Cited by 734Telomeres, Telomerase, and SenescenceImmunotherapy and Immune ResponsesVirus-based gene therapy research

The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.

Telomerase and cancer therapeutics

Harley, Calvin B.·2008·Nature Reviews Cancer

Open this paper in CoChat — free account

Abstract

Telomerase is an attractive cancer target as it appears to be required in essentially all tumours for immortalization of a subset of cells, including cancer stem cells. Moreover, differences in telomerase expression, telomere length and cell kinetics between normal and tumour tissues suggest that targeting telomerase would be relatively safe. Clinical trials are ongoing with a potent and specific telomerase inhibitor, GRN163L, and with several versions of telomerase therapeutic vaccines. The prospect of adding telomerase-based therapies to the growing list of new anticancer products is promising, but what are the advantages and limitations of different approaches, and which patients are the most likely to respond?

Integrity signals

Registry

Crossref · 10.1038/nrc2275

Cites

147 of 147 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Effects of oligonucleotide N3'-->P5' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells.
Akiyama, M., Hideshima, T., Shammas, M. A., Hayashi, T., Hamasaki, M., Tai, Y., Richardson, P. G. G., Gryaznov, S. M., Munshi, N. C., & Anderson, K. C. (2003) · PubMed · Cited by 84
Retracted
The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Self-citation
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Self-citation
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917
A survey of telomerase activity in human cancer
Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280

Flagged first, then by citations

Show all 147 references

Research works printed but not linked: 1

Dikmen, Z. et al. In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res. 7866–7873 (2005). · DOI · Paper page

Sorted by citations

Items 401–500 of 734

Assessment of telomerase as drug target in breast cancer
Jaiswal, R. K., & Yadava, P. K. (2020) · Journal of Biosciences · doi:10.1007/s12038-020-00045-2 · Cited by 17
Splice-switching as cancer therapy
Jbara, A., Siegfried, Z., & Karni, R. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.05.008 · Cited by 17
Targeting G-Quadruplex DNA for Cancer Chemotherapy
Acharya, P. C., & Debbarma, S. (2022) · Current Drug Discovery Technologies · doi:10.2174/1570163819666220214115408 · Cited by 19
Telomeres and telomerase in normal and malignant B‐cells
Lobetti‐Bodoni, C., Bernocco, E., Genuardi, E., Boccadoro, M., & Ladetto, M. (2010) · Hematological Oncology · doi:10.1002/hon.937 · Cited by 17
N-(1-Pyrenyl) maleimide inhibits telomerase activity in a cell free system and induces apoptosis in Jurkat cells
Huang, P., Yeh, Y., Pao, C., Chen, C., & Wang, T. V. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1757-y · Cited by 17
Telomeric function of mammalian telomerases at short telomeres
Fakhoury, J. J., Marie-Egyptienne, D. T., Londoño‐Vallejo, A., & Autexier, C. (2010) · Journal of Cell Science · doi:10.1242/jcs.063636 · Cited by 17
Poly(ADP-ribosylation) and Neoplastic Transformation: Effect of PARP Inhibitors
Donà, F., Chiodi, I., Belgiovine, C., Raineri, T., Ricotti, R., Mondello, C., & Scovassi, A. I. (2013) · Current Pharmaceutical Biotechnology · doi:10.2174/138920101405131111104642 · Cited by 17
A novel antisense oligonucleotide anchored on the intronic splicing enhancer of hTERT pre-mRNA inhibits telomerase activity and induces apoptosis in glioma cells
Wang, F., Cheng, Y., Zhang, C., Chang, G., & Geng, X. (2019) · Journal of Neuro-Oncology · doi:10.1007/s11060-019-03150-x · Cited by 17
Recent advances in the development of novel anti‐cancer drugs targeting cancer stem/progenitor cells
Mimeault, M., & Batra, S. K. (2008) · Drug Development Research · doi:10.1002/ddr.20273 · Cited by 17
Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from Microcystis aeruguinosa PCC 7806
Brahmi, M. M., Portmann, C., D’Ambrosio, D., Woods, T. M., Banfi, D., Reichenbach, P., Silva, L. D., Baudat, E., Turcatti, G., Lingner, J., et al. (2013) · Chemistry - A European Journal · doi:10.1002/chem.201203296 · Cited by 17
Target-controlled in situ formation of G-quadruplex DNAzyme for a sensitive visual assay of telomerase activity
Wang, Y., Yang, L., Wang, Y., Liu, W., Li, B., & Jin, Y. (2019) · The Analyst · doi:10.1039/c9an01271k · Cited by 16
TRAF2 inhibits senescence in hepatocellular carcinoma cells via regulating the ROMO1/ NAD+/SIRT3/SOD2 axis
Yao, J., Liang, X., Xu, S., Liu, Y., Shui, L., Li, S., Guo, H., Xiao, Z., Zhao, Y., & Zheng, M. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.11.035 · Cited by 17
Predicting the unpredictable: Recent structure–activity studies on peptide-based macrocycles
Wahyudi, H., & McAlpine, S. R. (2015) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2015.04.009 · Cited by 16
Enzyme-mimicking accelerated signal enhancement for visually multiplexed quantitation of telomerase activity
Sun, L., Zhao, Q. L., Liu, X., Pan, Y., Gao, Y., Yang, J., Wang, Y., & Song, Y. (2020) · Chemical Communications · doi:10.1039/d0cc01951h · Cited by 16
Telomerase reverse transcriptase promoter mutation– and O6-methylguanine DNA methyltransferase promoter methylation–mediated sensitivity to temozolomide in isocitrate dehydrogenase–wild-type glioblastoma: is there a link?
Gramatzki, D., Felsberg, J., Hentschel, B., Wolter, M., Schackert, G., Westphal, M., Regli, L., Thon, N., Tatagiba, M. S., Wick, W., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.01.014 · Cited by 16
Telomeres and telomerase in sarcomas.
Matsuo, T., Shimose, S., Kubo, T., Fujimori, J., Yasunaga, Y., & Ochi, M. (2009) · PubMed · Cited by 15
Therapeutic Targeting of Gastrointestinal Cancer Stem Cells
