Cited by 1,140Cancer, Hypoxia, and MetabolismDNA Repair MechanismsCell death mechanisms and regulation

The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.

Hypoxia, DNA repair and genetic instability

Bristow, Robert G., Hill, Richard P.·2008·Nature Reviews Cancer

Open this paper in CoChat — free account

Abstract

Areas of hypoxic tumour tissue are known to be resistant to treatment and are associated with a poor clinical prognosis. There are several reasons why this might be, including the capacity of hypoxia to drive genomic instability and alter DNA damage repair pathways. Significantly, current models fail to distinguish between the complexities of the hypoxic microenvironment and the biological effects of acute hypoxia exposures versus longer-term, chronic hypoxia exposures on the transcription and translation of proteins involved in genetic stability and cell survival. Acute and chronic hypoxia might lead to different biology within the tumour and this might have a direct effect on the design of new therapies for the treatment of hypoxic tumours.

Integrity signals

Registry

Crossref · 10.1038/nrc2344

Cites

112 of 112 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309
Retracted
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177
Exploiting tumour hypoxia in cancer treatment
Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828
Drug penetration in solid tumours
Minchinton, A. I., & Tannock, I. F. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1893 · Cited by 2,805
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature · doi:10.1038/379088a0 · Cited by 2,300
Hypoxia in cancer: significance and impact on clinical outcome
Vaupel, P., & Mayer, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9055-1 · Cited by 2,240
Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathway
Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113
Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · cited 1×
“When tissue metabolism exceeds metabolic supply, as is the case for most tumours, the hypoxic response leads to a series of changes in protein expression to protect against cell deat”
Background
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.
Höckel, M., Schlenger, K., Aral, B., Mitze, M., Schäffer, U., & Vaupel, P. W. (1996) · PubMed · Cited by 1,727
Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions
Salceda, S., & Caro, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22642 · Cited by 1,674
Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
McCabe, N., Turner, N. C., Lord, C. J., Kluzek, K., Białkowska, A., Swift, S., Giavara, S., O’Connor, M. J., Tutt, A. N. J., Zdzienicka, M. Z., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0140 · Cited by 1,311
Chromosomal stability and the DNA double-stranded break connection
van Gent, D. C., Hoeijmakers, J. H. J., & Kanaar, R. (2001) · Nature Reviews Genetics · doi:10.1038/35056049 · Cited by 1,219
Untitled work
(1996) · PubMed · Cited by 1,188
Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia
Guzy, R. D., & Schumacker, P. T. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.033506 · Cited by 881
HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity
Gordan, J. D., Bertout, J. A., Hu, C.-J., Diehl, J. A., & Simon, M. C. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.006 · Cited by 781
Preparing the “Soil”: The Premetastatic Niche
Kaplan, R. N., Rafii, S., & Lyden, D. C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2407 · Cited by 681
DNA double-strand break repair: From mechanistic understanding to cancer treatment
HELLEDAY, T., LO, J., VANGENT, D., & ENGELWARD, B. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.02.006 · Cited by 640
HIF-1 as a target for drug development
Giaccia, A., Siim, B. G., & Johnson, R. S. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1199 · Cited by 631
Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
Tatum, J. L. (2006) · International Journal of Radiation Biology · doi:10.1080/09553000601002324 · Cited by 626
Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers
Chi, J., Wang, Z., Nuyten, D. S. A., Rodriguez, E. H., Schaner, M. E., Salim, A., Wang, Y., Kristensen, G. B., Helland, Å., Børresen‐Dale, A., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030047 · Cited by 625
Hypoxic Radiosensitization: Adored and Ignored
Overgaard, J. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.7878 · Cited by 619
Hypoxia Induces Accumulation of p53 Protein, but Activation of a G 1 -Phase Checkpoint by Low-Oxygen Conditions Is Independent of p53 Status
Graeber, T. G., Peterson, J., Tsai, M., Monica, K., Fornace, A. J., & Giaccia, A. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.6264 · Cited by 617
Hypoxia-induced energy stress regulates mRNA translation and cell growth
Liu, L., Cash, T. P., Jones, R. G., Keith, B., Thompson, C. B., & Simon, M. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.010 · Cited by 607
Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies
Shannon, A. M., Bouchier-Hayes, D. J., Condron, C. M., & Toomey, D. (2003) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(03)00003-3 · Cited by 559
HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo
Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.004 · Cited by 523
Genetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences
Stark, J. M., Pierce, A. J., Oh, J., Pastink, A., & Jasin, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9305-9316.2004 · Cited by 501
The Basic Science of Oncology
Tannock, I. F., Hill, R. P., & Carey, R. W. (1989) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198905000-00037 · Cited by 473
Self-citation
Hypoxic gene expression and metastasis
Le, Q., Denko, N. C., & Giaccia, A. J. (2004) · Cancer and Metastasis Reviews · doi:10.1023/b:canc.0000031768.89246.d7 · Cited by 467
Chemical Radiosensitizers for Use in Radiotherapy
Wardman, P. (2007) · Clinical Oncology · doi:10.1016/j.clon.2007.03.010 · Cited by 467
The life and death of DNA-PK
Collis, S. J., DeWeese, T. L., Jeggo, P. A., & Parker, A. R. (2004) · Oncogene · doi:10.1038/sj.onc.1208332 · Cited by 434
23 Genetic instability induced by the tumor microenvironment
Glazer, P. M., Reynolds, T. Y., & Rockwell, S. (1997) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(97)80581-0 · Cited by 429
Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment
Moeller, B. J., Richardson, R. A., & Dewhirst, M. W. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9056-0 · Cited by 417
Expression of Fragile Sites Triggers Intrachromosomal Mammalian Gene Amplification and Sets Boundaries to Early Amplicons
Coquelle, A., Pipiras, E., Toledo, F., Buttin, G., & Debatisse, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80201-9 · Cited by 390
Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
Young, S. D., Marshall, R. S., & Hill, R. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9533 · Cited by 381
Self-citation
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
Moeller, B. J., Dreher, M. R., Rabbani, Z. N., Schroeder, T., Cao, Y., Li, C. Y., & Dewhirst, M. W. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.06.016 · Cited by 374
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
Koritzinsky, M., Magagnin, M. G., van den Beucken, T., Seigneuric, R., Savelkouls, K. G. M., Dostie, J., Pyronnet, S., Kaufman, R. J., Weppler, S. A., Voncken, J. W., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600998 · Cited by 369
Down-Regulation of Rad51 and Decreased Homologous Recombination in Hypoxic Cancer Cells
Bindra, R. S., Schaffer, P. J., Meng, A. X., Woo, J. M. P., Måseide, K., Roth, M. E., Lizardi, P. M., Hedley, D. W., Bristow, R. G., & Glazer, P. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8504-8518.2004 · Cited by 367
Self-citation
Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation
Powell, S. N., & Kachnic, L. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206678 · Cited by 364
Evaluation of HIF-1 inhibitors as anticancer agents
Semenza, G. L. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.08.006 · Cited by 363
HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression
Koshiji, M., To, K. K.-W., Hammer, S., Kumamoto, K., Harris, A. L., Modrich, P., & Huang, L. E. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.015 · Cited by 346
Microenvironment-induced cancer metastasis
Rofstad, E. K. (2000) · International Journal of Radiation Biology · doi:10.1080/095530000138259 · Cited by 335
The hypoxia-inducible factor-1α is a negative factor for tumor therapy
Unruh, A., Ressel, A., Mohamed, H. G., Johnson, R. S., Nadrowitz, R., Richter, E., Katschinski, D. M., & Wenger, R. H. (2003) · Oncogene · doi:10.1038/sj.onc.1206385 · Cited by 334
Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance
Chan, N. H. L., Koritzinsky, M., Zhao, H. W., Bindra, R. S., Glazer, P. M., Powell, S. N., Belmaaza, A., Wouters, B. G., & Bristow, R. G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5472 · Cited by 328
Self-citation
Perk-Dependent Translational Regulation Promotes Tumor Cell Adaptation and Angiogenesis in Response to Hypoxic Stress
Blais, J. D., Addison, C., Edge, R. E., Falls, T. J., Zhao, H., Wary, K. K., Koumenis, C., Harding, H. P., Ron, D., Holčı́k, M., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01145-06 · Cited by 313
Untitled work
(2001) · PubMed · Cited by 292
Self-citation
ATR/ATM Targets Are Phosphorylated by ATR in Response to Hypoxia and ATM in Response to Reoxygenation
Hammond, E. M., Dorie, M. J., & Giaccia, A. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212360200 · Cited by 288
Phosphorylation of histone H2AX as a measure of radiosensitivity
Olive, P. L., & Banáth, J. P. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2003.09.028 · Cited by 280
Hypoxia, gene expression, and metastasis
Chan, D. A., & Giaccia, A. J. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9063-1 · Cited by 280
Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells
Mihaylova, V. T., Bindra, R. S., Yuan, J., Hegan, D. C., Narayanan, L., Jensen, R. B., Giordano, F. J., Johnson, R. S., Rockwell, S., & Glazer, P. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.9.3265-3273.2003 · Cited by 275
Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo
Ouyang, H., Nussenzweig, A., Kurimasa, A., Soares, V. D. C., Li, X., Cordon‐Cardo, C., Li, W.-H., Cheong, N., Nussenzweig, M. C., Iliakis, G. E., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.6.921 · Cited by 270
Elevated levels of Rad51 recombination protein in tumor cells.
Raderschall, E., Stout, K., Freier, S., Suckow, V., Schweiger, S., & Haaf, T. (2002) · PubMed · Cited by 257
The mechanism of non-homologous end-joining: a synopsis of synapsis
Weterings, E., & van Gent, D. C. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.06.003 · Cited by 247
Basic Science of Oncology
(1999) · Oxford University Press eBooks · doi:10.1093/oso/9780192629784.003.0001 · Cited by 246
Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations
Nordsmark, M., Alsner, J., Keller, J. O., Nielsen, O. S., Jensen, O. M., Horsman, M. R., & Overgaard, J. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1728 · Cited by 228
Acute Hypoxia Enhances Spontaneous Lymph Node Metastasis in an Orthotopic Murine Model of Human Cervical Carcinoma
Cairns, R. A., & Hill, R. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3196 · Cited by 218
Self-citation
A New Role for Hypoxia in Tumor Progression
Coquelle, A., Toledo, F., Stern, S., Bieth, A., & Debatisse, M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80137-9 · Cited by 216
Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells
Meng, A. X., Jalali, F., Cuddihy, A. R., Chan, N. H. L., Bindra, R. S., Glazer, P. M., & Bristow, R. G. (2005) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2005.06.025 · Cited by 195
Self-citation
Regulation of DNA repair in hypoxic cancer cells
Bindra, R. S., Crosby, M. E., & Glazer, P. M. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9061-3 · Cited by 194
Preconditioning of the Tumor Vasculature and Tumor Cells by Intermittent Hypoxia: Implications for Anticancer Therapies
Martinive, P., Defresne, F., Bouzin, C., Saliez, J., Lair, F., Grégoire, V., Michiels, C., Dessy, C., & Feron, O. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2056 · Cited by 190
Fanconi anemia pathway–deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated
Kennedy, R. D., Chen, C. C., Stuckert, P., Archila, E. M., la Vega, M. A. D., Moreau, L. A., Shimamura, A., & D’Andrea, A. D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31245 · Cited by 178
Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis
Bindra, R. S., & Glazer, P. M. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.03.013 · Cited by 169
Fluctuating and Diffusion-Limited Hypoxia in Hypoxia-Induced Metastasis
Rofstad, E. K., Galappathi, K., Mathiesen, B. S., & Ruud, E. M. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1967 · Cited by 168
Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia
Bindra, R. R., & Glazer, P. M. (2006) · Oncogene · doi:10.1038/sj.onc.1210001 · Cited by 167
Control of the hypoxic response through regulation of mRNA translation
Wouters, B. G., van den Beucken, T., Magagnin, M. G., Koritzinsky, M., Fels, D. R., & Koumenis, C. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.03.009 · Cited by 158
The premetastatic niche
Mundy, G. R. (2008) · Bone · doi:10.1016/j.bone.2007.12.198 · Cited by 147
Effects of hypoxia on tumor metabolism
Kim, J., Gao, P., & Dang, C. V. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9060-4 · Cited by 146
RORA, a large common fragile site gene, is involved in cellular stress response
Zhu, Y., McAvoy, S., Kuhn, R. M., & Smith, D. I. (2006) · Oncogene · doi:10.1038/sj.onc.1209314 · Cited by 145
Hypoxia-induced genetic instability—a calculated mechanism underlying tumor progression
