Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

Karran, Peter, Attard, Natalie·2008·Nature Reviews Cancer

DOI 10.1038/nrc2292

Cited by (474)

Items 201–300 of 474

Excited State Lifetimes of Sulfur-Substituted DNA and RNA Monomers Probed Using the Femtosecond Fluorescence Up-Conversion Technique
Matthew M. Brister, T. Gustavsson, Carlos E. Crespo‐Hernández · 2020 · Molecules
Cost-effectiveness analysis of pretreatment screening for NUDT15 defective alleles
Kevin Zarca, Albain Chansavang, Marie‐Anne Loriot, Isabelle Durand‐Zaleski, Nicolas Pallet · 2020 · Pharmacogenetics and Genomics
Is there a role for thioguanine therapy in IBD in 2017 and beyond?
Kirstin M. Taylor, Mark G. Ward, Paul Andrew Blaker, Miles Sparrow · 2017 · Expert Review of Gastroenterology & Hepatology
Comparison of Direct Sequencing, Real-Time PCR-High Resolution Melt (PCR-HRM) and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) Analysis for Genotyping of Common Thiopurine Intolerant Variant Alleles NUDT15 c.415C>T and TPMT c.719A>G (TPMT*3C)
Wai-Ying Fong, Chi-Chun Ho, Wing‐Tat Poon · 2017 · Diagnostics
Maintenance therapy and risk of osteonecrosis in children and young adults with acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study
Linea Natalie Toksvang, Liv Andrés‐Jensen, Cecilie Utke Rank, Riitta Niinimäki, Jacob Nersting, Stine Nygaard Nielsen, Signe Sloth Mogensen, Arja H. Harila‐Saari, Jonas Abrahamsson, Joel Joelsson et al. · 2021 · Cancer Chemotherapy and Pharmacology
Double Thionated Pyrimidine Nucleobases: Molecular Tools with Tunable Photoproperties
Abed Mohamadzade, Artur Nenov, Marco Garavelli, Irene Conti, Susanne Ullrich · 2023 · Journal of the American Chemical Society
Absence of Mismatch Repair Deficiency–Related Microsatellite Instability in Non-Melanoma Skin Cancer
Miriam Reuschenbach, Claudia Sommerer, Wolfgang Hartschuh, Martin G. Zeier, Magnus von Knebel Doeberitz, Matthias Kloor · 2011 · Journal of Investigative Dermatology
Kaposi Sarcoma Mimicking Acute Flare of Ulcerative Colitis
Vivek Kumar, Parita Soni, Mohit Garg, Madina Abduraimova, Jonathan Harris · 2017 · Journal of Investigative Medicine High Impact Case Reports
Increase of PRPP enhances chemosensitivity of PRPS 1 mutant acute lymphoblastic leukemia cells to 5‐Fluorouracil
Dan Wang, Yao Chen, Houshun Fang, Liang Zheng, Ying Li, Fan Yang, Yan Xu, Lijuan Du, Bin‐Bing S. Zhou, Hui Li · 2018 · Journal of Cellular and Molecular Medicine
Optimizing thiopurine therapy in children with acute lymphoblastic leukemia: A promising “MINT” sequencing strategy and therapeutic “DNA-TG” monitoring
Hong‐Li Guo, Yuetao Zhao, Weijun Wang, Na Dong, Ya‐Hui Hu, Yuanyuan Zhang, Feng Chen, Li Zhou, Tao Li · 2022 · Frontiers in Pharmacology
Recent Developments and Future Perspectives of Purine Derivatives as a Promising Scaffold in Drug Discovery
Neha Rana, Parul Grover, Hridayanand Singh · 2024 · Current Topics in Medicinal Chemistry
Optical absorption and magnetic circular dichroism spectra of thiouracils: a quantum mechanical study in solution
Lara Martínez‐Fernández, Tobias Fahleson, Patrick Norman, Fabrizio Santoro, Sonia Coriani, Roberto Improta · 2017 · Photochemical & Photobiological Sciences
Pharmacokinetics of tablet and liquid formulations of oral 6-mercaptopurine in children with acute lymphoblastic leukemia
