Cited by 559Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in CancerCancer Cells and Metastasis

Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies

Shannon, Aoife M, Bouchier-Hayes, David J, Condron, Claire M, Toomey, Deirdre·2003·Cancer Treatment Reviews

Abstract

Tissue hypoxia occurs where there is an imbalance between oxygen supply and consumption. Hypoxia occurs in solid tumours as a result of an inadequate supply of oxygen, due to exponential cellular proliferation and an inefficient vascular supply. It is an adverse prognostic indicator in cancer as it is associated with tumour progression and resistance to therapy. The expression of several genes controlling tumour cell survival are regulated by hypoxia, e.g., growth factors governing the formation of new blood vessels, and hypoxia-responsive transcription factors modulating the expression of genes, which promote tumour cell survival. This review outlines some of the pathways by which tumour hypoxia leads to chemotherapeutic resistance, directly due to lack of oxygen availability, and indirectly due to alterations in the proteome/genome, angiogenesis and pH changes. Some innovative therapies are also detailed which may potentially minimise or eliminate these problems associated with targeting solid tumours.

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Registry

Crossref · 10.1016/s0305-7372(03)00003-3

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119 of 119 references verified0 citation errors · 0 not checkable

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Authors
Shannon, A. M., Bouchier-Hayes, D. J., Condron, C. M., & Toomey, D.
Affiliations
Royal College of Surgeons in Ireland (IE)
Corresponding author
Toomey, Deirdre
Venue
Cancer Treatment Reviews
Publisher
Elsevier BV
Published
2003-08
Volume
29
Issue
4
Pages
297-307
ISSN
0305-7372 (ISSN-L)
OpenAlex
W2112645200
Cited by
559
References
119
Citations by year
2026: 10 · 2025: 16 · 2024: 27 · 2023: 27 · 2022: 24 · 2021: 38 · 2020: 29 · 2019: 30 · 2018: 33 · 2017: 28 · 2016: 30 · 2015: 31 · 2014: 41 · 2013: 27 · 2012: 26
FWCI
1.36
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Treatment Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
tumor hypoxia, chemoresistance, solid tumors, angiogenesis, tumor cell survival, tumor microenvironment, tumor pH, hypoxia-targeted therapy, prognostic factors
MeSH terms
Tirapazamine, Acidosis, Respiratory, Animals, Antineoplastic Agents, DNA-Binding Proteins, Humans, Hydrogen-Ion Concentration, Lymphokines, Macrophages, Mutation, Neoplasms, Neovascularization, Pathologic, Nuclear Proteins, Oxygen Consumption, Risk Factors, Transcription Factors, Triazines, Genetic Therapy, Cell Hypoxia, Tumor Suppressor Protein p53, Endothelial Growth Factors, Apoptosis, Drug Resistance, Neoplasm, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit

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