Telomerase and cancer therapeutics

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091

Telomeres shorten during ageing of human fibroblasts

Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400

Shelterin: the protein complex that shapes and safeguards human telomeres

de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056

Accelerated telomere shortening in response to life stress

Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917

A survey of telomerase activity in human cancer

Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280

Telomerase inhibitors: a patent review (2010–2015)

Man, R., Chen, L., & Zhu, H. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2016.1181172 · Cited by 29

Cell Proliferation in the Presence of Telomerase

Blagoev, K. B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004622 · Cited by 30

DNA Nanotechnology Targeting Mitochondria: From Subcellular Molecular Imaging to Tailor‐Made Therapeutics

Yu, F., Li, X., Sheng, C., & Li, L. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202409351 · Cited by 29

Targeting DNA damage in ageing: towards supercharging DNA repair

Bujarrabal-Dueso, A., Garinis, G. A., Robbins, P. D., Vijg, J., & Schumacher, B. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01212-6 · Cited by 32

Imetelstat (a telomerase antagonist) exerts off-target effects on the cytoskeleton

Mender, I., Şentürk, Ş., Özgüneş, N., Akçalı, K. C., Kletsas, D., Gryaznov, S. M., Can, A., Shay, J. W., & Dikmen, Z. G. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1865 · Cited by 28

Potent Human Telomerase Inhibitors: Molecular Dynamic Simulations, Multiple Pharmacophore-Based Virtual Screening, and Biochemical Assays

Talari, F. S., Bagherzadeh, K., Golestanian, S., Jarstfer, M. B., & Amanlou, M. (2015) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5b00336 · Cited by 28

Enzyme-free dual-DNA walker based on catalytic hairpin assembled DNAzyme for sensing telomerase activity

Shen, Y., Gong, J., Li, S., Liu, C., Zhou, L., Sheng, J., & Xu, Q. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.129078 · Cited by 28

Dissecting the non-canonical functions of telomerase

Parkinson, E. K., Fitchett, C., & Cereser, B. (2008) · Cytogenetic and Genome Research · doi:10.1159/000167813 · Cited by 30

Identification of New Natural DNA G-Quadruplex Binders Selected by a Structure-Based Virtual Screening Approach

Artese, A., Costa, G., Ortuso, F., Parrotta, L., & Alcaro, S. (2013) · Molecules · doi:10.3390/molecules181012051 · Cited by 28

Universal tumor-reactive helper peptides from telomerase as new tools for anticancer vaccination

Dosset, M., Vauchy, C., Beziaud, L., Adotévi, O., & Godet, Y. (2013) · OncoImmunology · doi:10.4161/onci.23430 · Cited by 28

Toward the design of new DNA G-quadruplex ligands through rational analysis of polymorphism and binding data

Artese, A., Costa, G., Distinto, S., Moraca, F., Ortuso, F., Parrotta, L., & Alcaro, S. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.07.022 · Cited by 28

Telomerase enzymatic component hTERT shortens long telomeres in human cells

Zheng, Y., Zhang, F., Sun, B., Du, J., Sun, C., Yuan, J., Wang, Y., Tao, L., Kota, K. K., Liu, X., et al. (2014) · Cell Cycle · doi:10.4161/cc.28705 · Cited by 28

Means to the ends: The role of telomeres and telomere processing machinery in metastasis

Robinson, N. J., & Schiemann, W. P. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.10.005 · Cited by 28

Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance

Venturini, L., Daidone, M. G., Motta, R., Cimino-Reale, G., Hoare, S. F., Gronchi, A., Folini, M., Keith, W. N., & Zaffaroni, N. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos083 · Cited by 28

2.7 Å cryo-EM structure of human telomerase H/ACA ribonucleoprotein

Ghanim, G. E., Sekne, Z., Balch, S., van Roon, A. M., & Nguyen, T. H. D. (2024) · Nature Communications · doi:10.1038/s41467-024-45002-x · Cited by 29

A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and G

Banne, S., Reddy, D. P., Li, W., Wang, C., Guo, J. J., & He, Y. (2017) · Organic Letters · doi:10.1021/acs.orglett.7b02511 · Cited by 27

Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects

Liu, T., Liang, X., Li, B., Björkholm, M., Jia, J., & Xu, D. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.208 · Cited by 27

Telomerase-specific GV1001 peptide vaccination fails to induce objective tumor response in patients with cutaneous T cell lymphoma

