Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

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Items 401–474 of 474

1. Thiopurines
   Terreia S. Jones, Mary V. Relling · 2010 · Humana Press eBooks
2. Evaluation of the maternal and developmental toxicity of 6-methylmercaptopurine riboside in rats
   Maria Regina Gomes-Carneiro, Rosângela Ribeiro de Carvalho, Thamyris Figueiredo do Amaral, Ana Cecilia Amado Xavier De-Oliveira, Francisco José Roma Paumgartten · 2022 · Reproductive Toxicology
3. Severe myelosuppression and alopecia after thiopurine initiation in a patient with NUDT15 deficiency
   Annie Siyu Wu, Lee Mozessohn, Richard B. Kim, Jonathan S. Zipursky · 2025 · British Journal of Clinical Pharmacology
4. Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of Antileukemic Drugs
   Kjeld Schmiegelow, Inge Margriet van der Sluis · 2017 · Springer eBooks
5. Clinical Pharmacogenomics and Personalized Medicine: New Strategies to Maximize Drug Efficacy and Avoid Adverse Drug Reaction
   Chonlaphat Sukasem, Sadeep Medhasi · 2018 · Springer eBooks
6. Farmakogenetski označevalci v terapiji akutne limfoblastne levkemije pri otrocih
   Alenka Šmid, Janez Jazbec, Irena Mlinarič‐Raščan · 2019 · Slovenian Medical Journal
7. Pharmacogenomics of Thiopurine-Induced Toxicity in Children
   Hina Salahuddin, Muhammad Junaid Iqbal Tahir · 2020 · Springer eBooks
8. De-Novo Genitourinary Neoplasms in Transplant Recipients: The Present and Future
   K Regmi Subodh, Jiang Song, A. Warlick Christopher · 2020
9. Unusual photophysical properties of a new tricyclic derivative of thiopurines in terms of potential applications
   Katarzyna Krancewicz, Jacek Koput, Gordon L. Hug, Bronisław Marciniak, Katarzyna Taras‐Goślińska · 2022 · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
10. Mammalian Nudt15 hydrolytic and binding activity on methylated guanosine mononucleotides
    Maciej Łukaszewicz, Aleksandra Ferenc-Mrozek, Julia Kokosza, Anna Stefaniuk, Janusz Stȩpiński, Elżbieta Bojarska, Edward Darżynkiewicz · 2023 · European Biophysics Journal
11. Oxidation-Mediated DNA Crosslinking Contributes to Toxicity of 6-Thioguanine in Human Cells — Letter
    Nanne K.H. de Boer, Dirk P. van Asseldonk, Margien L. Seinen, Adriaan Anthonie Van Bodegraven · 2013 · Cancer Research
12. Response: Could mutations in the hypoxanthine-guanine phosphoribosyl transferase gene induced by thiopurine therapy promote the development of second malignant neoplasms?
    Kjeld Schmiegelow, Ibrahim Al-Modhawi, Mette Klarskov Andersen, Mikael Berendtz, Erik Forestier, Henrik Hasle, Mats Marshall Heyman, Jón Kristinsson, Jacob Nersting, Randi Nygaard et al. · 2009 · Blood
13. Identification and Functional Characterization of Powdery Mildew Effectors
    Sarah Maria Schmidt · 2009 · Kölner Universitäts PublikationsServer (Universität zu Köln)
14. Pyrimidine and Purine Antimetabolites
    Robert B. Diasio, Steven M. Offer · 2022 · Wiley eBooks
15. PHARMACOGENETIQUE DES MEDICAMENTS THIOPURINIQUES Implication des enzymes TPMT et IMPDH2 et de la RhoGTPase RAC1
    Anne Garat, Nicole Houdret · 2009 · OpenGrey (Institut de l'Information Scientifique et Technique)
16. Monocapas autoensambladas de tioles con aplicaciones biomédicas sobre sustratos de Au(111) y nanopartículas de Au
    Evangelina Pensa · 2014
17. Thiopurines and the Sun: What should be Done?
    Conal M. Perrett, Jane McGregor, Catherine A Harwood · 2011 · Wiley eBooks
18. Azathioprine Therapy in Multiple Sclerosis: Phosphoribosylated Metabolites and Thiopurine Methyltransferase Activity
    Evangelos Polychronopoulos, Peter Albrecht, Julia Tafazzoli-Lari, Heiko Iven, Andréas Moser · 2014 · The Open Neuroscience Journal
19. Response to Emanuele
    Quentin Guéranger, Feng Li, Matthew Peacock, A. Larnicol, Reto Brem, Peter Macpherson, Jean‐Marc Egly, Peter Karran · 2014 · Journal of Investigative Dermatology
20. Development of new methodology for therapeutic drug monitoringof thiopurine treatment
    Svante Vikingsson · 2012
21. Biochemical Characterization of Human Guanylate Kinase and Mitochondrial Thymidine Kinase: Essential Enzymes for the Metabolic Activation of Nucleoside Analog Prodrugs
    Nazimuddin Khan · 2015
22. leukemia: results from the NOPHO ALL-92 study of a second malignant neoplasm after childhood acute lymphoblastic Methotrexate/6-mercaptopurine maintenance therapy influences the risk
    Kim K. Vettenranta, Richard M. Weinshilboum, Henrik Hasle, Mats Marshall Heyman, Jón Kristinsson, Jacob Nersting, Randi Nygaard, Anne Kjeld Schmiegelow, Mette Klarskov Andersen, Mikael Behrendtz · 2013
23. Synthetic Lipids for Drug Delivery Applications
    Michael W. Meanwell · 2015 · UVic’s Research and Learning Repository (University of Victoria)
24. Engineering novel suicide enzymes for improved cancer gene therapy
    Andressa Ardiani · 2009
25. Establishment of human lymphoma cell lines with different thiopurine S-methyltransferase (TPMT) activities and differential proteome analysis after thiopurine exposure.
    Misbah Misdaq · 2013
26. Azathioprine-Associated Acute Myeloid Leukemia in a Patient with Crohn’s Disease (About One Case)
    Fahimi Mina · 2015 · Gastroenterology & Hepatology Open Access
27. Biológicos y cáncer: ¿una relación peligrosa?
    María Chaparro, Javier P. Gisbert · 2016 · Enfermedad Inflamatoria Intestinal al Día
28. Optimising the use of Azathioprine in the treatment of Inflammatory Bowel Disease
    Melissa A. Smith · 2016 · Research Portal (King's College London)
29. 5‐Azacytidine specifically inhibits the NIH‐3T3 PCD process induced by TNF‐alpha and cycloheximide via affecting BCL‐XL
    Qing Wang, Pu Wang, Hong Wei Zhou, Yan Hu, Chengshen Xie, Fei Gao, Ningjie Ma, Haoli Hou, Hao Zhang, Lijia Li · 2017 · Journal of Cellular Biochemistry
30. The effect of S-substitution at the O6-guanine site on the structure and dynamics of a DNA oligomer containing a G:T mismatch
    Elaine Ann Moore, Yao−Zhong Xu · 2017 · PLoS ONE
31. Glioma: A Tale of Corticosteroids, Thiopurines and Proposed Novel AntiGlioma Small Molecules
    Amira Ahmed · 2014
32. Targeting subtype-specific metabolic preferences in nucleotide biosynthesis inhibits tumor growth in a breast cancer model
    Martin P. Ogrodzinski, Shao Thing Teoh, Sophia Y. Lunt · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
33. Intestinal T-cell lymphoma presenting as colonic perforation in the setting of ulcerative colitis: a case report
    Ali Mourad, Marie Shella De Robles, Robert Duncan Winn · 2020 · Clinical Journal of Gastroenterology
34. A novel single-tube multiplex real-time PCR assay for genotyping of thiopurine intolerance-causing variant NUDT15 c.415C>T
    Xiao-yun Lian, Yanwei Li, Lan Li, U Kaicheng, Wenxia Wang, Yinmin Shi, Ji-Ying Ma, Huijuan Wang · 2021 · Experimental Biology and Medicine
35. Structural Characterization of 6-Thioguanosine and Its Monohydrate in the Gas Phase
    Hiroyuki Saigusa, Ayumi Oyama, Saki Kitamura, Hiroya Asami · 2021 · The Journal of Physical Chemistry A
36. Epidemiological Studies of Small Intestinal Tumours
    Niklas Zar · 2008 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
37. Pharmacogenomics
    Hitoshi Zembutsu · 2019 · Springer eBooks
38. Azathioprine
    Claudia Günther, Volker Meyer, Stefan Beissert · 2015 · Springer eBooks
39. Antimetabolites
    Adam Todd, Paul W. Groundwater, Jason H. Gill · 2017 · Wiley eBooks
40. Cumulative exposure to tacrolimus and incidence of cancer after liver transplantation
    Manuel Rodríguez‐Perálvarez, Gonzalo Crespo, Jesús Rivera‐Esteban, Antonio González Rodríguez, Estefanía Berge Garrido, Mikel Gastaca, Patricia Ruiz, Anna Benages Curell, Cristina Dopazo, Ainhoa Fernández‐Yunquera et al. · 2022 · Journal of Hepatology
41. Molecular dynamics simulations reveal the impact of NUDT15 R139C and R139H variants in structural conformation and dynamics
    Elena Gómez-Rubio, Javier García‐Marín · 2023 · Journal of Biomolecular Structure and Dynamics
42. Azathioprine
    Sara Salcedo, Emma Martínez-López, Antonio Juan García-Fernández · 2023 · Elsevier eBooks
43. Data from 6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance
    Natalia Issaeva, Huw D. Thomas, Tatjana Djurenovic, Janneke E. Jaspers, Ivaylo Stoimenov, Suzanne Kyle, Nicholas Pedley, Ponnari Gottipati, Rafal Zur, Kate M. Sleeth et al. · 2023
44. Data from Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model
    Martin P. Ogrodzinski, Shao Thing Teoh, Sophia Y. Lunt · 2023
45. Análise histológica e imuno-histoquímica da pele de transplantados renais submetidos a três esquemas de imunossupressão
    Maria Victoria Pinto Quaresma Santos · 2022 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
46. Excited state properties of 5‐fluoro ‐4‐thiouridine derivative†
    Rin Sato, Yoshino Yamada, Wataru Kashihara, Tatsuya Nishihara, Kazuhito Tanabe, Yao−Zhong Xu, Tadashi Suzuki · 2024 · Photochemistry and Photobiology
47. Real world data analysis of venous thromboembolism, adverse major cardiovascular events, neoplasia and serious infections in ulcerative colitis patients
    Víctor de la Oliva, Alberto Esteban-Medina, Patricia Fernández del Valle, Ana Sanchez, M. Belen Susin, Joaquı́n Dopazo, Carlos Loucera, Eduardo Leo‐Carnerero · 2025 · medRxiv
48. Cancer Risk in IBD Patients Treated with Thiopurines or Anti-TNF-α Therapy: A Meta- analysis of Population-Based Studies
    Zhenzhi Wang, Yukun Chen, Xinyu Li, Li Wei Lin, Bozhu Chen, Min Chen, Hui Zheng · 2025 · Research Square
49. B-cell–specific Wwox deletion promotes plasmablastic tumor development and proinflammatory signatures in myeloma model
    Tabish Hussain, Matthew D. Bramble, Bin Liu, Martı́n C. Abba, Marta Chesi, C. Marcelo Aldaz · 2025 · Blood Neoplasia
50. Insights into NT5C2 and PRPS1 Mutations Driving Thiopurine Resistance in Relapsed ALL: From Structural Destabilization to Clinical Biomarkers
    Ramita Sharma, Jeeshitha Kudithipudi, Himanshu Singh, Dhamodharan Prabhu, Sugunakar Vuree · 2025 · SSRN Electronic Journal
51. Diplotype analysis of NUDT15 using digital PCR in pediatric acute lymphoblastic leukemia
    Yasunori Iida, Reiji Fukano, Takuya Ichimura, Sachiyo Kamimura, Takuro Nishikawa, Shuichi Ozono, Yutaka Suehiro, Hiroshi Moritake, Yasuhiro Okamoto, Takahiro Yamasaki et al. · 2025 · Research Square
52. Additional file 1 of Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol
    Linea Natalie Toksvang, Bodil E. Thorhauge Als-Nielsen, Christopher Laurence Bacon, Ruta Bertasiute, Duarte, Ximo, Gabriele Escherich, Elin A. Helgadottir, Johannsdottir, Inga Rinvoll, Jónsson, Ólafur G., Kozlowski, Piotr et al. · 2022 · Figshare
53. Additional file 1 of Genetic effect of an InDel in the promoter region of the NUDT15 and its effect on myoblast proliferation in chickens
    Wei, Chengjie, Yufang Niu, Bingjie Chen, Panpan Qin, Wang, Yanxing, Hou, Dan, Li, Tong, Ruiting Li, Wang, Chunxiu, Yin, Huadong et al. · 2022 · Figshare
54. Additional file 2 of Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol
    Linea Natalie Toksvang, Bodil E. Thorhauge Als-Nielsen, Christopher Laurence Bacon, Ruta Bertasiute, Duarte, Ximo, Gabriele Escherich, Elin A. Helgadottir, Johannsdottir, Inga Rinvoll, Jónsson, Ólafur G., Kozlowski, Piotr et al. · 2022 · Figshare
55. Additional file 4 of Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol
    Linea Natalie Toksvang, Bodil E. Thorhauge Als-Nielsen, Christopher Laurence Bacon, Ruta Bertasiute, Duarte, Ximo, Gabriele Escherich, Elin A. Helgadottir, Johannsdottir, Inga Rinvoll, Jónsson, Ólafur G., Kozlowski, Piotr et al. · 2022 · Figshare
56. Additional file 6 of Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol
    Linea Natalie Toksvang, Bodil E. Thorhauge Als-Nielsen, Christopher Laurence Bacon, Ruta Bertasiute, Duarte, Ximo, Gabriele Escherich, Elin A. Helgadottir, Johannsdottir, Inga Rinvoll, Jónsson, Ólafur G., Kozlowski, Piotr et al. · 2022 · Figshare
57. Additional file 3 of Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol
    Linea Natalie Toksvang, Bodil E. Thorhauge Als-Nielsen, Christopher Laurence Bacon, Ruta Bertasiute, Duarte, Ximo, Gabriele Escherich, Elin A. Helgadottir, Johannsdottir, Inga Rinvoll, Jónsson, Ólafur G., Kozlowski, Piotr et al. · 2022 · Figshare
58. Additional file 5 of Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol
    Linea Natalie Toksvang, Bodil E. Thorhauge Als-Nielsen, Christopher Laurence Bacon, Ruta Bertasiute, Duarte, Ximo, Gabriele Escherich, Elin A. Helgadottir, Johannsdottir, Inga Rinvoll, Jónsson, Ólafur G., Kozlowski, Piotr et al. · 2022 · Figshare
59. De Novo Solid Organ Malignancy in Liver Transplant Recipients
    Sanjay Kumar Yadav, Sanjiv Saigal · 2026 · Springer eBooks
60. Sugarcane resistance to Xanthomonas albilineans was driven by m6A methylation-mediated defense reprogramming
    Wanying Zhao, Haibi Li, Kai Zhu, Yiyun Gui, Yanhang Tang, Hui Zhou, Ronghua Zhang, Yan Jing, Youxiong Que, Qibin Wu et al. · 2026 · Industrial Crops and Products
61. Induction d'un processus d'instabilité des microsatellites du génome dans des modèles murin et cellulaire : intérêt physiopathologique et clinique
    Sahra Bodo · 2014 · theses.fr (ABES)
62. Acquired thiopurine resistance and mismatch repair aberrations in paediatric B‐cell acute lymphoblastic leukaemia relapse: A real‐world data integrating mutational signatures, clones and clinical thiopurine dosing patterns
    Prateek Bhatia, Sharun Sharun, Swetha Palla, Samuel W. Brady, Sangeetha Kirubanandhan, Sada Ansari, Minu Singh, Sreejesh Sreedharanunni, Anirban Das, Amita Trehan · 2026 · British Journal of Haematology
63. Development of a Nucleoside Photosensitizer Efficiently Activated by One- or Two-Photon Absorption in the Optical Therapeutic Window
    Sourav Kanti Seth, Sean J. Hoehn, Chris Acquah, Liraz Levi, Carlos E. Crespo‐Hernández, Carlos E. Crespo‐Hernández · 2026 · Journal of the American Chemical Society
64. Treatment of Myasthenia Gravis
    Henry J. Kaminski · 2026 · Current clinical neurology
65. Targeting folate-dependent purine synthesis sensitizes melanoma cells to immune attack through suppressing glycolysis
    D J Li, Miaomiao Hou, Shoubao Wang, Xinyuan Wan, Haiqiong Wang, Yun-Hee Han, Xi Liu, Chaojiang Cheng, Jian Zhang, X Hu · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
66. A VALIDATED CHROMATOGRAPHIC METHOD FOR DETERMINATION OF THIOPURINE DRUGS METABOLITES CONCENTRATIONS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE
    Chadli Z, Mohammed Alshaikheid, Hannachi I, Lamia Hamdi, H. Ben Romdhane, Boughattas NA, Amel Chaabane, Nadia Ben Fredj · 2025 · Bulletin of Pharmaceutical Research
67. Transfer RNA Modifications in the Immune System Participate in Disease Pathogenesis
    Xinke Ma, Hejia Gu, Yi Zhang, Hanru Jia, Peiying Li, Yingjia Wang, Jiahui Wu, Aiwei Wu, Jing Wu · 2026 · International Journal of Molecular Sciences
68. Nucleotide Metabolism in Health and Disease
    Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu · 2026 · MedComm
69. A Phase Ib/II Study of Atezolizumab in Combination with Thiopurine Therapy in Patients with Metastatic Solid Tumors and Intermediate Tumor Mutational Burden
    Christine K. Federspiel, Martin Højgaard, Iben Spanggaard, Ane Yde Schmidt, Yuliu Guo, Luca Robinson, Daniela De Zio, Linea Natalie Toksvang, Frederik Otzen Bagger, Kjeld Schmiegelow et al. · 2026 · Cancer Research Communications
70. Catalytic Nucleophilic C(sp 3 )─H Functionalization/C─S Coupling via Iron Nitrenoids
    Taichi Yumura, Emmanuel Ramírez, Gang Li · 2026 · Chemistry - A European Journal
71. Multifaceted Computational Analysis of O 6-Methylguanine and O 6-Methylthioguanine Nucleobase Complexes
    Michael C. Bowman, Kirsten M. Stinson · 2026 · The Journal of Physical Chemistry B
72. Introducing 2-Thioxocoumarins as a New Class of Photosensitizers for Antimicrobial Photodynamic Therapy
    Javier Ordóñez-Hernández, Abel Jaume-Masferrer, Jordi Cornet Hernando, Marc Martínez-Miguel, Claire Brazzi, Elı́es Molins, Rosario Núñez · 2026 · ACS Omega
73. Personalized Therapy with Mercaptopurine in Acute Lymphoblastic Leukemia: Current Advances and Challenges
    Haoping He, Bowei Chen, Xiaoqiang Hao, Haoyue Li, Jia Du, 刘薇薇, Aijun Zhang · 2026 · Current Treatment Options in Oncology
74. Environmental and genetic risk factors for post-transplant lymphoproliferative disease :
    Jana Stojanova · 2013 · HAL