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The distinctive biology of cancer in adolescents and young adults

on behalf of the Biology and Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent and Young Adult Oncology, Bleyer, Archie, Barr, Ronald, Hayes-Lattin, Brandon, Thomas, David, Ellis, Chad, Anderson, Barry·2008·Nature Reviews Cancer

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Research works printed but not linked: 57

  1. Schmidt, C. Lack of progress in teen and young adult cancers concerns researchers, prompts study. J. Natl Cancer Inst 98, 1760–1761 (2006). · doi:10.1093/jnci/djj517
  2. Closing the gap: Research and care imperatives for adolescents and young adults with cancer. A report of the Adolescent and Young Adult Oncology Progress Review Group. Department of Health and Human Services, National Institutes of Health, National Cancer Institute and the LiveStrong Young Adult Alliance. National Cancer Institute [online] , (2006). The final report from the Progress Review Group convened by the National Institutes of Health to address the challenges of adolescent and young adult oncology.
  3. Bleyer, A. Young adult oncology: The patients and their survival challenges. CA Cancer J. Clin. 57, 242–255 (2007). A recent overview of the particular issues faced by adolescents and young adults with cancer. · DOI · Paper page
  4. LiveStrong Young Adult Alliance. Closing the Gap: A Strategic Plan. Addressing the Recommendations of the Adolescent and Young Adult Progress Review Group. (Lance Armstrong Foundation, Austin 2007). The response from the Young Adult Alliance to the recommendations of the Progress Review Group, in the form of a strategic plan for implementation.
  5. Nachman, J., Masera, G. & Bleyer, A. In Cancer in Adolescents and Young Adults (eds Bleyer, A., Barr, R. D., Albritton, K. H., Phillips, M. & Siegel, S.) 83–98 (Springer Verlag, Berlin Heidelburg New York, 2007). The first textbook dealing specifically and comprehensively with the topic of cancer in adolescents and young adults. · doi:10.1007/978-3-540-68152-6_6
  6. LaQuaglia, M. P. et al. Prognostic factors and outcome in patients 21 years and under with colorectal carcinoma. J. Pediatr. Surg. 27, 1085–1089 (1992). · DOI
  7. Cotterill, S. J. et al. Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J. Clin. Oncol. 18, 3108–3114 (2000). · DOI · Paper page
  8. Scurr, M. & Judson, I. How to treat the Ewing's family of sarcomas in adult patients. Oncologist 11, 65–72 (2006). · DOI
  9. Verrill, M. W. et al. The use of paediatric chemotherapy protocols at full dose is both a rational and feasible treatment strategy in adults with Ewing's family tumours. Ann. Oncol. 8, 1099–1105 (1997). · DOI
  10. Paulussen, M. et al. Localized Ewing tumor of bone: final results of the cooperative Ewing's Sarcoma Study CESS 86. J. Clin. Oncol. 19, 1818–1829 (2001). · DOI · Paper page
  11. Grier, H. E. et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N. Engl. J. Med. 348, 694–701 (2003). · DOI · Paper page
  12. Womer, R. B., West, D. C., Krailo, M. D., Dickman, P. S. & Pawel, B. Chemotherapy intensification by interval compression in localized Ewing sarcoma family of tumors (ESFT). Proc. 13th Ann. Meeting Connective Tissue Oncol. Soc. 31 October–3 November 2008, Seattle, Washington, USA. Abstract 855.
  13. Kalapurakal, J. A. et al. Treatment outcomes in adults with favorable histologic type Wilms tumor-an update from the National Wilms Tumor Study Group. Int. J. Radiat. Oncol. Biol. Phys. 60, 1379–1384 (2004). · doi:10.1016/j.ijrobp.2004.05.057
  14. Kushner, B. H., Kramer, K., LaQuaglia, MP., Modak, S. & Cheung, N. K. Neuroblastoma in adolescents and adults: the Memorial Sloan-Kettering experience. Med. Pediatr. Oncol. 41, 508–515 (2003). · doi:10.1002/mpo.10273
  15. Ferrari, A. et al. Rhabdomyosarcoma in adults. A retrospective analysis of 171 patients treated at a single institution. Cancer 98, 571–580 (2003). · DOI · Paper page
  16. Anders, C. K. et al. Molecular signatures characterize early stage breast cancer arising in young women and have prognostic and therapeutic implications independent of ER status. J. Clin. Oncol. 25, 18S, 522a (2007). · DOI
  17. Cleator, S., Heller, W. & Coombes, R. C. Triple-negative breast cancer: therapeutic options. Lancet Oncol. 8, 235–244 (2007). · DOI · Paper page
