Cited by 1,967Cancer-related Molecular PathwaysCell death mechanisms and regulationPI3K/AKT/mTOR signaling in cancer

The DOI matches its Crossref record; 168 of the 169 references it cites were found in a registry or an index.

The first 30 years of p53: growing ever more complex.

Open access

Levine, Arnold J., Oren, Moshe·2009·Nature Reviews Cancer

Open this paper in CoChat — free account

Abstract

Thirty years ago p53 was discovered as a cellular partner of simian virus 40 large T-antigen, the oncoprotein of this tumour virus. The first decade of p53 research saw the cloning of p53 DNA and the realization that p53 is not an oncogene but a tumour suppressor that is very frequently mutated in human cancer. In the second decade of research, the function of p53 was uncovered: it is a transcription factor induced by stress, which can promote cell cycle arrest, apoptosis and senescence. In the third decade after its discovery new functions of this protein were revealed, including the regulation of metabolic pathways and cytokines that are required for embryo implantation. The fourth decade of research may see new p53-based drugs to treat cancer. What is next is anybody's guess.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrc2723

Cites

168 of 168 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×
“More recently, induction of cellular senescence was identified as an additional mechanism whereby p53 curbs neoplastic processe”
p53, guardian of the genome
Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
Self-citation
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., & Howley, P. M. (1990) · Cell · doi:10.1016/0092-8674(90)90409-8 · Cited by 3,995
Self-citation
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765

Flagged first, then by citations

Show all 169 references

1 of the 169 references couldn’t be matched to a known paper.

Sorted by citations

Items 701–800 of 1,002

The Role of p53/p21/p16 in DNA-Damage Signaling and DNA Repair
Kulaberoglu, Y., Gündoğdu, R., & Hergovich, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803309-8.00015-x · Cited by 30
Optimization to detect TP53 mutations in circulating cell-free tumor DNA from patients with serous epithelial ovarian cancer
Park, Y. R., Kim, Y., Lee, H. Y., Lee, G. E., Lee, G. E., Lee, J.-E., & Kim, Y. (2018) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2018.61.3.328 · Cited by 30
Targeted Synthesis of Complex Spiro[3 H ‐indole‐3,2′‐pyrrolidin]‐2(1 H )‐ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2–p53 Inhibitors
Gollner, A., Weinstabl, H., Fuchs, J. E., Rudolph, D., Garavel, G., Hofbauer, K. S., Karolyi‐Oezguer, J., Gmaschitz, G., Hela, W., Kerres, N., et al. (2018) · ChemMedChem · doi:10.1002/cmdc.201800617 · Cited by 28
FBXO22, an epigenetic multiplayer coordinating senescence, hormone signaling, and metastasis
Johmura, Y., Harris, A. S., Ohta, T., & Nakanishi, M. (2020) · Cancer Science · doi:10.1111/cas.14534 · Cited by 28
A Rare TP53 Mutation Predominant in Ashkenazi Jews Confers Risk of Multiple Cancers
Powers, J. M., Pinto, E. M., Barnoud, T., Leung, J. C., Martynyuk, T., Kossenkov, A. V., Philips, A. H., Desai, H., Hausler, R. M., Kelly, G., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-1390 · Cited by 31
The tumor immune microenvironments of HPV + and HPV − head and neck cancers
Gameiro, S. F., Evans, A. M., & Mymryk, J. S. (2021) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1539 · Cited by 32
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53
Dixit, U., Liu, Z., Pandey, A. K., Kothari, R. K., & Pandey, V. N. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-925 · Cited by 28
Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies
Elmehdawi, F., Wheway, G., Szymańska, K., Adams, M., High, A. S., Johnson, C. A., & Robinson, P. A. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.10.002 · Cited by 29
Cancer Cell Analyses at the Single Cell-Level Using Electroactive Microwell Array Device
Kobayashi, M., Kim, S. H., Nakamura, H., Kaneda, S., & Fujii, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139980 · Cited by 29
Topic diffusion analysis of a weighted citation network in biomedical literature
Kim, M., Baek, I., & Song, M. (2017) · Journal of the Association for Information Science and Technology · doi:10.1002/asi.23960 · Cited by 29
Strategies for Predicting Response to Checkpoint Inhibitors
Zappasodi, R., Wolchok, J. D., & Merghoub, T. (2018) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-018-0471-9 · Cited by 29
Mechanistic insights into environmental and genetic risk factors for systemic lupus erythematosus.
Pan, Q., Chen, J., Guo, L., Lü, X., Liao, S., Zhao, C., Wang, S., & Liu, J. (2019) · Europe PMC (PubMed Central) · Cited by 29
Therapeutic advancements in nanomedicine: The multifaceted roles of silver nanoparticles
Karunakar, K. K., Cheriyan, B. V., Krithikeshvaran, R., Gnanisha, M., & Abinavi, B. (2024) · Biotechnology Notes · doi:10.1016/j.biotno.2024.05.002 · Cited by 30
The function, mechanisms, and role of the genes PTEN and TP53 and the effects of asbestos in the development of malignant mesothelioma: a review focused on the genes' molecular mechanisms
de Assis, L. V. M., & Isoldi, M. C. (2013) · Tumor Biology · doi:10.1007/s13277-013-1210-4 · Cited by 27
Dynamics of P53 in response to DNA damage: Mathematical modeling and perspective
Sun, T., & Cui, J. (2015) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2015.08.017 · Cited by 29
EPSIN 3, A Novel p53 Target, Regulates the Apoptotic Pathway and Gastric Carcinogenesis
Mori, J., Tanikawa, C., Ohnishi, N., Funauchi, Y., Toyoshima, O., Ueda, K., & Matsuda, K. (2017) · Neoplasia · doi:10.1016/j.neo.2016.12.010 · Cited by 28
Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell Proliferation
Li, X., Wilson, A. F., Du, W., & Pang, Q. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.12.006 · Cited by 28
Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression
Hirano, S., Yamamoto, H., Ichikawa, Y., Sato, B., Takefuji, Y., & Satoh, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168724 · Cited by 29
Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy
Izadi, M., Ali, T. A., & Pourkarimi, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212466 · Cited by 30
The Underestimated Role of the p53 Pathway in Renal Cancer
Amendolare, A., Marzano, F., Petruzzella, V., Vacca, R. A., Guerrini, L., Pesole, G., Sbisà, E., & Tullo, A. (2022) · Cancers · doi:10.3390/cancers14235733 · Cited by 31
Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types
Sasaki, K., Takahashi, S. I., Ouchi, K., Otsuki, Y., Wakayama, S., & Ishioka, C. (2023) · Scientific Reports · doi:10.1038/s41598-023-32092-8 · Cited by 28
The proto‐oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer
Read, M. L., Seed, R., Modasia, B., Kwan, P., Sharma, N., Smith, V. E., Watkins, R. J., Bansal, S. S., Gagliano, T., Stratford, A. L., et al. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22254 · Cited by 28
Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth
Zhang, Y.-W., Zhang, Q., Zeng, S. X., Zhang, Y., Mayo, L. D., & Lu, H. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.20844 · Cited by 28
Rhabdomyosarcomas: an overview on the experimental animal models
Zanola, A., Rossi, S., Faggi, F., Monti, E., & Fanzani, A. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01518.x · Cited by 28
Rad is a p53 direct transcriptional target that inhibits cell migration and is frequently silenced in lung carcinoma cells
Hsiao, B.-Y., Chen, C.-C., Hsieh, P.-C., Chang, T.-K., Yeh, Y., Wu, Y., Hsu, H., Wang, F.-F., & Chou, T. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0717-z · Cited by 28
DNA damage-centered signaling pathways are effectively activated during low dose-rate Auger radioimmunotherapy
Piron, B., Paillas, S., Boudousq, V., Pèlegrin, A., Mollévi, C., Chouin, N., Navarro‐Teulon, I., & Pouget, J. (2014) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2014.01.012 · Cited by 28
Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway
Crowther, A., Ocasio, J. K., Fang, F., Meidinger, J., Wu, J., Deal, A. M., Chang, S., Yuan, H., Schmid, R. S., Davis, I. J., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-0025 · Cited by 28
Modeling the response of a tumor-suppressive network to mitogenic and oncogenic signals
Tian, X., Huang, B. Y., Zhang, X., Lu, M., Liu, F., Onuchic, J. N., & Wang, W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702412114 · Cited by 28
Functional role of RRS 1 in breast cancer cell proliferation
Song, J., Ma, Z., Hua, Y., Xu, J., Li, N., Ju, C., & Hou, L. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13922 · Cited by 29
Recent Synthetic Approaches towards Small Molecule Reactivators of p53
Silva, J. L., Lima, C. G. S., Rangel, L. P., Ferretti, G. D. S., Pauli, F. P., Ribeiro, R. C. B., Silva, T. B., da Silva, F. D. C., & Ferreira, V. F. (2020) · Biomolecules · doi:10.3390/biom10040635 · Cited by 30
Rescue of p53 functions by in vitro‐transcribed mRNA impedes the growth of high‐grade serous ovarian cancer
Raab, M., Kostova, I., Peña‐Llopis, S., Fietz, D., Kressin, M., Aberoumandi, S. M., Ullrich, E., Becker, S., Sanhaji, M., & Strebhardt, K. (2023) · 癌症：英文版 · doi:10.1002/cac2.12511 · Cited by 27
RelB inhibits cell proliferation and tumor growth through p53 transcriptional activation
Jacque, É., Billot, K., Authier, H., Bordereaux, D., & Baud, V. (2012) · Oncogene · doi:10.1038/onc.2012.282 · Cited by 27
TP53, PIK3CA, FBXW7 and KRAS Mutations in Esophageal Cancer Identified by Targeted Sequencing.
Zheng, H., Wang, Y., Tang, C., Jones, L. E., Ye, H., Zhang, G., Cao, W., Li, J., Liu, L., Liu, Z., et al. (2016) · PubMed · Cited by 26
Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases
Hua, Y., Song, J., Peng, C., Wang, R., Ma, Z., Zhang, J., Zhang, Z., Li, N., & Hou, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.620925 · Cited by 29
Down-regulation of CLEC3B facilitates epithelial-mesenchymal transition, migration and invasion of lung adenocarcinoma cells
Lu, X., Shen, J., Huang, S., Wang, H., & Liu, D. (2022) · Tissue and Cell · doi:10.1016/j.tice.2022.101802 · Cited by 29
Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition
Aboukhatwa, S. M., Ibrahim, A. O., Aoyama, H., Al-Behery, A. S., Shaldam, M. A., Al‐Ashmawy, G. M., & Tawfik, H. O. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106126 · Cited by 27
Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds
Talib, W. H., Atawneh, S., Shakhatreh, A. N., Shakhatreh, G. N., aljarrah, I. S. R., Hamed, R. A., banyyounes, D. A., & Al-Yasari, I. H. (2024) · Pharmacia · doi:10.3897/pharmacia.71.e114556 · Cited by 29
The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women
Aboussekhra, A. (2012) · Oncology Letters · doi:10.3892/ol.2012.581 · Cited by 27
From tumor prevention to therapy: Empowering p53 to fight back
Frezza, C., & Martins, C. P. (2012) · Drug Resistance Updates · doi:10.1016/j.drup.2012.10.001 · Cited by 27
Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression
Ortega, F. J., Moreno‐Navarrete, J. M., Mayas, D., Sérino, M., Rodríguez‐Hermosa, J. I., Ricart, W., Luche, É., Burcelin, R., Tinahones, F. J., Frühbeck, G., et al. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.163 · Cited by 31
Cancer Cells Cue the p53 Response of Cancer-Associated Fibroblasts to Cisplatin
Schmid, J. O., Dong, M., Haubeiß, S., Friedel, G., Bode, S., Grabner, A., Ott, G., Mürdter, T. E., Oren, M., Aulitzky, W. E., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1201 · Cited by 27
Self-citation
RAP80 Is Critical in Maintaining Genomic Stability and Suppressing Tumor Development
Yin, Z., Menéndez, D., Resnick, M. A., French, J. E., Janardhan, K. S., & Jetten, A. M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1484 · Cited by 27
The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53
Gottifredi, V., & Wiesmüller, L. (2018) · Cancers · doi:10.3390/cancers10080250 · Cited by 30
p53 and its isoforms in DNA double-stranded break repair
Zhang, Y., Pan, W., & Chen, J. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900167 · Cited by 28
Targeting p53 for immune modulation: Exploring its functions in tumor immunity and inflammation
Wu, H. H., Leng, S., Eisenstat, D. D., Sergi, C. M., & Leng, R. P. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217614 · Cited by 27
Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships
Mantovani, F., Zannini, A., Rustighi, A., & Sal, G. D. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.01.013 · Cited by 30
Overlapping Region of p53/Wrap53 Transcripts: Mutational Analysis and Sequence Similarity with microRNA-4732-5p
Pouladi, N., Montasser-Kouhsari, S., Feizi, M. A. H., Gavgani, R. R., & Azarfam, P. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.6.3503 · Cited by 26
EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells
Sha, M.-Q., Zhao, X., Liang, L., Li, L., Li, Y., Dong, T., Niu, W., Jia, L., Shao, R., Zhen, Y., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.383 · Cited by 26
MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development
Xie, X., Wang, X., Liao, W., Fei, R., Wu, N., Xu, C., Chen, Q., Wei, L., Wang, Y., & Chen, H. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0693-7 · Cited by 26
The histone deacetylase inhibitor panobinostat exerts anticancer effects on esophageal squamous cell carcinoma cells by inducing cell cycle arrest
Cheng, Y., Liao, L., Yang, Q., Chen, Y., Nie, P., Zhang, X., Xie, J., Shan, B., Zhao, L., Xu, L., et al. (2018) · Cell Biochemistry and Function · doi:10.1002/cbf.3359 · Cited by 26
Anastatica hierochuntica (L.) methanolic and aqueous extracts exert antiproliferative effects through the induction of apoptosis in MCF-7 breast cancer cells
Babu, S. R., Messaoudi, S. A., Alehaideb, Z., Ali, M. S., Venktraman, A., Alajmi, H., Al‐Eidi, H., & Matou‐Nasri, S. (2020) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2020.06.020 · Cited by 24
The Changes in the p53 Protein across the Animal Kingdom Point to Its Involvement in Longevity
Bartas, M., Brázda, V., Volná, A., Červeň, J., Pečínka, P., & Zawacka‐Pankau, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168512 · Cited by 29
Virulence of Vibrio alginolyticus Accentuates Apoptosis and Immune Rigor in the Oyster Crassostrea hongkongensis
Mao, F., Liu, K., Wong, N.-K., Zhang, X., Yi, W., Xiang, Z., Xiao, S., Yu, Z., & Zhang, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.746017 · Cited by 26
Potential role of Marine Bioactive Compounds in cancer signaling pathways: A review
Manoharan, S., & Perumal, E. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175330 · Cited by 27
Nucleolin mediates SARS-CoV-2 replication and viral-induced apoptosis of host cells
Merino, V. F., Yan, Y., Ordoñez, A. A., Bullen, C. K., Lee, A. H., Saeki, H., Ray, K., Huang, T., Jain, S. K., & Pomper, M. G. (2023) · Antiviral Research · doi:10.1016/j.antiviral.2023.105550 · Cited by 26
Cell death and survival signalling in the cardiovascular system
Tucka, J. (2011) · Frontiers in bioscience · doi:10.2741/3925 · Cited by 26
Natural selection and functional genetic variation in the p53 pathway
Sucheston, L., Witonsky, D., Hastings, D., Yildiz, O., Clark, V. J., Rienzo, A. D., & Onel, K. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr028 · Cited by 27
How Glyphosate Impairs Liver Condition in the Field Lizard Podarcis siculus (Rafinesque-Schmaltz, 1810): Histological and Molecular Evidence
Verderame, M., & Scudiero, R. (2019) · BioMed Research International · doi:10.1155/2019/4746283 · Cited by 27
Emerging Roles for Maf1 beyond the Regulation of RNA Polymerase III Activity
Khanna, A., Pradhan, A., & Curran, S. P. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.06.022 · Cited by 26
Genetic modifiers of cancer risk in Lynch syndrome: a review
Talseth‐Palmer, B. A., Wijnen, J., Grice, D. M., & Scott, R. J. (2013) · Familial Cancer · doi:10.1007/s10689-013-9614-2 · Cited by 26
Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma
Li, X., Zhang, C., Lin, X., Zhang, J., Zhang, Y., Yu, H., Liu, Z., Gong, Y., Zhang, L.-D., & Xie, C. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01142-6 · Cited by 26
STOP gene Phactr4 is a tumor suppressor
Solimini, N. L., Liang, A. C. T., Xu, C., Pavlova, N. N., Xu, Q., Davoli, T., Li, M. Z., Wong, K., & Elledge, S. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221385110 · Cited by 25
Transcription Factors in Breast Cancer—Lessons From Recent Genomic Analyses and Therapeutic Implications
Zacksenhaus, E., Liu, J.-K., Jiang, Z., Yao, Y., Xia, L., Shrestha, M., & Ben‐David, Y. (2016) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2016.10.003 · Cited by 28
Gene networks and toxicity/detoxification pathways in juvenile largemouth bass (Micropterus salmoides) liver induced by acute lead stress
Qian, B., Xue, L., Qi, X., Bai, Y., & Wu, Y. (2019) · Genomics · doi:10.1016/j.ygeno.2019.06.023 · Cited by 25
CircCNTNAP3-TP53-positive feedback loop suppresses malignant progression of esophageal squamous cell carcinoma
Wang, H., Song, X., Wang, Y., Xuewen, Y., Liang, Y., Zhang, T., Xu, L., Jiang, F., & Dong, G. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03217-y · Cited by 25
The complex architecture of p53 binding sites
Senitzki, A., Safieh, J., Sharma, V., Golovenko, D., Danin‐Poleg, Y., Inga, A., & Haran, T. E. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1283 · Cited by 25
Senescent Cells in Cancer: Wanted or Unwanted Citizens
Niklander, S. E., Lambert, D., & Hunter, K. D. (2021) · Cells · doi:10.3390/cells10123315 · Cited by 28
Genetically prolonged beige fat in male mice confers long-lasting metabolic health
Wu, R., Park, J., Qian, Y., Shi, Z., Hu, R., Yuan, Y., Xiong, S., Wang, Z., Yan, G., Ong, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38471-z · Cited by 28
MG132 inhibition of proteasome blocks high-dose UV irradiation-induced apoptosis
Zhang, L., Hu, J. J., & Gong, F. (2011) · Cell Cycle · doi:10.4161/cc.10.20.17789 · Cited by 25
Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53
Reed, S. M., Hagen, J., Tompkins, V. S., Thies, K., Quelle, F. W., & Quelle, D. E. (2014) · Cell Cycle · doi:10.4161/cc.28202 · Cited by 25
Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters
Mungamuri, S. K., Wang, S., Manfredi, J. J., Gu, W., & Aaronson, S. A. (2014) · Oncogene · doi:10.1038/onc.2014.198 · Cited by 24
Meganucleases Revolutionize the Production of Genetically Engineered Pigs for the Study of Human Diseases
Redel, B. K., & Prather, R. S. (2015) · Toxicologic Pathology · doi:10.1177/0192623315613160 · Cited by 25
Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function
Bi, E., Liu, D., Li, Y., Mao, X., Wang, A., & Wang, J. (2018) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20187599 · Cited by 25
Sub-lethal Doses of Polybrominated Diphenyl Ethers, in Vitro, Promote Oxidative Stress and Modulate Molecular Markers Related to Cell Cycle, Antioxidant Balance and Cellular Energy Management
Manuguerra, S., Espinosa‐Ruíz, C., Santulli, A., & Messina, C. M. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16040588 · Cited by 25
Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance
Biber, S., Pospiech, H., Gottifredi, V., & Wiesmüller, L. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa974 · Cited by 25
Elucidating the chain of command: our current understanding of critical target genes for p53-mediated tumor suppression
Indeglia, A., & Murphy, M. E. (2024) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2024.2344465 · Cited by 27
Novel regulators and molecular mechanisms of p53R2 and its disease relevance
Cho, E. C., & Yen, Y. (2016) · Biochimie · doi:10.1016/j.biochi.2016.01.008 · Cited by 24
Pharmacological targeting of mutant p53
Kogan, S., & Carpizo, D. R. (2016) · Translational Cancer Research · doi:10.21037/tcr.2016.11.74 · Cited by 24
The codon 72 polymorphism of p53 influences cell fate following nutrient deprivation
Kung, C.-P., Liu, Q., & Murphy, M. E. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1323595 · Cited by 24
p53 involvement in clonal hematopoiesis of indeterminate potential
Chen, S., & Liu, Y. (2019) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000509 · Cited by 26
A Driver Never Works Alone—Interplay Networks of Mutant p53, MYC, RAS, and Other Universal Oncogenic Drivers in Human Cancer
Grzes, M., Oroń, M., Staszczak, Z., Jaiswar, A., Nowak-Niezgoda, M., & Walerych, D. (2020) · Cancers · doi:10.3390/cancers12061532 · Cited by 24
Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells
Dorandish, S., Williams, A., Atali, S., Sendo, S., Price, D., Thompson, C., Guthrie, J. W., Heyl, D., & Evans, H. G. (2021) · Scientific Reports · doi:10.1038/s41598-021-88574-0 · Cited by 23
Cancer‐cell‐secreted extracellular vesicles target p53 to impair mitochondrial function in muscle
Ruan, X., Cao, M., Yan, W., Jones, Y., Gustafsson, Å. B., Patel, H. H., Schenk, S., & Wang, S. E. (2023) · EMBO Reports · doi:10.15252/embr.202256464 · Cited by 23
p53 in liver pathologies—taking the good with the bad
Charni‐Natan, M., Rivlin, N., Molchadsky, A., Aloni-Grinstein, R., & Rotter, V. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1223-5 · Cited by 24
2ME and 2OHE2 exhibit growth inhibitory effects and cell cycle arrest at G2/M in RL95-2 human endometrial cancer cells through activation of p53 and Chk1
Gong, Q.-F., Liu, E., Xin, R., Huang, X., & Gao, N. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0757-x · Cited by 24
A clinical, pathologic, and molecular study of p53 and murine double minute 2 in penile carcinogenesis and its relation to prognosis
Rocha, R. M., Ignácio, J. A., Jordán, J. L. G., Carraro, D. M., Lisboa, B. G., Lopes, A., Carvalho, K. C., da Cunha, I. W., Cubilla, A. L., Guimarães, G. C., et al. (2011) · Human Pathology · doi:10.1016/j.humpath.2011.06.013 · Cited by 24
Combined Effects of Genetic Variants of the PTEN, AKT1, MDM2 and p53 Genes on the Risk of Nasopharyngeal Carcinoma
Zhang, X., Chen, X., Zhai, Y., Cui, Y., Cao, P., Zhang, H., Wu, Z., Li, P., Yu, L., Xia, X., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092135 · Cited by 24
In Situ Monitoring of p53 Protein and MDM2 Protein Interaction in Single Living Cells Using Single-Molecule Fluorescence Spectroscopy
Du, Z., Yu, J. Q., Li, F., Deng, L., Wu, F., Huang, X., Bergstrand, J., Widengren, J., Dong, C., & Ren, J. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b00473 · Cited by 24
Relevance of TP53 for CLL diagnostics
Catherwood, M. A., de Castro, D. G., Donaldson, D. M., Clifford, R. M., Mills, K., & Thornton, P. D. (2019) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2018-205622 · Cited by 24
Gain of function mutant p53 protein activates AKT through the Rac1 signaling to promote tumorigenesis
Yue, X., Wu, F., Li, Y., Liu, J., Boateng, M. N., Mandava, K., Zhang, C., Feng, Z., Gao, J., & Hu, W. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1749790 · Cited by 23
Proteasome inhibitors suppress the protein expression of mutant p53
Halasi, M., Pandit, B., & Gartel, A. L. (2014) · Cell Cycle · doi:10.4161/15384101.2014.950132 · Cited by 24
Tumor Suppressor Gene-Based Nanotherapy: From Test Tube to the Clinic
Shanker, M., Jin, J., Branch, C. D., Miyamoto, S., Grimm, E. A., Roth, J. A., & Ramesh, R. (2011) · Journal of Drug Delivery · doi:10.1155/2011/465845 · Cited by 24
The “Monkey‐Bar” Mechanism for Searching for the DNA Target Site: The Molecular Determinants
Vuzman, D., & Levy, Y. (2014) · Israel Journal of Chemistry · doi:10.1002/ijch.201400107 · Cited by 24
p53‐mediated regulation of bile acid disposition attenuates cholic acid‐induced cholestasis in mice
Chen, P., Li, D., Chen, Y., Sun, J., Fu, K., Guan, L., Zhang, H., Jiang, Y., Li, X., Zeng, X., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14035 · Cited by 24
Differential expression of senescence tumour markers and its implications on survival outcomes of breast cancer patients
Pare, R., Soon, P. S., Shah, A., & Lee, C. S. (2019) · PLOS ONE · doi:10.1371/journal.pone.0214604 · Cited by 23
Senescence and senolysis in cancer: The latest findings
Imawari, Y., & Nakanishi, M. (2024) · Cancer Science · doi:10.1111/cas.16184 · Cited by 25
Inauhzin Sensitizes p53-Dependent Cytotoxicity and Tumor Suppression of Chemotherapeutic Agents
Zhang, Y., Zhang, Q., Zeng, S. X., Hao, Q., & Lu, H. (2013) · Neoplasia · doi:10.1593/neo.13142 · Cited by 23
Clinical Response to Sorafenib in a Patient with Metastatic Colorectal Cancer and FLT3 Amplification
Moreira, R. B., Peixoto, R. D., & Cruz, M. R. (2015) · Case Reports in Oncology · doi:10.1159/000375483 · Cited by 23
Nanoscale Label-free Bioprobes to Detect Intracellular Proteins in Single Living Cells
Hong, W., Liang, F., Schaak, D., Lončar, M., & Quan, Q. (2014) · Scientific Reports · doi:10.1038/srep06179 · Cited by 22
TP53 Polymorphisms in Sporadic North Indian Breast Cancer Patients
Sharma, S., Sambyal, V., Guleria, K., Manjari, M., Sudan, M., Uppal, M. S., Singh, N. R., Bansal, D., & Gupta, A. K. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.16.6871 · Cited by 23

Authors: Levine, A. J., & Oren, M.
Affiliations: Institute for Advanced Study (US)
Weizmann Institute of Science (IL)
ORCID: Levine, Arnold J.
Oren, Moshe
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2009-10
Volume: 9
Issue: 10
Pages: 749-758
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2723
PMC: PMC2771725
OpenAlex: W1966163762
Cited by: 1,967
References: 169
Citations by year: 2026: 64 · 2025: 111 · 2024: 107 · 2023: 112 · 2022: 114 · 2021: 129 · 2020: 128 · 2019: 111 · 2018: 127 · 2017: 120 · 2016: 144 · 2015: 115 · 2014: 150 · 2013: 113 · 2012: 170
FWCI: 9.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P01CA087497, R37 CA40099, R37CA040099, P01CA87497.)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: p53, TP53, tumour suppressor, SV40 large T antigen, transcription factors, cell cycle arrest, apoptosis, cellular senescence, metabolic regulation, cytokine regulation, embryo implantation
MeSH terms: Animals, Humans, Neoplasms, Genes, p53, Tumor Suppressor Protein p53, History, 20th Century, History, 21st Century

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The first 30 years of p53: growing ever more complex.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks