Hyaluronan: from extracellular glue to pericellular cue

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CD44 is the principal cell surface receptor for hyaluronate

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HYTAD1-p20: A new paclitaxel-hyaluronic acid hydrosoluble bioconjugate for treatment of superficial bladder cancer

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Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis

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Hyaluronan and Its Interactions With Immune Cells in the Healthy and Inflamed Lung

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Influence of Hyaluronic Acid Transitions in Tumor Microenvironment on Glioblastoma Malignancy and Invasive Behavior

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Synovial fluid hyaluronan mediates MSC attachment to cartilage, a potential novel mechanism contributing to cartilage repair in osteoarthritis using knee joint distraction

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Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: A review

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Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44

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Hippo‐YAP signaling pathway: A new paradigm for cancer therapy

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The role of hyaluronan in the pathobiology and treatment of respiratory disease

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Robust PEGylated hyaluronic acid nanoparticles as the carrier of doxorubicin: Mineralization and its effect on tumor targetability in vivo

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Independently Tuning the Biochemical and Mechanical Properties of 3D Hyaluronan-Based Hydrogels with Oxime and Diels–Alder Chemistry to Culture Breast Cancer Spheroids

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Unveiling the Extracellular Space of the Brain: From Super-resolved Microstructure toIn VivoFunction

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Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance

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Engineering nanoparticles to overcome immunological barriers for enhanced drug delivery

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The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis

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Hyaluronic Acid: Known for Almost a Century, but Still in Vogue

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Hyaluronic Acid‐Based Bioconjugate Systems, Scaffolds, and Their Therapeutic Potential

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More than just a filler – the role of hyaluronan for skin homeostasis

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Abrogating Drug Resistance in Malignant Peripheral Nerve Sheath Tumors by Disrupting Hyaluronan-CD44 Interactions with Small Hyaluronan Oligosaccharides

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Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice

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The Combined Influence of Hydrogel Stiffness and Matrix‐Bound Hyaluronic Acid Content on Glioblastoma Invasion

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Mechanisms That Underly T Cell Immunity in Graves’ Orbitopathy

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Hyaluronan Constitutively Regulates Activation of COX-2-mediated Cell Survival Activity in Intestinal Epithelial and Colon Carcinoma Cells

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Gels as Functional Nanomaterials for Biology and Medicine

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Altered hyaluronan biosynthesis in cancer progression

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Nanoparticle Targeting CD44-Positive Cancer Cells for Site-Specific Drug Delivery in Prostate Cancer Therapy

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Highly Accurate Detection of Cancer In Situ with Intraoperative, Label-Free, Multimodal Optical Spectroscopy

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Hyaluronic acid-decorated PLGA-PEG nanoparticles for targeted delivery of SN-38 to ovarian cancer.

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The effects of 4-methylumbelliferone on hyaluronan synthesis, MMP2 activity, proliferation, and motility of human aortic smooth muscle cells

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Effect of hyaluronic acid in bone formation and its applications in dentistry

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Acetylated Hyaluronic Acid/Photosensitizer Conjugate for the Preparation of Nanogels with Controllable Phototoxicity: Synthesis, Characterization, Autophotoquenching Properties, and in vitro Phototoxicity against HeLa Cells

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CD44 regulates myoblast migration and differentiation

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Mechanisms of Invasion in Glioblastoma: Extracellular Matrix, Ca2+ Signaling, and Glutamate

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Collagen VI and Hyaluronan: The Common Role in Breast Cancer

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Importance of Hyaluronan-CD44 Interactions in Inflammation and Tumorigenesis

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Engineering biocompatible implant surfaces

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Hyaluronic acid-conjugated mesoporous silica nanoparticles: excellent colloidal dispersity in physiological fluids and targeting efficacy

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Hyaluronic acid facilitates bone repair effects of calcium phosphate cement by accelerating osteogenic expression

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Exploiting extracellular matrix-stem cell interactions: A review of natural materials for therapeutic muscle regeneration

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Hydrogel-Based 3D Model of Patient-Derived Prostate Xenograft Tumors Suitable for Drug Screening

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Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation

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Hyaluronic acid fuels pancreatic cancer cell growth

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Tumor spheroid assembly on hyaluronic acid-based structures: A review

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A Trickster in Disguise: Hyaluronan’s Ambivalent Roles in the Matrix

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Hyaluronan in immune dysregulation and autoimmune diseases

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Biomimetic tumor microenvironments based on collagen matrices

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Hyaluronic acid, CD44 and RHAMM regulate myoblast behavior during embryogenesis

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The effect of hyaluronic acid hydrogels on dental pulp stem cells behavior

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Hyaluronan Stabilizes Focal Adhesions, Filopodia, and the Proliferative Phenotype in Esophageal Squamous Carcinoma Cells

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Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development

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A Multifunctional 3D Co-Culture System for Studies of Mammary Tissue Morphogenesis and Stem Cell Biology

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Hyaluronan and the Fascial Frontier

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Deregulated hyaluronan metabolism in the tumor microenvironment drives cancer inflammation and tumor-associated immune suppression

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Controlled-release hydrogel loaded with magnesium-based nanoflowers synergize immunomodulation and cartilage regeneration in tendon-bone healing

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Agarose and polyacrylamide gel electrophoresis methods for molecular mass analysis of 5- to 500-kDa hyaluronan

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The Hyaluronan Synthase Catalyzes the Synthesis and Membrane Translocation of Hyaluronan

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The Human Hyaluronan Synthase 2 (HAS2) Gene and Its Natural Antisense RNA Exhibit Coordinated Expression in the Renal Proximal Tubular Epithelial Cell

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Developmentally regulated signaling pathways in glioma invasion

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In vitro modulation of preservative toxicity: High molecular weight hyaluronan decreases apoptosis and oxidative stress induced by benzalkonium chloride

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Hyaluronan-Based Nanocarriers with CD44-Overexpressed Cancer Cell Targeting

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Molecular basis for MMP9 induction and disruption of epithelial cell-cell contacts by galectin-3

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Fabrication and Characterization of Chitosan–Hyaluronic Acid Scaffolds with Varying Stiffness for Glioblastoma Cell Culture

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A Review on Extracellular Matrix Mimicking Strategies for an Artificial Stem Cell Niche

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Chain Gangs: New Aspects of Hyaluronan Metabolism

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Glycan Antagonists and Inhibitors: A Fount for Drug Discovery

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High-molecular-weight hyaluronan is a novel inhibitor of pulmonary vascular leakiness

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Delivery of CD44 shRNA/Nanoparticles within Cancer Cells

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3D porous chitosan–alginate scaffolds promote proliferation and enrichment of cancer stem-like cells

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Cancer Cell Glycocalyx and Its Significance in Cancer Progression

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Strong triaxial coupling and anomalous Poisson effect in collagen networks

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Effect of molecular weight and concentration of hyaluronan on cell proliferation and osteogenic differentiation In Vitro

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Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?

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Complication Management following Rejuvenation Procedures with Hyaluronic Acid Fillers—an Algorithm-based Approach

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The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue Engineering

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Hyaluronan Receptors as Mediators and Modulators of the Tumor Microenvironment

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An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy

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Chondroitin Sulfate E Fragments Enhance CD44 Cleavage and CD44-Dependent Motility in Tumor Cells

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Aging‐related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression

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Chemotherapy-induced hyaluronan production: a novel chemoresistance mechanism in ovarian cancer

Ricciardelli, C., Ween, M. P., Lokman, N. A., Tan, I. A., Pyragius, C. E., & Oehler, M. K. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-476 · Cited by 86

In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering

Han, S.-S., Yoon, H. Y., Yhee, J. Y., Cho, M. O., Shim, H.-E., Jeong, J.-E., Lee, D., Kim, K., Guim, H., Lee, J. H., et al. (2017) · Polymer Chemistry · doi:10.1039/c7py01654a · Cited by 86

Modulation of Drug Resistance in Ovarian Adenocarcinoma Using Chemotherapy Entrapped in Hyaluronan-Grafted Nanoparticle Clusters

Cohen, K., Emmanuel, R., Kisin‐Finfer, E., Shabat, D., & Peer, D. (2014) · ACS Nano · doi:10.1021/nn500205b · Cited by 85

Lymphatic Tissue Engineering and Regeneration

Alderfer, L., Wei, A. Y., & Hanjaya‐Putra, D. (2018) · Journal of Biological Engineering · doi:10.1186/s13036-018-0122-7 · Cited by 89

Drug distribution in tumors: Mechanisms, role in drug resistance, and methods for modification

Paolo, A. D., & Bocci, G. (2007) · Current Oncology Reports · doi:10.1007/s11912-007-0006-3 · Cited by 86

CD44 modulates Smad1 activation in the BMP-7 signaling pathway

Peterson, R. S., Andhare, R. A., Rousche, K. T., Knudson, W., Wang, W., Grossfield, J. B., thomas, R. O., Hollingsworth, R. E., & Knudson, C. B. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200402138 · Cited by 85

Hyaluronan digestion controls DC migration from the skin

Muto, J., Morioka, Y., Yamasaki, K., Kim, M., Garcia, A., Carlin, A. F., Varki, A., & Gallo, R. L. (2014) · Journal of Clinical Investigation · doi:10.1172/jci67947 · Cited by 84

Adhesive hydrogels in osteoarthritis: from design to application

Duan, W., Zhang, L., Bohara, R. A., Martín‐Saldaña, S., Yang, F., Zhao, Y., Xie, Y., Bu, Y., & Pandit, A. S. (2023) · Military Medical Research · doi:10.1186/s40779-022-00439-3 · Cited by 86

The Application of Hyaluronic Acid Hydrogels to Retinal Progenitor Cell Transplantation

Liu, Y., Wang, R., Zarembinski, T. I., Doty, N., Jiang, C., Regatieri, C. V., Zhang, X., & Young, M. J. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0209 · Cited by 84

Inter-α inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury

Chaaban, H., Keshari, R. S., Silasi‐Mansat, R., Popescu, N. I., Mehta-D’souza, P., Lim, Y., & Lupu, F. (2015) · Blood · doi:10.1182/blood-2014-06-582759 · Cited by 84

The crosstalk of hyaluronan-based extracellular matrix and synapses

Frischknecht, R., & Seidenbecher, C. I. (2008) · Neuron Glia Biology · doi:10.1017/s1740925x09990226 · Cited by 85

Cell survival and proliferation signaling pathways are downregulated by plasma-activated medium in glioblastoma brain tumor cells

Tanaka, H., Mizuno, M., Ishikawa, K., Nakamura, K., Utsumi, F., Kajiyama, H., Kano, H., Maruyama, S., Kikkawa, F., & Hori, M. (2012) · Plasma Medicine · doi:10.1615/plasmamed.2013008267 · Cited by 83

ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment

Gatti, V., Fierro, C., Annicchiarico‐Petruzzelli, M., Melino, G., & Peschiaroli, A. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12473 · Cited by 83

Hyaluronan oligosaccharides sensitize lymphoma resistant cell lines to vincristine by modulating P‐glycoprotein activity and PI3K/Akt pathway

Russo, R. I. C., García, M. G., Alaniz, L. D., Blanco, G. A. C., Álvarez, É., & Hajos, S. E. (2007) · International Journal of Cancer · doi:10.1002/ijc.23122 · Cited by 83

Targeting Tumor Architecture to Favor Drug Penetration: A New Weapon to Combat Chemoresistance in Pancreatic Cancer?

Yu, M., & Tannock, I. F. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.03.002 · Cited by 83

Targeting Hyaluronan Interactions in Malignant Gliomas and Their Drug-Resistant Multipotent Progenitors

Gilg, A. G., Tye, S. L., Tolliver, L. B., Wheeler, W. G., Visconti, R. P., Duncan, J. D., Kostova, F. V., Bolds, L. N., Toole, B. P., & Maria, B. L. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1228 · Cited by 84

Wound dressing based on chitosan/hyaluronan/nonwoven fabrics: Preparation, characterization and medical applications

Abdel-Rahman, R. M., Abdel-Mohsen, A. M., Hrdina, R., Burgert, L., Fohlerová, Z., Pavliňák, D., Sayed, O. N., & Jancar, J. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.04.087 · Cited by 82

Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for biomedical applications

Mendes, B. B., Daly, A. C., Reis, R. L., Domingues, R. M. A., Gomes, M. E., & Burdick, J. A. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.10.040 · Cited by 82

Hyaluronan promotes the malignant phenotype

Toole, B. P. (2002) · Glycobiology · doi:10.1093/glycob/12.3.37r · Cited by 202

Hyaluronan in the Tumor Microenvironment

Spinelli, F. M., Vitale, D. L., Sevic, I., & Alaniz, L. D. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-40146-7_3 · Cited by 50

Altered Hyaluronan Biosynthesis and Cancer Progression: an Immunological Perspective

Alaniz, L. D., García, M. G., Rizzo, M., Piccioni, F., & Mazzolini, G. D. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709790361485 · Cited by 25

Importance of Hyaluronan-CD44 Interactions in Inflammation and Tumorigenesis

Heldin, P., Karousou, E., Olofsson, B., Porsch, H., Nishitsuka, K., & Skandalis, S. S. (2008) · Connective Tissue Research · doi:10.1080/03008200802143323 · Cited by 94

Hyaluronan network: a driving force in cancer progression

Karalis, T. T., & Skandalis, S. S. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2022 · Cited by 22