The DOI matches its Crossref record; 187 of the 187 references it cites were found in a registry or an index.
BRCA1 and BRCA2: 1994 and beyond
Abstract
The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase our understanding of both hereditary and sporadic forms of breast cancer, and to lead to therapeutic and preventive breakthroughs. Much has been learned during the past decade about the genetic epidemiology of breast cancer, the ethnic distribution and clinical consequences of BRCA1 and BRCA2 mutations, and the central role of DNA repair in breast cancer susceptibility. The ability to translate this knowledge into novel treatments, however, remains elusive.
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“the lifetime risk of developing breast cancer in BRCA1/2 mutation carriers ranges from 45 to 80% [8–11]”
From Fear of cancer recurrence in breast cancer survivors carrying a BRCA1 or 2 genetic mutation : a cross-sectional study (2024) · cites this paper as [11]
In the citing paper
“The tumor suppressor complex BRCA1-BARD1 functions in DNA double-strand break repair by homologous recombination.”
From BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing (2017) · cites this paper as [1]
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Metadata
- Authors
- Narod, S. A., & Foulkes, W. D.
- Affiliations
- Sunnybrook Health Science Centre (CA)
- McGill University (CA)
- Corresponding author
- Narod, Steven A.
- Venue
- Nature Reviews Cancer
- Published
- 2004-09
- Volume
- 4
- Issue
- 9
- Pages
- 665-676
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2091961739
- Cited by
- 967
- References
- 187
- Citations by year
- 2026: 13 · 2025: 29 · 2024: 30 · 2023: 37 · 2022: 36 · 2021: 40 · 2020: 30 · 2019: 31 · 2018: 33 · 2017: 35 · 2016: 38 · 2015: 53 · 2014: 38 · 2013: 43 · 2012: 59
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- BRCA1, BRCA2, hereditary breast cancer, genetic susceptibility, DNA repair, genetic epidemiology, breast cancer prevention, breast cancer treatment
- MeSH terms
- Breast Neoplasms, DNA Damage, DNA Repair, Female, Humans, Mutation, Molecular Epidemiology, Genes, BRCA1, Genetic Predisposition to Disease, Genes, BRCA2
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