R. Larsen, Lisa Lyngsie Hjalgrim, Kathrine Grell, Kim Kristensen, Line Gerner Pedersen, Emilie Damgaard Brünner, Bodil E. Thorhauge Als-Nielsen, Kjeld Schmiegelow, Jacob Nersting · 2020 · Cancer Chemotherapy and Pharmacology
Evaluation of Anticancer Activity of 1,3‐Oxazol‐4‐ylphosphonium Salts in Vitro
M. Yu. Brusnakov, Aleksandr V. Golovchenko, Yevheniia S. Velihina, O. S. Liavynets, Victor V. Zhirnov, В. С. Броварец · 2022 · ChemMedChem
Conventional Cancer Treatment
Isabella dos Santos Guimarães, Renata Dalmaschio Daltoé, Alice Laschuk Herlinger, Klésia Pirola Madeira, Taciane Ladislau, Iuri Cordeiro Valadão, Paulo Cilas Morais Lyra Junior, Sarah Fernandes Teixeira, Gustavo Modesto, Diandra Zipinotti dos Santos et al. · 2013 · InTech eBooks
DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes
Hee Young Ju, Ji Won Lee, Hee Won Cho, Ju Kyung Hyun, Youngeun Ma, Eun Sang Yi, Keon Hee Yoo, Ki Woong Sung, Rihwa Choi, Hong Hoe Koo et al. · 2021 · PLoS ONE
Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients
Chih‐Hsiang Yu, Ya-Hsuan Chang, Der-Shiun Wang, Shiann‐Tarng Jou, Chien-Yu Lin, Kai‐Hsin Lin, Meng‐Yao Lu, Lovely Raghav, Hsiu‐Hao Chang, Kang‐Hsi Wu et al. · 2020 · Scientific Reports
Molecular Simulation Study of Gold Clusters for Transporting of Thioguanine Anticancer Drug in Aqueous Solution
Sepideh Ketabi, Forough Gholipour, Mohadeseh Naderi · 2021 · Journal of Cluster Science
TPMT and NUDT15 testing for thiopurine therapy: A major tertiary hospital experience and lessons learned
Liuh Ling Goh, Chia Wei Lim, Khai Pang Leong, Kiat Hoe Ong · 2022 · Frontiers in Pharmacology
DFT study on the potential of M@B40 (M = Mg and K) metalloborospherenes as nanocarrier for 6-Thioguanine anticancer drug
Maedeh Sadat Mussavi, Sharieh Hosseini · 2024 · Journal of Molecular Liquids
Structure–activity correlation in transfection promoted by pyridinium cationic lipids
Paria Parvizi, J. Mendez-Campos, Liji Raju, Nada Abdul Khalique, Emile Jubeli, Helge Bøvik Larsen, D. Nicholson, Michael D. Pungente, Thomas Murray Fyles · 2016 · Organic & Biomolecular Chemistry
Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy
Manabu Kodama, Gouji Toyokawa, Osamu Sugahara, Shigeaki Sugiyama, Naoki Haratake, Yuichi Yamada, Reona Wada, Shinkichi Takamori, Mototsugu Shimokawa, Tomoyoshi Takenaka et al. · 2023 · Cell Reports
Development of ambient storable meal for calamity victims and other targets employing radiation processing and evaluation of its nutritional, organoleptic, and safety parameters
Sanjeev Kumar, Sudhanshu Saxena, Jyoti Kumar Verma, Satyendra Gautam · 2016 · LWT
mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL
Thanh-Trang T. Vo, J. Scott Lee, Duc Minh Nguyen, Brandon Lui, William Pandori, Andrew Khaw, Sharmila Mallya, Mengrou Lu, Markus Müschen, Marina Y Konopleva et al. · 2017 · Molecular Cancer Therapeutics
Modeling the Outcome of Systematic TPMT Genotyping or Phenotyping Before Azathioprine Prescription: A Cost-Effectiveness Analysis
Kevin Zarca, Isabelle Durand‐Zaleski, Marie‐Anne Loriot, Gilles Châtellier, Nicolas Pallet · 2019 · Molecular Diagnosis & Therapy
Observation of Enhanced Dissociative Photochemistry in the Non-Native Nucleobase 2-Thiouracil
Kelechi O. Uleanya, Rosaria Cercola, Maria Nikolova, Edward Matthews, Natalie G. K. Wong, Caroline E. H. Dessent · 2020 · Molecules
COMO: a pipeline for multi-omics data integration in metabolic modeling and drug discovery
Brandt Bessell, Josh Loecker, Zhongyuan Zhao, Sara Sadat Aghamiri, Sabyasachi Mohanty, Rada Amin, Tomáš Helikar, Bhanwar Lal Puniya · 2023 · Briefings in Bioinformatics
Treatment of Myasthenia Gravis
Henry J. Kaminski · 2018 · Springer eBooks
Harmful Effects of the Azathioprine Metabolite 6-Mercaptopurine in Vascular Cells: Induction of Mineralization
Jasmin Prüfer, Mirjam Schuchardt, Markus Tölle, Nicole Prüfer, Matthias Höhne, Walter Zidek, Markus van der Giet · 2014 · PLoS ONE
Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia
Ji-Yuan Teng, Dingpeng Yang, Chao Shu Tang, Houshun Fang, Huiying Sun, Yue-Ning Xiang, Xiaomeng Li, Fan Yang, Ruixue Xia, Fu Fan et al. · 2023 · Leukemia
MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation
Francesca Grasso, Vitalba Ruggieri, Gabriele De Luca, Paola Leopardi, Maria Teresa Mancuso, Ida Casorelli, Pietro Pichierri, Peter Karran, Margherita Bignami · 2014 · Oncotarget
Transcriptomics Analysis of the Tumor-Inhibitory Pathways of 6-Thioguanine in MCF-7 Cells via Silencing DNMT1 Activity
Hao Li, Xinglan An, Daoyu Zhang, Qi Li, Nan Zhang, Hao Yu, Ziyi Li · 2020 · OncoTargets and Therapy
Review article: opportunities to improve and expand thiopurine therapy for autoimmune hepatitis
Albert J. Czaja · 2020 · Alimentary Pharmacology & Therapeutics
Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model
Martin P. Ogrodzinski, Shao Thing Teoh, Sophia Y. Lunt · 2020 · Cancer Research
Incidence of melanoma in organ transplant recipients in Alberta, Canada
Mimi Tran, Megan A. Sander, Pietro Ravani, Paule Régine Mydlarski · 2016 · Clinical Transplantation
Absorption Characteristics and Quantum Yields of Singlet Oxygen Generation of Thioguanosine Derivatives
Shoma Miyata, Takeshi Yamada, Tasuku Isozaki, Hideyuki Sugimura, Yao−Zhong Xu, Tadashi Suzuki · 2018 · Photochemistry and Photobiology
Population-Specific Distribution of TPMT Deficiency Variants and Ancestry Proportions in Ecuadorian Ethnic Groups: Towards Personalized Medicine
Jennifer Gallardo, Pablo Naranjo, Sebastián Atarihuana, Dayana Coello, Patricia Guevara‐Ramírez, Rodrigo Flores‐Espinoza, Germán Burgos, Andrés López‐Cortés, Alejandro Cabrera‐Andrade · 2023 · Therapeutics and Clinical Risk Management
Antiviral Potential of Azathioprine and Its Derivative 6- Mercaptopurine: A Narrative Literature Review
Carolina Ríos Úsuga, Marlén Martínez‐Gutierrez, Julián Ruíz-Saenz · 2024 · Pharmaceuticals
Uphill battle: Innovation of thiopurine therapy in global inflammatory bowel disease care
Ahmed B. Bayoumy, Chris Jacob Johan Mulder, Azhar R. Ansari, Murray L. Barclay, Tim Florin, Marianne Kiszka‐Kanowitz, Luc J. J. Derijks, Vishal Sharma, Nanne K.H. de Boer · 2024 · Indian Journal of Gastroenterology
Molecular Engineering of a Tumor‐Targeting Thione‐Derived Diketopyrrolopyrrole Photosensitizer to Attain NIR Excitation Over 850 nm for Efficient Dual Phototherapy
Gang Xu, Yunxia Song, Haifeng Jin, Pengmin Shi, Yubo Jiao, Fangzhou Cao, Jie Pang, Yanyan Sun, Lei Fang, Xing‐Hua Xia et al. · 2024 · Advanced Science
Therapeutic drug monitoring in the treatment of childhood acute lymphoblastic leukemia – A practical guideline
Miguel Vieira Martins, Annie Rasmussen, Jesper Heldrup, Linea Natalie Toksvang, Marianne Ifversen, Stine Nygaard Nielsen, Kjeld Schmiegelow, Inge Margriet van der Sluis · 2025 · EJC Paediatric Oncology
The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity
Maud Maillard, Rina Nishii, Hieu Vu, Kashi Raj Bhattarai, Wenjian Yang, Jing Li, Ute Hofmann, Daniel Savic, Smita Bhatia, Matthias Georg Schwab et al. · 2025 · Journal of Clinical Investigation
Change in Hematologic Indices over Time in Pediatric Inflammatory Bowel Disease Treated with Azathioprine
Sherman Soman, Dhandapani Ashok, Sally Connolly, Samantha J. Cordell, Chris J. Taylor, David I. Campbell · 2010 · Drugs in R&D
Simultaneous Two-Photon Absorption of the Thioguanosine Analogue 2′,3′,5′-Tri-O-acetyl-6,8-dithioguanosine with Its Potential Application to Photodynamic Therapy
Saki Ando, Tasuku Isozaki, Yao−Zhong Xu, Tadashi Suzuki · 2020 · The Journal of Physical Chemistry A
Effects of NT5C2 Germline Variants on 6‐Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia
Chuang Jiang, Wenjian Yang, Takaya Moriyama, Chengcheng Liu, Colton J. Smith, Wentao Yang, Maoxiang Qian, Ziping Li, Morten Tulstrup, Kjeld Schmiegelow et al. · 2020 · Clinical Pharmacology & Therapeutics
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells
Stella Karsten, Roland Fiskesund, Xing‐Mei Zhang, Petra Marttila, Kumar Sanjiv, Therese M. Pham, Azita Rasti, Lars Bräutigam, Ingrid Almlöf, Maritha Marcusson‐Ståhl et al. · 2021 · Cell Death and Differentiation
DNA ‐Thioguanine Nucleotides as a Marker for Thiopurine Induced Late Leukopenia after Dose Optimizing by NUDT15 C415T in Chinese Patients with IBD
Xia Zhu, Kang Chao, Ting Yang, Xue‐ding Wang, Shaoxing Guan, Jian Tang, Wen Xie, Ai‐Ming Yu, Qing fan Yang, Miao Li et al. · 2022 · Clinical Pharmacology & Therapeutics
Therapy-related myelodysplastic syndrome with der(17)t(12;17)(q13;p13) as a new recurrent cytogenetic abnormality after treatment for chronic lymphocytic leukemia
Tae Sung Park, June‐Won Cheong, Jaewoo Song, Jong Rak Choi · 2009 · Leukemia Research
How I treat my inflammatory bowel disease-patients with thiopurines?
Berrie Meijer, Chris Jacob Johan Mulder, Adriaan Anthonie Van Bodegraven, Nanne K.H. de Boer · 2016 · World Journal of Gastrointestinal Pharmacology and Therapeutics
Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues
Matthew A. Schaich, Mallory R. Smith, Ashley S. Cloud, Sean M. Holloran, Bret Freudenthal · 2017 · Chemical Research in Toxicology
Iatrogenic Kaposi sarcoma of the terminal ileum following short-term treatment with immunomodulators for Crohn disease
Elisa Stasi, Stefania De Santis, Elisabetta Cavalcanti, Raffaele Armentano · 2019 · Medicine
Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice
G. Tatsumi, M. Kawahara, Takayuki Imai, A. Nishishita-Asai, A. Nishida, O. Inatomi, A. Yokoyama, Y. Kakuta, Katsuyuki Kito, A. Andoh · 2019 · Leukemia
Cytostatic Drug 6-Mercaptopurine Degradation on Pilot Scale Reactors by Advanced Oxidation Processes: UV-C/H2O2 and UV-C/TiO2/H2O2 Kinetics
Luis A. González-Burciaga, Juan Carlos García-Prieto, Manuel G. Roig, Ismael Lares-Ásef, Cynthia M. Núñez-Núñez, José B. Proal-Nájera · 2021 · Catalysts
The Homologous Recombination Protein RAD51D Mediates the Processing of 6-Thioguanine Lesions Downstream of Mismatch Repair
Preeti Rajesh, Alexandra V. Litvinchuk, Douglas L. Pittman, Michael D. Wyatt · 2011 · Molecular Cancer Research
The oncogenic control of nucleotide synthesis
Olivia Vidal-Cruchez, Issam Ben‐Sahra · 2026 · Oncogenesis
How Deep Learning in Antiviral Molecular Profiling Identified Anti-SARS-CoV-2 Inhibitors
Mohamed A. Ali, In Ho Park, Junebeom Kim, Gwang‐Hee Kim, Jooyeon Oh, Jin Sun You, Jieun Kim, Jeon‐Soo Shin, Sang Sun Yoon · 2023 · Biomedicines