Stem, J., Flickinger, J. C., Merlino, D. J., Caparosa, E. M., Snook, A. E., & Waldman, S. A. (2019) · Regenerative Medicine · doi:10.2217/rme-2018-0146 · Cited by 16
Cancer Stem Cells - Therapeutic Boon!
Shrihari, T. G. (2011) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000088 · Cited by 16
Platinum‐Based Anticancer Agents
Klein, A. V., & Hambley, T. W. (2014) · doi:10.1002/9781118697191.ch2 · Cited by 16
Synthetic miRNA sponges driven by mutant hTERT promoter selectively inhibit the progression of bladder cancer
Zhuang, C., Fu, X., Liu, L., Liu, Y., Huang, W., & Cai, Z. (2015) · Tumor Biology · doi:10.1007/s13277-015-3169-9 · Cited by 15
Hypoxic regulation of extracellular vesicles: Implications for cancer therapy
Yoo, S., Choi, S., Kim, I., & Kim, I. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.034 · Cited by 15
Recent Progress in Prompt Molecular Detection of Exosomes Using CRISPR/Cas and Microfluidic‐Assisted Approaches Toward Smart Cancer Diagnosis and Analysis
Mousavi, S. M., Hashemi, S. A., Kalashgrani, M. Y., Rahmanian, V., Riazi, M., Omidifar, N., Althomali, R. H., Rahman, M. M., Chiang, W., & Gholami, A. (2023) · ChemMedChem · doi:10.1002/cmdc.202300359 · Cited by 15
Telomerase Contributes to Fludarabine Resistance in Primary Human Leukemic Lymphocytes
Shawi, M., Chu, T. W., Marignac, V. L. M., Yu, Y., Gryaznov, S. M., Johnston, J. B., Lees‐Miller, S. P., Assouline, S. E., Autexier, C., & Aloyz, R. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070428 · Cited by 15
Effects of rapamycin on the mechanistic target of rapamycin (mTOR) pathway and telomerase in breast cancer cells
Gopalakrishnan, K., Venkatesan, S., Low, E. S. H., & Hande, M. P. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.03.008 · Cited by 15
A Cooperatively Activatable, DNA‐based Fluorescent Reporter for Imaging of Correlated Enzymatic Activities
Fan, Z., Zhao, J., Chai, X., & Li, L. (2021) · Angewandte Chemie · doi:10.1002/ange.202104408 · Cited by 15
Differences in telomerase activity and the effects of AZT in aneuploid and euploid cells in colon cancer
Fang, X., Hu, T., Yin, H., Yang, J., Tang, W., Hu, S., & Xu, X. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4043 · Cited by 15
Convertible DNA ends-based silver nanoprobes for colorimetric detection human telomerase activity
Chen, W., Wang, L., He, R., Xu, X., & Jiang, W. (2017) · Talanta · doi:10.1016/j.talanta.2017.09.057 · Cited by 15
Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERT
Kellermann, G., Kaiser, M., Dingli, F., Lahuna, O., Naud‐Martin, D., Mahuteau‐Betzer, F., Loew, D., Ségal-Bendirdjian, E., Teulade‐Fichou, M., & Bombard, S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv425 · Cited by 14
Target-triggered core-satellite self-assemblies based on strong dipole plasmon Pt-tipped Au triangular nanoprism for dual-signal detection of telomerase and enhanced phototherapy
Shen, F., Zhang, C., Cai, Z., Qiu, Z., Wang, Y., Liu, Z., Guan, M., & Gao, F. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.135556 · Cited by 14
Advances in Cancer Chemotherapeutic Drug Research in China
Xu, B., Ding, J., Chen, K., Miao, Z., Huang, H., Liu, H., & Luo, X. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-397833-2.00012-1 · Cited by 14
Repression of Human Telomerase Reverse Transcriptase Using Artificial Zinc Finger Transcription Factors
Sohn, J. H., Yeh, B., Choi, J.-W., Yoon, J., Namkung, J., Park, K.-K., & Kim, H.-W. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0141 · Cited by 13
An ultra-sensitive colorimetric assay for reliable visual detection of telomerase activity
Wang, Y., Yang, L., Wang, Y., Liu, W., Li, B., & Jin, Y. (2017) · The Analyst · doi:10.1039/c7an00950j · Cited by 14
A DNA tetrahedron docking assembly for imaging telomerase activity in cancerous cells
Zhang, R., Zhang, R., Zhao, C., & Xu, X. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.339395 · Cited by 14
Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
