The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Telomerase and cancer therapeutics
Abstract
Telomerase is an attractive cancer target as it appears to be required in essentially all tumours for immortalization of a subset of cells, including cancer stem cells. Moreover, differences in telomerase expression, telomere length and cell kinetics between normal and tumour tissues suggest that targeting telomerase would be relatively safe. Clinical trials are ongoing with a potent and specific telomerase inhibitor, GRN163L, and with several versions of telomerase therapeutic vaccines. The prospect of adding telomerase-based therapies to the growing list of new anticancer products is promising, but what are the advantages and limitations of different approaches, and which patients are the most likely to respond?
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“The demonstration that dysfunctional telomeres could engage a senescence program to suppress tumorigenesis in vivo suggests possible future therapeutic applications63.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [63]
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BindingDB (2010) · UC San Diego · doi:10.7270/q2cn73ss
BindingDB (2013) · UC San Diego · doi:10.7270/q2df6sb3
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Metadata
- Authors
- Harley, C. B.
- Affiliations
- Geron (United States) (US)
- Corresponding author
- Harley, Calvin B.
- Venue
- Nature Reviews Cancer
- Published
- 2008-03
- Volume
- 8
- Issue
- 3
- Pages
- 167-179
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2078805336
- Cited by
- 728
- References
- 147
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 26 · 2023: 39 · 2022: 20 · 2021: 29 · 2020: 38 · 2019: 39 · 2018: 27 · 2017: 38 · 2016: 48 · 2015: 58 · 2014: 48 · 2013: 51 · 2012: 53
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- telomerase, telomerase inhibitors, GRN163L, cancer therapeutics, cancer stem cells, telomere length, cell kinetics, anticancer drug development
- MeSH terms
- Antineoplastic Agents, Clinical Trials as Topic, Enzyme Inhibitors, Humans, Immunotherapy, Kinetics, Medical Oncology, Models, Biological, Neoplasms, Oligonucleotides, Oligopeptides, Gene Expression Regulation, Neoplastic, Telomerase, Cancer Vaccines
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