Cited by 653Gene expression and cancer classificationBreast Cancer Treatment StudiesCancer-related Molecular Pathways

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Common markers of proliferation

Whitfield, Michael L., George, Lacy K., Grant, Gavin D., Perou, Charles M.·2006·Nature Reviews Cancer

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Abstract

When normal tissue and tumour samples are compared by microarray analysis, the biggest differences most often occur in the expression levels of genes that control cell proliferation. However, this difference is detected whenever mRNA samples that are taken from two cell populations with different proliferation rates are compared. Although the exact genes that comprise this 'proliferation signature' often differ, they are almost always genes that are involved in the fundamental process of cell proliferation. Can the proliferation signature be used to improve our understanding of the cell cycle and cancer pathogenesis, as well as being used as a biomarker for cancer diagnosis and prognosis?

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Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551
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Spellman, P. T., Sherlock, G. J., Zhang, M. Q., Iyer, V. R., Anders, K. R., Eisen, M. B., Brown, P. O., Botstein, D., & Futcher, B. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.12.3273 · Cited by 4,724
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Stewart, C. F. & Ratain, M. J. in Cancer: Principles and Practice in Oncology (eds. DeVita, V. T., Hellman, S. & Rosenberg, S. A.) 452–467 (Lippincott–Raven, Philadelphia, 1997).
O'Dwyer, P. J., Johnson, S. W. & Hamilton, T. C. in Cancer Principles and Practices of Oncology (eds. DeVita, V. T., Hellman, S. & Rosenberg, S. A.) 418–432 (Lippincott–Raven, Philadelphia, 1997).

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Súkeníková, L., Mallone, A., Schreiner, B., Ripellino, P., Nilsson, J., Stoffel, M., Ulbrich, S. E., Sallusto, F., & Latorre, D. (2024) · Nature · doi:10.1038/s41586-023-06916-6 · Cited by 70
“In brief, the reaction was carried out using HPLC-purified oligo dT(25) primers (Microsynth) and Maxima H Minus reverse transcriptase (Thermo Fisher Scientific), in a reaction mix containing 0.2% Triton, dNTPs and RNase inhibitor.”
MethodInfluential
Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice
Feng, G. J., Cotta, W., Wei, X., Poetz, O., Evans, R., Jardé, T., Reed, K. R., Méniel, V. S., Williams, G. T., Clarke, A. R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.08.047 · Cited by 69
Evaluation of biological pathways involved in chemotherapy response in breast cancer
Tordai, A., Wang, J., André, F., Liedtke, C., Yan, K., Sotiriou, C. P., Hortobágyi, G. N., Symmans, W. F., & Pusztai, L. (2008) · Breast Cancer Research · doi:10.1186/bcr2088 · Cited by 62
“A proliferation signature set reported by Whitfield and colleagues [17] that includes genes involved in cell proliferation was also examined.”
Background
A carbon nanotube field emission multipixel x-ray array source for microradiotherapy application
Wang, S., Calderón‐Colón, X., Peng, R., Schreiber, E. C., Zhou, O. Z., & Chang, S. (2011) · Applied Physics Letters · doi:10.1063/1.3595268 · Cited by 61
Chemokine CXCL14 is associated with prognosis in patients with colorectal carcinoma after curative resection
Zeng, J., Yang, X., Cheng, L., Liu, R., Lei, Y., Dong, D., Li, F., Lau, Q. C., Deng, L., Nice, E. C., et al. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-6 · Cited by 61
“To explore whether CXCL14 is correlated with the proliferation of colorectal cancer cells, levels of Ki67, a marker of cell proliferation [29], were analyzed in 118 resected colorectal cancer specimens, which were also examined with an antibody to CXCL14 (Figure 4A).”
Global mitotic phosphorylation of C2H2zinc finger protein linker peptides
Rizkallah, R., Alexander, K. E., & Hurt, M. M. (2011) · Cell Cycle · doi:10.4161/cc.10.19.17619 · Cited by 60
Proliferation and tissue remodeling in cancer: the hallmarks revisited
Markert, E. K., Levine, A. J., & Vázquez, A. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.140 · Cited by 57
Phase I study of adjuvant immunotherapy with autologous tumor-infiltrating lymphocytes in locally advanced cervical cancer
Huang, H., Nie, C., Liu, X., Song, B., Yue, J., Xu, J.-X., He, J., Li, K., Feng, Y., Wan, T., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci157726 · Cited by 59
“Gene set scores of interest were calculated for each cell using the AddModule-Score function (57–59).”
Robust prognostic value of a knowledge-based proliferation signature across large patient microarray studies spanning different cancer types
Starmans, M. H. W., Krishnapuram, B., Steck, H., Horlings, H. M., Nuyten, D. S. A., van de Vijver, M. J., Seigneuric, R., Buffa, F. M., Harris, A. L., Wouters, B. G., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604746 · Cited by 56
“Whitfield et al (2006) has further suggested that one of these processes is proliferation.”
BackgroundMethodInfluential
Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature
Tutt, A. N. J., Wang, A., Rowland, C. M., Gillett, C., Lau, K. F., Chew, K., Dai, H. A., Kwok, S., Ryder, K., Shu, H., et al. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-339 · Cited by 57
“tion genes (BUB1, CCNB1 and MYBL2) highlighted in Whitfield et al [45] appear in the 14 gene signature described here but only MYBL2 overlaps with the p53 status signature recently reported by Miller at al [46].”
Background
Generation of proliferating human adult hepatocytes using optimized 3D culture conditions
Rose, S., Ezan, F., Cuvellier, M., Bruyère, A., Legagneux, V., Langouët, S., & Baffet, G. (2021) · Scientific Reports · doi:10.1038/s41598-020-80019-4 · Cited by 60
Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironment
Wang, Y., Goliwas, K. F., Severino, P. E., Hough, K. P., Vessem, D. V., Wang, H., Tousif, S., Koomullil, R. P., Frost, A. R., Ponnazhagan, S., et al. (2020) · Laboratory Investigation · doi:10.1038/s41374-020-0452-1 · Cited by 59
The impact of microRNA expression on cellular proliferation
Lenkala, D., LaCroix, B. L., Gamazon, E. R., Geeleher, P., Im, H. K., & Huang, R. S. (2014) · Human Genetics · doi:10.1007/s00439-014-1434-4 · Cited by 57
An overview of synthesis, characterization, applications and associated adverse effects of bioactive nanoparticles
Bommakanti, V., Banerjee, M., Shah, D., Manisha, K., Sri, K., & Banerjee, S. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113919 · Cited by 58
Functionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma
Schütz, S., Solé‐Boldo, L., Lucena-Porcel, C., Hoffmann, J. H. O., Brobeil, A., Lonsdorf, A. S., Rodríguez‐Paredes, M., & Lyko, F. (2023) · Nature Communications · doi:10.1038/s41467-023-41141-9 · Cited by 59
“Cell proliferation analyses were performed calculating the average expression for each cell of a proliferation-related gene signature de ﬁ ned by Whit ﬁ eld et al. 61 , comprising MKI67 , MYBL2 , BUB1 , PLK1 , CCNE1 , CCND1 and CCNB .”
Method
The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing
Li, D., Liu, Z., Zhang, L., Bian, X., Wu, J., Li, L., Chen, Y., Luo, L., Pan, L., Kong, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52783-8 · Cited by 56
Wnt3a Reestablishes Osteogenic Capacity to Bone Grafts from Aged Animals
Leucht, P., Jiang, J., Cheng, D., Liu, B., Dhamdhere, G. R., Fang, M. Y., Monica, S. D., Urena, J. J., Cole, W., Smith, R. L., et al. (2013) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.l.01502 · Cited by 54
BIRC5 (survivin): a pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy
Hamy, A., Bièche, I., Lehmann‐Che, J., Scott, V., Bertheau, P., Jm, G., Matthieu, M.-C., Sigal‐Zafrani, B., Tembo, O., Marty, M. E., et al. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3961-2 · Cited by 54
Digital Holographic Microscopy for Non-Invasive Monitoring of Cell Cycle Arrest in L929 Cells
Miniotis, M. F., Mukwaya, A., & Wingren, A. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106546 · Cited by 53
“In fact, the majority of the proliferation-associated genes are cell cycle regulated [3].”
