Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069 · see citing works

Identification of the breast cancer susceptibility gene BRCA2

Wooster, R., Bignell, G. R., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S. G., Gumbs, C. E., Micklem, G., et al. (1995) · Nature · doi:10.1038/378789a0 · Cited by 3,645 · see citing works

Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.

Ford, D., Easton, D., Stratton, M. R., Narod, S., Goldgar, D., Devilee, P., Bishop, D., Weber, B., Lenoir, G., Chang-Claude, J., et al. (1998) · American Journal of Human Genetics · doi:10.1086/301749 · Cited by 2,766 · see citing works

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

Hall, J., Lee, M. K., Newman, B. M., Morrow, J. E., Anderson, L. A., Huey, B., & King, M. (1990) · Science · doi:10.1126/science.2270482 · Cited by 2,544 · see citing works

Risks of cancer in BRCA1-mutation carriers

FORD, D. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91578-4 · Cited by 1,850 · cited 1× · see citing works

Gatekeepers and caretakers

Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386761a0 · Cited by 1,240 · see citing works

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221 · see citing works

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,071 · see citing works

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

Moynahan, M. E., Pierce, A. J., & Jasin, M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00174-5 · Cited by 1,007 · see citing works

Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer.

Peto, J., Collins, N., Barfoot, R., Seal, S., Warren, W., Rahman, N., Easton, D., Evans, C., Deacon, J., & Stratton, M. R. (1999) · Journal of the National Cancer Institute · doi:10.1093/jnci/91.11.943 · Cited by 909 · see citing works

The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

Lakhani, S., van de Vijver, M., Jacquemier, J., Anderson, T., Osin, P., McGuffog, L., & Easton, D. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.09.023 · Cited by 888 · see citing works

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819 · see citing works

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

Xu, X., Wagner, K., Larson, D. M., Ohler, Z. W., Li, C., Ried, T., Hennighausen, L. G., Wynshaw-Boris, A. J., & Deng, C. (1999) · Nature Genetics · doi:10.1038/8743 · Cited by 758 · see citing works

Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein

Davies, A. A., Masson, J., McIlwraith, M. J., Stasiak, A. Z., Stasiak, A., Venkitaraman, A. R., & West, S. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00175-7 · Cited by 720 · see citing works

Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations

Lakhani, S. R., Jacquemier, J., Sloane, J. P., Gusterson, B. A., Anderson, T. J., van de Vijver, M. J., Farid, L. M., Venter, D., Antoniou, A., Storfer-Isser, A., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.15.1138 · Cited by 707 · see citing works

BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure

Yang, H., Jeffrey, P. D., Miller, J. J., Kinnucan, E., Sun, Y., Thomä, N. H., Zheng, N., Chen, P., Lee, W., & Pavletich, N. P. (2002) · Science · doi:10.1126/science.297.5588.1837 · Cited by 705 · see citing works

Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M., Blundell, T. L., & Venkitaraman, A. R. (2002) · Nature · doi:10.1038/nature01230 · Cited by 704 · see citing works

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.

Hakem, R., de la Pompa, J. L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81302-1 · Cited by 680 · see citing works

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G. E., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80276-2 · Cited by 635 · see citing works

Involvement of Brca2 in DNA Repair

Patel, K. J., Yu, V. P. C. C., Lee, H., Corcoran, A. E., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A. J., & Venkitaraman, A. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80035-0 · Cited by 631 · see citing works

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626 · see citing works

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

Bhattacharyya, A., Ear, U., Koller, B. H., Weichselbaum, R. R., & Bishop, D. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000276200 · Cited by 584 · see citing works

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

Harkin, D. P., Bean, J. M., Miklos, D. B., Song, Y., Truong, V. B., Englert, C., Christians, F. C., Ellisen, L. W., Maheswaran, S., Oliner, J. D., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80769-2 · Cited by 558 · see citing works

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 540 · see citing works

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development · doi:10.1101/gad.851000 · Cited by 512 · see citing works

BRCA1 is a component of the RNA polymerase II holoenzyme

Scully, R., Anderson, S. F., Chao, D. M., Wei, W., Ye, L., Young, R. A., Livingston, D. M., & Parvin, J. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5605 · Cited by 454 · see citing works

Mutation in Brca2 stimulates error‐prone homology‐directed repair of DNA double‐strand breaks occurring between repeated sequences

Tutt, A. N. J., Bertwistle, D., Valentine, J., Gabriel, A., Swift, S., Ross, G., Griffin, C. S., Thacker, J., & Ashworth, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4704 · Cited by 429 · see citing works

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

Wilson, C., Ramos, L., Villaseñor, M. R., Anders, K. H., Press, M. F., Clarke, K., Karlan, B. Y., Chen, J.-J., Scully, R., Livingston, D. M., et al. (1999) · Nature Genetics · doi:10.1038/6029 · Cited by 414 · see citing works

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

Chen, P., Chen, C., Chen, Y., Xiao, J., Sharp, Z. D., & Lee, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5287 · Cited by 394 · see citing works

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

Anderson, S. F., Schlegel, B. P., Nakajima, T., Wolpin, E. S., & Parvin, J. D. (1998) · Nature Genetics · doi:10.1038/930 · Cited by 393 · see citing works

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80238-5 · Cited by 359 · see citing works

Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivationPreprint

Yu, V. P. C. C., Koehler, M., Steinlein, C., Schmid, M., Hanakahi, L. A., van Gool, A. J., West, S. C., & Venkitaraman, A. R. (2000) · Genes & Development · doi:10.1101/gad.14.11.1400 · Cited by 321 · see citing works

Brca2 is required for embryonic cellular proliferation in the mouse.Preprint

Suzuki, A., de la Pompa, J. L., Hakem, R., Elia, A., Yoshida, R., Mo, R., Nishina, H., Chuang, T., Wakeham, A. C., Itié, A., et al. (1997) · Genes & Development · doi:10.1101/gad.11.10.1242 · Cited by 287 · see citing works

Direct DNA binding by Brca1

Paull, T. T., Cortez, D., Bowers, B., Elledge, S. J., & Gellert, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111125998 · Cited by 282 · see citing works

Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions

der Zwet, M. K.-V., Overkamp, W. J., van Lange, R. E. E., Essers, J., van Duijn-Goedhart, A., Wiggers, I., Swaminathan, S., van Buul, P. V., Errami, A., Tan, R., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.2.669-679.2002 · Cited by 267 · see citing works

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

Xia, F., Taghian, D. G., DeFrank, J. S., Zeng, Z., Willers, H., Iliakis, G. E., & Powell, S. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151253498 · Cited by 263 · see citing works

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

Baer, R. J. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00269-6 · Cited by 261 · see citing works

BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression

MacLachlan, T. K., Somasundaram, K., Sgagias, M. K., Shifman, Y., Muschel, R. J., Cowan, K. H., & El‐Deiry, W. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2777 · Cited by 212 · see citing works

Expression of BRC Repeats in Breast Cancer Cells Disrupts the BRCA2-Rad51 Complex and Leads to Radiation Hypersensitivity and Loss of G2/M Checkpoint Control

Chen, C.-F., Chen, P.-L., Zhong, Q., Sharp, Z. D., & Lee, W.-H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32931 · Cited by 207 · see citing works

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

Snouwaert, J. N., Gowen, L. C., Latour, A. M., Mohn, A. R., Xiao, A., DiBiase, L., & Koller, B. H. (1999) · Oncogene · doi:10.1038/sj.onc.1203334 · Cited by 197 · see citing works

Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage

Li, S., Chen, P., Subramanian, T., Chinnadurai, G., Tomlinson, G. E., Osborne, C. K., Sharp, Z. D., & Lee, W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.11334 · Cited by 192 · see citing works

Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites

Gatei, M. H., Zhou, B. S., Hobson, K., Scott, S. P., Young, D., & Khanna, K. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011681200 · Cited by 189 · see citing works

p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

Crook, T., Brooks, L. A., Crossland, S., Osin, P., Barker, K. T., Waller, J., Philp, E., Smith, P. D., Yuluğ, I. G., Peto, J., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1202106 · Cited by 179 · see citing works

p53 mutations in BRCA1-associated familial breast cancer

Crook, T., Crossland, S., Crompton, M. R., Osin, P., & Gusterson, B. A. (1997) · The Lancet · doi:10.1016/s0140-6736(05)63327-2 · Cited by 179 · see citing works

Chromosomal Double-Strand Breaks Induce Gene Conversion at High Frequency in Mammalian Cells

Taghian, D. G., & Nickoloff, J. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6386 · Cited by 172 · see citing works

BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines

Thangaraju, M., Kaufmann, S. H., & Couch, F. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005824200 · Cited by 149 · see citing works

A Human BRCA2 Complex Containing a Structural DNA Binding Component Influences Cell Cycle Progression

Marmorstein, L. Y., Kinev, A. V., Chan, G. K. T., Bochar, D. A., Beniya, H., Epstein, J. A., Yen, T. J., & Shiekhattar, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00209-4 · Cited by 147 · see citing works

Environmental signals and cell fate specification in premigratory neural crest

Dorsky, R. I., Moon, R. T., & Raible, D. W. (2000) · BioEssays · doi:10.1002/1521-1878(200008)22:8 · Cited by 111 · see citing works

Coping with replication ‘train wrecks’ in Escherichia coli using Pol V, Pol II and RecA proteins

Goodman, M. F. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01564-4 · Cited by 107 · see citing works

The Expanding Role of Cell Cycle Regulators

Jacks, T., & Weinberg, R. A. (1998) · Science · doi:10.1126/science.280.5366.1035 · Cited by 103 · see citing works

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions

Smith, P. D., Crossland, S., Parker, G. A., Osin, P., Brooks, L. A., Waller, J., Philp, E., Crompton, M. R., Gusterson, B. A., Allday, M. J., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202565 · Cited by 101 · see citing works

The Fuss about Mus81

Haber, J. E., & Heyer, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00593-1 · Cited by 97 · see citing works

Developmental Studies of Brca1 and Brca2 Knock-Out Mice

Hakem, R., de la Pompa, J. L., & Mak, T. W. (1998) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1018792200700 · Cited by 91 · see citing works

Activation of Transcription in Vitro by the BRCA1 Carboxyl-terminal Domain

Haile, D. T., & Parvin, J. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2113 · Cited by 81 · see citing works

A Derivative of an Ataxia-telangiectasia (A-T) Cell Line with Normal Radiosensitivity but A-T-like Inhibition of DNA Synthesis

Lehmann, A. R., Arlett, C. F., Burke, J. F., Green, M. H. L., James, M. R., & Lowe, J. E. (1985) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008514552881 · Cited by 67 · see citing works

BRCA1 signals ARF-dependent stabilization and coactivation of p53

Somasundaram, K., MacLachlan, T. K., Burns, T. F., Sgagias, M. K., Cowan, K. H., Weber, B. L., & El‐Deiry, W. S. (1999) · Oncogene · doi:10.1038/sj.onc.1203284 · Cited by 66 · see citing works

BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10α in activated transcription

Schlegel, B. P., Green, V. J., Ladias, J. A. A., & Parvin, J. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3148 · Cited by 63 · see citing works

BRCA2 Keeps Rad51 in Line

Powell, S. N., Willers, H., & Xia, F. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00789-x · Cited by 48 · see citing works

BRCA1 and BRCA2 - breast cancer susceptibility genes

Hofmann, W., & Schlag, P. M. (2000) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s004320000140 · Cited by 43 · see citing works

BRCA1 at a branch point

Parvin, J. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121184998 · Cited by 36 · see citing works

The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase

Milner, J., Fuks, F., Hughes‐Davies, L., & Kouzarides, T. (2000) · Oncogene · doi:10.1038/sj.onc.1203793 · Cited by 25 · see citing works

Independence of R/M/N Focus Formation and the Presence of Intact BRCA1

Wu, X., Petrini, J. H. J., Heine, W. F., Weaver, D. T., Livingston, D. M., & Chen, J. (2000) · Science · doi:10.1126/science.289.5476.11 · Cited by 22 · see citing works

Involvement ofBRCA1 andBRCA2 in breast cancer in a western Finnish sub-population

P��kk�nen, K., Sauramo, S., Sarantaus, L., Vahteristo, P., Hartikainen, A., Vehmanen, P., Ignatius, J., Ollikainen, V., K��ri�inen, H., Vauramo, E., et al. (2001) · Genetic Epidemiology · doi:10.1002/1098-2272(200102)20:2 · Cited by 11 · see citing works

Hypoxia, DNA repair and genetic instability

Bristow, R. G., & Hill, R. P. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2344 · Cited by 1,140 · see citing works

Role of cell cycle in mediating sensitivity to radiotherapy

Pawlik, T. M., & Keyomarsi, K. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.03.005 · Cited by 1,101 · see citing works

Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

Murr, R., Loizou, J. I., Yang, Y.-G., Cuenin, C., Li, H., Wang, Z.-Q., & Herceg, Z. (2006) · Nature Cell Biology · doi:10.1038/ncb1343 · Cited by 613 · see citing works

Ionizing Radiation-Induced DNA Damage, Response, and Repair

Santivasi, W. L., & Xia, F. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5668 · Cited by 603 · see citing works

Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

Orth, M., Metzger, P., Gerum, S., Mayerle, J. V., Schneider, G., Belka, C., Schnurr, M., & Lauber, K. (2019) · Radiation Oncology · doi:10.1186/s13014-019-1345-6 · Cited by 488 · see citing works

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

Kurz, E. U., & Lees‐Miller, S. P. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.029 · Cited by 478 · see citing works

Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

Burma, S., Chen, B. P. C., & Chen, D. J. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.026 · Cited by 423 · see citing works

GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability

Hu, W. L., Jin, L., Xu, A., Wang, Y. F., Thorne, R. F., Zhang, X. D., & Wu, M. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0066-7 · Cited by 348 · see citing works

Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance

Chan, N. H. L., Koritzinsky, M., Zhao, H. W., Bindra, R. S., Glazer, P. M., Powell, S. N., Belmaaza, A., Wouters, B. G., & Bristow, R. G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5472 · Cited by 328 · see citing works

