Hyaluronan: from extracellular glue to pericellular cue

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219

Prospective identification of tumorigenic breast cancer cells

Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,579

Epithelial–mesenchymal transitions in tumour progression

Thiery, J. P. (2002) · Nature reviews. Cancer · doi:10.1038/nrc822 · Cited by 6,767

New functions for the matrix metalloproteinases in cancer progression

Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108

Multidrug resistance in cancer: role of ATP–dependent transporters

Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536

Dissemination and growth of cancer cells in metastatic sites

Chambers, A. F., Groom, A. C., & MacDonald, I. C. (2002) · Nature reviews. Cancer · doi:10.1038/nrc865 · Cited by 4,018

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

Nelson, W. J., & Nusse, R. (2004) · Science · doi:10.1126/science.1094291 · Cited by 2,537

CD44: From adhesion molecules to signalling regulators

Ponta, H., Sherman, L. S., & Herrlich, P. A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1004 · Cited by 2,458

CD44 is the principal cell surface receptor for hyaluronate

Aruffo, A. A., Stamenkovic, I., Melnick, M., Underhill, C. B., & Seed, B. (1990) · Cell · doi:10.1016/0092-8674(90)90694-a · Cited by 2,439

Putting tumours in context

Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180

Peroxisome Proliferator-activated Receptor γ Ligands Inhibit Transforming Growth Factor-β-induced, Hyaluronan-dependent, T Cell Adhesion to Orbital Fibroblasts

Guo, N., Woeller, C. F., Feldon, S. E., & Phipps, R. P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.179317 · Cited by 40

Highly sensitive and selective anticancer effect by conjugated HA-cisplatin in non-small cell lung cancer overexpressed with CD44

Quan, Y. H., Kim, B., Park, J., Choi, Y., Choi, Y. H., & Kim, H. K. (2014) · Experimental Lung Research · doi:10.3109/01902148.2014.905656 · Cited by 40

Directing neural stem cell fate with biomaterial parameters for injured brain regeneration

Yao, S., Liu, X., Wang, X., Merolli, A., Chen, D., & Cui, F. (2013) · Progress in Natural Science Materials International · doi:10.1016/j.pnsc.2013.02.009 · Cited by 40

Acide hyaluronique : structure, métabolisme et implication dans la cicatrisation

Gall, Y. (2010) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/s0151-9638(10)70007-7 · Cited by 40

Is Breast Augmentation Using Hyaluronic Acid Safe?

McCleave, M. J. (2009) · Aesthetic Plastic Surgery · doi:10.1007/s00266-009-9450-9 · Cited by 40

Hyaluronan: A critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation

Lagendijk, A. K., Szabó, A., Merks, R. M. H., & Bakkers, J. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.10.002 · Cited by 40

Epigenetic silencing of miR-200b is associated with cisplatin resistance in bladder cancer

Shindo, T., Niinuma, T., Nishiyama, N., Shinkai, N., Kitajima, H., Kai, M., Maruyama, R., Tokino, T., Masumori, N., & Suzuki, H. (2018) · Oncotarget · doi:10.18632/oncotarget.25326 · Cited by 40

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability

Shin, J. A., Yoo, K., Kim, M., Kim, D., & Baek, K. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-292 · Cited by 40

Preparation and application of biologically active fluorescent hyaluronan oligosaccharides

Seyfried, N. T., Blundell, C. D., Day, A. J., & Almond, A. (2004) · Glycobiology · doi:10.1093/glycob/cwi008 · Cited by 40

The ubiquitous hyaluronan: Functionally implicated in the oviduct?

