Cited by 653Gene expression and cancer classificationBreast Cancer Treatment StudiesCancer-related Molecular Pathways

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Common markers of proliferation

Whitfield, Michael L., George, Lacy K., Grant, Gavin D., Perou, Charles M.·2006·Nature Reviews Cancer

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Abstract

When normal tissue and tumour samples are compared by microarray analysis, the biggest differences most often occur in the expression levels of genes that control cell proliferation. However, this difference is detected whenever mRNA samples that are taken from two cell populations with different proliferation rates are compared. Although the exact genes that comprise this 'proliferation signature' often differ, they are almost always genes that are involved in the fundamental process of cell proliferation. Can the proliferation signature be used to improve our understanding of the cell cycle and cancer pathogenesis, as well as being used as a biomarker for cancer diagnosis and prognosis?

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Authors: Whitfield, M. L., George, L. K., Grant, G. D., & Perou, C. M.
Affiliations: Dartmouth College (US)
University of North Carolina at Chapel Hill (US)
Corresponding author: Whitfield, Michael L.
ORCID: Whitfield, Michael L.
Grant, Gavin D.
Perou, Charles M.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2006-02
Volume: 6
Issue: 2
Pages: 99-106
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc1802
OpenAlex: W2018173663
Cited by: 650
References: 66
Citations by year: 2026: 31 · 2025: 46 · 2024: 35 · 2023: 54 · 2022: 53 · 2021: 54 · 2020: 33 · 2019: 29 · 2018: 22 · 2017: 27 · 2016: 34 · 2015: 15 · 2014: 17 · 2013: 27 · 2012: 26
FWCI: 2.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: cell proliferation, proliferation signature, gene expression profiling, tumor markers, cell cycle, carcinogenesis, cancer diagnosis, cancer prognosis
MeSH terms: Cell Cycle, Genetic Markers, Humans, Neoplasms, Prognosis, RNA, Messenger, Biomarkers, Tumor, Gene Expression Profiling, Cell Proliferation

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Common markers of proliferation

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