Background
Telomere Length Maintenance and Its Transcriptional Regulation in Lynch Syndrome and Sporadic Colorectal Carcinoma
Nersisyan, L., Hopp, L., Loeffler‐Wirth, H., Galle, J., Loeffler, M., Arakelyan, A., & Binder, H. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01172 · Cited by 55
Dynamic fibroblast–immune interactions shape recovery after brain injury
Ewing-Crystal, N. A., Mroz, N. M., Larpthaveesarp, A., Lizama, C. O., Pennington, R., Chiaranunt, P., Dennis, J. I., Chang, A. A., Merrill, E. D., Caryotakis, S. E., et al. (2025) · Nature · doi:10.1038/s41586-025-09449-2 · Cited by 65
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Balamuth, N., Wood, A., Wang, Q., Jagannathan, J., Mayes, P. A., Zhang, Z., Chen, Z., Rappaport, E. R., Courtright, J., Pawel, B., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3844 · Cited by 54
“defined gene expression signature, we established that genes identified as being upregulated in rapidly dividing cells (25) were more likely to show upregulation in larger tumors compared with ∼18,000 other murine transcripts (Supplementary”
BackgroundMethodInfluential
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Nelson, D. M., McBryan, T., Jeyapalan, J. C., Sedivy, J. M., & Adams, P. D. (2014) · AGE · doi:10.1007/s11357-014-9637-0 · Cited by 53
“The proliferation arrest restrains tumor growth, and the SASP recruits innate immune cells to clear the damaged premalignant cells (Xue et al. 2007; Kang et al. 2011).”
Background
Peyer’s patch myeloid cells infection by Listeria signals through gp38+ stromal cells and locks intestinal villus invasion
Disson, O., Blériot, C., Jacob, J.-M., Serafini, N., Dulauroy, S., Jouvion, G., Fèvre, C., Gessain, G., Thouvenot, P., Eberl, G., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20181210 · Cited by 54
“In line with these results, more Ki67+ cycling cells were counted in crypts and at crypt-villous junctions upon Lm oral infection (Fig. 1 C and Fig. S1 C; Whitfield et al., 2006; Cuylen et al., 2016).”
Result
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Sun, F., Li, L., Yan, P., Zhou, J., Shapiro, S. D., Xiao, G., & Qu, Z. (2019) · Nature Communications · doi:10.1038/s41467-019-13331-x · Cited by 55
TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation
Fischer, M., Schwarz, R. J., Riege, K., DeCaprio, J. A., & Hoffmann, S. (2022) · NAR Cancer · doi:10.1093/narcan/zcac009 · Cited by 47
“Cell cycle genes play essential roles in cell cycle progression and therefore are typical markers of proliferation that are dysregulated in many cancers (55).”
Background
Lentivirus-Mediated Silencing of Tiam1 Gene Influences Multiple Functions of a Human Colorectal Cancer Cell Line
Liu, L., Zhang, Q., Zhang, Y., Wang, S., & Ding, Y. (2006) · Neoplasia · doi:10.1593/neo.06364 · Cited by 50
“ability of tumor cells always correlates with metastatic phenotype and poor outcome [24].”
Background
Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized
Li, Y., Pan, J., Li, J., Lee, J. H., Tunkey, C., Saraf, K., Garbe, J. C., Whitley, M. Z., Jelinsky, S. A., Stampfer, M. R., et al. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-7 · Cited by 49
Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle
Wang, Z., Zhang, H., Zhou, J., Zhang, X., Chen, L., Chen, K., & Huang, Z. (2016) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-016-3171-y · Cited by 51
“It is known that most of tumor proliferation-associated genes are cell cycle-regulated during the microarray analysis [18].”
Background
Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell FormationPreprint
Shetzer, Y., Molchadsky, A., & Rotter, V. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026203 · Cited by 53
“This set of genes is involved in DNA replication, spindle assembly and checkpoint, chromosome segregation, and mitotic processes (Whitfield et al. 2006).”