  18. Lalloo, F. et al. BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives. Eur. J. Cancer 42, 1143–1150 (2006). · DOI · Paper page
  19. Anderson, W. F., Brinton, L. A., Chen, B. & Devesa, S. S. Qualitative age interactions (or effect modification) suggest divergent pathways for early-onset and late-onset breast cancers. J. Clin. Oncol. 25, 21036a (2007). · doi:10.1200/jco.2007.25.18_suppl.21036
  20. Rajagopalan, H., Nowak, M. A., Vogelstein, B. & Lengauer, C. The significance of unstable chromosomes in colorectal cancer. Nature Rev. Cancer 3, 695–701 (2003). · DOI · Paper page
  21. Popat, S., Hubner, R. & Houlston, R. S. Systematic review of microsatellite instability and colorectal cancer prognosis. J. Clin. Oncol. 23, 609–618 (2005). · DOI · Paper page
  22. Chiang, J. M. et al. Favorable influence of age on tumor characteristics of sporadic colorectal adenocarcinoma: patients 30 years of age or younger may be a distinct patient group. Dis. Colon Rectum 46, 904–910 (2003). · DOI
  23. Datta, R. V., LaQuaglia, M. P. & Paty, P. B. Genetic and phenotypic correlates of colorectal cancer in young patients. N. Engl. J. Med. 342, 137–138 (2000). · DOI
  24. Kam, M. H., Eu, K. W., Barben, C. P. & Seow-Choen, F. Colorectal cancer in the young: a 12-year review of patients 30 years or less. Colorectal Dis. 6, 191–194 (2004). · doi:10.1111/j.1463-1318.2004.00596.x
  25. Al-Jaberi, T. M., Yaghan, R. J., El-Heis, H. A. Colorectal cancer in young patients under 40 years of age. Comparison with old patients in a well defined Jordanian population. Saudi Med. J. 8, 871–874 (2003).
  26. Hill AD et al. Colorectal carcinoma in childhood and adolescence: A clinicopathological review. J. Clin. Oncol. 2007; 25, 5808–5814. · DOI · Paper page
  27. Ferrari A et al. Colorectal carcinoma in children and adolescents: The experience of the Istituto Nazionale Tumori of Milan, Italy. Pediatr. Blood Cancer 50, 588–593 (2008). · doi:10.1002/pbc.21220
  28. Kanerva, J. et al. Reemphasis on lymphoblast L2 morphology as a poor prognostic factor in childhood acute lymphoblastic leukemia. Med. Pediatr. Oncol. 33, 388–394 (1999). · doi:10.1002/(sici)1096-911x(199910)33:4<388::aid-mpo8>3.0.co;2-n
  29. Möricke, A. et al. Prognostic impact of age in children and adolescents with acute lymphoblastic leukemia: Data from the Trials ALL-BFM 86, 90, and 95. Klin. Pädiatr 217, 310–320 (2005). · doi:10.1055/s-2005-872515
  30. Hoelzer, D. Advances in the management of Ph-positive ALL. Clin. Adv. Hematol. Oncol. 4, 804–805 (2006).
  31. Baldus, C. D. et al. High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults. J. Clin. Oncol. 24, 4714–4720 (2006). · DOI
  32. Gutierrez, M. I., Siraj, A. K., Ibrahim, M. M., Hussain, A. & Bhatia, K. Childhood and adult ALL: differences in epigenetic lesions associated with cell cycle genes. Am. J. Hematol. 80, 158–160 (2005). · doi:10.1002/ajh.20458
  33. Stock, W. et al. Outcome of adolescents and young adults with ALL: A comparison of Children's Cancer Group and Cancer and Leukemia Group B Regimens. Blood 96, 467a (2000).
  34. Boissel, N. et al. Should adolescents with acute lymphoblastic leukemia be treated as old children or young adults? Comparison of the French FRALLE-93 and LALA-94 trials. J. Clin. Oncol. 21, 760–761 (2003). · DOI · Paper page
  35. de Bont, J. M. et al. Significant difference in outcome for adolescents with acute lymphoblastic leukemia treated on pediatric vs adult protocols in the Netherlands. Leukemia 18, 2032–2035 (2004). · DOI · Paper page
  36. Schroeder, H. et al. Prognosis of ALL in 10–20 year old patients in Denmark 1992–2001. Pediatr. Blood Cancer 45, 578a (2005).
  37. Testi, A. et al. Difference in outcome of adolescents (14–17 years) with acute lymphoblastic leukaemia (ALL) enrolled in the Italian pediatric (AIEOP) an adult (GIMEMA) multicenter treatment protocols. J. Clin. Oncol. 24, 9024a (2006). · DOI
  38. Ramanujachar, R. et al. Adolescents with acute lymphoblastic leukaemia: Outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials. Pediatr. Blood Cancer 48, 254–261 (2006). · DOI · Paper page
  39. Ramanujachar, R., Richards, S., Hann, I. & Webb, D. Adolescents with acute lymphoblastic leukaemia: Emerging from the shadow of paediatric and adult treatment protocols. Pediatr. Blood Cancer 43, 748–756 (2006). · DOI
  40. Oschlies, I. et al. Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the germinal-center type B-cell lymphomas: A clinicopathologic analysis of cases included in the German BFM (Berlin–Frankfurt–Münster) Multicenter Trial. Blood. 107, 4047–4052 (2006). · doi:10.1182/blood-2005-10-4213
  41. Hattinger, C. M. et al. Prognostic impact of chromosomal aberrations in Ewing tumours. Br. J. Cancer 86, 1763–1769 (2002). · DOI
  42. Prakash, S. et al. Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature. J. Pediatr. Hematol. Oncol. 27, 179–187 (2005). · DOI · Paper page
  43. Pappo, A. S., Helman, I. J. & Furman, W. L. Rare cancers in children: When adult tumors occur in children. ASCO 2006 Education Book (2006).
  44. Prokurat, A. et al. Transitional liver cell tumors in older children and adolescents: A novel group of aggressive hepatic tumors expressing b-catenin. Med. Pediatr. Oncol. 39, 510–518 (2002). · doi:10.1002/mpo.10177
  45. Strouse, J. J., Fears, T. R., Tucker, M. A. & Wayne, A. S. Pediatric melanoma: risk factor and survival analysis of the Surveillance, Epidemiology and End Results Database. J. Clin. Oncol. 23, 4735–4741 (2005). · DOI · Paper page
  46. Lange, J. R., Palis, B. E., Chang, D. C., Soong, S. J. & Balch, C. M. Melanoma in children and teenagers: An analysis of patients from the National Cancer Data Base. J. Clin. Oncol. 25, 1363–1368 (2007). · DOI · Paper page
  47. Liu, W. et al. Distinct clinical and pathological features are associated with the BRAFT1799A(V600E) mutation in primary melanoma. J. Invest. Dermatol. 127, 900–905 (2007). · DOI · Paper page
  48. Lu, K. et al. Prospective determination of prevalence of Lynch Syndrome in young women with endometrial cancer. J. Clin. Oncol. 25, 5158–5164 (2007). · doi:10.1200/jco.2007.10.8597
  49. Butturini, A. M. et al. Obesity and outcome in pediatric acute lymphoblastic leukemia. J. Clin. Oncol. 25, 2063–2069 (2007). · DOI · Paper page
  50. Lange, B. J. et al. Mortality in overweight and underweight children with acute myeloid leukemia. JAMA 293, 203–211 (2005). · DOI · Paper page
  51. Haim, N. et al. Full dose vincristine (without 2-mg dose limit) in the treatment of lymphomas. Cancer 73, 2515–2519 (1994). · doi:10.1002/1097-0142(19940515)73:10<2515::aid-cncr2820731011>3.0.co;2-g
  52. Roberson, J. R., Raju, S., Shelso, J., Pui, C. H. & Howard, S. C. Diabetic ketoacidosis during therapy for pediatric acute lymphoblastic leukemia. Pediatr. Blood Cancer. 11 Feb 2008 (doi:10.1002/pbc.21505). · DOI
  53. Bürger, B. et al. Osteonecrosis: a treatment related toxicity in childhood acute lymphoblastic leukemia (ALL) — experiences from trial ALL-BFM 95. Pediatr. Blood Cancer 49, 764. (2007). · doi:10.1002/pbc.21141
  54. Aricò, M. et al. Osteonecrosis: an emerging complication of intensive chemotherapy for childhood acute lymphoblastic leukemia. Haematologica 88, 747–753 (2003).
  55. Juergens, C et al. Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO.-E.W.I.N.G. 99 clinical trial. Pediatr. Blood Cancer 47, 22–29 (2006). · DOI · Paper page
  56. Bleyer, A., Budd, T. & Montello, M. Adolescents and young adults with cancer: The scope of the problem and criticality of clinical trials. Cancer 107 (Suppl. 7), 1645–1655 (2006). · DOI · Paper page
  57. Barr, R. D., Holowaty, E. J., Birch, J. M. Classification schemes for tumors diagnosed in adolescents and young adults. Cancer 106, 1425–1430 (2006). · DOI

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Metadata

Authors
on behalf of the Biology and Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent and Young Adult Oncology, Bleyer, A., Barr, R., Hayes-Lattin, B., Thomas, D., Ellis, C., & Anderson, B.
Venue
Nature Reviews Cancer
Published
2008-04
Volume
8
Issue
4
Pages
288-298
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W1991401391
Cited by
660
References
1
FWCI
3.68
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

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on behalf of the Biology and Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent and Young Adult Oncology, Bleyer, A., Barr, R., Hayes-Lattin, B., Thomas, D., Ellis, C., & Anderson, B. (2008). The distinctive biology of cancer in adolescents and young adults. Nature Reviews Cancer. https://doi.org/10.1038/nrc2349

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