Cited by 576Cancer, Stress, Anesthesia, and Immune ResponseImmune cells in cancerVagus Nerve Stimulation Research

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Sympathetic nervous system regulation of the tumour microenvironment

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Cole, Steven W., Nagaraja, Archana S., Lutgendorf, Susan K., Green, Paige A., Sood, Anil K.·2015·Nature Reviews Cancer

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Abstract

The peripheral autonomic nervous system (ANS) is known to regulate gene expression in primary tumours and their surrounding microenvironment. Activation of the sympathetic division of the ANS in particular modulates gene expression programmes that promote metastasis of solid tumours by stimulating macrophage infiltration, inflammation, angiogenesis, epithelial-mesenchymal transition and tumour invasion, and by inhibiting cellular immune responses and programmed cell death. Haematological cancers are modulated by sympathetic nervous system (SNS) regulation of stem cell biology and haematopoietic differentiation programmes. In addition to identifying a molecular basis for physiologic stress effects on cancer, these findings have also identified new pharmacological strategies to inhibit cancer progression in vivo.

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Background

Authors: Cole, S. W., Nagaraja, A. S., Lutgendorf, S. K., Green, P. A., & Sood, A. K.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
University of Iowa (US)
National Cancer Institute (US)
ORCID: Nagaraja, Archana S.
Lutgendorf, Susan K.
Green, Paige A.
Sood, Anil K.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2015-08-24
Volume: 15
Issue: 9
Pages: 563-572
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc3978
PMC: PMC4828959
OpenAlex: W1959055352
Cited by: 576
References: 132
Citations by year: 2026: 66 · 2025: 53 · 2024: 47 · 2023: 63 · 2022: 66 · 2021: 57 · 2020: 67 · 2019: 57 · 2018: 43 · 2017: 32 · 2016: 22 · 2015: 3
FWCI: 4.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (AG017265, R37AG033590, AG033590, R01AG033590, P30AG017265)
National Cancer Institute (CA 109298, CA177909, P50CA098258, U54CA151668, R01CA177909, CA083639, CA-104825, R01CA109298, CA140933, R01CA116778, R01CA104825, CA151668, CA-116778, R01CA140933, P50CA083639, CA098258, P30CA016672)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: sympathetic nervous system, tumor microenvironment, peripheral autonomic nervous system, beta-adrenergic signaling, physiological stress, metastasis, macrophage infiltration, tumor inflammation, angiogenesis, epithelial-mesenchymal transition, tumor invasion, antitumor immunity, hematologic cancer, cancer stem cells, hematopoietic differentiation
MeSH terms: Cell Differentiation, Humans, Neoplasms, Neovascularization, Pathologic, Sympathetic Nervous System, Gene Expression Regulation, Neoplastic, Epithelial-Mesenchymal Transition, Tumor Microenvironment

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Sympathetic nervous system regulation of the tumour microenvironment

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