Cited by 734Telomeres, Telomerase, and SenescenceImmunotherapy and Immune ResponsesVirus-based gene therapy research

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Telomerase and cancer therapeutics

Harley, Calvin B.·2008·Nature Reviews Cancer

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Abstract

Telomerase is an attractive cancer target as it appears to be required in essentially all tumours for immortalization of a subset of cells, including cancer stem cells. Moreover, differences in telomerase expression, telomere length and cell kinetics between normal and tumour tissues suggest that targeting telomerase would be relatively safe. Clinical trials are ongoing with a potent and specific telomerase inhibitor, GRN163L, and with several versions of telomerase therapeutic vaccines. The prospect of adding telomerase-based therapies to the growing list of new anticancer products is promising, but what are the advantages and limitations of different approaches, and which patients are the most likely to respond?

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Effects of oligonucleotide N3'-->P5' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells.
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Dikmen, Z. et al. In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res. 7866–7873 (2005). · DOI · Paper page

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Authors: Harley, C. B.
Affiliations: Geron (United States) (US)
Corresponding author: Harley, Calvin B.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2008-03
Volume: 8
Issue: 3
Pages: 167-179
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2275
OpenAlex: W2078805336
Cited by: 728
References: 147
Citations by year: 2026: 11 · 2025: 22 · 2024: 26 · 2023: 39 · 2022: 20 · 2021: 29 · 2020: 38 · 2019: 39 · 2018: 27 · 2017: 38 · 2016: 48 · 2015: 58 · 2014: 48 · 2013: 51 · 2012: 53
FWCI: 6.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords: telomerase, telomerase inhibitors, GRN163L, cancer therapeutics, cancer stem cells, telomere length, cell kinetics, anticancer drug development
MeSH terms: Antineoplastic Agents, Clinical Trials as Topic, Enzyme Inhibitors, Humans, Immunotherapy, Kinetics, Medical Oncology, Models, Biological, Neoplasms, Oligonucleotides, Oligopeptides, Gene Expression Regulation, Neoplastic, Telomerase, Cancer Vaccines

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