Cited by 978BRCA gene mutations in cancerGenetic factors in colorectal cancerPARP inhibition in cancer therapy

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BRCA1 and BRCA2: 1994 and beyond

Narod, Steven A., Foulkes, William D.·2004·Nature Reviews Cancer

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Abstract

The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase our understanding of both hereditary and sporadic forms of breast cancer, and to lead to therapeutic and preventive breakthroughs. Much has been learned during the past decade about the genetic epidemiology of breast cancer, the ethnic distribution and clinical consequences of BRCA1 and BRCA2 mutations, and the central role of DNA repair in breast cancer susceptibility. The ability to translate this knowledge into novel treatments, however, remains elusive.

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Background
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Authors: Narod, S. A., & Foulkes, W. D.
Affiliations: Sunnybrook Health Science Centre (CA)
McGill University (CA)
Corresponding author: Narod, Steven A.
ORCID: Narod, Steven A.
Foulkes, William D.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2004-09
Volume: 4
Issue: 9
Pages: 665-676
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc1431
OpenAlex: W2091961739
Cited by: 967
References: 187
Citations by year: 2026: 13 · 2025: 29 · 2024: 30 · 2023: 37 · 2022: 36 · 2021: 40 · 2020: 30 · 2019: 31 · 2018: 33 · 2017: 35 · 2016: 38 · 2015: 53 · 2014: 38 · 2013: 43 · 2012: 59
FWCI: 6.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BRCA1, BRCA2, hereditary breast cancer, genetic susceptibility, DNA repair, genetic epidemiology, breast cancer prevention, breast cancer treatment
MeSH terms: Breast Neoplasms, DNA Damage, DNA Repair, Female, Humans, Mutation, Molecular Epidemiology, Genes, BRCA1, Genetic Predisposition to Disease, Genes, BRCA2

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