Huang, E. L., Bindra, R. S., Glazer, P. M., & Harris, A. L. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0133-6 · Cited by 144
HIF-1-mediated activation of telomerase in cervical cancer cells
Yatabe, N., Kyo, S., Maida, Y., Nishi, H., Nakamura, M., Kanaya, T., Tanaka, M., Isaka, K., Ogawa, S., & Inoue, M. (2004) · Oncogene · doi:10.1038/sj.onc.1207460 · Cited by 132
Carrot and stick: HIF-α engages c-Myc in hypoxic adaptation
Huang, E. L. (2008) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402302 · Cited by 131
Anoxia Is Necessary for Tumor Cell Toxicity Caused by a Low-Oxygen Environment
Papandreou, I., Krishna, C. H. R., Kaper, F., Cai, D., Giaccia, A. J., & Denko, N. C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3395 · Cited by 128
Effects of Reoxygenation on Cells From Hypoxic Regions of Solid Tumors: Anticancer Drug Sensitivity and Metastatic Potential
Young, S. D., & Hill, R. P. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.5.371 · Cited by 125
Self-citation
The phosphorylation status of PAS‐B distinguishes HIF‐1α from HIF‐2α in NBS1 repression
To, K. K. W., Sedelnikova, O. A., Samons, M., Bonner, W. M., & Huang, E. L. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601369 · Cited by 121
The hypoxic proteome is influenced by gene-specific changes in mRNA translation
Koritzinsky, M., Seigneuric, R., Magagnin, M. G., van den Beucken, T., Lambin, P., & Wouters, B. G. (2005) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2005.06.036 · Cited by 110
Hypoxia Enhances Metastatic Efficiency by Up-Regulating Mdm2 in KHT Cells and Increasing Resistance to Apoptosis
Zhang, L., & Hill, R. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3038 · Cited by 108
Self-citation
Hypoxia and Metastasis
Chaudary, N., & Hill, R. P. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2971 · Cited by 105
Self-citation
Radiation and New Molecular Agents Part I: Targeting ATM-ATR Checkpoints, DNA Repair, and the Proteasome
Choudhury, A., Cuddihy, A. R., & Bristow, R. G. (2005) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2005.08.007 · Cited by 104
Self-citation
Hypoxia-induced and stress-specific changes in chromatin structure and function
Johnson, A. B., & Barton, M. C. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.10.007 · Cited by 104
Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms
Anderson, C. J., Hoare, S. F., Ashcroft, M. A., Bilsland, A. E., & Keith, W. N. (2005) · Oncogene · doi:10.1038/sj.onc.1209011 · Cited by 96
Co-repression of mismatch repair gene expression by hypoxia in cancer cells: Role of the Myc/Max network
Bindra, R. S., & Glazer, P. M. (2007) · Cancer Letters · doi:10.1016/j.canlet.2006.12.011 · Cited by 95
Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation.
Wang, J., BIEDERMANN, K. A., & Brown, J. (1992) · PubMed · Cited by 92
Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species
Bell, E. L., & Chandel, N. S. (2007) · Essays in Biochemistry · doi:10.1042/bse0430017 · Cited by 90
Hypoxia-Induced Phosphorylation of Chk2 in an Ataxia Telangiectasia Mutated–Dependent Manner
Gibson, S. L., Bindra, R. S., & Glazer, P. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1160 · Cited by 85
Increased radiosensitivity with chronic hypoxia in four human tumor cell lines
Zölzer, F., & Streffer, C. (2002) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)02963-2 · Cited by 85
Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells
Bertrand, P., Lambert, S., Joubert, C., & López, B. S. (2003) · Oncogene · doi:10.1038/sj.onc.1206998 · Cited by 80
Tumor Hypoxia, Dna Repair and Prostate Cancer Progression: New Targets and New Therapies
Chan, N. H. L., Milosevic, M., & Bristow, R. G. (2007) · Future Oncology · doi:10.2217/14796694.3.3.329 · Cited by 77
Self-citation
Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures.
Li, C., Little, J. B., Hu, K., Zhang, W., Zhang, L., Dewhirst, M. W., & Huang, Q. (2001) · PubMed · Cited by 76
Effect of Transient Hypoxia on Sensitivity to Doxorubicin in Human and Murine Cell Lines
Luk, C. K., Veinot-Drebot, L. M., Tjan, E., & Tannock, I. F. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.8.684 · Cited by 75
Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells
Um, J. H., Kang, C., Bae, J. H., Shin, G. G., Kim, D. W., Kim, D. W., Chung, B., & Kim, S. H. (2004) · Experimental & Molecular Medicine · doi:10.1038/emm.2004.32 · Cited by 73
Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status
Sprong, D., Janssen, H. L., Vens, C., & Begg, A. C. (2005) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2005.09.031 · Cited by 70
Homologous Recombination Is the Principal Pathway for the Repair of DNA Damage Induced by Tirapazamine in Mammalian Cells
Evans, J., Chernikova, S. B., Kachnic, L. A., Banáth, J. P., Sordet, O., Delahoussaye, Y. M., Treszezamsky, A. D., Chon, B. H., Feng, Z., Gu, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-06-4497 · Cited by 68
DNA Damage during Reoxygenation Elicits a Chk2-Dependent Checkpoint Response
Freiberg, R. A., Hammond, E. M., Dorie, M. J., Welford, S. M., & Giaccia, A. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.5.1598-1609.2006 · Cited by 64
Hypoxic Suppression of the Cell Cycle GeneCDC25Ain Tumor Cells
Hammer, S., To, K. K. W., Yoo, Y., Koshiji, M., & Huang, E. L. (2007) · Cell Cycle · doi:10.4161/cc.6.15.4515 · Cited by 60
The prediction of human tumor radiosensitivity in situ: An approach using chromosome aberrations detected by fluorescence in situ hybridization
Brown, J. M., Evans, J., & Kovacs, M. S. (1992) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(92)90682-8 · Cited by 59
Phosphorylation of eIF2α is required for mRNA translation inhibition and survival during moderate hypoxia
Koritzinsky, M., Rouschop, K. M. A., van den Beucken, T., Magagnin, M. G., Savelkouls, K. G. M., Lambin, P., & Wouters, B. G. (2007) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2007.04.031 · Cited by 55
Microenvironmental influences on mutagenesis in mammary epithelial cells
Papp-Szabó, E., Josephy, P. D., & Coomber, B. L. (2005) · International Journal of Cancer · doi:10.1002/ijc.21088 · Cited by 47
Radiation-Induced DNA Damage in Tumors and Normal Tissues. III. Oxygen Dependence of the Formation of Strand Breaks and DNA-Protein Crosslinks
Zhang, H., Koch, C. J., Wallen, C. A., & Wheeler, K. T. (1995) · Radiation Research · doi:10.2307/3579024 · Cited by 45
ERCC1/ERCC4 5-endonuclease activity as a determinant of hypoxic cell radiosensitivity
MURRAY, D. (1996) · International Journal of Radiation Biology · doi:10.1080/095530096145878 · Cited by 43
Thein VitroSensitivity of Chronically Hypoxic EMT6/SF Cells to X-radiation and Hypoxic Cell Radiosensitizers
Shrieve, D. C., & Harris, J. (1985) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008514551131 · Cited by 39
Rapid effects of acute anoxia on spindle kinetochore interactions activate the mitotic spindle checkpoint
Pandey, R. K., Heeger, S., & Lehner, C. F. (2007) · Journal of Cell Science · doi:10.1242/jcs.007690 · Cited by 37
Genetic susceptibility and oxidative stress in prostate cancer: Integrated model with implications for prevention
Klein, E. A., Casey, G., & Silverman, R. H. (2006) · Urology · doi:10.1016/j.urology.2006.08.1074 · Cited by 37
Cell cycle progression and radiation survival following prolonged hypoxia and re-oxygenation
Koritzinsky, M., Wouters, B. G., Åmellem, Ø., & Pettersen, E. O. (2001) · International Journal of Radiation Biology · doi:10.1080/09553000010019278 · Cited by 29
Hypoxia Enhances Metastatic Efficiency in HT1080 Fibrosarcoma Cells by Increasing Cell Survival in Lungs, Not Cell Adhesion and Invasion
Zhang, L., & Hill, R. P. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4221 · Cited by 28
Self-citation
DNA-Binding Properties of Poly(ADP-Ribose) Polymerase: A Target for Anti-Cancer Therapy
Солдатенков, В. А., & Potaman, V. N. (2004) · Current Drug Targets · doi:10.2174/1389450043345498 · Cited by 27
Sensitivity of nucleotide excision repair-deficient human cells to ionizing radiation and cyclophosphamide.
Murray, D. L., Vallee-Lucic, L., Rosenberg, E., & Andersson, B. S. (2002) · PubMed · Cited by 27
Antiangiogenesis, Anti-VEGF(R) and Outlook
Petersen, I. (2007) · Springer eBooks · doi:10.1007/978-3-540-46091-6_16 · Cited by 25
Different Oxygen Enhancement Ratios for Induced and Unrejoined DNA Double-Strand Breaks in Eukaryotic Cells
Frankenberg-Schwager, M., Frankenberg, D., & Harbich, R. (1991) · Radiation Research · doi:10.2307/3578046 · Cited by 22
Estimating DNA Repair by Sequential Evaluation of Head and Neck Tumor Radiation Sensitivity Using the Comet Assay
Terris, D. J., Ho, E. Y., Ibrahim, H. Z., Dorie, M. J., Kovacs, M. S., Le, Q., Koong, A. C., Pinto, H. A., & Brown, J. M. (2002) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.128.6.698 · Cited by 21
Effect of Dietary Vitamin E on Spontaneous or Nitric Oxide Donor-Induced Mutations in a Mouse Tumor Model
Sandhu, J. K. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.17.1429 · Cited by 19
Growth of V79 Cells as Xenograft Tumors Promotes Multicellular Resistance but does not Increase Spontaneous or Radiation-Induced Mutant Frequency
Banáth, J. P., Sinnott, L., Larrivée, B., MacPhail, S. H., & Olive, P. L. (2005) · Radiation Research · doi:10.1667/3474.1 · Cited by 10

Flagged first, then by citations

Sorted by citations

The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092
Regulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744
Targeting hypoxia in cancer therapy
Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172
Role of hypoxia in cancer therapy by regulating the tumor microenvironment
Jing, X., Yang, F., Shao, C., Wei, K., Xie, M., Shen, H., & Shu, Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1089-9 · Cited by 2,054
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
Chen, Z., Han, F., Du, Y., Shi, H., & Zhou, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01332-8 · Cited by 1,612

See all 1,140

Authors: Bristow, R. G., & Hill, R. P.
Affiliations: University Health Network (CA)
Corresponding author: Bristow, Robert G.
ORCID: Bristow, Robert G.
Hill, Richard P.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2008-03
Volume: 8
Issue: 3
Pages: 180-192
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2344
OpenAlex: W2012276721
Cited by: 1,140
References: 112
Citations by year: 2026: 29 · 2025: 60 · 2024: 44 · 2023: 51 · 2022: 75 · 2021: 86 · 2020: 70 · 2019: 70 · 2018: 78 · 2017: 66 · 2016: 54 · 2015: 50 · 2014: 63 · 2013: 66 · 2012: 73
FWCI: 4.89
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: chronic hypoxia, acute hypoxia, genomic instability, DNA repair, treatment resistance, cancer prognosis, cancer therapy design
MeSH terms: Animals, Hypoxia, DNA Damage, DNA Repair, Humans, Models, Biological, Neoplasm Metastasis, Neoplasms, Phenotype, Transcription, Genetic, Protein Biosynthesis, Gene Expression Regulation, Neoplastic, Disease Progression, Genomic Instability

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hypoxia, DNA repair and genetic instability

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks