Cited by 526MicroRNA in disease regulationCancer-related Molecular PathwaysCancer-related molecular mechanisms research

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MicroRNAs in the p53 network: micromanagement of tumour suppression

Hermeking, Heiko·2012·Nature Reviews Cancer

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Abstract

In recent years, microRNAs (miRNAs) have been identified as mediators of tumour suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated miRNAs contribute to tumour suppression by controlling the expression of central components of multiple processes, including cell cycle progression, epithelial-mesenchymal transition, stemness, metabolism, cell survival and angiogenesis. The expression and activity of p53 itself is also under the control of miRNAs. Finally, genetic and epigenetic alterations identified in the p53-miRNA network indicate that these pathways are important for the initiation and progression of tumours. In the future, knowledge about the p53-miRNA network may be able to be exploited for diagnostic and therapeutic approaches in cancer prevention and treatment.

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Authors: Hermeking, H.
Affiliations: Pathologisches Institut (DE)
Corresponding author: Hermeking, Heiko
ORCID: Hermeking, Heiko
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2012-08-17
Volume: 12
Issue: 9
Pages: 613-626
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc3318
OpenAlex: W1970431885
Cited by: 518
References: 185
Citations by year: 2026: 13 · 2025: 8 · 2024: 29 · 2023: 23 · 2022: 34 · 2021: 29 · 2020: 32 · 2019: 31 · 2018: 31 · 2017: 44 · 2016: 54 · 2015: 59 · 2014: 76 · 2013: 47 · 2012: 8
FWCI: 4.53
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: microRNA, p53, tumor suppression, p53 pathway, cell cycle regulation, epithelial-mesenchymal transition, cancer stemness, cancer metabolism, angiogenesis, cell survival, epigenetic modifications, cancer diagnosis, cancer therapeutics
MeSH terms: Humans, Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, MicroRNAs

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MicroRNAs in the p53 network: micromanagement of tumour suppression

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