Schlapbach, C., Yerly, D., Daubner, B., Yawalkar, N., & Hunger, R. E. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2011.02.001 · Cited by 27

Single-stranded DNA repeat synthesis by telomerase

Collins, K. (2011) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2011.07.011 · Cited by 28

Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human

Wang, Y., Yesselman, J. D., Zhang, Q., Kang, M., & Feigon, J. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607411113 · Cited by 28

Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics

Shou, S., Maolan, A., Zhang, D., Jiang, X., Liu, F., Li, Y., Zhang, X., Geer, E., Pu, Z., Hua, B., et al. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00597-9 · Cited by 29

Nanomedicine strategies for sustained, controlled, and targeted treatment of cancer stem cells of the digestive system

Xie, F., Xu, W., Yin, C., Zhang, G., Zhong, Y., & Gao, J. (2016) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v8.i10.735 · Cited by 26

Telomerase antagonist imetelstat increases radiation sensitivity in esophageal squamous cell carcinoma

Wu, X., Zhang, J., Yang, S., Kuang, Z., Tan, G., Yang, G., Wei, Q., & Guo, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.14618 · Cited by 26

Nuclear-Shell Biopolymers Initiated by Telomere Elongation for Individual Cancer Cell Imaging and Drug Delivery

Zhang, Z., Jiao, Y., Zhu, M., & Zhang, S. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00591 · Cited by 26

DNAzyme-Powered DNA Walker for Cooperative Expression Imaging of Mutant p53 and Telomerase in Cancer Cells

Zhou, Z., Li, D., Qian, R., & Ju, H. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c05111 · Cited by 26

The Combined Use of Known Antiviral Reverse Transcriptase Inhibitors AZT and DDI Induce Anticancer Effects at Low Concentrations

Aschacher, T., Sampl, S., Käser, L., Bernhard, D., Spittler, A., Holzmann, K., & Bergmann, M. M. (2012) · Neoplasia · doi:10.1593/neo.11426 · Cited by 26

Cellular senescence, telomere recombination and maintenance

Yang, Q. (2008) · Cytogenetic and Genome Research · doi:10.1159/000167806 · Cited by 28

Immunoprevalence and magnitude of HLA-DP4 versus HLA-DR-restricted spontaneous CD4+Th1 responses against telomerase in cancer patients

Laheurte, C., Galaine, J., Beziaud, L., Dosset, M., Kerzerho, J., Jacquemard, C., Gaugler, B., Ferrand, C., Dormoy, A., Aubin, F., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2015.1137416 · Cited by 33

Naturally Occurring Telomerase-Specific CD4 T-Cell Immunity in Melanoma

Nardin, C., Laheurte, C., Puzenat, E., Boullerot, L., Ramseyer, M., Marguier, A., Jacquin, M., Godet, Y., Aubin, F., & Adotévi, O. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.07.160 · Cited by 27

Regulation of telomere length and homeostasis by telomerase enzyme processivity

D’Souza, Y., Lauzon, C., Chu, T. W., & Autexier, C. (2012) · Journal of Cell Science · doi:10.1242/jcs.119297 · Cited by 26

Targeting antitumor CD4 helper T cells with universal tumor-reactive helper peptides derived from telomerase for cancer vaccine

Adotévi, O., Dosset, M., Galaine, J., Beziaud, L., Godet, Y., & Borg, C. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.23587 · Cited by 29

Posttranslational control of telomere maintenance and the telomere damage response

Peuscher, M. H., & Jacobs, J. J. L. (2012) · Cell Cycle · doi:10.4161/cc.19847 · Cited by 27

Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert−/− mice

Zhou, Q.-G., Wu, H.-Y., Zhou, H., Liu, M.-Y., Lee, H. W., Liu, X., Devkota, S., Ro, E., Zhu, D.-Y., & Suh, H. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.106 · Cited by 25

Association between TERT rs2853669 polymorphism and cancer risk: A meta-analysis of 9,157 cases and 11,073 controls

Liu, Z., Wang, T., Wu, Z., Zhang, K., Li, W., Yang, J., Chen, C., Chen, L., & Xing, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191560 · Cited by 24

A Driver Never Works Alone—Interplay Networks of Mutant p53, MYC, RAS, and Other Universal Oncogenic Drivers in Human Cancer

Grzes, M., Oroń, M., Staszczak, Z., Jaiswar, A., Nowak-Niezgoda, M., & Walerych, D. (2020) · Cancers · doi:10.3390/cancers12061532 · Cited by 24

