The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.
Engineered T cells: the promise and challenges of cancer immunotherapy
Open accessAbstract
The immune system evolved to distinguish non-self from self to protect the organism. As cancer is derived from our own cells, immune responses to dysregulated cell growth present a unique challenge. This is compounded by mechanisms of immune evasion and immunosuppression that develop in the tumour microenvironment. The modern genetic toolbox enables the adoptive transfer of engineered T cells to create enhanced anticancer immune functions where natural cancer-specific immune responses have failed. Genetically engineered T cells, so-called 'living drugs', represent a new paradigm in anticancer therapy. Recent clinical trials using T cells engineered to express chimeric antigen receptors (CARs) or engineered T cell receptors (TCRs) have produced stunning results in patients with relapsed or refractory haematological malignancies. In this Review we describe some of the most recent and promising advances in engineered T cell therapy with a particular emphasis on what the next generation of T cell therapy is likely to entail.
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“CAR-T cells with the same antibody have been less successful and less reproducible for other B-cell tumours (such as chronic lymphoblastic leukaemia) and for other antibodies and solid tumours107.”
From How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation (2018) · cites this paper as [107]
Experimental — accuracy not yet measuredIn the citing paper
“Genetically engineered immune cell therapies have proven effective for treatment of some cancer types (Esensten et al., 2017; Fesnak et al., 2016; June and Sadelain, 2018; Sadelain et al., 2017), but they still cannot cure most tumors.”
From Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies (2020) · cites this paper as Fesnak et al., 2016
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Metadata
- Authors
- Fesnak, A. D., June, C. H., & Levine, B. L.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Fesnak, Andrew D.
- Levine, Bruce L.
- Venue
- Nature Reviews Cancer
- Published
- 2016-08-23
- Volume
- 16
- Issue
- 9
- Pages
- 566-581
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC5543811
- OpenAlex
- W2515679023
- Cited by
- 1,074
- References
- 251
- Citations by year
- 2026: 55 · 2025: 76 · 2024: 73 · 2023: 71 · 2022: 91 · 2021: 144 · 2020: 134 · 2019: 127 · 2018: 161 · 2017: 122 · 2016: 13
- FWCI
- 14.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Parker Foundation
- Leukemia and Lymphoma Society
- National Institutes of Health
- National Heart, Lung, and Blood Institute (T32HL007775)
- National Cancer Institute (R01CA165206, R01CA120409, P30CA016520)
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- engineered T cells, adoptive cell transfer, cancer immunotherapy, chimeric antigen receptor, engineered T cell receptors, B-cell malignancies, hematologic malignancies, solid tumors, tumor immune evasion, tumor microenvironment, immune tolerance
- MeSH terms
- Gene Editing, Antigens, Neoplasm, Clinical Trials as Topic, Forecasting, Genetic Engineering, HLA Antigens, Humans, Neoplasms, Receptors, Antigen, T-Cell, Recombinant Fusion Proteins, Syndrome, T-Lymphocyte Subsets, Cytokines, Immunotherapy, Adoptive, Antigen Presentation, Gene Transfer Techniques, Models, Immunological, Antigens, CD19, Tumor Escape, Hematologic Neoplasms, T-Cell Antigen Receptor Specificity, Tumor Microenvironment, Costimulatory and Inhibitory T-Cell Receptors
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