Background
Clinically oriented prediction of patient response to targeted and immunotherapies from the tumor transcriptome
Dinstag, G., Shulman, E. D., Elis, E., Ben-Zvi, D. S., Tirosh, O., Maimon, E., Meilijson, I., Elalouf, E., Temkin, B., Vitkovsky, P., et al. (2022) · Med · doi:10.1016/j.medj.2022.11.001 · Cited by 49
Prognostic Biomarkers of Cell Proliferation in Colorectal Cancer (CRC): From Immunohistochemistry to Molecular Biology Techniques
Kasprzak, A. (2023) · Cancers · doi:10.3390/cancers15184570 · Cited by 54
Cisplatin nanoparticles possess stronger anti-tumor synergy with PD1/PD-L1 inhibitors than the parental drug
Shen, N., Yang, C., Zhang, X., Tang, Z., & Chen, X. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.08.013 · Cited by 49
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Tedesco, D., Zhang, J., Trinht, L., Lalehzadeh, G., Meisner, R., Yamaguchi, K. D., Ruderman, D., Dinter, H., & Zajchowski, D. A. (2007) · Neoplasia · doi:10.1593/neo.07385 · Cited by 49
Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma
Gadbail, A. R., Sarode, S. C., Chaudhary, M. S., Gondivkar, S. M., Tekade, S. A., Yuwanati, M. B., & Patil, S. (2021) · Journal of Applied Oral Science · doi:10.1590/1678-7757-2020-0751 · Cited by 48
Quantification of epithelial cell proliferation, cell dynamics, and cell kinetics in vivo
Goodlad, R. A. (2017) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.274 · Cited by 50
“The importance of cell proliferation studies in cancer has been reaffirmed by the finding that the biggest changes in gene expression between normal and tumor tissue samples occurs in those genes involved in the control of cell proliferation.(2) Given the important role of cell proliferation in carcinogenesis, quantit…”
Background
Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility
Saatcioglu, H. D., Kano, M., Horn, H., Zhang, L., Samore, W. R., Nagykery, N. G., Meinsohn, M.-C., Hyun, M., Suliman, R., Poulo, J., et al. (2019) · eLife · doi:10.7554/elife.46349 · Cited by 46
“Markers include Smoc2 (Mucenski et al., 2019) for stromal cells; Ptn (Mucenski et al., 2019) for myometrial cells; Epcam and Wnt7a (Litvinov et al., 1997) (Miller and Sassoon, 1998) for luminal epithelium cells; Top2a (Whitfield et al., 2006) for proliferating cells, Cdh5 (Bhasin et al., 2010) for vascular endothelial…”
Co-Expression Effect of SLC7A5/SLC3A2 to Predict Response to Endocrine Therapy in Oestrogen-Receptor-Positive Breast Cancer
Alfarsi, L. H., Ansari, R. E., Craze, M. L., Masisi, B. K., Mohammed, O. J., Ellis, I. O., Rakha, E. A., & Green, A. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041407 · Cited by 48
Histone methyltransferase SETDB1 promotes colorectal cancer proliferation through the STAT1-CCND1/CDK6 axis
Yu, L., Feng, Y., Li, Y.-Y., Zhan, Y., Liu, Y., Yan, H.-M., Fang, Y., Xie, Y., Zhang, F.-J., Chen, L., et al. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz131 · Cited by 47
Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer
Barger, C. J., Chee, L., Albahrani, M., Muñoz-Trujillo, C., Boghean, L., Branick, C., Odunsi, K. O., Drapkin, R., Zou, L., & Karpf, A. R. (2021) · eLife · doi:10.7554/elife.55070 · Cited by 46
Inhibition of CBF/NF-Y mediated transcription activation arrests cells at G2/M phase and suppresses expression of genes activated at G2/M phase of the cell cycle
Hu, Q., Lu, J.-F., Luo, R., Sen, S., & Maity, S. N. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl801 · Cited by 47
“Also, expression of both Cyclin B1 and Aurora A genes is increased in various human tumors (5,6).”
Background
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
Sirko, S., Schichor, C., Vecchia, P. D., Metzger, F., Sonsalla, G., Simon, T., Bürkle, M., Kalpazidou, S., Ninkovic, J., Masserdotti, G., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02644-6 · Cited by 45
“Thus, GAL3 predicts the proliferative status of reactive human astrocytes irrespective of the etiology of the BBB disruption at earlier stages in cell cycle than MIB1(Ki67) and PCNA that label cells in S phase 47 .”
Background
Poly-Omic Prediction of Complex Traits: OmicKriging
Wheeler, H. E., Aquino-Michaels, K., Gamazon, E. R., Trubetskoy, V., Dolan, M. E., Huang, R. S., Cox, N. J., & Im, H. K. (2014) · Genetic Epidemiology · doi:10.1002/gepi.21808 · Cited by 51
“…with proliferation are strong prognostic factors in several types of cancers (Dai, 2005; Damasco et al., 2011; Rosenwald et al., 2003; Starmans et al., 2008) and such genes are differentially expressed in most cancer tissues (Rhodes et al., 2004; Ross et al., 2000; Whitfield et al., 2006).”
Background
Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics
Sargent, J. L., Li, Z., Aliprantis, A. O., Greenblatt, M. B., Lemaire, R., Wu, M., Wei, J., Taroni, J., Harris, A., Long, K. B., et al. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39658 · Cited by 47
“A large number of the genes found to be coordinately regulated in the subset of patients with fibroproliferative SSc and in Tsk2/1 mice at 4 weeks of age are associated with cell proliferation, including MKI67, CENPE, KIF20A, and MCM10 (Figure 2F) (27).”
BackgroundSelf-citation
Novel polyethyleneimine-R8-heparin nanogel for high-efficiency gene delivery in vitro and in vivo
Song, L., Liang, X., Yang, S., Wang, N., He, T., Wang, Y., Zhang, L., Wu, Q., & Gong, C. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1417512 · Cited by 47
“Ki-67 is widely utilized as a proliferation maker in tumor prognosis (Whitfield et al., 2006; Yerushalmi et al., 2010).”
Background
Dissecting the DNA binding landscape and gene regulatory network of p63 and p53
Riege, K., Kretzmer, H., Sahm, A., McDade, S. S., Hoffmann, S., & Fischer, M. (2020) · eLife · doi:10.7554/elife.63266 · Cited by 46
“While the up-regulation of cell cycle genes occurs in most cancers (Whitfield et al., 2006), we find that p63 additionally regulates genes that are specifically altered across SCCs (Figure 2D).”
Background
Preclinical and clinical studies of estrogen deprivation support the PDGF/Abl pathway as a novel therapeutic target for overcoming endocrine resistance in breast cancer
Weigel, M. T., Ghazoui, Z. F., Dunbier, A. K., Pancholi, S., Dowsett, M., & Martin, L. (2012) · Breast Cancer Research · doi:10.1186/bcr3191 · Cited by 44
“These two clusters were derived from each of these two breast cancer datasets independently as the smallest clusters that contained 95% of the genes previously reported to be associated with proliferation [25-27].”
Background
RNA sequencing-based cell proliferation analysis across 19 cancers identifies a subset of proliferation-informative cancers with a common survival signature
Ramaker, R. C., Lasseigne, B. N., Hardigan, A. A., Palacio, L. Q., Gunther, D. S., Kirby, M. K., Myers, R., & Cooper, S. J. (2017) · Oncotarget · doi:10.18632/oncotarget.16961 · Cited by 44
The Non-Coding RNA Llme23 Drives the Malignant Property of Human Melanoma Cells
Wu, C., Tan, G., Ma, C., & Li, L. (2013) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2013.03.001 · Cited by 46
The pathophysiology, diagnosis and prognosis of adrenocortical tumors revisited by transcriptome analyses
Assié, G., Guillaud-Bataille, M., Ragazzon, B., BERTAGNA, X. Y., Bertherat, J. Y., & Clauser, É. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.12.009 · Cited by 48
Application of bioactivity database of Chinese herbal medicine on the therapeutic prediction, drug development, and safety evaluation
Cheng, H.-M., Li, C., Chen, C. Y., Lo, H., Cheng, W.-Y., Lee, C.-H., Yang, S.-Z., Wu, S., Hsiang, C., & Ho, T. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.08.022 · Cited by 42

Authors: Whitfield, M. L., George, L. K., Grant, G. D., & Perou, C. M.
Affiliations: Dartmouth College (US)
University of North Carolina at Chapel Hill (US)
Corresponding author: Whitfield, Michael L.
ORCID: Whitfield, Michael L.
Grant, Gavin D.
Perou, Charles M.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2006-02
Volume: 6
Issue: 2
Pages: 99-106
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc1802
OpenAlex: W2018173663
Cited by: 650
References: 66
Citations by year: 2026: 31 · 2025: 46 · 2024: 35 · 2023: 54 · 2022: 53 · 2021: 54 · 2020: 33 · 2019: 29 · 2018: 22 · 2017: 27 · 2016: 34 · 2015: 15 · 2014: 17 · 2013: 27 · 2012: 26
FWCI: 2.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: cell proliferation, proliferation signature, gene expression profiling, tumor markers, cell cycle, carcinogenesis, cancer diagnosis, cancer prognosis
MeSH terms: Cell Cycle, Genetic Markers, Humans, Neoplasms, Prognosis, RNA, Messenger, Biomarkers, Tumor, Gene Expression Profiling, Cell Proliferation

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