaff, C., & Fauth, M. J. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00009 · Cited by 25 · see citing works

Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity

Neustadtl, A. L., Winston, C. N., Parsadanian, M., Main, B. S., Villapol, S., & Burns, M. P. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000811 · Cited by 19 · see citing works

Synapse Density Related to Cerebral Blood Flow and Symptomatology in Frontal Lobe Degeneration and Alzheimer’s Disease

Liu, X., Passant, U., Risberg, J., Warkentin, S., & Brun, A. E. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051216 · Cited by 16 · see citing works

Klotho deficiency affects the spine morphology and network synchronization of neurons

Vo, H. T., Phillips, M. L., Herskowitz, J. H., & King, G. D. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.04.002 · Cited by 13 · see citing works

Prevalence of dementia after age 90: Results from The 90+ Study

Corrada, M. M., Brookmeyer, R., Berlau, D., Paganini-Hill, A., & Kawas, C. H. (2008) · Neurology · doi:10.1212/01.wnl.0000310773.65918.cd · Cited by 11 · see citing works

Neocortical neuron number in humans: Effect of sex and age

(1997) · doi:10.1002/(sici)1096-9861(19970728)384:2

Untitled work

(1997) · doi:10.1002/(sici)1096-9861(19971006)386:4

Spine dynamics in the brain, mental disorders and artificial neural networks

Kasai, H., Ziv, N. E., Okazaki, H., Yagishita, S., & Toyoizumi, T. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00467-3 · Cited by 180 · see citing works

A concerted neuron–astrocyte program declines in ageing and schizophrenia

Ling, E., Nemesh, J. C., Goldman, M., Kamitaki, N., Reed, N. M., Handsaker, R. E., Genovese, G., Vogelgsang, J. S., Gerges, S., Kashin, S., et al. (2024) · Nature · doi:10.1038/s41586-024-07109-5 · Cited by 161 · see citing works

Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons

Mishra, R., Phan, T., Kumar, P., Morrissey, Z. D., Gupta, M., Hollands, C., Shetti, A., Lopez, K. L., Maienschein‐Cline, M., Suh, H., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220391 · Cited by 68 · see citing works

Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer’s disease

Chang, J., Li, Y. Y., Shan, X., Chen, X., Yan, X., Liu, J., & Zhao, L. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.380874 · Cited by 56 · see citing works

Synaptic Compensatory Plasticity in Alzheimer’s Disease

Bhembre, N., Bonthron, C., & Opazo, P. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0379-23.2023 · Cited by 51 · see citing works

Sex differences in the effects of sleep disorders on cognitive dysfunction

Zhou, L., Kong, J., Li, X., & Ren, Q. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105067 · Cited by 51 · see citing works

Super-Resolution Microscopy: Shedding New Light on In Vivo Imaging

Jing, Y., Zhang, C., Yu, B., Lin, D., & Qu, J. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.746900 · Cited by 51 · see citing works

Homomeric and Heteromeric α7 Nicotinic Acetylcholine Receptors in Health and Some Central Nervous System Diseases

Borroni, V., & Barrantes, F. J. (2021) · Membranes · doi:10.3390/membranes11090664 · Cited by 47 · see citing works

Synapse vulnerability and resilience underlying Alzheimer’s disease

Taddei, R. N., & Duff, K. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105557 · Cited by 46 · see citing works

Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment

Poor, S. R., Ettcheto, M., Cano, A. C., Sánchez‐López, E., Manzine, P. R., Olloquequi, J., Camins, A., & Javan, M. (2021) · Pharmaceuticals · doi:10.3390/ph14090890 · Cited by 40 · see citing works

Memory related molecular signatures: The pivots for memory consolidation and Alzheimer's related memory decline

Kaushik, M., Kaushik, P., & Parvez, S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101577 · Cited by 38 · see citing works

Aerobic Exercise Alleviates Abnormal Autophagy in Brain Cells of APP/PS1 Mice by Upregulating AdipoR1 Levels

Jian, Y., Yuan, S., Yang, J., Lei, Y., Li, X., & Liu, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179921 · Cited by 36 · see citing works

Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats

Tan, Z.-N., Li, Y., Guan, Y., Iqbal, J., Wang, C., Yan, R., & Ma, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021206 · Cited by 32 · see citing works

Impaired Cognitive Function and Hippocampal Changes Following Chronic Diazepam Treatment in Middle-Aged Mice

Furukawa, T., Nikaido, Y., Shimoyama, S., Masuyama, N., Notoya, A., & Ueno, S. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.777404 · Cited by 27 · see citing works

Masitinib for the Treatment of Alzheimer’s Disease

Ettcheto, M., Cano, A., Sanchez-López, E., Verdaguer, E., Folch, J., Auladell, C., & Camins, A. (2021) · Neurodegenerative Disease Management · doi:10.2217/nmt-2021-0019 · Cited by 28 · see citing works

Charting Alzheimer’s Disease and Dementia: Epidemiological Insights, Risk Factors and Prevention Pathways

Contador, I., Buch-Vicente, B., del Ser, T., Velasco, S. L., Villarejo‐Galende, A., Benito‐León, J., & Bermejo‐Pareja, F. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144100 · Cited by 30 · see citing works

NRF2 Activation Ameliorates Oxidative Stress and Improves Mitochondrial Function and Synaptic Plasticity, and in A53T α-Synuclein Hippocampal Neurons

Brandes, M. S., Zweig, J. A., Tang, A. L., & Gray, N. E. (2021) · Antioxidants · doi:10.3390/antiox11010026 · Cited by 25 · see citing works

Aging and cognitive resilience: Molecular mechanisms as new potential therapeutic targets

Cordeiro, A., Gomes, C., Bicker, J., & Fortuna, A. C. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.104093 · Cited by 27 · see citing works

Pharmacological Strategies to Improve Dendritic Spines in Alzheimer’s Disease

Ettcheto, M., Busquets, O., Cano, A. C., Sánchez‐López, E., Manzine, P. R., Espinosa-Jiménez, T., Verdaguer, E., Sureda, F. X., Olloquequi, J., Castro-Torres, R. D., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201106 · Cited by 25 · see citing works

Astrocytic C–X–C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity

Perez‐Nievas, B. G., Johnson, L., Beltran-Lobo, P., Hughes, M. M., Gammallieri, L., Tarsitano, F., Myszczynska, M. A., Vázquez-Villaseñor, I., Jiménez-Sánchez, M., Troakes, C., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02371-0 · Cited by 25 · see citing works

Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?

Fonseca, C., Ettcheto, M., Bicker, J., Fernandes, M. J., Falcão, A. C., Camins, A., & Fortuna, A. C. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101998 · Cited by 26 · see citing works

Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease

Jury-Garfe, N., Redding-Ochoa, J., You, Y., Martínez, P., Karahan, H., Chimal-Juárez, E., Johnson, T. S., Zhang, J., Resnick, S., Kim, J., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02775-1 · Cited by 22 · see citing works

Synapse vulnerability and resilience across the clinical spectrum of dementias

Taddei, R. N., & Duff, K. (2025) · Nature Reviews Neurology · doi:10.1038/s41582-025-01094-7 · Cited by 26 · see citing works

Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment

Olloquequi, J., Ettcheto, M., Cano, A. C., Fortuna, A. C., Bicker, J., Sánchez‐López, E., Paz, C., Ureña, J. M., Verdaguer, E., Auladell, C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814177 · Cited by 22 · see citing works

Novel approaches to increase synaptic resilience as potential treatments for Alzheimer’s disease

Pham, A. Q., & Dore, K. (2023) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2022.03.032 · Cited by 21 · see citing works

Zebrafish as a model organism to study sporadic Alzheimer's disease: Behavioural, biochemical and histological validation

Dhiman, N., Deshwal, S., Rishi, V., Singhal, N. K., & Sandhir, R. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115034 · Cited by 20 · see citing works

Impact of New Drugs for Therapeutic Intervention in Alzheimer’s Disease

Olloquequi, J., Ettcheto, M., Cano, A. C., Sánchez‐López, E., Carrasco, M., Espinosa-Jiménez, T., Beas‐Zárate, C., Gudiño‐Cabrera, G., Ureña‐Guerrero, M. E., Verdaguer, E., et al. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2705146 · Cited by 21 · see citing works

Post-Synapses in the Brain: Role of Dendritic and Spine Structures

Meldolesi, J. (2022) · Biomedicines · doi:10.3390/biomedicines10081859 · Cited by 19 · see citing works

Cognitive integrity in Non‐Demented Individuals with Alzheimer's Neuropathology is associated with preservation and remodeling of dendritic spines

Guptarak, J., Scaduto, P., Tumurbaatar, B., Zhang, W. R., Jupiter, D. C., Taglialatela, G., & Fracassi, A. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13900 · Cited by 16 · see citing works

Increased Expression of KIF11/Kinesin5 Offsets Alzheimer Aβ-Mediated Toxicity and Cognitive Dysfunction in Cell Culture, Mice, and Humans

Lucero, E., Freund, R. K., Smith, A. N., Johnson, N. R., Dooling, B. R., Sullivan, E. J., Prikhodko, O., Ahmed, M. M., Bennett, D. A., Hohman, T. J., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105288 · Cited by 14 · see citing works

Engineering memory with an extrinsically disordered kinase

Ripoli, C., Dağliyan, O., Renna, P., Pastore, F., Paciello, F., Sollazzo, R., Rinaudo, M., Battistoni, M., Martini, S., Tramutola, A., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh1110 · Cited by 17 · see citing works

System-Level Analysis of Alzheimer’s Disease Prioritizes Candidate Genes for Neurodegeneration

Brabec, J. L., Lara, M. K., Tyler, A. L., & Mahoney, J. M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.625246 · Cited by 16 · see citing works

Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models

Gurdon, B., & Kaczorowski, C. C. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105558 · Cited by 16 · see citing works

Actin capping protein regulates postsynaptic spine development through CPI-motif interactions

Myers, K. R., Fan, Y., McConnell, P., Cooper, J. A., & Zheng, J. Q. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1020949 · Cited by 14 · see citing works

Cognitive heterogeneity reveals molecular signatures of age-related impairment

Logan, S., Baier, M. P., Owen, D. B., Peasari, J. R., Jones, K. L., Ranjit, R., Yarbrough, H. P., Masingale, A. M., Bhandari, S., Rice, H. C., et al. (2023) · PNAS Nexus · doi:10.1093/pnasnexus/pgad101 · Cited by 15 · see citing works

Morphological Features of Human Dendritic Spines

Renner, J., & Rasia‐Filho, A. A. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-36159-3_9 · Cited by 16 · see citing works

Polystyrene nanoplastics induce cognitive dysfunction and dendritic spine deterioration via excessive mitochondrial fission

Yu, H., Jin, L., Zi, Y., Lu, J., Long, Y., Xiong, R., & Zhang, B. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.119133 · Cited by 13 · see citing works

Lipopolysaccharide exacerbates depressive‐like behaviors in obese rats through complement C1q‐mediated synaptic elimination by microglia

Chunchai, T., Chinchapo, T., Sripetchwandee, J., Thonusin, C., Chattipakorn, N., & Chattipakorn, S. C. (2024) · Acta Physiologica · doi:10.1111/apha.14130 · Cited by 13 · see citing works

Nrf2 Ameliorates Sevoflurane-Induced Cognitive Deficits in Aged Mice by Inhibiting Neuroinflammation in the Hippocampus

Li, J., Li, J., Liu, Y., Hu, C., Xu, H., Cao, D., Zhang, R., & Zhang, K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04777-w · Cited by 13 · see citing works

A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet

Espinosa-Jiménez, T., Cano, A. C., Sánchez‐López, E., Olloquequi, J., Folch, J., Bulló, M., Verdaguer, E., Auladell, C., Pont, C., Muñoz‐Torrero, D., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01000-y · Cited by 12 · see citing works

Dendritic spine head diameter predicts episodic memory performance in older adults

Walker, C. K., Liu, E., Greathouse, K. M., Adamson, A. B., Wilson, J. P., Poovey, E. H., Curtis, K. A., Muhammad, H. M., Weber, A. J., Bennett, D. A., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn5181 · Cited by 11 · see citing works

Comparison of Golgi-Cox and Intracellular Loading of Lucifer Yellow for Dendritic Spine Density and Morphology Analysis in the Mouse Brain

Walker, C. K., Greathouse, K. M., Liu, E., Muhammad, H. M., Boros, B. D., Freeman, C. D., Seo, J. V., & Herskowitz, J. H. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.029 · Cited by 11 · see citing works

Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length

Walker, C. K., Greathouse, K. M., Tuscher, J. J., Dammer, E. B., Weber, A. J., Liu, E., Curtis, K. A., Boros, B. D., Freeman, C. D., Seo, J. V., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2102-22.2023 · Cited by 10 · see citing works

Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome

Hurst, C. D., Dunn, A. R., Dammer, E. B., Duong, D. M., Shapley, S. M., Seyfried, N. T., Kaczorowski, C. C., & Johnson, E. C. B. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1239116 · Cited by 10 · see citing works

Comparative efficacy and safety of non-pharmacological interventions as adjunctive treatment for vascular dementia: a systematic review and network meta-analysis

Yi, Y., Qu, Y., Lv, S., Zhang, G., Rong, Y., & Li, M. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1397088 · Cited by 9 · see citing works

Astrocyte-microglia crosstalk in the hippocampus mediates cognitive impairments induced by chronic intermittent hypoxia

Wu, Z., Zhai, M., Wang, Y., Ren, L., Pan, J., Xiao, L., & Liu, Y. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107117 · Cited by 11 · see citing works

JRM-28, a Novel HDAC2 Inhibitor, Upregulates Plasticity-Associated Proteins in Hippocampal Neurons and Enhances Morphological Plasticity via Activation of CREB: Implications for Alzheimer’s Disease

Rahman, A. F. M. T., Bulbule, S. R., Belayet, J. B., Benko, A. M., Gottschalk, C. G., Frick, D. N., Arnold, L. A., Hossain, M. M., & Roy, A. (2024) · Cells · doi:10.3390/cells13231964 · Cited by 8 · see citing works

SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

Pereyra, G., Mateo, M. I., Miaja, P., Martín‐Bermejo, M. J., Martinez-Baños, M., Klaassen, R. V., Gruart, A., Rueda‐Carrasco, J., Fernández‐Rodrigo, A., López-Merino, E., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115535 · Cited by 8 · see citing works

Contribution of Nischarin/IRAS in CNS development, injury and diseases

Zheng, P., Pan, C., Zhou, C., Liu, B., Wang, L., Duan, S., & Ding, Y. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.01.020 · Cited by 8 · see citing works

Vertigoheel promotes rodent cognitive performance in multiple memory tests

Ott, K., Heikkinen, T., Lehtimäki, K. K., Paldanius, K. M. A., Puoliväli, J. T., Pussinen, R., Andriambeloson, E., Huyard, B., Wagner, S., Schnack, C., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1183023 · Cited by 8 · see citing works

Dehydroepiandrosterone Attenuates Astroglial Activation, Neuronal Loss and Dendritic Degeneration in Iron-Induced Post-Traumatic Epilepsy

Prakāsh, C., Rabidas, S. S., Tyagi, J., & Sharma, D. (2023) · Brain Sciences · doi:10.3390/brainsci13040563 · Cited by 7 · see citing works

The emerging role of disulfidptosis in Alzheimer's disease

Zhou, Q., Zheng, N., Chen, Z., Xie, L., Yang, X., Sun, Q., Lin, J., Li, B., & Li, L. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178085 · Cited by 8 · see citing works

Impact of Dendritic Spine Loss on Excitability of Hippocampal CA1 Pyramidal Neurons: A Computational Study of Early Alzheimer Disease

Tian, C., Reyes, I., Johnson, A., & Masurkar, A. V. (2025) · Hippocampus · doi:10.1002/hipo.70025 · Cited by 4 · see citing works

Astrocyte-derived extracellular vesicular NFIA mediates obesity-associated cognitive impairment

Wu, L., Deng, L., Xu, X., Chang, H., Liu, C., Wu, J., Zhang, C., Wang, R., Gao, R., Chen, H., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03473-9 · Cited by 5 · see citing works

Effects of exercise intensity on spatial memory performance and hippocampal synaptic function in SAMP8 mice

Guo, L., Li, S., Zhang, Y., Yang, X., Zhang, Y., Cui, H., & Li, Y. (2023) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2023.107791 · Cited by 5 · see citing works

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age

Kragness, S., Clark, Z., Mullin, A., Guidry, J. J., & Earls, L. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269404 · Cited by 5 · see citing works

Neuroplasticity and brain health: insights from natural torpor

Shi, Z., Wang, X., Duan, W., Du, Y., Ling, S., Zhang, Z., Wang, G., Zhao, D., Ding, J., Zhang, K., et al. (2025) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.70069 · Cited by 4 · see citing works

Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice

Cook, A. K., Greathouse, K. M., Manuel, P. N., Cooper, N. H., Eberhardt, J. M., Freeman, C. D., Weber, A. J., Herskowitz, J. H., & Arrant, A. E. (2024) · Molecular Brain · doi:10.1186/s13041-024-01095-5 · Cited by 4 · see citing works

Steroid Hormone Interaction with Dendritic Spines: Implications for Neuropsychiatric Disease

Frankfurt, M., Nasrallah, Z., & Luine, V. N. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-36159-3_8 · Cited by 4 · see citing works

The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases

Lane-Donovan, C., Paredes, M., & Kao, A. W. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102854 · Cited by 3 · see citing works

Direct evidence for dendritic spine compensation and regeneration in Alzheimer's disease models

Bhembre, N., Boskovic, Z., Willshaw, J. L., Castello-Waldow, T. P., Bonthron, C., Paolino, A., & Opazo, P. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70829 · Cited by 3 · see citing works

Plasma biomarkers in drug-naïve schizophrenia with severe cognitive impairment via targeted metabolomics

Dong, Y., Wang, S., Qiu, Y., Su, Q., Sun, X., Li, M., & Li, J. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107711 · Cited by 3 · see citing works

NRN1 as a therapeutic target for Alzheimer's disease

Pugh, D. A., Cary, G. A., Greathouse, K. M., Nassour-Caswell, L. C., Hobby, E. L., Seyfried, N. T., & Herskowitz, J. H. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71149 · Cited by 3 · see citing works

Chronic pramipexole and rasagiline treatment enhances dendritic spine structural neuroplasticity in striatal and prefrontal cortex neurons of rats with bilateral intrastriatal 6-hydroxydopamine lesions

de Oca, A. B.-M., Tendilla‐Beltrán, H., Bringas, M. E., Flores, G., & Aceves, J. (2024) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2024.102468 · Cited by 3 · see citing works

PAK1 inhibitor NVS‐PAK1‐1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice

Yang, T., Huhe, H., Williams, S. G., Kaur, S., Ay, Y. A., Davis‐Gilbert, Z. W., Cary, G. A., Paisie, C. A., Butler, R. R., Wiley, J. C., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.71033 · Cited by 3 · see citing works

Initiation of dendritic NMDA spikes co-regulated via distance-dependent and dynamic distribution of the spine number and morphology in neuron dendrites

Cao, Y., Shen, C., Qiu, H., & Guo, W. (2023) · Science China Technological Sciences · doi:10.1007/s11431-022-2165-3 · Cited by 2 · see citing works

Therapeutic benefits of central LH receptor agonism in the APP/PS1 AD model involve trophic and immune regulation and are reproductive status dependent

Mey, M., Bhatta, S., Suresh, S., Labrador, L., Piontkivska, H., & Casadesús, G. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167165 · Cited by 2 · see citing works

Multifunctional Tasks and an Energy Crisis are Crucial Players in Determining the Vulnerability of the Entorhinal Cortex to Early Damage in Alzheimer’s Disease

Sivanesan, S., Howell, M. D., Kaushik, V., Rajadas, J., Pari, S. S., & Goyal, P. (2024) · Current Alzheimer Research · doi:10.2174/0115672050324909240823104209 · Cited by 1 · see citing works

Regular exercise ameliorates cognitive function in APOE-/- mice via the VEGF/ERK signaling pathway

Wang, Z., Yang, Q., Tong, X., Liao, M., Hu, Z., Huang, S., Wang, P., Tong, Z., Chen, Y. Q., Wang, Y., et al. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.116005 · Cited by 1 · see citing works

Age-related loss of large dendritic spines in the precuneus is statistically mediated by proteins which are predicted targets of existing drugs

Krivinko, J. M., Fan, P., Sui, Z., Happe, C. L., Hensler, C., Gilardi, J., Ikonomović, M. D., McKinney, B. C., Newman, J., Ding, Y., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02817-w · Cited by 2 · see citing works

The LH receptor regulates hippocampal spatial memory and restores dendritic spine density in ovariectomized APP/PS1 AD micePreprint

Mey, M., Bhatta, S., Suresh, S., Labrador, L., Piontkivska, H., & Casadesús, G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.22.573087 · Cited by 1 · see citing works

Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicityPreprint

Perez‐Nievas, B. G., Johnson, L., Beltran-Lobo, P., Hughes, M. M., Gammallieri, L., Tarsitano, F., Myszczynska, M. A., Vázquez-Villaseñor, I., Jiménez-Sánchez, M., Troakes, C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.22.458716

Kif11 overexpression rescues cognition, long-term potentiation, and spine defects in mouse and cell models of Alzheimer’s diseasePreprint

Lucero, E., Freund, R. K., Johnson, N. R., Dooling, B. R., Sullivan, E. M., Prikhodko, O., Ahmed, M. M., Dell’Acqua, M. L., Chial, H. J., & Potter, H. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.09.459627

Increased Expression of KIF11/Kinesin5 Offsets Alzheimer Aβ-Mediated Toxicity and Cognitive Dysfunction in Cell Culture, Mice, and HumansPreprint

Lucero, E., Freund, R. K., Smith, A. N., Johnson, N., Dooling, B. R., Sullivan, E. M., Prikhodko, O., Ahmed, M. M., Bennett, D. A., Hohman, T. J., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4050072

Walnut peptide and ginseng Rg1 co-treatment prevents the loss of neurons and cognitive decline in mouse model with memory impairment

Fu, J., Damira, K., Song, W., Li, W., Li, F., Leng, Y., Liu, C., Wu, D., & Min, W. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250156

Additional file 1 of Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice

Cook, A. K., Greathouse, K. M., Manuel, P. N., Cooper, N. H., Eberhardt, J. M., Freeman, C. D., Weber, A. J., Herskowitz, J. H., & Arrant, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.25980513

How Do Amyloid Pathology and Aberrant Neuronal Activity Disrupt Plasticity and Memory in Alzheimer’s Disease?

Subramanian, J. (2026) · The Neuroscientist · doi:10.1177/10738584251414384 · Cited by 1 · see citing works

tDCS improves early Alzheimer’s disease by synaptic vesicle fusion and release

Zhuang, Y.-Y., Yan, J., Wu, T.-C., Xu, W.-S., Wu, B. J., Xie, X., Wang, W.-J., Lin, H., Jian, J.-W., Wang, J.-Z., et al. (2026) · Military Medical Research · doi:10.1016/j.mmr.2026.100003

Bone marrow-derived mesenchymal stem cells and their exosomes in Alzheimer's disease: Mechanisms and therapeutic potential

Su, R., & Yang, Q.-Y. (2026) · New cell · doi:10.61958/ncjg8269

CHKA knockout impairs dendritic development and Wnt pathway regulation in neurodevelopment

Liu, H. Y., Qian, X., Chen, S.-D., Feng, J., Zou, Y.-R., Liu, Y., Gao, P., & Ma, H. (2026) · Cytokine · doi:10.1016/j.cyto.2026.157153

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Podder, A., Liew, Y. J., Cary, G. A., Carter, G. W., & Uyar, A. (2026) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70264

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Carrasco, M., Guzman, L., Barroso, E., Olloquequi, J., Cano, A., Ureña, J., Verdaguer, E., Prohens, R., Fortuna, A., Auladell, C., et al. (2026) · GeroScience · doi:10.1007/s11357-026-02321-9

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Eliazer, G. R., & Kandasamy, M. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.06.004

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Zhao, S., Li, Y., Peng, H., & Liu, Y. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117712

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Zheng, J. Q., Joubert, S., Gonzalez-Islas, C. E., Ogawa, Y., Poddar, A., Penas, A. B., Liu, E., Wenner, P., & Myers, K. R. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113465

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Handsaker, R. (2024) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.11035396

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Boros, B. D., Greathouse, K. M., Gentry, E. G., Curtis, K. A., Birchall, E. L., Gearing, M., & Herskowitz, J. H. (2017) · Annals of Neurology · doi:10.1002/ana.25049 · Cited by 198 · see citing works

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Boros, B. D., & Herskowitz, J. H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817990-1.00022-6

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Bloss, E. B., Morrison, J. H., Hof, P. R., & Dickstein, D. L. (2011) · Translational Neuroscience · doi:10.2478/s13380-011-0008-3 · Cited by 12 · see citing works

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Krivinko, J. M., Fan, P., Sui, Z., Erickson, S. L., Happe, C. L., Hensler, C., Lehman, N., McKinney, B. C., Newman, J., Ding, Y., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.02.392