BRCA1 and BRCA2: 1994 and beyond

Molecular portraits of human breast tumours

Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551

Gene expression profiling predicts clinical outcome of breast cancer

van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069

Repeated observation of breast tumor subtypes in independent gene expression data sets

Sørlie, T., Tibshirani, R. J., Parker, J. S., Hastie, T. J., Marron, J. S., Nobel, A. B., Deng, S., Johnsen, H., Pesich, R., Geisler, S. B., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0932692100 · Cited by 5,508

Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies

Antoniou, A., Pharoah, P. D. P., Narod, S., Risch, H. A., Eyfjord, J. E., Hopper, J. L., Loman, N., Olsson, H., Johannsson, O., Borg, Å., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/375033 · Cited by 3,680

Identification of the breast cancer susceptibility gene BRCA2

Wooster, R., Bignell, G. R., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S. G., Gumbs, C. E., Micklem, G., et al. (1995) · Nature · doi:10.1038/378789a0 · Cited by 3,645

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

Orita, M., Iwahana, H., Kanazawa, H., Hayashi, K., & Sekiya, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2766 · Cited by 3,589

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Greenblatt, M. S., Bennett, W. P., Hollstein, M., & Harris, C. C. (1994) · PubMed · Cited by 3,463

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

Hall, J., Lee, M. K., Newman, B. M., Morrow, J. E., Anderson, L. A., Huey, B., & King, M. (1990) · Science · doi:10.1126/science.2270482 · Cited by 2,544

The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.

Struewing, J., Hartge, P., Wacholder, S., Baker, S. M., Berlin, M., McAdams, M., Timmerman, M. M., Brody, L., & Tucker, M. A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199705153362001 · Cited by 2,399

Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

Wooster, R., Neuhausen, S. L., Mangion, J., Quirk, Y., Ford, D., Collins, N., Nguyen, K. N., Seal, S., Tran, T. D., Averill, D., et al. (1994) · Science · doi:10.1126/science.8091231 · Cited by 1,918

Gene-Expression Profiles in Hereditary Breast Cancer

Hedenfalk, I. A., Duggan, D. J., Chen, Y., Radmacher, M. D., Bittner, M. L., Simon, R., Meltzer, P. S., Gusterson, B. A., Esteller, M., Raffeld, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102223440801 · Cited by 1,732

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

Versteege, I., Sévenet, N., Lange, J., Rousseau-Merck, M.-F., Ambros, P. F., Handgretinger, R., Aurias, A., & Delattre, O. (1998) · Nature · doi:10.1038/28212 · Cited by 1,552

Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations

Rebbeck, T. R., Lynch, H. T., Neuhausen, S. L., Narod, S. A., Veer, L. V., Garber, J. E., Evans, D. G., Isaacs, C. J., Daly, M. B., Matloff, E. T., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012158 · Cited by 1,462

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459

BRCA1 mutations in primary breast and ovarian carcinomas.

Futreal, P., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L., Haugen-Strano, A., Swensen, J., & Miki, Y. (1994) · Science · doi:10.1126/science.7939630 · Cited by 1,378

Risk-Reducing Salpingo-oophorectomy in Women with aBRCA1orBRCA2Mutation

Kauff, N. D., Satagopan, J. M., Robson, M. E., Scheuer, L., Hensley, M. L., Hudis, C. A., Ellis, N. A., Boyd, J. A., Borgen, P. I., Barakat, R. R., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020119 · Cited by 1,250

Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

Esteller, M. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.7.564 · Cited by 1,233

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221

Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group

Rebbeck, T. R., Friebel, T., Lynch, H. T., Neuhausen, S. L., van ’t Veer, L., Garber, J. E., Evans, G. R., Narod, S. A., Isaacs, C., Matloff, E., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.04.188 · Cited by 1,171

Biallelic Inactivation of BRCA2 in Fanconi Anemia

Howlett, N. G., Taniguchi, T., Olson, S., Cox, B., Waisfisz, Q., de Die-Smulders, C., Persky, N., Grompe, M., Joenje, H., Pals, G., et al. (2002) · Science · doi:10.1126/science.1073834 · Cited by 1,149

Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations

The CHEK2-Breast Cancer Consortium (2002) · Nature Genetics · doi:10.1038/ng879 · Cited by 1,104

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,087

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Falck, J., Mailand, N., Syljuåsen, R. G., Bartek, J., & Lukas, J. (2001) · Nature · doi:10.1038/35071124 · Cited by 1,085

Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer

Foulkes, W. D. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg050 · Cited by 997

Prevalence and Penetrance of Germline BRCA1 and BRCA2 Mutations in a Population Series of 649 Women with Ovarian Cancer

Risch, H. A., McLaughlin, J. R., Cole, D. E. C., Rosen, B. P., Bradley, L., Kwan, E., Jack, E., Vesprini, D., Kuperstein, G., Abrahamson, J., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/318787 · Cited by 985

Breast Cancer after Prophylactic Bilateral Mastectomy in Women with a BRCA1 or BRCA2 Mutation

Meijers-Heijboer, H., van Geel, B., van Putten, W. L. J., Henzen-Logmans, S. C., Seynaeve, C., Menke-Pluymers, M. B. E., Bartels, C. C. M., Verhoog, L. C., van den Ouweland, A. M. W., Niermeijer, M. F., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107193450301 · Cited by 973

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., & Prives, C. (2000) · Genes & Development · doi:10.1101/gad.14.3.289 · Cited by 972

Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome

Bell, D. W., Varley, J. M., Szydlo, T. E., Kang, D. H., Wahrer, D. C. R., Shannon, K. E., Lubratovich, M. L., Verselis, S. J., Isselbacher, K. J., Fraumeni, J. F., et al. (1999) · Science · doi:10.1126/science.286.5449.2528 · Cited by 899

Polygenic susceptibility to breast cancer and implications for prevention

Pharoah, P. D. P., Antoniou, A. C., Bobrow, M., Zimmern, R. L., Easton, D. F., & Ponder, B. A. J. (2002) · Nature Genetics · doi:10.1038/ng853 · Cited by 898

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., & Elledge, S. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190030497 · Cited by 849

BRCA1 Testing in Families With Hereditary Breast-Ovarian Cancer

Lerman, C. E. (1996) · JAMA · doi:10.1001/jama.1996.03530480027036 · Cited by 826

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819

Chk2/hCds1 functions as a DNA damage checkpoint in G1by stabilizing p53

Chehab, N. H., Malikzay, A., Appel, M., & Halazonetis, T. D. (2000) · Genes & Development · doi:10.1101/gad.14.3.278 · Cited by 805

Re: Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer

van der Groep, P., Bouter, A., van der Zanden, R. A., Menko, F. H., Buerger, H., Verheijen, R. H. M., van der Wall, E., & van Diest, P. J. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh114 · Cited by 792

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Wu, L. C., Wang, Z. W., Tsan, J. T., Spillman, M. A., Phung, A., Xu, X. L., Yang, M.-C. W., Hwang, L.-Y., Bowcock, A. M., & Baer, R. J. (1996) · Nature Genetics · doi:10.1038/ng1296-430 · Cited by 743

Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations

Lakhani, S. R., Jacquemier, J., Sloane, J. P., Gusterson, B. A., Anderson, T. J., van de Vijver, M. J., Farid, L. M., Venter, D., Antoniou, A., Storfer-Isser, A., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.15.1138 · Cited by 707

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.

Hakem, R., de la Pompa, J. L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81302-1 · Cited by 680

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns.

Gruvberger-Saal, S. K., Ringnér, M., Chen, Y., Panavally, S., Saal, L. H., Borg, Å., Fernö, M., Peterson, C., & Meltzer, P. S. (2001) · PubMed · Cited by 677

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674

Breast Cancer Risk After Bilateral Prophylactic Oophorectomy in BRCA1 Mutation Carriers

Rebbeck, T. R., Levin, A. M., Eisen, A. F., Snyder, C., Watson, P. A., Cannon‐Albright, L., Isaacs, C. J., Olopade, O., Garber, J. E., Godwin, A. K., et al. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.17.1475 · Cited by 670

Involvement of Brca2 in DNA Repair

Patel, K. J., Yu, V. P. C. C., Lee, H., Corcoran, A. E., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A. J., & Venkitaraman, A. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80035-0 · Cited by 646

In search of the tumour-suppressor functions of BRCA1 and BRCA2

Scully, R., & Livingston, D. M. (2000) · Nature · doi:10.1038/35044000 · Cited by 643

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

Hashizume, R., Fukuda, M., Maeda, I., Nishikawa, H., Oyake, D., Yabuki, Y., Ogata, H., & Ohta, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000881200 · Cited by 634

Pattern formation by local self-activation and lateral inhibition

Meinhardt, H., & Gierer, A. (2000) · BioEssays · doi:10.1002/1521-1878(200008)22:8 · Cited by 629

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

Friedman, L. S., Ostermeyer, E. A., Szabo, C. I., Dowd, P., Lynch, E. D., Rowell, S. E., & King, M. (1994) · Nature Genetics · doi:10.1038/ng1294-399 · Cited by 622

Contralateral Breast Cancer in BRCA1 and BRCA2 Mutation Carriers

Metcalfe, K. A., Lynch, H. T., Ghadirian, P., Tung, N., Olivotto, I. A., Warner, E., Olopade, O. I., Eisen, A. F., Weber, B., McLennan, J., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.04.033 · Cited by 620

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

Thompson, M. E., Jensen, R. A., Obermiller, P. S., Page, D. L., & Holt, J. T. (1995) · Nature Genetics · doi:10.1038/ng0495-444 · Cited by 584

Clinicopathologic features of BRCA-linked and sporadic ovarian cancer.

Boyd, J., Sonoda, Y., Federici, M. G., Bogomolniy, F., Rhei, E., Maresco, D., Saigo, P., Almadrones, L., Barakat, R., Brown, C., et al. (2000) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.283.17.2260 · Cited by 570

Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Hereditary Breast Cancer Clinical Study Group.

Narod, S., Brunet, J., Ghadirian, P., Robson, M., Heimdal, K., Neuhausen, S., Stoppa-Lyonnet, D., Lerman, C., Pasini, B., Ríos, P. D. L., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03258-x · Cited by 557

BRCA1 Is Associated with a Human SWI/SNF-Related Complex

Bochar, D. A., Wang, L., Beniya, H., Kinev, A. V., Xue, Y., Lane, W. S., Wang, W., Kashanchi, F., & Shiekhattar, R. (2000) · Cell · doi:10.1016/s0092-8674(00)00030-1 · Cited by 546

RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2

Wong, A. K. C., Pero, R. S., Ormonde, P. A., Tavtigian, S. V., & Bartel, P. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.31941 · Cited by 544

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

Lee, J., Collins, K. M., Brown, A. L., Lee, C. H., & Chung, J. H. (2000) · Nature · doi:10.1038/35004614 · Cited by 529

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

Callebaut, I., & Mornon, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01312-9 · Cited by 524

Variation in Cancer Risks, by Mutation Position, in BRCA2 Mutation Carriers

Thompson, D. J., & Easton, D. F. (2001) · The American Journal of Human Genetics · doi:10.1086/318181 · Cited by 492

A CHEK2 Genetic Variant Contributing to a Substantial Fraction of Familial Breast Cancer

Vahteristo, P., Bártková, J., Eerola, H., Syrjäkoski, K., Ojala, S., Kilpivaara, O., Tamminen, A., Kononen, J., Aittomäki, K., Heikkilä, P., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/341943 · Cited by 476

EFFECTS OF DIOXIN EXPOSURE

Laporte, J. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91274-0 · Cited by 448

EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer

Hughes‐Davies, L., Huntsman, D. D., Ruas, M., Fuks, F., Bye, J. M., Chin, S., Milner, J., Brown, L. A., Hsu, F. D., Gilks, C. B., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00930-9 · Cited by 422

Prevalence and penetrance of BRCA1 and BRCA2 gene mutations in unselected Ashkenazi Jewish women with breast cancer.

