Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

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7. Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations
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8. The Triplet State of 6‐thio‐2′‐deoxyguanosine: Intrinsic Properties and Reactivity Toward Molecular Oxygen
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10. DNA breakage and cell cycle checkpoint abrogation induced by a therapeutic thiopurine and UVA radiation
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11. Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols
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15. Measures of 6-mercaptopurine and methotrexate maintenance therapy intensity in childhood acute lymphoblastic leukemia
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17. 6-mercaptopurine promotes energetic failure in proliferating T cells
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18. A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD
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20. Oxidation-Mediated DNA Cross-Linking Contributes to the Toxicity of 6-Thioguanine in Human Cells
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31. Incorporation of 6‐Thioguanine Nucleotides into DNA During Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia—The Influence of Thiopurine Methyltransferase Genotypes
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33. Anticancer efficacy of 6-thioguanine loaded chitosan nanoparticles with or without curcumin
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35. Excited State Dynamics of 6-Thioguanine
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37. Thiopurine Therapy in Patients With Inflammatory Bowel Disease: A Focus on Metabolism and Pharmacogenetics
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38. Monitoring of Thiopurine Metabolites in Patients With Inflammatory Bowel Disease-What Is Actually Measured?
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39. Analytical Pitfalls of Therapeutic Drug Monitoring of Thiopurines in Patients With Inflammatory Bowel Disease
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42. Highly Potent Activation of Nrf2 by Topical Tricyclic Bis(Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy
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46. Increments in DNA-thioguanine level during thiopurine-enhanced maintenance therapy of acute lymphoblastic leukemia
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53. Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era?
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54. The Role of Inosine-5′-Monophosphate Dehydrogenase in Thiopurine Metabolism in Patients With Inflammatory Bowel Disease
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55. Theoretical investigation on the therapeutic applications of C2B and C2O as targeted drug delivery systems for hydroxyurea and 6-thioguanine in cancer treatment
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58. On The Population of Triplet Excited States of 6-Aza-2-Thiothymine
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59. The associations of thiopurines with male fertility and paternally exposed offspring: a systematic review and meta-analysis
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60. Mechanisms of NT5C2 -Mediated Thiopurine Resistance in Acute Lymphoblastic Leukemia
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63. A drug‐repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6‐thioguanine as an effective therapeutic agent for TPMT‐low cancer cells
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64. Gene set analysis of purine and pyrimidine antimetabolites cancer therapies
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67. Effects of 6-Thioguanine and S6-Methylthioguanine on Transcription in Vitro and in Human Cells
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68. Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21
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70. Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol
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71. Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair, and p53
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72. 6-Thioguanine damages mitochondrial DNA and causes mitochondrial dysfunction in human cells
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73. Safety and Efficacy of 6-thioguanine as a Second-line Treatment for Autoimmune Hepatitis
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74. Role of TPMT and ITPA variants in mercaptopurine disposition
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76. Fruits and Vegetables as Dietary Sources of Antimutagens
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77. Methotrexate polyglutamate levels and co-distributions in childhood acute lymphoblastic leukemia maintenance therapy
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78. Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity
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81. NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir
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82. Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway
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85. Thiopurines related malignancies in inflammatory bowel disease: Local experience in Granada, Spain
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87. Development of a chemical probe against NUDT15
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88. Comprehensive characterization of pharmacogenetic variants in TPMT and NUDT15 in children with acute lymphoblastic leukemia
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89. Innovating Thiopurine Therapeutic Drug Monitoring: A Systematic Review and Meta-Analysis on DNA-Thioguanine Nucleotides (DNA-TG) as an Inclusive Biomarker in Thiopurine Therapy
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90. 6-Thioguanine and zebularine down-regulate DNMT1 and globally demethylate canine malignant lymphoid cells
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92. Immune Effector Cells Produce Lethal DNA Damage in Cells Treated with a Thiopurine
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93. Construction and analysis of competing endogenous RNA network of MCF‑7 breast cancer cells based on the inhibitory effect of 6‑thioguanine on cell proliferation
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94. Mercaptopurine metabolite levels are predictors of bone marrow toxicity following high-dose methotrexate therapy of childhood acute lymphoblastic leukaemia
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98. Nonmelanoma skin cancer risk awareness in azathioprine‐treated myasthenia gravis patients
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