Breast Cancer Screening for Women at Higher-Than-Average Risk: Updated Recommendations From the ACR

Monticciolo, D. L., Newell, M. S., Moy, L. P., Lee, C. S., & Destounis, S. V. (2023) · Journal of the American College of Radiology · doi:10.1016/j.jacr.2023.04.002 · Cited by 297 · see citing works

Splice variants as cancer biomarkers

Brinkman, B. M. N. (2004) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.05.015 · Cited by 265 · see citing works

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

Clapperton, J. A., Manke, I. A., Lowery, D. M., Ho, T., Haire, L. F., Yaffe, M. B., & Smerdon, S. J. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb775 · Cited by 243 · see citing works

Biomarkers of platinum resistance in ovarian cancer: what can we use to improve treatment

van Zyl, B., Tang, D., & Bowden, N. A. (2018) · Endocrine Related Cancer · doi:10.1530/erc-17-0336 · Cited by 228 · see citing works

Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK)

Pijpe, A., Andrieu, N., Easton, D., Kesminiene, A., Cardis, E., Noguès, C., Gauthier‐Villars, M., Lasset, C., Fricker, J., Peock, S., et al. (2012) · BMJ · doi:10.1136/bmj.e5660 · Cited by 228 · see citing works

Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy

Samstein, R. M., Krishna, C., Ma, X., Pei, X., Lee, K.-W., Makarov, V., Kuo, F., Chung, J., Srivastava, R. M., Purohit, T. A., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-00139-8 · Cited by 219 · see citing works

Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant

Hua, G., Thin, T. H., Feldman, R., Haimovitz‐Friedman, A., Clevers, H. C., FUKS, Z. Y., & Kolesnick, R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.106 · Cited by 206 · see citing works

Molecular and Cellular Pharmacology of the Hypoxia-Activated Prodrug TH-302

Meng, F., Evans, J., Bhupathi, D., Banica, M., Lan, L., Lorente, G., Duan, J.-X., Cai, X., Mowday, A. M., Guise, C. P., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0634 · Cited by 205 · see citing works

The molecular pathology of hereditary breast cancer: genetic testing and therapeutic implications

Honrado, E., Benitez, J. J., & Palacios, J. (2005) · Modern Pathology · doi:10.1038/modpathol.3800453 · Cited by 190 · see citing works

The biology of DHX9 and its potential as a therapeutic target

Lee, T., & Pelletier, J. (2016) · Oncotarget · doi:10.18632/oncotarget.8446 · Cited by 190 · see citing works

Effect of Chest X-Rays on the Risk of Breast Cancer Among BRCA1/2 Mutation Carriers in the International BRCA1/2 Carrier Cohort Study: A Report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators’ Group

Andrieu, N., Easton, D. F., Chang-Claude, J. C., Rookus, M. A., Brohet, R. M., Cardis, E., Antoniou, A. C., Wagner, T. M. U., Simard, J., Evans, D. G., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.3126 · Cited by 188 · see citing works

DNA damage response – A double-edged sword in cancer prevention and cancer therapy

Tian, H., Gao, Z., Li, H., Zhang, B., Wang, G., Zhang, Q., Pei, D., & Zheng, J. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.12.038 · Cited by 186 · see citing works

Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention

Vietri, M. T., D’Elia, G., Caliendo, G., Resse, M., Casamassimi, A., Passariello, L., Albanese, L., Cioffi, M., & Molinari, A. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073753 · Cited by 171 · see citing works

Role of BRCA Mutations in the Modulation of Response to Platinum Therapy

Mylavarapu, S., Das, A., & Roy, M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00016 · Cited by 172 · see citing works

Review and evaluation of updated research on the health effects associated with low-dose ionising radiation

Dauer, L. T., Brooks, A. L., Hoel, D. G., Morgan, W. F., Stram, D. O., & Tran, P. (2010) · Radiation Protection Dosimetry · doi:10.1093/rpd/ncq141 · Cited by 160 · see citing works

Poly(ADP-Ribose) Polymerase Inhibition: “Targeted” Therapy for Triple-Negative Breast Cancer

Anders, C. K., Winer, E. P., Ford, J. M., Dent, R. A., Silver, D. P., Sledge, G. W., & Carey, L. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0939 · Cited by 154 · see citing works

Repair of radiation damage to DNA

Willers, H., Dahm‐Daphi, J., & Powell, S. N. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601729 · Cited by 152 · see citing works

Epigenetic changes and nontargeted radiation effects—Is there a link?

Kovalchuk, O., & Baulch, J. E. (2008) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20361 · Cited by 144 · see citing works

ATM regulates target switching to escalating doses of radiation in the intestines

Ch'ang, H.-J., Maj, J. G., Paris, F., Xing, H. R., Zhang, J. J., Truman, J., Cardon‐Cardo, C., Haimovitz‐Friedman, A., Kolesnick, R., & FUKS, Z. Y. (2005) · Nature Medicine · doi:10.1038/nm1237 · Cited by 139 · see citing works

Women at high risk of breast cancer: Molecular characteristics, clinical presentation and management

Kleibl, Z., & Kristensen, V. N. (2016) · The Breast · doi:10.1016/j.breast.2016.05.006 · Cited by 137 · see citing works

BRCA2 BRC motifs bind RAD51–DNA filaments

Galkin, V. E., Esashi, F., Yu, X., Yang, S., West, S. C., & Egelman, E. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407266102 · Cited by 139 · see citing works

The interplay between DNA repair and autophagy in cancer therapy

Zhang, D., Tang, B., Xie, X., Xiao, Y., Yang, S., & Zhang, J. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1046022 · Cited by 131 · see citing works

Risk of breast cancer recurrence and contralateral breast cancer in relation to BRCA1 and BRCA2 mutation status following breast-conserving surgery and radiotherapy

Kirova, Y. M., Stoppa-Lyonnet, D., Savignoni, A., Sigal-Zafrani, B., Fabre, N., & Fourquet, A. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.02.037 · Cited by 129 · see citing works

PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells

Yin, L., Liu, Y., Peng, Y., Peng, Y., Yu, X., Gao, Y., Yuan, B., Zhu, Q., Cao, T., He, L., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0810-7 · Cited by 127 · see citing works

Breast Cancer Risk and the DNA Double-Strand Break End-Joining Capacity of Nonhomologous End-Joining Genes Are Affected by BRCA1

Bau, D., Fu, Y., Chen, S.-T., Cheng, T., Yu, J.-C., Wu, P.-E., & Shen, C. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0403 · Cited by 126 · see citing works

Ubiquitination and Proteasomal Degradation of the BRCA1 Tumor Suppressor Is Regulated during Cell Cycle Progression

Choudhury, A. D., Xu, H., & Baer, R. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403646200 · Cited by 123 · see citing works

Autoantibodies in breast cancer sera: candidate biomarkers and reporters of tumorigenesis

Fernández-Madrid, F. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.12.017 · Cited by 120 · see citing works

Inhibitors of PARP: Number crunching and structure gazing

Rudolph, J., Jung, K., & Luger, K. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121979119 · Cited by 118 · see citing works

Contribution of mammography to MRI screening in BRCA mutation carriers by BRCA status and age: individual patient data meta-analysis

Phi, X.-A., Saadatmand, S., de Bock, G. H., Warner, E., Sardanelli, F., Leach, M. O., Riedl, C. C., Trop, I., Hooning, M. J., Mandel, R., et al. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.32 · Cited by 116 · see citing works

Assembly of checkpoint and repair machineries at DNA damage sites

Huen, M. S. Y., & Chen, J. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.09.001 · Cited by 116 · see citing works

Utility of DNA Repair Protein Foci for the Detection of Putative BRCA1 Pathway Defects in Breast Cancer Biopsies

Willers, H., Taghian, A. G., Luo, C., Treszezamsky, A. D., Sgroi, D. C., & Powell, S. N. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0149 · Cited by 110 · see citing works

BRCA1- and BRCA2-Deficient Cells Are Sensitive to Etoposide-Induced DNA Double-Strand Breaks via Topoisomerase II

Treszezamsky, A. D., Kachnic, L. A., Feng, Z., Zhang, J., Tokadjian, C., & Powell, S. N. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0601 · Cited by 109 · see citing works

Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivo

Sinha, S., Pal, K., Elkhanany, A. M., Dutta, S. K., Cao, Y., Mondal, G., Iyer, S. R., Somasundaram, V., Couch, F. J., Shridhar, V., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27724 · Cited by 108 · see citing works

Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins

Campos, A., & Clemente‐Blanco, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020446 · Cited by 106 · see citing works

Minding the gap: The underground functions of BRCA1 and BRCA2 at stalled replication forks

Nagaraju, G., & Scully, R. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.020 · Cited by 103 · see citing works

Is the breast-conserving treatment with radiotherapy appropriate in BRCA1/2 mutation carriers? Long-term results and review of the literature

Kirova, Y. M., Savignoni, A., Sigal-Zafrani, B., de La Rochefordiere, A., Salmon, R. J., This, P., Asselain, B., Stoppa-Lyonnet, D., & Fourquet, A. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0685-6 · Cited by 102 · see citing works

The evolution of meiosis: Recruitment and modification of somatic DNA-repair proteins

Marcon, E., & Møens, P. B. (2005) · BioEssays · doi:10.1002/bies.20264 · Cited by 103 · see citing works

Inhibition of ATR Leads to Increased Sensitivity to Hypoxia/Reoxygenation

Hammond, E. M., Dorie, M. J., & Giaccia, A. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1520 · Cited by 101 · see citing works

Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End Joining

Liu, Q., Ma, L., Jones, T., Palomero, L., Pujana, M. Á., Martinez‐Ruiz, H., Ha, P. K., Murnane, J. P., Cuartas, I., Seoane, J., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1346 · Cited by 99 · see citing works

The mTOR Inhibitor Rapamycin Suppresses DNA Double-Strand Break Repair

Chen, H., Ma, Z., Vanderwaal, R. P., Feng, Z., González-Suárez, I., Wang, S., Zhang, J., Roti, J. L. R., Gonzalo, S., & Zhang, J. (2010) · Radiation Research · doi:10.1667/rr2323.1 · Cited by 97 · see citing works

The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy

Li, M., & Yu, X. (2014) · Oncogene · doi:10.1038/onc.2014.295 · Cited by 96 · see citing works

Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase

Gravells, P., Grant, E. K., Smith, K. M., James, D. I., & Bryant, H. E. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.02.010 · Cited by 96 · see citing works

Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer

Agalliu, I., Karlins, E., Kwon, E. M., Iwasaki, L. M., Diamond, A. G., Ostrander, E. A., & Stanford, J. L. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603929 · Cited by 95 · see citing works

Fanconi Anemia Proteins Are Required To Prevent Accumulation of Replication-Associated DNA Double-Strand Breaks

Sobeck, A., Stone, S., Costanzo, V., de Graaf, B., Reuter, T., de Winter, J. P., Wallisch, M., Akkari, Y. M. N., Olson, S. B., Wang, W., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.2.425-437.2006 · Cited by 92 · see citing works

Attenuated DNA Damage Repair by Trichostatin A through BRCA1 Suppression

Zhang, Y., Carr, T., Dimtchev, A., Zaer, N., Dritschilo, A., & Jung, M. (2007) · Radiation Research · doi:10.1667/rr0811.1 · Cited by 93 · see citing works

BET proteins: Biological functions and therapeutic interventions

Guo, J., Zheng, Q., & Peng, Y. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108354 · Cited by 91 · see citing works

Epigenetics in radiation biology: a new research frontier

Merrifield, M., & Kovalchuk, O. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00040 · Cited by 91 · see citing works

DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development

Ichijima, Y., Yoshioka, K., Yoshioka, Y., Shinohe, K., Fujimori, H., Unno, J., Takagi, M., Goto, H., Inagaki, M., Mizutani, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008821 · Cited by 79 · see citing works

BRCA1 tumor suppressor network: focusing on its tail

Wang, B. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-6 · Cited by 78 · see citing works

Imaging and Oncologic Drug Development

El‐Deiry, W. S., Sigman, C. C., & Kelloff, G. J. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.5623 · Cited by 78 · see citing works

Good Timing in the Cell Cycle for Precise DNA Repair by BRCA1

Durant, S. T., & Nickoloff, J. A. (2005) · Cell Cycle · doi:10.4161/cc.4.9.2027 · Cited by 77 · see citing works

Hydrocortisone down‐regulates the tumor suppressor gene BRCA1 in mammary cells: A possible molecular link between stress and breast cancer

Antonova, L., & Mueller, C. R. (2008) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20538 · Cited by 75 · see citing works

Breast cancer intratumor genetic heterogeneity: causes and implications

Ng, C. K. Y., Pemberton, H. N., & Reis-Filho, J. S. (2012) · Expert Review of Anticancer Therapy · doi:10.1586/era.12.85 · Cited by 74 · see citing works

The role of p53-mediated apoptosis as a crucial anti-tumor response to genomic instability: lessons from mouse models

Attardi, L. D. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.04.019 · Cited by 73 · see citing works

The S phase checkpoint: When the crowd meets at the fork

Gottifredi, V., & Prives, C. L. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.02.011 · Cited by 68 · see citing works

Homologous Recombination Is the Principal Pathway for the Repair of DNA Damage Induced by Tirapazamine in Mammalian Cells

Evans, J., Chernikova, S. B., Kachnic, L. A., Banáth, J. P., Sordet, O., Delahoussaye, Y. M., Treszezamsky, A. D., Chon, B. H., Feng, Z., Gu, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-06-4497 · Cited by 68 · see citing works

The Rad51/RadA N-Terminal Domain Activates Nucleoprotein Filament ATPase Activity

Galkin, V. E., Wu, Y., Zhang, X., Qian, X., He, Y., Yu, X., Heyer, W., Luo, Y., & Egelman, E. H. (2006) · Structure · doi:10.1016/j.str.2006.04.001 · Cited by 67 · see citing works

Association of abnormal morphology and altered gene expression in human preimplantation embryos

Wells, D., García-Bermúdez, M., Steuerwald, N., Malter, H. E., Thornhill, A. R., & Cohen, J. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.01.143 · Cited by 67 · see citing works

Tumor Cells Require Thymidylate Kinase to Prevent dUTP Incorporation during DNA Repair

Hu, C.-M., Yeh, M.-T., Tsao, N., Chen, C., Gao, Q.-Z., Chang, C.-Y., Lee, M.-H., Fang, J., Sheu, S., Lin, C.-J., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.038 · Cited by 65 · see citing works

Effect of Mammography on Breast Cancer Risk in Women with Mutations in BRCA1 or BRCA2

Goldfrank, D. J., Chuai, S., Bernstein, J. L., y Cajal, T. R., Lee, J. B., Alonso, M. C., Dı́ez, O., Baiget, M., Kauff, N. D., Offit, K., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0176 · Cited by 64 · see citing works

A Decade of Advances in Treatment for Advanced Non–Small Cell Lung Cancer

Gettinger, S. N., & Lynch, T. J. (2011) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2011.08.017 · Cited by 63 · see citing works

C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis

Bergman, L., & Blaydes, J. P. (2006) · APOPTOSIS · doi:10.1007/s10495-006-6651-4 · Cited by 62 · see citing works

The ?portrait? of hereditary breast cancer

Lacroix, M., & Leclercq, G. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-004-2172-4 · Cited by 62 · see citing works

Hereditary breast cancer: From molecular pathology to tailored therapies

Tan, D. S. P., Marchiò, C., & Reis-Filho, J. S. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2008.057950 · Cited by 60 · see citing works

PRMT2 and RORγ Expression Are Associated With Breast Cancer Survival Outcomes

Oh, T. G., Bailey, P. J., Dray, E. V., Smith, A. G., Goode, J. M., Eriksson, N. A., Funder, J. W., Fuller, P. J., Simpson, E. R., Tilley, W. D., et al. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1403 · Cited by 60 · see citing works

Presynaptic filament dynamics in homologous recombination and DNA repair

Liu, J., Ehmsen, K. T., Heyer, W., & Morrical, S. W. (2011) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2011.576007 · Cited by 59 · see citing works

Histone acetylation dynamics in repair of DNA double-strand breaks

Aricthota, S., Rana, P. P., & Haldar, D. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.926577 · Cited by 59 · see citing works

BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication

Fridlich, R., Annamalai, D., Roy, R., Bernheim, G., & Powell, S. N. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.03.002 · Cited by 59 · see citing works

Common variation in BRCA2 and breast cancer risk: a haplotype-based analysis in the Multiethnic Cohort

Freedman, M. L., Penney, K. L., Stram, D. O., Marchand, L. L., Hirschhorn, J. N., Kolonel, L. N., Altshuler, D., Henderson, B. E., & Haiman, C. A. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh270 · Cited by 59 · see citing works

Efficient Deletion of Normal Brca2-Deficient Intestinal Epithelium by Poly(ADP-Ribose) Polymerase Inhibition Models Potential Prophylactic Therapy

Hay, T., Jenkins, H., Sansom, O. J., Martin, N. M. B., Smith, G. C. M., & Clarke, A. R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1186 · Cited by 59 · see citing works

Tumor oxygenation and cancer therapy—then and now

Hughes, V. S., Wiggins, J. M., & Siemann, D. W. (2018) · British Journal of Radiology · doi:10.1259/bjr.20170955 · Cited by 59 · see citing works

Multiomics analyses reveal DARS1-AS1 /YBX1–controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance

Zheng, C., Wei, Y., Zhang, Q., Sun, M., Wang, Y., Hou, J., Zhang, P., Lv, X., Su, D., Jiang, Y., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf3984 · Cited by 57 · see citing works

Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

Britto, J. S. J., Guan, X., Tran, T. K. A., Lei, Z., Bahadur, R., Patel, V., Zhang, X., Wong, S. L., & Vinu, A. (2024) · Small Science · doi:10.1002/smsc.202300221 · Cited by 57 · see citing works

The UBXN1 Protein Associates with Autoubiquitinated Forms of the BRCA1 Tumor Suppressor and Inhibits Its Enzymatic Function

Wu-Baer, F., Ludwig, T., & Baer, R. J. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01056-09 · Cited by 57 · see citing works

DNA double-strand breaks induced by mammographic screening procedures in human mammary epithelial cells

Colin, C., Devic, C., Noël, A., Rabilloud, M., Zabot, M. T., Isaac, S., Giraud, S., Riche, B., Valette, P., Rodriguez‐Lafrasse, C., et al. (2011) · International Journal of Radiation Biology · doi:10.3109/09553002.2011.608410 · Cited by 57 · see citing works

Saccharomyces cerevisiae as a Model System To Define the Chromosomal Instability Phenotype

Putnam, C. D., Pennaneach, V., & Kolodner, R. D. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7226-7238.2005 · Cited by 55 · see citing works

Recombination rate plasticity: revealing mechanisms by design

Stevison, L. S., Sefick, S. A., Rushton, C., & Graze, R. M. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0459 · Cited by 53 · see citing works

Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches

Şahin, İ. H., Lowery, M. A., Stadler, Z. K., Salo‐Mullen, E. E., Iacobuzio–Donahue, C. A., Kelsen, D. P., & O'Reilly, E. M. (2016) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2016.1153424 · Cited by 52 · see citing works

The genetic prediction of risk for gynecologic cancers

Randall, L. M., & Pothuri, B. (2016) · Gynecologic Oncology · doi:10.1016/j.ygyno.2016.03.007 · Cited by 51 · see citing works

Screening BRCA1 and BRCA2 Mutation Carriers for Breast Cancer

Warner, E. (2018) · Cancers · doi:10.3390/cancers10120477 · Cited by 51 · see citing works

DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders

Provasek, V. E., Mitra, J., Malojirao, V. H., & Hegde, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094653 · Cited by 51 · see citing works

Cancer predisposition genes: molecular mechanisms and clinical impact on personalized cancer care: examples of Lynch and HBOC syndromes

Wang, Q. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.89 · Cited by 51 · see citing works

The value of adjuvant radiotherapy on survival and recurrence in triple-negative breast cancer: A systematic review and meta-analysis of 5507 patients

O’Rorke, M. A., Murray, L., Brand, J. S., & Bhoo‐Pathy, N. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.05.001 · Cited by 48 · see citing works

Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation

Kim, S., Jin, H. K., Seo, H. R., Lee, H. J., & Lee, Y. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0153-0 · Cited by 46 · see citing works

The Epstein-Barr Virus Replication Protein BBLF2/3 Provides an Origin-Tethering Function through Interaction with the Zinc Finger DNA Binding Protein ZBRK1 and the KAP-1 Corepressor

Liao, G., Huang, J., Fixman, E. D., & Hayward, S. D. (2004) · Journal of Virology · doi:10.1128/jvi.79.1.245-256.2005 · Cited by 46 · see citing works

Gastric Cancer Risk and Pathogenesis in BRCA1 and BRCA2 Carriers

Buckley, K. H., Niccum, B. A., Maxwell, K. N., & Katona, B. (2022) · Cancers · doi:10.3390/cancers14235953 · Cited by 41 · see citing works

Dss1 Interaction with Brh2 as a Regulatory Mechanism for Recombinational Repair

Zhou, Q., Kojić, M., Cao, Z., Lisby, M., Mazloum, N. A., & Holloman, W. K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01907-06 · Cited by 45 · see citing works

Misrepair in Context: TGFβ Regulation of DNA Repair

Liu, Q., Lopez, K. A. P., Murnane, J. P., Humphrey, T. C., & Barcellos‐Hoff, M. H. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00799 · Cited by 45 · see citing works

Roles of BCCIP in chromosome stability and cytokinesis

Meng, X., Fan, J., & Shen, Z. (2007) · Oncogene · doi:10.1038/sj.onc.1210460 · Cited by 45 · see citing works

Inhibition of PKM2 Enhances Sensitivity of Olaparib to Ovarian Cancer Cells and Induces DNA Damage

Zhou, S., Li, D., Xiao, D., Wu, T., Hu, X., Zhang, Y., Deng, J., Long, J., Xu, S., Wu, J., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.62947 · Cited by 43 · see citing works

DNA Damage Response and Repair: Insights Into Strategies for Radiation Sensitization of Gliomas

Kesari, S., Advani, S. J., Lawson, J. D., Kahle, K. T., Ng, K., Carter, B. S., & Chen, C. C. (2011) · Future Oncology · doi:10.2217/fon.11.111 · Cited by 40 · see citing works

Therapeutic Exploitation of Tumor Cell Defects in Homologous Recombination

Powell, S. N., & Kachnic, L. A. (2008) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152008784220267 · Cited by 49 · see citing works

Abstract SY28-02: Connections in the BRCA1-BRCA2 pathway of homologous recombination: Implications for breast cancer development and treatment

Powell, S. N. (2010) · Cancer Research · doi:10.1158/1538-7445.am10-sy28-02

Breast cancer cells with deficiencies in BRCA1/BRCA2 show hypersensitivity to mitomycin C

Powell, S. N., Xia, F., Zhang, J., & Feng, Z. (2002) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)03146-2 · Cited by 3 · see citing works

Progress of BRCA1 in radiation induced breast carcinoma

Liu, W. (2006) · Zhonghua zhongliu fangzhi zazhi

Homologous repair of DNA damage and tumorigenesis:the BRCA connection

Jasin, M. (2002) · Oncogene · doi:10.1038/sj.onc.1206176 · Cited by 356 · see citing works