An electrochemical DNA sensor for determination of 6-thioguanine using adsorptive stripping voltammetry at HMDE: An anticancer drug DNA interaction study
Elham Mirmomtaz, Ali Zirakbash, Ali Asghar Ensafi · 2016 · Russian Journal of Electrochemistry
SLX4 dampens MutSα-dependent mismatch repair
Jean-Hugues Guervilly, Marion Blin, Luisa Laureti, Émilie Baudelet, Stéphane Audebert, Pierre-Henri L. Gaillard · 2022 · Nucleic Acids Research
Effect of ITPA Polymorphism on Adverse Drug Reactions of 6-Mercaptopurine in Pediatric Patients with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis
Yeonhong Lee, Eun Jeong Jang, Ha-Young Yoon, Jeong Yee, Hye Sun Gwak · 2022 · Pharmaceuticals
Recent advances in targeting myeloid-derived suppressor cells and their applications to radiotherapy
Zi‐Zhan Li, Jing-Yu He, Qiuji Wu, Bing Liu, Lin‐Lin Bu · 2023 · International review of cytology
First-principles design of heavy-atom-free singlet oxygen photosensitizers for photodynamic therapy
Arun Kumar Pal, Ayan Datta · 2024 · The Journal of Chemical Physics
Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia
Soo Young Moon, Ji-Hyun Lim, Eun‐Hee Kim, Youngwon Nam, Kyung‐Sang Yu, Kyung Taek Hong, Jung Yoon Choi, Che Ry Hong, Hyery Kim, Hyoung Jin Kang et al. · 2018 · Therapeutic Drug Monitoring
Insights into open/closed conformations of the catalytically active human guanylate kinase as investigated by small-angle X-ray scattering
Rohit Jain, Nazimuddin Khan, Andreas Menzel, Ivan Rajković, Manfred Konrad, Simone Techert · 2015 · European Biophysics Journal
HPRT1 activity loss is associated with resistance to thiopurine in ALL
Fan Yang, Houshun Fang, Dan Wang, Yao Chen, Yonggong Zhai, Bin‐Bing S. Zhou, Hui Li · 2017 · Oncotarget
Network-based Drug Repurposing for Human Coronavirus
Yadi Zhou, Yuan Hou, Jiayu Shen, Yin Huang, Martin, William, Feixiong Cheng · 2020 · Figshare
Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex
Samantha L. Sanford, Mareike Badstübner, Michael H. Gerber, William P. Mannherz, Noah M. Lampl, Rachel L. Dannenberg, Angela M. Hinchie, Matthew A. Schaich, Sua Myong, Mark Hedglin et al. · 2025 · Nature Communications
The influence of UV light on the azathioprine photodegradation: New evidences by photoluminescence
Ion Smaranda, Andreea Nilă, Corina-Mihaela Manta, Dumitru Samohvalov, Daniel Ghercă, Mihaela A. Baibarac · 2019 · Results in Physics
Detection of Hypoxanthine from Inosine and Unusual Hydrolysis of Immunosuppressive Drug Azathioprine through the Formation of a Diruthenium(III) System
Marta Orts-Arroyo, Isabel Castro, José Martínez‐Lillo · 2021 · Biosensors
Thiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade
Loulieta Nazerai, Shona Caroline Willis, Patricio Yankilevich, Luca Di Leo, Francesca Maria Bosisio, Alex Frías, Corine Bertolotto, Jacob Nersting, Maria Thastrup, Søren Buus et al. · 2022 · OncoImmunology
FTO regulates the DNA damage response via effects on cell-cycle progression
Weiying Liu, Manabu Yasui, Akira Sassa, Xinyue You, Jingjing Wan, Yiyi Cao, Jing Xi, Xinyu Zhang, Masamitsu Honma, Yang Luan · 2023 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Recombinogenic, genotoxic, and cytotoxic effects of azathioprine using in vivo assays
Abel Vieira de Melo Bisneto, Luara Cristiane Dourado Neves Oliveira, Amanda Silva Fernandes, Luana Santos Silva, Jefferson Hollanda Véras, Cléver Gomes Cardoso, Carolina R. E Silva, Aroldo Vieira de Moraes Filho, Cristiene Costa Carneiro, Lee Chen-Chen · 2020 · Journal of Toxicology and Environmental Health
Genetic effect of an InDel in the promoter region of the NUDT15 and its effect on myoblast proliferation in chickens
Chengjie Wei, Yufang Niu, Bingjie Chen, Panpan Qin, Yanxing Wang, Dan Hou, Tong Li, Ruiting Li, Wang Chun-xiu, Huadong Yin et al. · 2022 · BMC Genomics
Seleno‐Nucleobases and Their Water‐Soluble Ruthenium–Arene Half‐Sandwich Complexes: Chemistry and Biological Activity
Raja Mitra, Anup K. Pramanik, Ashoka G. Samuelson · 2014 · European Journal of Inorganic Chemistry
Electronic Structure of a Self-Assembled Monolayer with Two Surface Anchors: 6-Mercaptopurine on Au(111)
Cynthia Carolina Fernández, Evangelina Pensa, Pilar Carro, Roberto Carlos Salvarezza, Federico José Williams · 2018 · Langmuir
Pyrimidine and Purine Antimetabolites
Robert B. Diasio · 2017 · Wiley eBooks
Mechanical stress confers nuclear and functional changes in derived leukemia cells from persistent confined migration
Ana de Lope-Planelles, Raquel González-Novo, Elena Madrazo, Gracia Peralta-Carrero, María Pilar Cruz Rodríguez, Héctor Zamora‐Carreras, Verónica Torrano, Horacio López‐Menéndez, Pedro Roda‐Navarro, Francisco Monroy et al. · 2023 · Cellular and Molecular Life Sciences
Combined use of chemically modified nucleobases and nanostructured DNA for enhanced immunostimulatory activity of CpG oligodeoxynucleotide
Yuki Araie, Shozo Ohtsuki, Soyoung Park, Makoto Nagaoka, Keisuke Umemura, Hiroshi Sugiyama, Kosuke Kusamori, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa · 2020 · Bioorganic & Medicinal Chemistry
The Inhibitory Effects of 6-Thioguanine and 6-Mercaptopurine on the USP2a Target Fatty Acid Synthase in Human Submaxillary Carcinoma Cells
Chiao-Pei Cheng, Shuting Liu, Yi‐Lin Chiu, Shih-Ming Huang, Ching‐Liang Ho · 2021 · Frontiers in Oncology
LC–MS/MS Method for Measurement of Thiopurine Nucleotides (TN) in Erythrocytes and Association of TN Concentrations With TPMT Enzyme Activity
Amol O. Bajaj, Mark M. Kushnir, Erik Kish‐Trier, Rachel Law, Lauren M. Zuromski, Alejandro R. Molinelli, Gwendolyn A. McMillin, Kamisha L. Johnson‐Davis · 2022 · Frontiers in Pharmacology
Dual Molecular Design toward a Lysosome-Tagged AIEgen and Heavy-Atom-Free Photosensitizers for Hypoxic Cancer Photodynamic Therapy
Thanh Chung Pham, Thi Thuy Hang Hoang, Yeonghwan Choi, Seongman Lee, Sang‐Woo Joo, Gun Kim, Dongwon Kim, Ok‐Sang Jung, Songyi Lee · 2022 · Biosensors
Optimising use of thiopurines in inflammatory bowel disease
Lawrence Sunder Raj, Antony Barney Hawthorne · 2010 · Frontline Gastroenterology
EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy
Sarah Elitzur, Ajay J Vora, Birgit Burkhardt, Hiroto Inaba, Andishe Attarbaschi, André Baruchel, Gabriele Escherich, Brenda E. S. Gibson, Hsi‐Che Liu, Mignon L. Loh et al. · 2022 · Blood
Azathioprine in the Treatment of Autoimmune Blistering Diseases
Volker Meyer, Stefan Beissert · 2012 · Immunology and Allergy Clinics of North America
Thiopurine Methyltransferase Predicts the Extent of Cytotoxicty and DNA Damage in Astroglial Cells after Thioguanine Exposure
Amira Hosni-Ahmed, Joseph D. Barnes, Jim Y. Wan, Terreia S. Jones · 2011 · PLoS ONE
Mutations at serine 37 in mouse guanylate kinase confer resistance to 6-thioguanine
Andressa Ardiani, A. Goyke, Margaret E. Black · 2009 · Protein Engineering Design and Selection
Genotoxicity of anticancer drug Azathioprine (Imuran): role of Omega-3 (ω-3) oil as protective agent
Elelaimy I.A. · 2012 · Journal of Applied Pharmaceutical Science
Synthesis, crystal structure and cytotoxic activity of novel 5-methyl-4-thiopyrimidine derivatives
Marcin Stolarczyk, I. Bryndal, Agnieszka Matera-Witkiewicz, Tadeusz Lis, Karolina Królewska‐Golińska, Marcin Cieślak, Julia Kaźmierczak-Barańska, Jerzy Cieplik · 2018 · Acta Crystallographica Section C Structural Chemistry
GSH-responsive nanofibrous prodrug formed by a short naphthylacetic acid-terminated peptide for 6-mercaptopurine delivery
Ju Liang, Maosong Xuan, Wenlan Wu, Junbo Li · 2021 · Journal of Drug Delivery Science and Technology
Degradable Metal‐Small Molecule Drug Coordination Nanomedicines for DNA Damage‐Augmented Cancer Chemodynamic Therapy
Renting Jiang, Jinchan Rao, Hua Su, Ming Li · 2025 · Small
Converging Fate of the Oxidation and Reduction of 8-Thioguanosine
Katarzyna Taras‐Goślińska, Fabrizio Vetica, Sebastián Barata‐Vallejo, Virginia Triantakostanti, Bronisław Marciniak, Chryssostomos Chatgilialoglu · 2019 · Molecules
Comprehensive analyses of one-carbon metabolism related genes and their association with prognosis, tumor microenvironment, chemotherapy resistance and immunotherapy in lung adenocarcinoma
Ning Zhou, Quanying Tang, Haochuan Yu, Tong Li, Fan Ren, Lingling Zu, Gang Chen, Jun Chen, Song Xu · 2022 · Frontiers in Molecular Biosciences
Azathioprine in the Treatment of Autoimmune Blistering Diseases
Volker Meyer, Stefan Beissert · 2011 · Dermatologic Clinics
Lessons Learned From a Case of Gastric Cancer After Liver Transplantation for Hepatocellular Carcinoma
Kun Yang, Hong Zhu, Chong-Cheng Chen, Tianfu Wen, Weihan Zhang, Kai Liu, Xin‐Zu Chen, Dong-Jiao Guo, Zong‐Guang Zhou, Jian-Kun Hu · 2016 · Medicine
How DNA damage and non-canonical nucleotides alter the telomerase catalytic cycle
Samantha L. Sanford, Griffin A. Welfer, Bret Freudenthal, Patricia Lynn Opresko · 2021 · DNA repair
Acute erythroleukemia with der(1;7)(q10;p10) as a sole acquired abnormality after treatment with azathioprine
Tae Sung Park, June‐Won Cheong, Jaewoo Song, Kyung‐A Lee, Sang‐Guk Lee, Juwon Kim, Seoyoung Yoon, Jong Rak Choi, Rojin Park · 2008 · Cancer Genetics and Cytogenetics
The effect of Msh2 knockdown on methylating agent induced toxicity in DNA glycosylase deficient cells
N. Cooley, Rhoderick H. Elder, Andrew C. Povey · 2009 · Toxicology
Simultaneous production of singlet oxygen and superoxide anion by thiocarbonyl coumarin for photodynamic therapy
Zhijing Xu, Yingzhuang Song, Jinyu Sun · 2024 · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine Therapy
Isfahan Shah Lubis, Kusnandar Anggadiredja, Anita Artarini, Nur Melani Sari, Nur Suryawan, Zulfan Zazuli · 2025 · Medical Sciences
Acid-Responsive Thiocarbonylated Coumarin Photosensitizer for Hypoxia-Tolerant Photodynamic Therapy
Gahyun Kim, Van Kieu Thuy Nguyen, Jeonghye Han, Lei Cao, Sang Gil Lee, Dai Lam Tran, Thanh Chung Pham, Songyi Lee · 2025 · ACS Applied Bio Materials
CRISPR/Cas9-Mediated Induction of Relapse-Specific NT5C2 and PRPS1 Mutations Confers Thiopurine Resistance as a Relapsed Lymphoid Leukemia Model
Thao Thu Thi Nguyen, Yoïchi Tanaka, Masashi Sanada, Masumi Hosaka, Minori Tamai, Keiko Kagami, Chiaki Komatsu, Shinpei Somazu, Daisuke Harama, Shin Kasai et al. · 2023 · Molecular Pharmacology