Warner, E., Foulkes, W., Goodwin, P., Meschino, W., Blondal, J., Paterson, C., Ozçelik, H., Goss, P., Allingham-Hawkins, D., Hamel, N., et al. (1999) · Journal of the National Cancer Institute · doi:10.1093/jnci/91.14.1241 · Cited by 421

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Chaturvedi, P., Eng, W.-K., Zhu, Y., Mattern, M. R., Mishra, R., Hurle, M. R., Zhang, X., Annan, R. S., Lu, Q., Faucette, L. F., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202925 · Cited by 420

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours

Merajver, S., Pham, T. M., Caduff, R., Chen, M., Poy, E. L., Cooney, K., Weber, B., Collins, F., Johnston, C., & Frank, T. S. (1995) · Nature Genetics · doi:10.1038/ng0495-439 · Cited by 417

Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild–type chromosome

Smith, S. A., Easton, D. F., Evans, D. G., & Ponder, B. A. J. (1992) · Nature Genetics · doi:10.1038/ng1092-128 · Cited by 410

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.

Yuan, S. F., Lee, S. Y., Chen, G., Song, M., Tomlinson, G. E., & Lee, E. Y.-H. P. (1999) · PubMed · Cited by 404

ATM Mutations and Phenotypes in Ataxia-Telangiectasia Families in the British Isles: Expression of Mutant ATM and the Risk of Leukemia, Lymphoma, and Breast Cancer

Stanković, T., Kidd, A., Sutcliffe, A., McGuire, G. M., Robinson, P. N., Weber, P., Bedenham, T., Bradwell, A. R., Easton, D. F., Lennox, G. G., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301706 · Cited by 401

BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis.

Quinn, J. E., Kennedy, R. D., Mullan, P. B., Gilmore, P. M., Carty, M., Johnston, P. G., & Harkin, D. P. (2003) · PubMed · Cited by 400

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.

Ahn, J. Y., Schwarz, J. K., Piwnica-Worms, H. M., & Canman, C. E. (2000) · PubMed · Cited by 396

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

Moynahan, M. E., Cui, T. Y., & Jasin, M. (2001) · PubMed · Cited by 382

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

Castilla, L. H., Couch, F. J., Erdos, M. R., Hoskins, K. F., Calzone, K., Garber, J. E., Boyd, J. A., Lubin, M. B., DeShano, M. L., Brody, L. C., et al. (1994) · Nature Genetics · doi:10.1038/ng1294-387 · Cited by 381

The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1%

Oddoux, C., Struewing, J. P., Clayton, C. M., Neuhausen, S. L., Brody, L. C., Kaback, M. M., Haas, B. R., Norton, L., Borgen, P. I., Jhanwar, S. C., et al. (1996) · Nature Genetics · doi:10.1038/ng1096-188 · Cited by 381

Dominant Negative ATM Mutations in Breast Cancer Families

Chenevix‐Trench, G. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.3.205 · Cited by 376

Two Percent of Men with Early-Onset Prostate Cancer Harbor Germline Mutations in the BRCA2 Gene

Edwards, S. M., Kote‐Jarai, Z., Meitz-Hopkins, J. C., Hamoudi, R., Hope, Q., Osin, P., Jackson, R., Southgate, C., Singh, R., Falconer, A., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/345310 · Cited by 365

Homologous repair of DNA damage and tumorigenesis:the BRCA connection

Jasin, M. (2002) · Oncogene · doi:10.1038/sj.onc.1206176 · Cited by 363

BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells

Tassone, P., Tagliaferri, P., Perricelli, A., Blotta, S., Quaresima, B., Martelli, M. L., Goel, A., Barbieri, V., Costanzo, F. S., Boland, C. R., et al. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600859 · Cited by 361

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80238-5 · Cited by 359

Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations.

Tirkkonen, M., Johannsson, O. T., Agnarsson, B. A., Olsson, H. L., Ingvarsson, S., Karhu, R., Tanner, M., Isola, J. J., Barkardottir, R. B., Borg, Å., et al. (1997) · PubMed · Cited by 354

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

Catteau, A., Harris, W. H., Xu, C.-F., & Solomon, E. (1999) · Oncogene · doi:10.1038/sj.onc.1202509 · Cited by 354

BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer.

Moslehi, R., Chu, W., Karlan, B., Fishman, D., Risch, H., Fields, A., Smotkin, D., ben-David, Y., Rosenblatt, J., Russo, D., et al. (2000) · American Journal of Human Genetics · doi:10.1086/302853 · Cited by 341

Rapid detection of BRCA1 mutations by the protein truncation test

Hogervorst, F., Cornelis, R., Bout, M., van Vliet, M., Oosterwijk, J., Olmer, R., Bakker, B., Klijn, J., Vasen, H., Meijers-Heijboer, H., et al. (1995) · Nature Genetics · doi:10.1038/ng0695-208 · Cited by 341

Heterozygous ATM mutations do not contribute to early onset of breast cancer

FitzGerald, M. G., Bean, J. M., Hegde, S. R., Ünsal, H., MacDonald, D. J., Harkin, D. P., Finkelstein, D. M., Isselbacher, K. J., & Haber, D. A. (1997) · Nature Genetics · doi:10.1038/ng0397-307 · Cited by 340

BRCA1 interacts with components of the histone deacetylase complex

Yarden, R. I., & Brody, L. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4983 · Cited by 328

Occult Carcinoma in Prophylactic Oophorectomy Specimens

Colgan, T. J., Murphy, J., Cole, D. E. C., Narod, S. A., & Rosen, B. P. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200110000-00009 · Cited by 327

Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families

Simard, J., Tonin, P. N., Durocher, F., Morgan, K., Rommens, J. M., Gingras, S., Samson, C., LEBLANC, J., Bélanger, C., Dion, F., et al. (1994) · Nature Genetics · doi:10.1038/ng1294-392 · Cited by 324

Fanconi anaemia

Tischkowitz, M. D., & Hodgson, S. V. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.1.1 · Cited by 324

Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families

Tonin, P., Weber, B., Offit, K., Couch, F., Rebbeck, T., Neuhausen, S., Godwin, A., Daly, M., Wagner-Costalos, J., Berman, D. B., et al. (1996) · Nature Medicine · doi:10.1038/nm1196-1179 · Cited by 319

A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment

Robson, M. E., Chappuis, P. O., Satagopan, J., Wong, N., Boyd, J., Goffin, J. R., Hudis, C., Roberge, D., Norton, L., Bégin, L. R., et al. (2003) · Breast Cancer Research · doi:10.1186/bcr658 · Cited by 307

Cancer Risks in A-T Heterozygotes

Easton, D. F. (1994) · International Journal of Radiation Biology · doi:10.1080/09553009414552011 · Cited by 288

Gene Expression Profiles of BRCA1-Linked, BRCA2-Linked, and Sporadic Ovarian Cancers

Jazaeri, A. A., Yee, C. J., Sotiriou, C. P., Brantley, K., Boyd, J. A., & Liu, E. T. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.13.990 · Cited by 282

Common Adult Stem Cells in the Human Breast Give Rise to Glandular and Myoepithelial Cell Lineages: A New Cell Biological Concept

Böcker, W., Moll, R., Poremba, C., Holland, R., van Diest, P. J., Dervan, P. A., Buerger, H., Wai, D., Diallo, R. I., Brandt, B., et al. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000017371.72714.c5 · Cited by 282

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

Morris, J. R., & Solomon, E. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh095 · Cited by 282

Cancer Risk in ATM Heterozygotes: A Model of Phenotypic and Mechanistic Differences between Missense and Truncating Mutations

Gatti, R. A., Tward, A. D., & CONCANNON, P. J. (1999) · Molecular Genetics and Metabolism · doi:10.1006/mgme.1999.2942 · Cited by 281

Microscopic Benign and Invasive Malignant Neoplasms and a Cancer-Prone Phenotype in Prophylactic Oophorectomies

Salazar, H., Godwin, A. K., Daly, M. B., Laub, P. B., Hogan, W. M., Rosenblum, N., Boente, M. P., Lynch, H. T., & Hamilton, T. C. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.24.1810 · Cited by 263

Screening for germ-line rearrangements and regulatory mutations in BRCA1 led to the identification of four new deletions.

Puget, N., Stoppa‐Lyonnet, D., Sinilnikova, O. M., Pagès-Berhouet, S., Lynch, H. T., Lenoir, G., & Mazoyer, S. (1999) · PubMed · Cited by 257

Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation

Hakem, R., de la Pompa, J. L., Elia, A., Potter, J., & Mak, T. W. (1997) · Nature Genetics · doi:10.1038/ng0797-298 · Cited by 252

Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors.

Wessels, L. F. A., van Welsem, T., Hart, A. A. M., Veer, L. J. V., Reinders, M. J. T., & Nederlof, P. M. (2002) · PubMed · Cited by 252

Cytogenetic Alterations and Cytokeratin Expression Patterns in Breast Cancer: Integrating a New Model of Breast Differentiation into Cytogenetic Pathways of Breast Carcinogenesis

Korsching, E., Packeisen, J., Agelopoulos, K., Eisenacher, M., Voß, R., Isola, J. J., van Diest, P. J., Brandt, B., Boecker, W., & Buerger, H. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000038508.86221.b3 · Cited by 243

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair

Hartman, A., & Ford, J. M. (2002) · Nature Genetics · doi:10.1038/ng953 · Cited by 238

RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with the RAD51 protein

Mizuta, R., LaSalle, J. M., Cheng, H.-L., Shinohara, A., Ogawa, H., Copeland, N. G., Jenkins, N. A., Lalande, M., & Alt, F. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6927 · Cited by 235

Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer

Scott, S. P., Bendix, R., Chen, P., Clark, R., Dörk, T., & Lavin, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012329699 · Cited by 227

Denaturing High-Performance Liquid Chromatography Detects Reliably BRCA1 and BRCA2 Mutations

Wagner, T. M. U., Stoppa‐Lyonnet, D., Fleischmann, E., Muhr, D., Pagès-Berhouet, S., Sandberg, T., Caux‐Moncoutier, V., Möslinger, R., Langbauer, G., Borg, Å., et al. (1999) · Genomics · doi:10.1006/geno.1999.6026 · Cited by 224

The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2.

Lakhani, S. R., Gusterson, B. A., Jacquemier, J. D., Sloane, J. P., Anderson, T. J., van de Vijver, M. J., Venter, D. J., Freeman, A., Antoniou, A., McGuffog, L., et al. (2000) · PubMed · Cited by 222

Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families.

Rothfuß, A., Schütz, P., Bochum, S., Volm, T., Eberhardt, E., Kreienberg, R., Vogel, W., & Speit, G. (2000) · PubMed · Cited by 212

Tracing the network connecting brca and fanconi anaemia proteins

Venkitaraman, A. R. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1321 · Cited by 202

Shared Genetic Susceptibility to Breast Cancer, Brain Tumors, and Fanconi Anemia

Offit, K., Levran, O., Mullaney, B., Mah, K., Nafa, K., Batish, S. D., Diotti, R. A., Schneider, H., Deffenbaugh, A. M., Scholl, T., et al. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg072 · Cited by 200

A high proportion of founder BRCA1 mutations in Polish breast cancer families

Górski, B., Jakubowska, A., Huzarski, T., Byrski, T., Gronwald, J., Grzybowska, E. A., Mackiewicz, A. A., Stawicka, M., Bębenek, M., Sorokin, D., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20162 · Cited by 195

Hereditary breast cancer

Conejero, R. A., del Prado, R. L., Berjaga, M. Z., & Vázquez, E. A. (2022) · Revisiones en cáncer · doi:10.20960/revcancer.00003 · Cited by 193

BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.

Page, F. L., Randrianarison-Huetz, V., Marot, D., Cabannes, J., Perricaudet, M., Feunteun, J., & Sarasin, A. R. (2000) · PubMed · Cited by 190

Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus

Kainu, T., Juo, S. H., Desper, R., Schäffer, A. A., Gillanders, E. M., Rozenblum, E., Freas‐Lutz, D., Weaver, D., Stephan, D. A., Wilson, J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.17.9603 · Cited by 189

BRCA1 functions as a breast stem cell regulator

Foulkes, W. D. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.013805 · Cited by 184

Molecular classification of familial non- BRCA1/BRCA2 breast cancer

Hedenfalk, I. A., Ringnér, M., Ben‐Dor, A., Yakhini, Z., Chen, Y., Chebil, G., Ach, R. A., Loman, N., Olsson, H. L., Meltzer, P. S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0533805100 · Cited by 180

Modifiers of risk of hereditary breast and ovarian cancer

Narod, S. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc726 · Cited by 179

BRCA1— Lots of Mutations, Lots of Dilemmas

Collins, F. S. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601183340311 · Cited by 179

A 1-kb Alu-mediated germ-line deletion removing BRCA1 exon 17.

Puget, N., Torchard, D., Sinilnikova, O. M., Lynch, H. T., Feunteun, J., Lenoir, G., & Mazoyer, S. (1997) · PubMed · Cited by 174

Characterization of Tumor-associated Chk2 Mutations

Wu, X., Webster, S. R., & Chen, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009727200 · Cited by 173

Hormonal regulation of apoptosis in breast cells and tissues

Gompel, A. (2000) · Steroids · doi:10.1016/s0039-128x(00)00172-0 · Cited by 166

Estrogen receptor-negative epithelial cells in mouse mammary gland development and growth

Zeps, N., Bentel, J. M., Papadimitriou, J. M., D’Antuono, M. F., & Dawkins, H. J. S. (1998) · Differentiation · doi:10.1046/j.1432-0436.1998.6250221.x · Cited by 161

Contribution of BRCA1 and BRCA2 Mutations to Breast and Ovarian Cancer in Pakistan

Liede, A., Malik, I. A., Aziz, Z., Rios, P. D. L., Kwan, E., & Narod, S. A. (2002) · The American Journal of Human Genetics · doi:10.1086/342506 · Cited by 159

Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q

Stratton, M. R., Ford, D., Neuhasen, S., Seal, S., Wooster, R., Friedman, L. S., King, M., Egilsson, V., Devilee, P., McManus, R., et al. (1994) · Nature Genetics · doi:10.1038/ng0594-103 · Cited by 156

An alternative to FISH: detecting deletion and duplication carriers within 24 hours

White, S. J., Sterrenburg, E., van Ommen, G. B., den Dunnen, J. T., & Breuning, M. H. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.10.e113 · Cited by 154

High Prevalence of Premalignant Lesions in Prophylactically Removed Breasts From Women at Hereditary Risk for Breast Cancer

Hoogerbrugge, N., Bult, P., de Widt-Levert, L. M., Beex, L. V. A. M., Kiemeney, L. A. L. M., Ligtenberg, M. J. L., Massuger, L., Boetes, C., Manders, P., & Brunner, H. G. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2003.02.137 · Cited by 149

Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2

Foray, N., Randrianarison-Huetz, V., Marot, D., Perricaudet, M., Lenoir, G., & Feunteun, J. (1999) · Oncogene · doi:10.1038/sj.onc.1203165 · Cited by 149

Hereditary breast and ovarian cancer in Asia: genetic epidemiology of BRCA1 and BRCA2

Liede, A., & Narod, S. (2002) · Human Mutation · doi:10.1002/humu.10154 · Cited by 148

A significant response to neoadjuvant chemotherapy in BRCA1/2 related breast cancer: Table 1

Chappuis, P. O., Goffin, J., Wong, N., Perret, C., Ghadirian, P., Tonin, P. N., & Foulkes, W. D. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.8.608 · Cited by 147

Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations inBRCA1

Eng, C., Brody, L. C., Wagner, T. M. U., Devilee, P., Vijg, J., Szabo, C., Tavtigian, S. V., Nathanson, K. L., Ostrander, E. A., & Frank, T. S. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.12.824 · Cited by 142

Frequency of CHEK2*1100delC in New York breast cancer cases and controls

Offit, K., Pierce, H., Kirchhoff, T., Kolachana, P., Rapaport, B., Gregersen, P. K., Johnson, S., Yossepowitch, O., Huang, H. J., Satagopan, J. M., et al. (2003) · BMC Medical Genetics · doi:10.1186/1471-2350-4-1 · Cited by 137

Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region

Magdinier, F., Ribieras, S., Lenoir, G., Frappart, L., & Dante, R. (1998) · Oncogene · doi:10.1038/sj.onc.1202248 · Cited by 134

Hereditary breast cancer

Robson, M. E., Boyd, J. A., Borgen, P. I., & Cody, H. S. (2001) · Current Problems in Surgery · doi:10.1016/s0011-3840(01)70035-4 · Cited by 133

A somatic BRCA1 mutation in an ovarian tumour

Hosking, L. K., Trowsdale, J., Nicolai, H., Solomon, E., Foulkes, W. D., Stamp, G., Signer, E. N., & Jeffreys, A. J. (1995) · Nature Genetics · doi:10.1038/ng0495-343 · Cited by 132

BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability.

Grétarsdóttir, S., Thorlacius, S., Valgardsdottir, R., Gudlaugsdottir, S., Sigurðsson, S., Steinarsdóttir, M., Jonasson, J. G., Anamthawat‐Jónsson, K., & Eyfjörd, J. E. (1998) · PubMed · Cited by 131

Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing.

Humphrey, J. S., Salim, A., Erdos, M., Collins, F., Brody, L. C., & Klausner, R. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.11.5820 · Cited by 120

High allele loss rates at I7q I2‐q2I in breast and ovarian tumors from BRCAI‐linked families

Cornelis, R. S., Neuhausen, S. L., Johansson, O., Arason, A., Kelsell, D. P., Ponder, B. A. J., Tonin, P. N., Hamann, U., Lindblom, A., Lalle, P., et al. (1995) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870130310 · Cited by 119

Strong indication for a breast cancer susceptibility gene on chromosome 8p12-p22: linkage analysis in German breast cancer families

Seitz, S., Rohde, K., Bender, E., Nothnagel, A., Kölble, K., Schlag, P. M., & Scherneck, S. (1997) · Oncogene · doi:10.1038/sj.onc.1200881 · Cited by 118

Survival in prospectively ascertained familial breast cancer: Analysis of a series stratified by tumour characteristics, BRCA mutations and oophorectomy

Møller, P., Borg, Å., Evans, D. G., Kingsbury, N., Reis, M. M., Vasen, H. F. A., Anderson, E. D. C., Steel, C. M., Apold, J., Goudie, D. R., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10641 · Cited by 113

The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families.

Oldenburg, R. A., Kroeze‐Jansema, K., Kraan, J., Morreau, H. M., Klijn, J. G. M., Hoogerbrugge, N., Ligtenberg, M. J. L., van Asperen, C. J., Vasen, H. F. A., Meijers, C., et al. (2003) · PubMed · Cited by 112

Functions of the BRCA1 and BRCA2 genes

Bertwistle, D., & Ashworth, A. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80056-7 · Cited by 110

Germline mutations of the BRCA1‐associated ring domain (BARD1) gene in breast and breast/ovarian families negative for BRCA1 and BRCA2 alterations

Ghimenti, C., Sensi, E., Presciuttini, S., Brunetti, I. M., Conte, P., Bevilacqua, G., & Caligo, M. A. (2002) · Genes Chromosomes and Cancer · doi:10.1002/gcc.1223 · Cited by 110

After BRCA1 and BRCA2—What Next? Multifactorial Segregation Analyses of Three-Generation, Population-Based Australian Families Affected by Female Breast Cancer

Cui, J. S., Antoniou, A. C., Dite, G. S., Southey, M. C., Venter, D. J., Easton, D. F., Giles, G. G., McCredie, M. R. E., & Hopper, J. L. (2001) · The American Journal of Human Genetics · doi:10.1086/318187 · Cited by 110

Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma

Goffin, J. R., Chappuis, P. O., Bégin, L. R., Wong, N., Brunet, J., Hamel, N., Paradis, A.-J., Boyd, J. A., & Foulkes, W. D. (2003) · Cancer · doi:10.1002/cncr.11080 · Cited by 109

Disruption of the expected positive correlation between breast tumor size and lymph node status in BRCA1‐related breast carcinoma

Foulkes, W. D., Metcalfe, K. A., Hanna, W. M., Lynch, H. T., Ghadirian, P., Tung, N., Olopade, O. I., Weber, B., McLennan, J., Olivotto, I. A., et al. (2003) · Cancer · doi:10.1002/cncr.11688 · Cited by 103

The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients

Elledge, S. J., & Amon, A. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00041-7 · Cited by 100

Inheritance of Proliferative Breast Disease in Breast Cancer Kindreds

Skolnick, M. H., Cannon‐Albright, L., Goldgar, D. E., Ward, J. H., Marshall, C. J., Schumann, G. B., Hogle, H. H., McWhorter, W. P., Wright, E. C., Tran, T. D., et al. (1990) · Science · doi:10.1126/science.2270486 · Cited by 100

A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining

Baldeyron, C., Jacquemin, E., Smith, J., Jacquemont, C. F., Oliveira, I. D., Gad, S., Feunteun, J., Stoppa‐Lyonnet, D., & Papadopoulo, D. (2002) · Oncogene · doi:10.1038/sj.onc.1205200 · Cited by 99

Expression of FAS (CD95/APO-1) and FAS ligand in lung cancer, its prognostic and predictive relevance

gi, R. K., & Volm, M. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990621)84:3 · Cited by 99

Germ‐line mutations in BRCA1 or BRCA2 in the normal breast are associated with altered expression of estrogen‐responsive proteins and the predominance of progesterone receptor A

Mote, P. A., Leary, J. A., Avery‐Kiejda, K. A., Sandelin, K., Chenevix‐Trench, G., Kirk, J., & Clarke, C. L. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10321 · Cited by 96

Incidence of non-founder BRCA1 and BRCA2 mutations in high risk Ashkenazi breast and ovarian cancer families

Kauff, N. D., Pérez‐Segura, P., Robson, M. E., Scheuer, L., Siegel, B., Schluger, A. E., Rapaport, B., Frank, T. S., Nafa, K., Ellis, N. A., et al. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.8.611 · Cited by 94

Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium

Thompson, D. J., Szabo, C. I., Mangion, J., Oldenburg, R. A., Odefrey, F., Seal, S., Barfoot, R., Kroeze‐Jansema, K., Teare, M. D., Rahman, N., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012584499 · Cited by 91

Comparison of Prophylactic Oophorectomy Specimens From Carriers and Noncarriers of a BRCA1 or BRCA2 Gene Mutation

Stratton, J. F., BUCKLEY, C. H., Lowe, D., & Ponder, B. A. J. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.7.626 · Cited by 91

Epithelial lesions in prophylactic mastectomy specimens from women with BRCA mutations

Kauff, N. D., Brogi, E., Scheuer, L., Pathak, D. R., Borgen, P. I., Hudis, C. A., Offit, K., & Robson, M. E. (2003) · Cancer · doi:10.1002/cncr.11225 · Cited by 90

Regional methylation of the 5' end CpG island of BRCA1 is associated with reduced gene expression in human somatic cells

Magdinier, F., Billard, L.-M., Wittmann, G., Frappart, L., Benchaïb, M., Lenoir, G., Guérin, J.-F., & Dante, R. (2000) · The FASEB Journal · doi:10.1096/fj.99-0817com · Cited by 90

The effect of a single BRCA2 mutation on cancer in Iceland

Tulinius, H., Ólafsdóttir, G. H., Sigvaldason, H., Arason, A., Barkardottir, R. B., Egilsson, V., Ogmundsdottir, H. M., Tryggvadóttír, L., Gudlaugsdottir, S., & Eyfjord, J. E. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.7.457 · Cited by 89

Functional assay for BRCA1: mutagenesis of the COOH-terminal region reveals critical residues for transcription activation.

Hayes, F., Cayanan, C. S., Barillà, D., & Monteiro, Á. N. A. (2000) · PubMed · Cited by 87

Pathologic characteristics of breast parenchyma in patients with hereditary breast carcinoma, including BRCA1 and BRCA2 mutation carriers

Adem, C., Reynolds, C. A., Soderberg, C. L., Slezak, J. M., McDonnell, S. K., Sebo, T. J., Schaid, D. J., Myers, J. L., Sellers, T. A., Hartmann, L. C., et al. (2002) · Cancer · doi:10.1002/cncr.11048 · Cited by 84

Comparison of DNA- and RNA-Based Methods for Detection of TruncatingBRCA1 Mutations

Andrulis, I. L., Anton‐Culver, H., Beck, J. C., Bove, B. A., Boyd, J. A., Buys, S. S., Godwin, A. K., Hopper, J. L., Li, F., Neuhausen, S. L., et al. (2002) · Human Mutation · doi:10.1002/humu.10097 · Cited by 77

Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group

Available, N. A. N. (2004) · The Women s Oncology Review · doi:10.1080/14733400400013030 · Cited by 76

Genetic heterogeneity of breast-ovarian cancer revisited. Breast Cancer Linkage Consortium.

Narod, S. A., Ford, D., Devilee, P., Barkardottir, R. B., Eyfjord, J. E., Lenoir, G., Serova, O., Easton, D. F., & Goldgar, D. E. (1995) · Europe PMC (PubMed Central) · Cited by 75

Mutational analysis of BARD1 in familial breast cancer patients in Japan

Ishitobi, M., Miyoshi, Y., Hasegawa, S., Egawa, C., Tamaki, Y., Monden, M., & Noguchi, S. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00387-2 · Cited by 74

Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus

Tainu, T. (2000) · Medical Entomology and Zoology · Cited by 74

BRCA1: the enigma of tissue-specific tumor development.

Monteiro, A. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00110-0 · Cited by 71

A low frequency of non-founder BRCA1 mutations in Ashkenazi Jewish breast-ovarian cancer families

Phelan, C. M., Kwan, E., Jack, E., Li, S., Morgan, C., Aubé, J., Hanna, D., & Narod, S. A. (2002) · Human Mutation · doi:10.1002/humu.10123 · Cited by 70

Color bar coding the BRCA1 gene on combed DNA: A useful strategy for detecting large gene rearrangements

Gad, S., Aurias, A., Puget, N., Mairal, A., Schurra, C., Montagna, M., Pagès-Berhouet, S., Caux‐Moncoutier, V., Mazoyer, S., Bensimon, A., et al. (2001) · Genes Chromosomes and Cancer · doi:10.1002/gcc.1120 · Cited by 66

Prognostic significance of BRCA1 expression in sporadic breast carcinomas

Lambie, H., Miremadi, A., Pinder, S. E., Bell, J., Wencyk, P. M., Paish, E. C., Macmillan, R. D., & Ellis, I. O. (2003) · The Journal of Pathology · doi:10.1002/path.1348 · Cited by 64

Survival of breast cancer patients in BRCA1, BRCA2, and non-BRCA1/2 breast cancer families: A relative survival analysis from Finland

Eerola, H., Vahteristo, P., Sarantaus, L., nen, P. K., Pyrh�nen, S., BLOMQVIST, C. P., Pukkala, E., Nevanlinna, H. A., & Sankila, R. J. (2001) · International Journal of Cancer · doi:10.1002/ijc.1341 · Cited by 64

HER‐2/neu status and tumor morphology of invasive breast carcinomas in Ashkenazi women with known BRCA1 mutation status in the Ontario Familial Breast Cancer Registry

Quenneville, L., Phillips, K., Özçelik, H., Parkes, R. K., Knight, J. A., Goodwin, P. J., Andrulis, I. L., & O’Malley, F. P. (2002) · Cancer · doi:10.1002/cncr.10949 · Cited by 56

Breast cancer susceptibility—A new look at an old model

Peto, J. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00079-x · Cited by 51

CANCER AND CARDIAC DEATHS IN OBLIGATORY ATAXIA-TELANGIECTASIA HETEROZYGOTES

Swift, M. R., & Chase, C. L. (1983) · The Lancet · doi:10.1016/s0140-6736(83)92678-8 · Cited by 51

Are ATM Mutations 7271T→G and IVS10-6T→G Really High-Risk Breast Cancer-Susceptibility Alleles?

Szabo, C. I., Schutte, M. E. M., Broeks, A., Houwing‐Duistermaat, J. J., Thorstenson, Y. R., Durocher, F., Oldenburg, R. A., Wasielewski, M., Odefrey, F., Thompson, D. J., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2678 · Cited by 50

Rates of Jewish Ancestral Mutations in BRCAI and BRCA2 in Borderline Ovarian Tumors

Gotlieb, W. H., Ben‐Baruch, G., Friedman, E., Bar-Sade, R. B., Сергеевна, К. А., Hirsh‐Yechezkel, G., Modan, B., Novikov, I., Davidson, B., Kopolovic, J., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.13.995 · Cited by 50

Bar code screening on combed DNA for large rearrangements of the BRCA1 and BRCA2 genes in French breast cancer families

Gad, S., Klinger, M., Caux‐Moncoutier, V., Pages-Berhouet, S., Gauthier‐Villars, M., Coupier, I., Bensimon, A., Aurias, A., & Stoppa‐Lyonnet, D. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.11.817 · Cited by 48

Antiestrogens are pro‐apoptotic in normal human breast epithelial cells

Somaı̈, S., Chaouat, M., Jacob, D., Perrot, J., Rostène, W. H., Forgez, P., & Gompel, A. (2003) · International Journal of Cancer · doi:10.1002/ijc.11147 · Cited by 47

Detection of base mutations in genomic DNA using denaturing gradient gel electrophoresis (DGGE) followed by transfer and hybridization with gene-specific probes

Børresen, A., Hovig, E. J., & Brögger, A. (1988) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(88)90166-2 · Cited by 46

Absence of evidence for a familial breast cancer susceptibility gene at chromosome 8p12-p22

Rahman, N., Teare, M. D., Seal, S., Renard, H., Mangion, J., Cour, C., Thompson, D. J., Shugart, Y. Y., Eccles, D., Devilee, P., et al. (2000) · Oncogene · doi:10.1038/sj.onc.1203735 · Cited by 43

Fidelity of DNA double-strand break repair in heterozygous cell lines harbouring BRCA1 missense mutations

Coupier, I., Baldeyron, C., Rousseau, A., Mosseri, V., Pagès-Berhouet, S., Caux‐Moncoutier, V., Papadopoulo, D., & Stoppa‐Lyonnet, D. (2003) · Oncogene · doi:10.1038/sj.onc.1207191 · Cited by 37

Evidence for a third breast-cancer susceptibility gene

Sobol, H., Birnbaum, D., & Eisinger, F. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90655-6 · Cited by 35

Genes implicated in hereditary breast cancer syndromes.

Tonin, P. (2000) · Seminars in surgical oncology · doi:10.1002/(sici)1098-2388(200006)18:4 · Cited by 35

The relative importance of proliferation and cell death in breast cancer growth and response to tamoxifen

Cameron, D., Ritchie, A., & Miller, W. R. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00166-6 · Cited by 32

Roads Leading to Breast Cancer

Haber, D. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011233432111 · Cited by 29

Mutation screening of BRCA1 using PTT and LOH analysis at 17q21 in breast carcinomas from familial and non-familial cases

Sørlie, T., Andersen, T. I., Bukholm, I. K., & Børresen‐Dale, A. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1005953519972 · Cited by 24

Are BRCA1- and BRCA2-related breast cancers associated with increased mortality?

Evans, D. G., & Howell, A. (2003) · Breast Cancer Research · doi:10.1186/bcr748 · Cited by 23

Ethnicity, but not cancer family history, is related to response to a population-based mailed questionnaire

Mancuso, C., Glendon, G., Anson-Cartwright, L., Shi, E. J., Andrulis, I., & Knight, J. (2003) · Annals of Epidemiology · doi:10.1016/s1047-2797(03)00073-5 · Cited by 21

Locus-specific multifluor FISH analysis allows physical characterization of complex chromosome abnormalities in neoplasia

Gisselsson, D., Mandahl, N., P�lsson, E., Gorunova, L., & H�glund, M. (2000) · Genes Chromosomes and Cancer · doi:10.1002/1098-2264(200007)28:3 · Cited by 18

Correspondence re: A. Rothfuss et al., Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res., 60: 390-394, 2000.

Baria, K., Warren, C., Roberts, S. A., West, C., Evans, D. G., Varley, J. M., & Scott, D. (2001) · PubMed · Cited by 16

Assessing the risk of BRCA1‐associated breast cancer using individual morphological criteria

Jacquemier, J. D., Lidereau, R., Birnbaum, D., Eisinger, F., & Sobol, H. (2001) · Histopathology · doi:10.1046/j.1365-2559.2001.01131.x · Cited by 10

Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families

Baria, K., Warren, C., Roberts, S., West, C., Evans, D. G., Varley, J. M., & Scott, D. A. (2001) · Cancer Research · Cited by 9

Roads to Breast Cancer

Friedenson, B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103223441214 · Cited by 4

Of Two Minds

Narod, S. A. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103223441215 · Cited by 2

Untitled work

(2000) · doi:10.1002/1097-0142(20000715)89:2

Triple-negative breast cancer: clinical features and patterns of recurrence

Dent, R., Trudeau, M., Pritchard, K. I., Hanna, W. M., Kahn, H. K., Sawka, C. A., Lickley, L. A., Rawlinson, E., Sun, P., & Narod, S. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-3045 · Cited by 5,091

Molecular mechanisms of cisplatin resistance

Galluzzi, L., Senovilla, L., Vitale, I., Michels, J., Martins, I., Kepp, O., Castedo, M., & Kroemer, G. (2012) · Oncogene · doi:10.1038/onc.2011.384 · Cited by 2,760

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

kConFab, Lim, E., Vaillant, F., Wu, D., Forrest, N. C., Pal, B., Hart, A. H., Asselin-Labat, M.-L., Gyorki, D. E., Ward, T., et al. (2009) · Nature Medicine · doi:10.1038/nm.2000 · Cited by 1,492

Cells of origin in cancer

Visvader, J. E. (2011) · Nature · doi:10.1038/nature09781 · Cited by 1,524

Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications

Nguyen, H. H., Park, J., Kang, S., & Kim, M. (2015) · Sensors · doi:10.3390/s150510481 · Cited by 1,372

Clinically Relevant Biology of Hereditary Breast Cancer

Foulkes, W. D. (2007) · Seminars in Oncology · doi:10.1053/j.seminoncol.2007.07.010 · Cited by 17

Editorial - A decade of discovery of BRCA1 and BRCA2: Are we turning\nthe tide against hereditary breast cancers?

Rajiv, S. (2007) · Bioline International (Bioline International)

Role of tumor-suppressor gene BRCA1 and BRCA2 mutations in breast cancer

Qin, X. (2002)

In Brief: BRCA1 and BRCA2

Foulkes, W. D., & Shuen, A. Y. (2013) · The Journal of Pathology · doi:10.1002/path.4205 · Cited by 105

Breast Cancer Gene, BRCA1 and BRCA2

Choi, D. H. (2003) · Journal of Breast Cancer · doi:10.4048/jkbcs.2003.6.2.45 · Cited by 4