The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis
Open accessAbstract
Although autophagy controls cell death and survival, underlying mechanisms are poorly understood, and it is unknown whether autophagy affects only whether or not cells die or also controls other aspects of programmed cell death. MAP3K7 is a tumor suppressor gene associated with poor disease-free survival in prostate cancer. Here, we report that Map3k7 deletion in mouse prostate cells sensitizes to cell death by TRAIL (TNF-related apoptosis-inducing ligand). Surprisingly, this death occurs primarily through necroptosis, not apoptosis, due to assembly of the necrosome in association with the autophagy machinery, mediated by p62/SQSTM1 recruitment of RIPK1. The mechanism of cell death switches to apoptosis if p62-dependent recruitment of the necrosome to the autophagy machinery is blocked. These data show that the autophagy machinery can control the mechanism of programmed cell death by serving as a scaffold rather than by degrading cargo.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Necroptosis is favored by a necrosome-scaffolding function of the autophagy apparatus and by autophagic degradation of c-IAP1 and c-IAP2.
“necroptosis, which is favored by a necrosome-scaffolding function of the autophagy apparatus [823–825], as well as by the autophagic degradation of c-IAP1 and c-IAP2 [826].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [823]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Martinez, J., Malireddi, R. K. S., Lu, Q., Cunha, L. D., Pelletier, S., Gingras, S., Orchard, R., Guan, J.-L., Tan, H., Peng, J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3192 · Cited by 758 · cited 1× · see citing works
“No rescue in cell viability was observed with knockdown ofRubicon, suggesting that autophagy rather than LC3-associated phagocytosis is responsible for these effects (Martinez et al., 2015) (Figure S3B).”
BackgroundSelf-citationRetractedCerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455 · see citing works
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160 · see citing works
Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21208 · Cited by 11,499 · see citing works
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069 · see citing works
Integrative Genomic Profiling of Human Prostate Cancer
Taylor, B. S., Schultz, N. D., Hieronymus, H., Gopalan, A., Xiao, Y., Carver, B. S., Arora, V. K., Kaushik, P., Cerami, E. G., Reva, B. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.05.026 · Cited by 3,653 · see citing works
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506 · see citing works
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.031 · Cited by 2,698 · see citing works
Cho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435 · see citing works
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
He, S., Wang, L., Miao, L., Wang, T., Du, F., Zhao, L., & Wang, X. (2009) · Cell · doi:10.1016/j.cell.2009.05.021 · Cited by 2,214 · see citing works
Necroptosis and its role in inflammation
Pasparakis, M., & Vandenabeele, P. (2015) · Nature · doi:10.1038/nature14191 · Cited by 2,148 · see citing works
Autophagy in mammalian development and differentiation
Mizushima, N., & Levine, B. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-823 · Cited by 1,555 · see citing works
Lindsten, T., Ross, A. J., King, A., Zong, W.-X., Rathmell, J. C., Shiels, H. A., Ulrich, E., Waymire, K. G., Mahar, P., Frauwirth, K., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00136-2 · Cited by 1,489 · see citing works
TNF-α Induces Two Distinct Caspase-8 Activation Pathways
Wang, L., Du, F., & Wang, X. (2008) · Cell · doi:10.1016/j.cell.2008.03.036 · Cited by 1,352 · see citing works
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
Cai, Z., Jitkaew, S., Zhao, J., Chiang, H.-C., Choksi, S., Liu, J., Ward, Y., Wu, L.-G., & Liu, Z.-G. (2014) · Nature Cell Biology · doi:10.1038/ncb2883 · Cited by 1,322 · see citing works
Punctuated Evolution of Prostate Cancer Genomes
Baca, S. C., Prandi, D., Lawrence, M. S., Mosquera, J. M., Romanel, A., Drier, Y., Park, K., Kitabayashi, N., MacDonald, T. Y., Ghandi, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.021 · Cited by 1,300 · see citing works
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G. S., & Green, D. R. (2011) · Nature · doi:10.1038/nature09852 · Cited by 1,278 · cited 2× · see citing works
“For instance, repression of the necroptotic pathway by apoptotic regulators, such as FADD and caspase-8, is essential for proper mammalian development (Kaiser et al., 2011; Oberst et al., 2011; Zhang et al., 2011).”
BackgroundSelf-citationCaspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis
Lakhani, S. A., Masud, A. J., Kuida, K., Porter, G. A., Jr., Booth, C. J., Mehal, W. Z., Inayat, I., & Flavell, R. A. (2006) · Science · doi:10.1126/science.1115035 · Cited by 1,175 · see citing works
Linkermann, A., & Green, D. R. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1310050 · Cited by 1,103 · see citing works
Self-citationBertrand, M. J. M., Milutinovic, S., Dickson, K. M., Ho, W. C., Boudreault, A., Durkin, J. P., Gillard, J. W., Jaquith, J. B., Morris, S. J., & Barker, P. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.014 · Cited by 1,102 · see citing works
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
Kaiser, W. J., Upton, J. W., Long, A. B., Livingston-Rosanoff, D., Daley-Bauer, L. P., Hakem, R., Caspary, T., & Mocarski, E. S. (2011) · Nature · doi:10.1038/nature09857 · Cited by 1,057 · see citing works
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.137 · Cited by 1,002 · see citing works
Self-citationZhao, J., Jitkaew, S., Cai, Z., Choksi, S., Li, Q., Luo, J., & Liu, Z.-G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200012109 · Cited by 901 · see citing works
The TRAIL apoptotic pathway in cancer onset, progression and therapy
Johnstone, R. W., Frew, A. J., & Smyth, M. J. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2465 · Cited by 835 · see citing works
Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
Egan, D. F., Chun, M. G. H., Vamos, M., Zou, H., Rong, J., Miller, C. J., Lou, H. J., Raveendra-Panickar, D., Yang, C.-C., Sheffler, D. J., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.031 · Cited by 715 · see citing works
To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate
Green, D. R., & Levine, B. (2014) · Cell · doi:10.1016/j.cell.2014.02.049 · Cited by 687 · see citing works
Self-citationLive to die another way: modes of programmed cell death and the signals emanating from dying cells
Fuchs, Y., & Steller, H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3999 · Cited by 632 · see citing works
RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8 + T cells
Yatim, N., Jusforgues-Saklani, H., Orozco, S. L., Schulz, O., da Silva, R. B., Sousa, C. R. E., Green, D. R., Oberst, A., & Albert, M. L. (2015) · Science · doi:10.1126/science.aad0395 · Cited by 625 · see citing works
Self-citationRIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
Dillon, C. P., Weinlich, R., Rodriguez, D. A., Cripps, J. G., Quarato, G., Gurung, P., Verbist, K. C., Brewer, T. L., Llambi, F., Gong, Y.-N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.018 · Cited by 562 · see citing works
Self-citationRIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
Dannappel, M., Vlantis, K., Kumari, S., Polykratis, A., Kim, C., Wachsmuth, L., Eftychi, C., Lin, J., Corona, T., Hermance, N., et al. (2014) · Nature · doi:10.1038/nature13608 · Cited by 534 · see citing works
Koo, G.-B., Morgan, M. J., Lee, D., Kim, W.-J., Yoon, J.-H., Koo, J. S., Kim, S. H., Kim, S., Son, M. K., Hong, S. S., et al. (2015) · Cell Research · doi:10.1038/cr.2015.56 · Cited by 489 · see citing works
Self-citationThe Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis
Vandenabeele, P., Declercq, W., Van Herreweghe, F., & Vanden Berghe, T. (2010) · Science Signaling · doi:10.1126/scisignal.3115re4 · Cited by 482 · see citing works
Getting TRAIL back on track for cancer therapy
Lemke, J., von Karstedt, S., Zinngrebe, J., & Walczak, H. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.81 · Cited by 455 · see citing works
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis
Wu, J., Huang, Z., Ren, J., Zhang, Z., He, P., Li, Y., Ma, J., Chen, W., Zhang, Y., Zhou, X., et al. (2013) · Cell Research · doi:10.1038/cr.2013.91 · Cited by 452 · see citing works
Mcafee, Q. W., Zhang, Z., Samanta, A., Levi, S. M., Ma, X.-H., Piao, S., Lynch, J. P., Uehara, T., Sepulveda, A. R., Davis, L. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118193109 · Cited by 423 · see citing works
Functional complementation between FADD and RIP1 in embryos and lymphocytes
Zhang, H., Zhou, X., McQuade, T. J., Li, J., Chan, F. K.-M., & Zhang, J. (2011) · Nature · doi:10.1038/nature09878 · Cited by 422 · see citing works
p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding
Itakura, E., & Mizushima, N. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201009067 · Cited by 415 · see citing works
The interaction of p62 with RIP links the atypical PKCs to NF‐κB activation
Sanz, L., Sánchez‐Gómez, P., Lallena, M., Díaz-Meco, M. T., & Moscat, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.3044 · Cited by 410 · see citing works
Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis
Rodríguez, D. A., Weinlich, R., Brown, S., Guy, C. S., Fitzgerald, P., Dillon, C. P., Oberst, A., Quarato, G., Low, J. A., Cripps, J. G., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.70 · Cited by 379 · see citing works
Self-citationProgrammed necrosis: backup to and competitor with apoptosis in the immune system
Han, J., Zhong, C., & Zhang, D. (2011) · Nature Immunology · doi:10.1038/ni.2159 · Cited by 365 · see citing works
Vanlangenakker, N., Vanden Berghe, T., Bogaert, P., Laukens, B., Zobel, K., Deshayes, K., Vucic, D., Fulda, S., Vandenabeele, P., & Bertrand, M. J. M. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.138 · Cited by 339 · see citing works
Dondelinger, Y., Aguileta, M. A., Goossens, V, Dubuisson, C., Grootjans, S., Dejardin, E., Vandenabeele, P., & Bertrand, M. J. M. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.94 · Cited by 312 · see citing works
RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis
Orozco, S., Yatim, N., Werner, M. R., Tran, H., Gunja, S. Y., Tait, S. W., Albert, M. L., Green, D. R., & Oberst, A. (2014) · Cell Death & Differentiation · doi:10.1038/cdd.2014.76 · Cited by 294 · see citing works
Self-citationEmerging strategies to effectively target autophagy in cancer
Rebecca, V. W., & Amaravadi, R. K. (2015) · Oncogene · doi:10.1038/onc.2015.99 · Cited by 283 · see citing works
Life in the balance – a mechanistic view of the crosstalk between autophagy and apoptosis
Rubinstein, A. D., & Kimchi, A. (2012) · Journal of Cell Science · doi:10.1242/jcs.115865 · Cited by 248 · see citing works
Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors
Levy, J. M. M., Thompson, J. C., Griesinger, A. M., Amani, V. M., Donson, A. M., Birks, D. K., Morgan, M. J., Mirsky, D. M., Handler, M. H., Foreman, N. K., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0049 · Cited by 246 · see citing works
Self-citationGump, J. M., Staskiewicz, L., Morgan, M. J., Bamberg, A., Riches, D. W. H., & Thorburn, A. (2014) · Nature Cell Biology · doi:10.1038/ncb2886 · Cited by 230 · see citing works
Self-citationBasit, F., Cristofanon, S., & Fulda, S. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.45 · Cited by 211 · see citing works
Recent insights into cell death and autophagy
Fitzwalter, B. E., & Thorburn, A. M. (2015) · FEBS Journal · doi:10.1111/febs.13515 · Cited by 171 · see citing works
Self-citationAutophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels
Thorburn, J., Andrysík, Z., Staskiewicz, L., Gump, J. M., Maycotte, P., Oberst, A., Green, D. R., Espinosa, J. M., & Thorburn, A. M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.036 · Cited by 118 · see citing works
Self-citationGoodall, M. L., Wang, T., Martin, K. R., Kortus, M. G., Kauffman, A. L., Trent, J. M., Gately, S. T., & MacKeigan, J. P. (2014) · Autophagy · doi:10.4161/auto.28594 · Cited by 109 · see citing works
Self-citationSorting cells for basal and induced autophagic flux by quantitative ratiometric flow cytometry
Gump, J. M., & Thorburn, A. M. (2014) · Autophagy · doi:10.4161/auto.29394 · Cited by 102 · see citing works
Self-citationTAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation
Morioka, S., Broglie, P. M., Omori, E., Ikeda, Y., Takaesu, G., Matsumoto, K., & Ninomiya‐Tsuji, J. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201305070 · Cited by 101 · see citing works
Lamothe, B., Lai, Y., Xie, M., Schneider, M. D., & Darnay, B. G. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.01225-12 · Cited by 98 · see citing works
Coordinate Loss of MAP3K7 and CHD1 Promotes Aggressive Prostate Cancer
Rodrigues, L. U., Rider, L. C., Nieto, C., Romero, L. M., Karimpour‐Fard, A., Loda, M. F., Lucia, M. S., Wu, M., Shi, L., Cimic, A., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-1596 · Cited by 84 · see citing works
Self-citationLiu, W., Chang, B., Cramer, S. D., Koty, P. P., Li, T., Sun, J., Turner, A. R., Kap-Herr, C. V., Bobby, P., Rao, J., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0300 · Cited by 67 · see citing works
Self-citationSuppression of Tak1 Promotes Prostate Tumorigenesis
Wu, M., Shi, L., Cimic, A., Romero, L. M., Sui, G., Lees, C. J., Cline, J. M., Seals, D. F., Sirintrapun, J. S., McCoy, T. P., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2724 · Cited by 60 · see citing works
Self-citationSorafenib-induced defective autophagy promotes cell death by necroptosis
Kharaziha, P., Chioureas, D., Baltatzis, G., Fonseca, P., Rodriguez, P. Q., Gogvadze, V. G., Lennartsson, L., Björklund, A.-C., Zhivotovsky, B., Grandér, D., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5797 · Cited by 56 · see citing works
Nezis, I. P., Shravage, B. V., Sagona, A. P., Johansen, T., Baehrecke, E. H., & Stenmark, H. (2010) · Autophagy · doi:10.4161/auto.6.8.13694 · Cited by 51 · see citing works
TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP
Morioka, S., Omori, E., Kajino, T., Kajino‐Sakamoto, R., Matsumoto, K., & Ninomiya‐Tsuji, J. (2009) · Oncogene · doi:10.1038/onc.2009.110 · Cited by 49 · see citing works
Choo, M., Kawasaki, N., Singhirunnusorn, P., Koizumi, K., Sato, S., Akira, S., Saiki, I., & Sakurai, H. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0379 · Cited by 47 · see citing works
The Prevalence of TNFα-Induced Necrosis over Apoptosis Is Determined by TAK1-RIP1 Interplay
Arslan, S. Ç., & Scheidereit, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026069 · Cited by 46 · see citing works
Morgan, M. J., Kim, Y., & Liu, Z.-G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803428 · Cited by 37 · see citing works
Self-citationLluis, J. M., Nachbur, U., Cook, W. D., Gentle, I. E., Moujalled, D. M., Moulin, M., Wong, W. W.-L., Khan, N. R., Chau, D., Callus, B. A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008620 · Cited by 24 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Rodriguez DA Weinlich R Brown S Guy C Fitzgerald P Dillon CP Oberst A Quarato G Low J Cripps JG 2016 Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis Cell Death Differ 23 76 88 26024392 PMC4815980
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Self-citationLevy, J. M. M., Towers, C. G., & Thorburn, A. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.53 · Cited by 2,526 · see citing works
Self-citationAutophagy-Independent Functions of the Autophagy Machinery
Galluzzi, L., & Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.05.026 · Cited by 863 · see citing works
“Such necroptotic response is exacerbated, rather than blunted, by chemical inhibitors of lysosomal degradation (Goodall et al., 2016), pointing to a non-autophagic role for ATG5, ATG7, and VPS34 in this setting.”
BackgroundInfluentialSelf-citationAutophagy-dependent cell death—where.; how and why a cell eats itself to death
Bialik, S., Dasari, S. K., & Kimchi, A. (2018) · Journal of Cell Science · doi:10.1242/jcs.215152 · Cited by 295 · see citing works
Recent Advances in Understanding of Pathogenesis of Alcohol-Associated Liver Disease
Wu, X., Fan, X., Miyata, T., Kim, A., Cajigas-Du Ross, C. K., Ray, S., Huang, E., Taiwo, M., Arya, R., Wu, J., et al. (2023) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-030435 · Cited by 289 · see citing works
The linear ubiquitin chain assembly complex regulates TRAIL‐induced gene activation and cell death
Lafont, E., Kantari‐Mimoun, C., Draber, P., De Miguel, D., Hartwig, T., Reichert, M., Kupka, S., Shimizu, Y., Taraborrelli, L., Spit, M., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695699 · Cited by 114 · see citing works
Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death
Dasari, S. K., Bialik, S., Levin-Zaidman, S., Levin-Salomon, V., Merrill, A. H., Futerman, A. H., & Kimchi, A. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.80 · Cited by 95 · see citing works
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling.
Samson, A. L., Garnish, S. E., Hildebrand, J. M., & Murphy, J. M. (2021) · Science Signaling · doi:10.1126/scisignal.abc6178 · Cited by 82 · see citing works
The interplay of autophagy and non-apoptotic cell death pathways
(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.12.004 · Cited by 50 · see citing works
Escobar, S. J. D. M., Fong, G. M., Winnischofer, S. M. B., Simone, M., Munoz, L., Dennis, J. M., Rocha, M. E. M., & Witting, P. K. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.11.022 · Cited by 33 · see citing works
A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α
Saha, B., Chisholm, D., Kell, A. M., & Mandell, M. A. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1009017 · Cited by 16 · see citing works
- Authors
- Goodall, M. L., Fitzwalter, B. E., Zahedi, S., Wu, M., Rodriguez, D., Mulcahy-Levy, J. M., Green, D. R., Morgan, M., Cramer, S. D., & Thorburn, A.
- Affiliations
- University of Colorado Denver (US)
- The University of Texas MD Anderson Cancer Center (US)
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Thorburn, Andrew
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 37
- Issue
- 4
- Pages
- 337-349
- ISSN
- 1534-5807 (ISSN-L)
- PMC
- PMC4886731
- OpenAlex
- W2402677148
- Cited by
- 314
- References
- 64
- Citations by year
- 2026: 23 · 2025: 22 · 2024: 26 · 2023: 20 · 2022: 38 · 2021: 37 · 2020: 43 · 2019: 44 · 2018: 26 · 2017: 28 · 2016: 7
- FWCI
- 18.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (RO1CA150925, RO1CA190170, RO1CA199741, R21CA187354, 1F32CA196080, P30CA046934)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- autophagy machinery, apoptosis, necroptosis, TAK1, TRAIL sensitivity, necrosome, RIPK1, p62, prostate cancer, programmed cell death
- MeSH terms
- Autophagosomes, Autophagy-Related Protein 5, MAP Kinase Kinase Kinase 7, Animals, Autophagy, Epithelial Cells, Humans, Male, Necrosis, Prostatic Neoplasms, RNA-Binding Proteins, Apoptosis, MAP Kinase Kinase Kinases, Mice, Receptors, Death Domain, TNF-Related Apoptosis-Inducing Ligand, Receptor-Interacting Protein Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