Nguyen, D.-D., Kim, E. Y., Le, N. T., Ding, X., Jaiswal, R. K., Kostlan, R. J., Nguyen, T. N. T., Shiva, O., Le, M. T., & Chai, W. (2023) · Science Advances · doi:10.1126/sciadv.add8023 · Cited by 15
The non-reverse transcriptase activity of the human telomerase reverse transcriptase promotes tumor progression (Review)
Qin, Y., Guo, H. Y., Tang, B., & Yang, S. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2470 · Cited by 15
Activin inhibits telomerase activity in cancer
Katik, I., Mackenzie-Kludas, C., Nicholls, C., Jiang, F., Zhou, S., Li, H., & Liu, J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.055 · Cited by 14
Activation of Telomerase in Glioma Cells by Human Cytomegalovirus: Another Piece of the Puzzle
Cinátl, J., Nevels, M. M., Paulus, C., & Michaelis, M. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp047 · Cited by 14
Human Telomerase Reverse Transcriptase as a Therapeutic Target of Dihydroartemisinin for Esophageal Squamous Cancer
Li, Q., Ma, Q., Xu, L., Gao, C., Yao, L., Wen, J., Yang, M., Cheng, J., Zhou, X., Zou, J., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.769787 · Cited by 14
Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice
Rusakiewicz, S., Dosset, M., Mollier, K., Souque, P., Charneau, P., Wain–Hobson, S., Langlade‐Demoyen, P., & Adotévi, O. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.06.071 · Cited by 16
Multiscalein situanalysis of the role of dyskerin in lung cancer cells
Fernandez‐Garcia, I., Marcos, T. K., Muñoz‐Barrutia, A., Serrano, D., Pı́o, R., Montuenga, L. M., & Ortíz-de-Solórzano, C. (2012) · Integrative Biology · doi:10.1039/c2ib20219k · Cited by 14
PCR-free paper-based nanobiosensing platform for visual detection of telomerase activity via gold enhancement
Mahmoudi, T., Tazehkand, A. P., Pourhassan‐Moghaddam, M., Alizadeh‐Ghodsi, M., Ding, L., Baradaran, B., Bazaz, S. R., Jin, D., & Warkiani, M. E. (2020) · Microchemical Journal · doi:10.1016/j.microc.2020.104594 · Cited by 13
Bacteriophages: cancer diagnosis, treatment, and future prospects
Abbaszadeh, F., Leylabadlo, H. E., Alinezhad, F., Feizi, H., Mobed, A., Baghbanijavid, S., & Baghi, H. B. (2020) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-020-00503-x · Cited by 14
Synthetic regulatory RNAs selectively suppress the progression of bladder cancer
Zhuang, C., Huang, X., Zhuang, C., Luo, X., Zhang, X., Cai, Z., & Gui, Y. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0626-x · Cited by 13
Association between mutant IDHs and tumorigenesis in gliomas
Ohba, S., & Hirose, Y. (2018) · Medical Molecular Morphology · doi:10.1007/s00795-018-0189-8 · Cited by 15
An Overview of the Genomic Characterization of Hepatocellular Carcinoma
Yim, S. Y., & Lee, J.-S. (2021) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s270533 · Cited by 11
Differential Regulation of Telomerase Reverse Transcriptase Promoter Activation and Protein Degradation by Histone Deacetylase Inhibition
青华, Aono, J., Findeisen, H. M., Jones, K. L., Heywood, E. B., & Bruemmer, D. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25226 · Cited by 13
Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach
Amin, A., Morello, M., Petrara, M. R., Rizzo, B., Argenton, F., Rossi, A. D., & Giunco, S. (2023) · Cancers · doi:10.3390/cancers15102673 · Cited by 13
Innovating Cancer Treatment Through Cell Cycle, Telomerase, Angiogenesis, and Metastasis
Yousefi, T., Jobani, B. M., Taebi, R., & Qujeq, D. (2024) · DNA and Cell Biology · doi:10.1089/dna.2024.0109 · Cited by 12
Dual targeting carbonic anhydrase inhibitors as promising therapeutic approach: a structural overview
D’Ambrosio, K., Fiore, A. D., & Langella, E. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1511281 · Cited by 12
Tumor biology and cancer therapy – an evolving relationship
Seufferlein, T. T. W., Ahn, J., Krndija, D., Lother, U., Adler, G., & von Wichert, G. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-19 · Cited by 12
CRISPR genome editing and its medical applications
Mahmoudian‐Sani, M., Farnoosh, G., Mahdavinezhad, A., & Saidijam, M. (2017) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2017.1406823 · Cited by 13
Characterization of In Vitro G-Quadruplex Formation of Imetelstat Telomerase Inhibitor
Carloni, L., Wechselberger, R. W., & Vijlder, T. D. (2021) · Nucleic Acid Therapeutics · doi:10.1089/nat.2020.0918 · Cited by 12
Hepatocellular Carcinoma: Current Therapeutic Algorithm for Localized and Advanced Disease
Jose, A., Bavetta, M. G., Martinelli, E., Bronte, F., Giunta, E. F., & Manu, K. A. (2022) · Journal of Oncology · doi:10.1155/2022/3817724 · Cited by 12
A mathematical model of immune competition related to cancer dynamics
Brazzoli, I., Angelis, E. D., & Jabin, P. (2009) · Mathematical Methods in the Applied Sciences · doi:10.1002/mma.1190 · Cited by 12
Association of genetic polymorphisms in the telomerase reverse transcriptase gene with prostate cancer aggressiveness
Wu, D., YU, H., Sun, J., Qi, J., Liu, Q., LI, R., Zheng, S., Xu, J., & Kang, J. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3410 · Cited by 12
Safety of Whole-Body Abrogation of the TRF1 Shelterin Protein in Wild-Type and Cancer-Prone Mouse Models
Bejarano, L., Louzame, J., Montero, J. J., Megı́as, D., Flores, J. M., & Blasco, M. A. (2019) · iScience · doi:10.1016/j.isci.2019.08.012 · Cited by 11
Pancreatic adenocarcinoma: molecular drivers and the role of targeted therapy
Al-Share, B. A., Hammad, N., & Diab, M. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09948-w · Cited by 12
SERS-based copper-mediated signal amplification strategy for simple and sensitive detection of telomerase activity
Fan, G., Li, X., Xu, S., Dai, C., Xue, Q., & Wang, H. (2021) · Talanta · doi:10.1016/j.talanta.2021.122814 · Cited by 12
Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas
Honoki, K., & Tsujiuchi, T. (2013) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2013.820010 · Cited by 12
Design and study of telomerase inhibitors based on G-quadruplex ligands
Negrutska, V. V., Dubey, L. V., Ilchenko, M. M., & Dubey, I. Y. (2013) · Biopolymers and Cell · doi:10.7124/bc.000817 · Cited by 12
Update on Clinical Trials: Genetic Targets in Breast Cancer
Lim, B., Cream, L., & Harvey, H. A. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6176-0_2 · Cited by 11
Inhibition of human telomerase reverse transcriptase in vivo and in vitro for retroviral vector-based antisense oligonucleotide therapy in ovarian cancer
Qi, Z., & Mi, R. (2016) · Cancer Gene Therapy · doi:10.1038/cgt.2015.64 · Cited by 11
Novel Therapeutics Targeting Telomerase and Telomeres
Puri, N. (2013) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000e127 · Cited by 11
Transient redirection of T cells for adoptive cell therapy with telomerase-specific T helper cell receptors isolated from long term survivors after cancer vaccination
Kyte, J. A., Fåne, A., Pulè, M. A., & Gaudernack, G. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1565236 · Cited by 12
Coaxial sensing bio-amplifier for ultrasensitive detections of circulating tumor DNAs
Zhang, Z., Zhu, M., Chen, Z., Wang, X., Chen, G., & Zhang, S. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.111414 · Cited by 11
Identification of G-Quadruplex Inducers Usinga Simple, Inexpensiveand Rapid High Throughput Assay, and TheirInhibition of Human Telomerase
Sassano, M. F., Schlesinger, A. P., & Jarstfer, M. B. (2012) · The Open Medicinal Chemistry Journal · doi:10.2174/1874104501206010020 · Cited by 11
Impact of Heavy Metal Carcinogens on Human Health
Mishra, S., Tiwari, A. K. M., & Mahdi, A. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-74814-6_13 · Cited by 11
Telomerase Triggered Strand Displacement Cycles at DNA Tetrahedron Layer for Highly Sensitive Electrochemical Biosensing
Chen, X., Guo, J., Chai, H., Tang, Y., & Miao, P. (2025) · ACS Materials Letters · doi:10.1021/acsmaterialslett.4c02414 · Cited by 10
Telomerase trafficking and assembly in Xenopus oocytes