HnRNP-F promotes the proliferation of bladder cancer cells mediated by PI3K/AKT/FOXO1

Li, F., Xie, W., Fang, Y., Xie, K., Liu, W., Hou, L., & Tan, W. (2020) · Journal of Cancer · doi:10.7150/jca.50490 · Cited by 24

In Situ Track-Generated DNA Walker for AND-Gate Logic Imaging of Telomerase and Flap Endonuclease 1 Activities in Living Cells

Wang, C., Zhang, Z., Qiu, Y., Bao, Y., Song, Q., & Zou, B. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c03952 · Cited by 24

Coadministration of Telomerase Genetic Vaccine and a Novel TLR9 Agonist in Nonhuman Primates

Dharmapuri, S., Peruzzi, D., Mennuni, C., Calvaruso, F., Giampaoli, S., Barbato, G., Kandimalla, E. R., Agrawal, S., Scarselli, E., Mesiti, G., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.165 · Cited by 24

Effect of G-Quadruplex Polymorphism on the Recognition of Telomeric DNA by a Metal Complex

Musetti, C., Krapcho, A. P., Palumbo, M., & Sissi, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058529 · Cited by 24

The impact of cellular senescence in cancer therapy: is it true or not?

Zhang, Y., & Yang, J. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.108 · Cited by 24

Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers

Guo, W., Lu, J., Dai, M., Wu, T., Yu, Z., Wang, J., Chen, W., Shi, D., Yu, W., Xiao, Y., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2430 · Cited by 24

Prognostic Significance of Telomerase Polymorphism in Non–Small Cell Lung Cancer

Catarino, R., Araújo, A., Coelho, A., Gomes, M. P., Nogueira, A., Lopes, C., & Medeiros, R. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3030 · Cited by 27

Synthetic Bax-Anti Bcl2 combination module actuated by super artificial hTERT promoter selectively inhibits malignant phenotypes of bladder cancer

Liu, L., Liu, Y., Zhang, T., Wu, H., Lin, M., Wang, C., Zhan, Y., Zhou, Q., Qiao, B., Sun, X., et al. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0279-6 · Cited by 24

Coupling a DNA-Based Machine with Glucometer Readouts for Amplified Detection of Telomerase Activity in Cancer Cells

Wang, W., Huang, S., Li, J., Rui, K., Zhang, J., & Zhu, J. (2016) · Scientific Reports · doi:10.1038/srep23504 · Cited by 23

RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth

Yu, Q., Chen, W., Xiao, Y., Yu, W., Cai, X., Dai, M., Xu, T., Huang, W., Guo, W., Deng, W., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4825 · Cited by 23

Troglitazone suppresses telomerase activity independently of PPARγ in estrogen-receptor negative breast cancer cells

Rashid-Kolvear, F., Taboski, M. A. S., Nguyen, J., Wang, D., Harrington, L. A., & Done, S. J. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-390 · Cited by 23

Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase

Zhu, S., Rousseau, P., Lauzon, C., Gandin, V., Topisirović, I., & Autexier, C. (2014) · Biochimie · doi:10.1016/j.biochi.2013.12.023 · Cited by 23

A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase

Wong, L. H., Unciti‐Broceta, A., Spitzer, M., White, R., Tyers, M., & Harrington, L. A. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.12.008 · Cited by 23

Selectivity of Oncolytic Viral Replication Prevents Antiviral Immune Response and Toxicity, but Does Not Improve Antitumoral Immunity

Gürlevik, E., Woller, N., Strüver, N., Schache, P., Kloos, A., Manns, M. P., Zender, L., Kühnel, F., & Kubicka, S. (2010) · Molecular Therapy · doi:10.1038/mt.2010.163 · Cited by 23

Exploiting cellular senescence to treat cancer and circumvent drug resistance

Yan, Q., & Wajapeyee, N. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.3.11166 · Cited by 24

A multicolor DNA tetrahedron nanoprobe for analyzing human telomerase in living cells

Zhang, R., Zhang, R., Jiang, W., & Xu, X. (2021) · Chemical Communications · doi:10.1039/d0cc07893j · Cited by 23

A New Strategy for Detection and Development of Tractable Telomerase Inhibitors

Cohn, E. P. M. T., Wu, K., Pettus, T. R. R., & Reich, N. O. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm201191d · Cited by 22

Association Between Human Telomerase Reverse Transcriptase Gene Variations and Risk of Developing Breast Cancer

Öztaş, E., Kara, H., Kara, Z. P., Aydogan, M. U., Uras, C., & Özhan, G. (2016) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2015.0339 · Cited by 24

Recombinant Fusion Streptavidin as a Scaffold for DNA Nanotetrads for Nucleic Acid Delivery and Telomerase Activity Imaging in Living Cells

Huang, Z., Lin, M.-Y., Zhang, C., Wu, Z., Yu, R., & Jiang, J. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b02115 · Cited by 22

Human telomerase reverse transcriptase regulates cyclin D1 and G1/S phase transition in laryngeal squamous carcinoma

Li, J., Huang, X., Xie, X., Wang, J., & Duan, M. (2011) · Acta Oto-Laryngologica · doi:10.3109/00016489.2011.557393 · Cited by 22

E2F1 acts as a negative feedback regulator of c-Myc-induced hTERT transcription during tumorigenesis

Zhang, Y., Zhang, A., Shen, C., Zhang, B., RAO, Z., Wang, R., Yang, S., Ning, S., Mao, G.-P., & Fang, D.-C. (2014) · Oncology Reports · doi:10.3892/or.2014.3287 · Cited by 21

From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides

Scognamiglio, P. L., Platella, C., Napolitano, E., Musumeci, D., & Roviello, G. N. (2021) · Molecules · doi:10.3390/molecules26123558 · Cited by 23

The levels of telomere-binding proteins in human tumours and therapeutic implications

Cookson, J. C., & Laughton, C. A. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.11.014 · Cited by 23

Targeting critical steps of cancer metastasis and recurrence using telomerase template antagonists

Dikmen, Z. G., Özgürtaş, T., Gryaznov, S. M., & Herbert, B. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.01.018 · Cited by 21

New Models of Tetrahymena Telomerase RNA from Experimentally Derived Constraints and Modeling

Cole, D., Legassie, J. D., Bonifacio, L. N., Sekaran, V. G., Ding, F., Dokholyan, N. V., & Jarstfer, M. B. (2012) · Journal of the American Chemical Society · doi:10.1021/ja305636u · Cited by 21

Quantitative assays for measuring human telomerase activity and DNA binding properties

Tomlinson, C. G., Sasaki, N., Jurczyluk, J., Bryan, T. M., & Cohen, S. B. (2016) · Methods · doi:10.1016/j.ymeth.2016.08.002 · Cited by 22

Hybrid Nanoparticles for Cancer Imaging and Therapy

He, C., & Lin, W. (2015) · Cancer treatment and research · doi:10.1007/978-3-319-16555-4_8 · Cited by 21

Cyclic Naphthalene Diimide Dimer with a Strengthened Ability to Stabilize Dimeric G‐Quadruplex

Takeuchi, R., Zou, T., Wakahara, D., Nakano, Y., Sato, S., & Takenaka, S. (2019) · Chemistry - A European Journal · doi:10.1002/chem.201901468 · Cited by 22

Multi-code magnetic beads based on DNAzyme-mediated double-cycling amplification for a point-of-care assay of telomerase activity

Liu, C., Zhang, S., Li, X., Xue, Q., & Jiang, W. (2019) · The Analyst · doi:10.1039/c9an00589g · Cited by 21

T-helper cell receptors from long-term survivors after telomerase cancer vaccination for use in adoptive cell therapy

Kyte, J. A., Gaudernack, G., Faane, A., Lislerud, K., Inderberg, E. M., Brunsvig, P. F., Aamdal, S., Kvalheim, G., Wälchli, S., & Pulè, M. A. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1249090 · Cited by 22

The catalytic and the RNA subunits of human telomerase are required to immortalize equid primary fibroblasts

Vidale, P., Magnani, E., Nergadze, S. G., Santagostino, M., Cristofari, G., Smirnova, A., Mondello, C., & Giulotto, E. (2012) · Chromosoma · doi:10.1007/s00412-012-0379-4 · Cited by 19

Uncovering the Interaction between Intracellular Telomerase Activity and Hydrogen Peroxide during Cancer Cell Apoptosis Utilizing a Dual-Color Fluorescent Nanoprobe

Yang, L., Guo, H., Hou, T., & Li, F. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c03695 · Cited by 20

Computational Selection and Experimental Validation of Allosteric Ribozymes That Sense a Specific Sequence of Human Telomerase Reverse Transcriptase mRNAs as Universal Anticancer Therapy Agents

Prof. Robert Penchovsky, D. R. N., & Kostova, G. (2013) · Nucleic Acid Therapeutics · doi:10.1089/nat.2013.0446 · Cited by 20

Histone deacetylase inhibition as an anticancer telomerase‐targeting strategy

Rahman, R., & Grundy, R. G. (2011) · International Journal of Cancer · doi:10.1002/ijc.26241 · Cited by 21

Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells

Fujiwara, C., Muramatsu, Y., Nishii, M., Tokunaka, K., Tahara, H., Ueno, M., Yamori, T., Sugimoto, Y., & Seimiya, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-33139-x · Cited by 19

Potential Telomere-Related Pharmacological Targets

Berei, J., Eckburg, A., Miliavski, E., Anderson, A. D., Miller, R. J., Dein, J., Giuffre, A. M., Tang, D., Deb, S., Racherla, K. S., et al. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200109114339 · Cited by 21

Inhibition of the hTERT promoter by the proto-oncogenic protein TAL1

Terme, J.-M., Mocquet, V., Kuhlmann, A.-S., Zane, L. K., Mortreux, F., Wattel, E., Dodon, M. D., & Jalinot, P. (2009) · Leukemia · doi:10.1038/leu.2009.131 · Cited by 20

Telomerase inhibition induces acute ATM-dependent growth arrest in human astrocytomas

Wong, V. C. H., Ma, J., & Hawkins, C. E. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.09.012 · Cited by 20

Dual EGFR and telomerase inhibitory potential of new triazole tethered Schiff bases endowed with apoptosis: design, synthesis, and biological assessments

Zeidan, M. A., Ashour, H. F., Yassen, A. S. A., Elmaaty, A. A., Farag, A. B., Sharaky, M. M., Alzahrani, A. Y. A., Mughram, M. H. A., & Al-Karmalawy, A. A. (2024) · RSC Medicinal Chemistry · doi:10.1039/d4md00750f · Cited by 19

Design and synthesis of new 1,2,3-triazole derivatives as VEGFR-2/telomerase downregulatory candidates endowed with apoptotic potential for cancer treatment

Al-Karmalawy, A. A., Zeidan, M. A., Elmaaty, A. A., Sharaky, M. M., Yassen, A. S. A., Khaleel, E. F., Eldehna, W. M., & Ashour, H. F. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108159 · Cited by 19

PTEN/AKT signaling pathway related to hTERT downregulation and telomere shortening induced in Toxoplasma GRA16-expressing colorectal cancer cells

Seo, S., Shin, J., Ham, D.-W., & Shin, E. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113366 · Cited by 19

Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers

Shanmugam, R., Majee, P., Shi, W., Ozturk, M. B., Vaiyapuri, T. S., Idzham, K., Raju, A., Shin, S. H., Fidan, K., Low, J.-L., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1379 · Cited by 20

Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors

Roe, S. J., Gunaratnam, M., Spiteri, C., Sharma, P., Alharthy, R. D., Neidle, S., & Moses, J. E. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob01177a · Cited by 19

Telomerase Reverse Transcriptase ( TERT ) Gene Variations and Susceptibility of Colorectal Cancer

Jannuzzi, A. T., Karaman, E. F., Öztaş, E., Yanar, H. T., & Özhan, G. (2015) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2015.0150 · Cited by 19

Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation

Fairlie, J., & Harrington, L. A. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.11.005 · Cited by 20

Positive association of long telomeres with the invasive capacity of hepatocellular carcinoma cells

Ko, E., & Jung, G. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.022 · Cited by 19

Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell‐based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telomerase activation therapies

Babizhayev, M. A., & Yegorov, Y. E. (2015) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35515 · Cited by 20

Telomere Maintenance as Therapeutic Target in Embryonal Tumours

Shalaby, T., Hiyama, E., & Grotzer, M. A. (2010) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520611009030196 · Cited by 20

Nuclear localization and antisense effect of PNA internalized by ASGP-R-mediated endocytosis with protein/DNA conjugates

Ishihara, T., Kano, A., Obara, K., Saito, M., Chen, X., Park, T. G., Akaike, T., & Maruyama, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.014 · Cited by 19

Platinum(II) phenanthroimidazole G-quadruplex ligand induces selective telomere shortening in A549 cancer cells

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