Rodríguez‐Martínez, H., Tienthai, P., Atikuzzaman, M., Vicente‐Carrillo, A., Rubèr, M., & Álvarez‐Rodríguez, M. (2015) · Theriogenology · doi:10.1016/j.theriogenology.2015.11.025 · Cited by 39

Isolation and Characterization of Hyaluronic Acid from Marine Organisms

Sadhasivam, G., & Arumugam, M. (2014) · Advances in food and nutrition research · doi:10.1016/b978-0-12-800269-8.00004-x · Cited by 39

Hyaluronic Acid Stabilized Iodine-Containing Nanoparticles with Au Nanoshell Coating for X-ray CT Imaging and Photothermal Therapy of Tumors

Liu, X., Gao, C., Gu, J., Jiang, Y., Yang, X., Li, S., Gao, W., Duan, H., Duan, H., Fu, J., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b11918 · Cited by 39

Hyaluronic acid synthesis is required for zebrafish tail fin regeneration

Ouyang, X., Panetta, N. J., Talbott, M., Payumo, A. Y., Halluin, C., Longaker, M. T., & Chen, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171898 · Cited by 39

Serum levels of hyaluronic acid are associated with COPD severity and predict survival

Papakonstantinou, E., Bonovolias, I. D., Roth, M., Tamm, M., Schumann, D., Baty, F., Louis, R. E., Milenkovic, B. A., Boersma, W. G., Stieltjes, B., et al. (2019) · European Respiratory Journal · doi:10.1183/13993003.01183-2018 · Cited by 39

Hyaluronic Acid: The Reason for Its Variety of Physiological and Biochemical Functional Properties

Al-Khateeb, R., & Prpić, J. (2019) · Applied Clinical Research Clinical Trials and Regulatory Affairs · doi:10.2174/2213476x06666190405094637 · Cited by 39

Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44

Amorim, S., Pashkuleva, I., Reis, C. A., Reis, R. L., & Pires, R. A. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00407c · Cited by 39

Evaluation of Hyaluronic Acid/Agarose Hydrogel for Cartilage Tissue Engineering Biomaterial

Choi, J. H., Kim, J. S., Kim, W. K., Lee, W., Kim, N., Song, C. U., Jung, J. J., Song, J. E., & Khang, G. (2020) · Macromolecular Research · doi:10.1007/s13233-020-8137-6 · Cited by 39

PCL/HA Hybrid Microspheres for Effective Osteogenic Differentiation and Bone Regeneration

Jang, H. Y., Shin, J. Y., Oh, S. H., Byun, J., & Lee, J. H. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00550 · Cited by 39

Cutaneous mucinosis in shar‐pei dogs is due to hyaluronic acid deposition and is associated with high levels of hyaluronic acid in serum

Zanna, G., Fondevila, D., Bardagí, M., Docampo, M. J., Bassols, A., & Ferrer, L. (2008) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2008.00703.x · Cited by 39

Hyaluronan promotes the chondrocyte response to BMP-7

Andhare, R. A., Takahashi, N., Knudson, W., & Knudson, C. B. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2008.12.007 · Cited by 39

Epigenetic Regulation of HYAL-1 Hyaluronidase Expression

Lokeshwar, V. B., Gomez, P., Kramer, M. W., Knapp, J., McCornack, M. A., López, L. E., Fregien, N. L., Dhir, N., Scherer, S., Klumpp, D. J., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801101200 · Cited by 39

Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) promotes lung fibroblast proliferation, survival and differentiation to myofibroblasts

Hasaneen, N. A., Cao, J. P., Pulkoski‐Gross, A., Zucker, S., & Foda, H. D. (2016) · Respiratory Research · doi:10.1186/s12931-016-0334-7 · Cited by 39

Sirolimus blocks the accumulation of hyaluronan (HA) by arterial smooth muscle cells and reduces monocyte adhesion to the ECM

Gouëffic, Y., Potter‐Perigo, S., Chan, C. K., Johnson, P. Y., Braun, K. R., Evanko, S. P., & Wight, T. N. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.023 · Cited by 39

CD44 signaling in skin wound healing and regeneration

Guan, A. Y., Chen, Y., Tseng, S. C. G., & Lin, Q. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06913-5 · Cited by 39

Hyaluronan metabolism in remodeling extracellular matrix: probes for imaging and therapy of breast cancer

Veiseh, M., & Turley, E. A. (2011) · Integrative Biology · doi:10.1039/c0ib00096e · Cited by 38

Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance

Lien, H., Lee, Y., Jeng, Y., Lin, C., Lu, Y., & Yao, Y. (2014) · Histopathology · doi:10.1111/his.12390 · Cited by 38

Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells

Kievit, F. M., Wang, K., Erickson, A. E., Levengood, S. K. L., Ellenbogen, R. G., & Zhang, M. (2015) · Biomaterials Science · doi:10.1039/c5bm00514k · Cited by 38

Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation

Ferrari, L. F., Araldi, D., Bogen, O., & Levine, J. D. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.032 · Cited by 38

Regulation of Breast Cancer Progression by Extracellular Matrix Mechanics: Insights from 3D Culture Models

Lee, J. Y., & Chaudhuri, O. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00071 · Cited by 39

Polysaccharide and protein-based functional wound dressing materials and applications

Debele, T. A., & Su, W. (2020) · International Journal of Polymeric Materials · doi:10.1080/00914037.2020.1809403 · Cited by 38

N-Glycosylation can selectively block or foster different receptor–ligand binding modes

Vuorio, J., Škerlová, J., Fábry, M., Veverka, V., Vattulainen, I., Řezáčová, P., & Martinez‐Seara, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-84569-z · Cited by 38

Two-dimensional LDH nanodisks modified with hyaluronidase enable enhanced tumor penetration and augmented chemotherapy

Li, G., Fan, Y., Lin, L., WU, R. T., Shen, M., & Shi, X. (2021) · Science China Chemistry · doi:10.1007/s11426-020-9933-4 · Cited by 38

Role of CD44 in the organization of keratinocyte pericellular hyaluronan

Pasonen‐Seppänen, S., Hyttinen, J. M. T., Rilla, K. J., Jokela, T. A., Noble, P. W., Tammi, M., & Tammi, R. (2011) · Histochemistry and Cell Biology · doi:10.1007/s00418-011-0883-2 · Cited by 38

Benefits of concurrent delivery of hyaluronan and IGF-1 cues to regeneration of crosslinked elastin matrices by adult rat vascular cells

Kothapalli, C. R., & Ramamurthi, A. (2008) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.70 · Cited by 38

Functional surfaces for high-resolution analysis of cancer cell interactions on exogenous hyaluronic acid

Dickinson, L. E., Ho, C. C. M., Wang, G. M., Stebe, K. J., & Gerecht, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.044 · Cited by 38

Hyaluronic Acid

Allegra, L., Patrona, S. D., & Petrigni, G. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-23056-1_17 · Cited by 38

Determining the Molecular Basis for the pH-dependent Interaction between the Link Module of Human TSG-6 and Hyaluronan

Blundell, C. D., Mahoney, D. J., Cordell, M. R., Almond, A., Kahmann, J. D., Perczel, A., Taylor, J. D., Campbell, I. D., & Day, A. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611713200 · Cited by 39

From molecules to behavior: Implications for perineuronal net remodeling in learning and memory

Sanchez, B., Kraszewski, P., Lee, S., & Cope, E. C. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16036 · Cited by 41

Tumor vessel-adaptable adhesive and absorbable microspheres for sustainable transarterial chemoembolization therapy

Guo, J., Huang, J., Huang, Z., Hu, D., Tan, H., Wang, Y., Deng, C., Zhu, X., & Zhong, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-61621-4 · Cited by 37

Spatial Organization and Mechanical Properties of the Pericellular Matrix on Chondrocytes

McLane, L. T., Chang, P., Granqvist, A., Boehm, H., Kramer, A., Scrimgeour, J., & Curtis, J. E. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2013.01.028 · Cited by 37

The effect of hyaluronan on the motility of skin dermal fibroblasts in nanofibrous scaffolds

Qian, Y., Li, L., Jiang, C., Xu, W., Lv, Y., Li, Z., Cai, K., & Yang, L. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.04.059 · Cited by 37

CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells

Wang, S. (2012) · Oncology Reports · doi:10.3892/or.2012.1729 · Cited by 37

In Vitro Investigation of Self-Assembled Nanoparticles Based on Hyaluronic Acid-Deoxycholic Acid Conjugates for Controlled Release Doxorubicin: Effect of Degree of Substitution of Deoxycholic Acid

Wei, W., Dong, X., & Liu, C. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047195 · Cited by 37

Improved stability and tumor targeting of 5‐fluorouracil by conjugation with hyaluronan

Dong, Z., Zheng, W., Xu, Z., & Yin, Z. (2013) · Journal of Applied Polymer Science · doi:10.1002/app.39247 · Cited by 37

Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles

Zhong, Y., Meng, F., Deng, C., Mao, X., & Zhong, Z. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1384864 · Cited by 37

Effects of Nanoprobe Morphology on Cellular Binding and Inflammatory Responses: Hyaluronan-Conjugated Magnetic Nanoworms for Magnetic Resonance Imaging of Atherosclerotic Plaques

Nasr, S. H., Tonson, A., El‐Dakdouki, M. H., Zhu, D. C., Agnew, D., Wiseman, R., Qian, C., & Huang, X. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19708 · Cited by 37

Extracellular Domains I and II of cell-surface glycoprotein CD44 mediate its trans-homophilic dimerization and tumor cluster aggregation

Kawaguchi, M., Dashzeveg, N. K., Cao, Y., Jia, Y., Liu, X., Shen, Y., & Liu, H. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010252 · Cited by 37

Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition

Osmond, M. J., Krebs, M. D., & Pantcheva, M. B. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27477 · Cited by 37

Hepatocellular Carcinoma

Carlessi, R., Köhn‐Gaone, J., Olynyk, J. K., & Tirnitz‐Parker, J. E. E. (2019) · Codon Publications eBooks · doi:10.15586/hepatocellularcarcinoma.2019 · Cited by 39

Physically Cross-Linked Hyaluronan-Based Ultrasoft Cryogel Prepared by Freeze–Thaw Technique as a Barrier for Prevention of Postoperative Adhesions

Cai, Z., Tang, Y., Wei, Y. Z., Wang, P., & Zhang, H. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c00878 · Cited by 37

Molecularly Imprinted Polymer Hydrogel Nanoparticles: Synthetic Antibodies for Cancer Diagnosis and Therapy

Bui, B. T. S., & Haupt, K. (2021) · ChemBioChem · doi:10.1002/cbic.202100598 · Cited by 38

Phytochemical Analysis and Antioxidant, Antimicrobial, and Antiaging Activities of Ethanolic Seed Extracts of Four Mucuna Species

Theansungnoen, T., Nitthikan, N., Wilai, M., Chaiwut, P., Kiattisin, K., & Intharuksa, A. (2022) · Cosmetics · doi:10.3390/cosmetics9010014 · Cited by 37

CEMIP, a Promising Biomarker That Promotes the Progression and Metastasis of Colorectal and Other Types of Cancer

Domanegg, K., Sleeman, J. P., & Schmaus, A. (2022) · Cancers · doi:10.3390/cancers14205093 · Cited by 37

Hyaluronan/RHAMM Interactions in Mesenchymal Tumor Pathogenesis

Kouvidi, K., Nikitovic, D., Berdiaki, A., & Tzanakakis, G. N. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-800092-2.00012-5 · Cited by 37

Acellular matrices derived from differentiating embryonic stem cells

Nair, R., Shukla, S., & McDevitt, T. C. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31851 · Cited by 37

The Impact of the Receptor of Hyaluronan-Mediated Motility (RHAMM) on Human Urothelial Transitional Cell Cancer of the Bladder

Niedworok, C., Kretschmer, I., Roeck, K., Dorp, F. V., Szarvas, T., Heß, J., Freudenberger, T., Melchior‐Becker, A., Rubben, H., & Fischer, J. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075681 · Cited by 37

Down-regulation of UDP-glucose dehydrogenase affects glycosaminoglycans synthesis and motility in HCT-8 colorectal carcinoma cells

Wang, T.-P., Pan, Y., Fu, C., & Chang, H. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.07.017 · Cited by 38

Increased HAS2‐driven hyaluronic acid synthesis in shar‐pei dogs with hereditary cutaneous hyaluronosis (mucinosis)

Docampo, M. J., Zanna, G., Fondevila, D., Cabrera, J. S., López‐Iglesias, C., Carvalho, A., Cerrato, S., Ferrer, L., & Bassols, A. (2011) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2011.00986.x · Cited by 37

Molecular mass dependence of hyaluronan detection by sandwich ELISA-like assay and membrane blotting using biotinylated hyaluronan binding protein

Yuan, H., Tank, M., Alsofyani, A., Shah, N., Talati, N., LoBello, J., Kim, J. R., Oonuki, Y., de la Motte, C. A., & Cowman, M. K. (2013) · Glycobiology · doi:10.1093/glycob/cwt064 · Cited by 37

Hyaluronic acid hydrogels with defined crosslink density for the efficient enrichment of breast cancer stem cells

Tan, S., Yamashita, A., Gao, S. J., & Kurisawa, M. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.040 · Cited by 37

CD44: A New Prognostic Marker in Colorectal Cancer?

Ziranu, P., Pretta, A., Aimola, V., Cau, F., Mariani, S., D’Agata, A. P., Codipietro, C., Rizzo, D., Dell’Utri, V., Sanna, G., et al. (2024) · Cancers · doi:10.3390/cancers16081569 · Cited by 38

Plasma hyaluronic acid level as a prognostic and monitoring marker of metastatic breast cancer

Peng, C., Wallwiener, M., Rudolph, A., Ćuk, K., Eilber, U., Celik, M., Modugno, C., Trumpp, A., Heil, J., Marmé, F., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29975 · Cited by 36

One-Step Solvothermal Synthesis of Targetable Optomagnetic Upconversion Nanoparticles for in Vivo Bimodal Imaging

Wang, X., Chen, J., Zhu, H., Chen, X., & Yan, X. (2013) · Analytical Chemistry · doi:10.1021/ac401934p · Cited by 36

Plasma High Mobility Group Box 1 (HMGB1), Osteopontin (OPN), and Hyaluronic Acid (HA) as Admissible Biomarkers for Endometriosis

Cao, Y., Liu, X., & Guo, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45785-w · Cited by 36

Systemic blockade of the hyaluronan receptor for endocytosis prevents lymph node metastasis of prostate cancer

Simpson, M. A., Weigel, J. A., & Weigel, P. H. (2012) · International Journal of Cancer · doi:10.1002/ijc.27427 · Cited by 36

The hyaluronan synthesis inhibitor 4-methylumbelliferone exhibits antitumor effects against mesenchymal-like canine mammary tumor cells

Saito, T., Tamura, D., & Asano, R. (2013) · Oncology Letters · doi:10.3892/ol.2013.1124 · Cited by 36

Hyaluronan/Hyaladherins - a Promising Axis for Targeted Drug Delivery in Cancer

Nikitovic, D., Kouvidi, K., Kavasi, R., Berdiaki, A., & Tzanakakis, G. N. (2015) · Current Drug Delivery · doi:10.2174/1567201813666151109103013 · Cited by 36

CD44 and its implication in neoplastic diseases

Xu, Y., Bai, Z., Lan, T., Fu, C., & Cheng, P. (2024) · MedComm · doi:10.1002/mco2.554 · Cited by 35

Transactivation of the Receptor-tyrosine Kinase Ephrin Receptor A2 Is Required for the Low Molecular Weight Hyaluronan-mediated Angiogenesis That Is implicated in Tumor Progression

Lennon, F. E., Mirzapoiazova, T., Mambetsariev, N., Mambetsariev, B., Salgia, R., & Singleton, P. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.554766 · Cited by 35

A Role for Versican in the Development of Leiomyosarcoma

Keire, P. A., Bressler, S. L., Lemire, J. M., Edris, B., Rubin, B. P., Rahmani, M., McManus, B. M., van de Rijn, M., & Wight, T. N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.607168 · Cited by 35

Bioactive polymer scaffold for fabrication of vascularized engineering tissue

Sukmana, I. (2012) · Journal of Artificial Organs · doi:10.1007/s10047-012-0644-6 · Cited by 35

Sox10 Controls Migration of B16F10 Melanoma Cells through Multiple Regulatory Target Genes

Seong, I., Min, H. J., Lee, J., Yeo, C., Kang, D. M., Oh, E., Hwang, E. S., & Kim, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031477 · Cited by 35

Internalized compartments encapsulated nanogels for targeted drug delivery

Yu, J., Zhang, Y., Sun, W., Wang, C., Ranson, D., Ye, Y., Weng, Y., & Gu, Z. (2016) · Nanoscale · doi:10.1039/c5nr08895j · Cited by 37

Reversing Cancer Multidrug Resistance in Xenograft Models via Orchestrating Multiple Actions of Functional Mesoporous Silica Nanoparticles

Yang, D., Wang, T., Su, Z., Xue, L., Mo, R., & Zhang, C. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b04885 · Cited by 35

Signaling at the Crossroads: Matrix-Derived Proteoglycan and Reactive Oxygen Species Signaling

Nastase, M.-V., Janicova, A., Wygrecka, M., & Schaefer, L. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7165 · Cited by 36

Impact of Attrition, Intercellular Shear in Dry Eye Disease: When Cells are Challenged and Neurons are Triggered

van Setten, G. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124333 · Cited by 35

Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc

Yan, C., Wang, X., Xiang, C., Wang, Y., Pu, C., Chen, L., Jiang, K., & Li, Y. (2021) · BioMed Research International · doi:10.1155/2021/2818624 · Cited by 35

Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT

Tian, H., Shi, H., Yu, J., Ge, S., & Ruan, J. (2022) · Global Challenges · doi:10.1002/gch2.202100094 · Cited by 36

HABP2 is a Novel Regulator of Hyaluronan-Mediated Human Lung Cancer Progression

Mirzapoiazova, T., Mambetsariev, N., Lennon, F. E., Mambetsariev, B., Berlind, J. E., Salgia, R., & Singleton, P. A. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00164 · Cited by 35

Inhibition of Hyaluronan Synthesis Reduces Versican and Fibronectin Levels in Trabecular Meshwork Cells

Keller, K. E., Sun, Y. Y., Vranka, J. A., Hayashi, L., & Acott, T. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048523 · Cited by 35

TGF-β2: A Novel Target of CD44-Promoted Breast Cancer Invasion

Ouhtit, A., Madani, S., Gupta, I., Shanmuganathan, S., Abdraboh, M. E., Al‐Riyami, H., Al-Farsi, Y. M., & Raj, M. H. G. (2013) · Journal of Cancer · doi:10.7150/jca.6638 · Cited by 35

A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications

Fu, X., Shang, W., Wang, S., Liu, Y., Qu, J., Chen, X., Wang, P. G., & Fang, J. (2017) · Chemical Communications · doi:10.1039/c6cc09431g · Cited by 35

Hyaluronan in the Cancer Cells Microenvironment

Karousou, E. G., Parnigoni, A., Moretto, P., Passi, A. G., Viola, M., & Vigetti, D. (2023) · Cancers · doi:10.3390/cancers15030798 · Cited by 35

Polysaccharide–porphyrin–fullerene supramolecular conjugates as photo-driven DNA cleavage reagents

Chen, Y., Zhao, D., & Liu, Y. (2015) · Chemical Communications · doi:10.1039/c5cc04625d · Cited by 34

Methyl-β-cyclodextrin Suppresses Hyaluronan Synthesis by Down-regulation of Hyaluronan Synthase 2 through Inhibition of Akt

Kultti, A. H., Kärnä, R., Rilla, K. J., Nurminen, P., Koli, E., Makkonen, K. M., Si, J., Tammi, M., & Tammi, R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.088435 · Cited by 34

Biomimetic stiffening of cell-laden hydrogels via sequential thiol-ene and hydrazone click reactions

Chang, C., Johnson, H. C., Babb, O., Fishel, M. L., & Lin, C. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.054 · Cited by 34

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Meng, Q., Zhong, S., He, S., Gao, Y., & Cui, X. (2021) · Colloids and Interface Science Communications · doi:10.1016/j.colcom.2021.100503 · Cited by 34

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Evrard, C., de Rouvroit, C. L., & Poumay, Y. (2021) · Cells · doi:10.3390/cells10113096 · Cited by 34

Ocular extracellular matrices in development

Hausman, R. E. (2006) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.11.001 · Cited by 35

A polymeric conjugate foreignizing tumor cells for targeted immunotherapy in vivo

Lee, Y., Yoon, H. Y., Shin, J. M., Saravanakumar, G., Noh, K. H., Song, K., Jeon, J., Kim, D., Lee, K., Kim, K., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.007 · Cited by 35

Hyaluronan Accumulation in Wounded Epidermis: A Mediator of Keratinocyte Activation

Tammi, R., & Tammi, M. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.91 · Cited by 34

Ultraviolet‐B Irradiation Induces Differential Regulations of Hyaluronidase Expression and Activity in Normal Human Keratinocytes

Kurdykowski, S., Mine, S., Bardey, V., Danoux, L., Jeanmaire, C., Pauly, G., Brabencová, E., Wegrowski, Y., & Maquart, F. X. (2011) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.00959.x · Cited by 34

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Maturavongsadit, P., Bi, X., Metavarayuth, K., Luckanagul, J. A., & Wang, Q. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b12437 · Cited by 34

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Mehić, M., de, V. K., Hebestreit, S., Heldin, C., & Heldin, P. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.45 · Cited by 34

Inflammation and Cancer

Misra, S., Hascall, V., Markwald, R. R., O’Brien, P. E., & Ghatak, S. (2017) · Wiley eBooks · doi:10.1002/9781119282518.ch18 · Cited by 34

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Pasquinelli, G., Vinci, M. C., Gamberini, C., Orrico, C., Foroni, L., Guarnieri, C., Parenti, A., Gargiulo, M., Ledda, F., Caldarera, C. M., et al. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0232 · Cited by 33

Mapping the mechanics and macromolecular organization of hyaluronan-rich cell coats

Boehm, H., Mundinger, T. A., Boehm, C. H. J., Hagel, V., Rauch, U., Spatz, J. P., & Curtis, J. E. (2009) · Soft Matter · doi:10.1039/b905574f · Cited by 33

Polysaccharide-Based Biomaterials for Protein Delivery

Wang, K., Liu, M., & Mo, R. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100031 · Cited by 34

Anti-tumor effect of local injectable hydrogel-loaded endostatin alone and in combination with radiotherapy for lung cancer

Wang, N., Gao, Q., Tang, J., Jiang, Y., Yang, L., Shi, X., Chen, Y., Zhang, Y., Fu, S., & Lin, S. (2021) · Drug Delivery · doi:10.1080/10717544.2020.1869864 · Cited by 33

Bioinspired 3D Culture in Nanoliter Hyaluronic Acid‐Rich Core‐Shell Hydrogel Microcapsules Isolates Highly Pluripotent Human iPSCs

Xu, J., Shamul, J. G., Staten, N. A., White, A. M., Jiang, B., & He, X. (2021) · Small · doi:10.1002/smll.202102219 · Cited by 35

Hyaluronan promotes the malignant phenotype

Toole, B. P. (2002) · Glycobiology · doi:10.1093/glycob/12.3.37r · Cited by 202

Hyaluronan in the Tumor Microenvironment

Spinelli, F. M., Vitale, D. L., Sevic, I., & Alaniz, L. D. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-40146-7_3 · Cited by 50

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Alaniz, L. D., García, M. G., Rizzo, M., Piccioni, F., & Mazzolini, G. D. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709790361485 · Cited by 25

Importance of Hyaluronan-CD44 Interactions in Inflammation and Tumorigenesis

Heldin, P., Karousou, E., Olofsson, B., Porsch, H., Nishitsuka, K., & Skandalis, S. S. (2008) · Connective Tissue Research · doi:10.1080/03008200802143323 · Cited by 94

Hyaluronan network: a driving force in cancer progression

Karalis, T. T., & Skandalis, S. S. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2022 · Cited by 22