Li, Z., Tomlinson, R. L., Terns, R. M., & Terns, M. P. (2010) · Journal of Cell Science · doi:10.1242/jcs.063750 · Cited by 10
Human telomerase inhibitors from microbial source
Kiran, K. G., PALANISWAMY, M., & Angayarkanni, J. (2015) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-015-1893-3 · Cited by 10
Hole Migration in Telomere‐Based Oligonucleotide Anions and G‐Quadruplexes
Li, W., Mjekiqi, E., Douma, W., Wang, X., Kavatsyuk, O., Hoekstra, R., Poully, J., & Schlathölter, T. (2019) · Chemistry - A European Journal · doi:10.1002/chem.201904105 · Cited by 10
CRISPR: a journey of gene-editing based medicine
Golkar, Z. (2020) · Genes & Genomics · doi:10.1007/s13258-020-01002-x · Cited by 13
Sensitive electrochemiluminescent detection of telomerase activity based on nicking enzyme assisted signal amplification
Ye, S.-Y., Pan, C.-G., Dai, Y.-H., & Liang, G. (2021) · Microchemical Journal · doi:10.1016/j.microc.2021.106123 · Cited by 10
Prognostic significance of telomerase activity and some tumor markers in non-small cell lung cancer
Hashim, M., Sayed, M., Samy, N., & Elshazly, S. (2010) · Medical Oncology · doi:10.1007/s12032-010-9444-0 · Cited by 10
Telomere Shortening: A Biological Marker of Sporadic Colorectal Cancer with Normal Expression of p53 and Mismatch Repair Proteins
Haghighi, M. M., Aghagolzadeh, P., Zadeh, S. M., Molaei, M., Zali, M. R., & Radpour, R. (2014) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2013.0436 · Cited by 9
Selective recognition of specific G-quadruplex vs. duplex DNA by a phenanthroline derivative
Zhang, H., Xiang, J., Hu, H., Liu, Y., Yang, F., Shen, G., Tang, Y., & Chen, C. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.03.034 · Cited by 10
Accuracy of telomerase in estimating breast cancer risk: A systematic review and meta-analysis
Winnikow, E. P., Medeiros, L. R., Edelweiss, M. I. A., Rosa, D. D., Edelweiss, M., Simões, P. W. T. D. A., Silva, F. R., Silva, B. R., & da Rosa, M. I. (2011) · The Breast · doi:10.1016/j.breast.2011.08.136 · Cited by 10
Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells
Sapir, E., Chianea, Y. G., Al-Wahiby, S., Ravindran, S., Yasaei, H., & Slijepčević, P. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-9 · Cited by 11
Synthesis of asymmetrically substituted scyllo -inositol
Rodriguez, J., & Walczak, M. A. A. (2016) · Tetrahedron Letters · doi:10.1016/j.tetlet.2016.06.038 · Cited by 10
Comprehensive behavioural assessment of TERT in bladder cancer
Azzouzi, M. E., Ahanidi, H. E., Hassan, I., Tetou, M., Ameur, A., Bensaid, M., Bouzidi, A. A., Oukabli, M., Alaoui, C. H., Addoum, B., et al. (2024) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2024.06.024 · Cited by 9
Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities
Pan, Q., Ye, Z., Ye, Z., Zhang, H., Wang, J., Yi, G., Li, Z., Xu, R., Wang, L., Wu, Z., et al. (2025) · BMEMat · doi:10.1002/bmm2.12137 · Cited by 9
A hybridization chain reaction amplification strategy for fluorescence imaging of human telomerase activity in living cells
Zhang, Z., Zhong, C., Yuan, T., Zhou, X., Zhao, M., Qian, H., Cheng, W., & Chen, T. (2018) · Methods and Applications in Fluorescence · doi:10.1088/2050-6120/aacded · Cited by 9
Interleukin 8 is a biomarker of telomerase inhibition in cancer cells
Solomon, P. D., Dong, Y., Dogra, S. K., & Gupta, R. (2018) · BMC Cancer · doi:10.1186/s12885-018-4633-x · Cited by 9
Chemopreventive role of green tea in head and neck cancers
Kim, Y. S., & Kim, C. (2013) · Integrative Medicine Research · doi:10.1016/j.imr.2013.12.005 · Cited by 9
Sulfated liposaccharides inspired by telomerase inhibitor axinelloside A
Guang, J., Rumlow, Z. A., Wiles, L. M., O’Neill, S., & Walczak, M. A. A. (2017) · Tetrahedron Letters · doi:10.1016/j.tetlet.2017.11.038 · Cited by 9
Therapeutic Targets in Telomerase and Telomere Biology of Cancers
Prasad, R., Pal, D., & Mohammad, W. (2020) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-020-00876-8 · Cited by 9
Impact of FKBP52 on cell proliferation and hormone‐dependent cancers
Hanaki, S., & Shimada, M. (2023) · Cancer Science · doi:10.1111/cas.15811 · Cited by 7
Human telomerase reverse transcriptase (hTERT) synergistic with Sp1 upregulate Gli1 expression and increase gastric cancer invasion and metastasis
Wu, L., Wang, S., Tang, B., Tang, L., Lei, Y., Liu, Y., Yang, M., Yang, G., Zhang, D., & Liu, E. (2021) · Journal of Molecular Histology · doi:10.1007/s10735-021-10019-9 · Cited by 8
Advance in intracellular telomerase imaging for cancer diagnosis and therapy
Han, Y. P., Xu, Q., Liu, H., Ma, F., & Zhang, C. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215801 · Cited by 8
DNA Nanotechnology Targeting Mitochondria: From Subcellular Molecular Imaging to Tailor‐Made Therapeutics
Yu, F., Li, X., Sheng, C., & Li, L. (2024) · Angewandte Chemie · doi:10.1002/ange.202409351 · Cited by 9
Telomere function in colorectal cancer
Frías, C. (2009) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v1.i1.3 · Cited by 9
TERT rs2736098 (Ex2-659G>A) polymorphism and cancer susceptibility: evidence from a comprehensive meta-analysis
Pang, T., Zhou, M., Liu, R., Luo, J., & Xia, R. (2017) · Oncotarget · doi:10.18632/oncotarget.21703 · Cited by 8
Enzymatic DNA repair cascade-driven fluorophore encoding for sensitively sensing telomerase activity in cancer cells
Liu, M., Yu, W., Liu, M., Zhang, Y., Wang, L., & Zhang, C. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.131603 · Cited by 8
Fuel‐Powered DNA Nanomachines for Biosensing and Cancer Therapy
Li, J., & Huang, J. L. (2022) · ChemPlusChem · doi:10.1002/cplu.202200098 · Cited by 8
At a crossroads in oncology
Kamb, A. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.05.006 · Cited by 8
Telomerase as a Target for Cancer Therapeutics
Shay, J. W. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6102-0_13 · Cited by 8
Role of telomeres and telomerase in aging and cancer
Shay, J. W., Wright, W. E., & Schultz, R. A. (2003) · Garland Science eBooks · doi:10.4324/9780203450383_chapter_21 · Cited by 11
The promise of telomere length, telomerase activity and its regulation in the translocation-dependent cancer ESFT; clinical challenges and utility
Proctor, A., Brownhill, S. C., & Burchill, S. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.02.011 · Cited by 9
Label-free molecular beacons-based cascade amplification DNA machine for sensitive detection of telomerase activity
Li, K., Wang, L., Xu, X., & Jiang, W. (2017) · Talanta · doi:10.1016/j.talanta.2017.03.003 · Cited by 7
Reproductive aging weakens offspring survival and constrains the telomerase response to herpesvirus in Pacific oysters
Dupoué, A., Koechlin, H., Huber, M., Merrien, P., Grand, J. L., Corporeau, C., Fleury, E., Bernay, B., de Villemereuil, P., Morga, B., et al. (2024) · Science Advances · doi:10.1126/sciadv.adq2311 · Cited by 7

Authors: Harley, C. B.
Affiliations: Geron (United States) (US)
Corresponding author: Harley, Calvin B.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2008-03
Volume: 8
Issue: 3
Pages: 167-179
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2275
OpenAlex: W2078805336
Cited by: 728
References: 147
Citations by year: 2026: 11 · 2025: 22 · 2024: 26 · 2023: 39 · 2022: 20 · 2021: 29 · 2020: 38 · 2019: 39 · 2018: 27 · 2017: 38 · 2016: 48 · 2015: 58 · 2014: 48 · 2013: 51 · 2012: 53
FWCI: 6.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords: telomerase, telomerase inhibitors, GRN163L, cancer therapeutics, cancer stem cells, telomere length, cell kinetics, anticancer drug development
MeSH terms: Antineoplastic Agents, Clinical Trials as Topic, Enzyme Inhibitors, Humans, Immunotherapy, Kinetics, Medical Oncology, Models, Biological, Neoplasms, Oligonucleotides, Oligopeptides, Gene Expression Regulation, Neoplastic, Telomerase, Cancer Vaccines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Telomerase and cancer therapeutics

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks