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Sympathetic nervous system regulation of the tumour microenvironment
Open accessAbstract
The peripheral autonomic nervous system (ANS) is known to regulate gene expression in primary tumours and their surrounding microenvironment. Activation of the sympathetic division of the ANS in particular modulates gene expression programmes that promote metastasis of solid tumours by stimulating macrophage infiltration, inflammation, angiogenesis, epithelial-mesenchymal transition and tumour invasion, and by inhibiting cellular immune responses and programmed cell death. Haematological cancers are modulated by sympathetic nervous system (SNS) regulation of stem cell biology and haematopoietic differentiation programmes. In addition to identifying a molecular basis for physiologic stress effects on cancer, these findings have also identified new pharmacological strategies to inhibit cancer progression in vivo.
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“Catecholaminergic signaling has been shown to stimulate macrophage infiltration in the solid-tumor microenvironment, inflammation, angiogenesis, and epithelialmesenchymal transition and to promote metastasis (Cole et al., 2015).”
An energetic view of stress: Focus on mitochondria
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“Stress influences the biology of multiple diseases including cancer growth and metastasis (Thaker et al., 2006; Cole et al., 2015); diabetes (Faulenbach et al., 2012); neurodegenerative disorders (Schon and Przedborski, 2011; Picard and McManus, 2016), as well as cellular aging (Epel et al., 2004)…”
Adrenergic nerves activate an angio-metabolic switch in prostate cancer
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Metadata
- Authors
- Cole, S. W., Nagaraja, A. S., Lutgendorf, S. K., Green, P. A., & Sood, A. K.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- University of Iowa (US)
- National Cancer Institute (US)
- Venue
- Nature Reviews Cancer
- Published
- 2015-08-24
- Volume
- 15
- Issue
- 9
- Pages
- 563-572
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC4828959
- OpenAlex
- W1959055352
- Cited by
- 576
- References
- 132
- Citations by year
- 2026: 66 · 2025: 53 · 2024: 47 · 2023: 63 · 2022: 66 · 2021: 57 · 2020: 67 · 2019: 57 · 2018: 43 · 2017: 32 · 2016: 22 · 2015: 3
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG017265, R37AG033590, AG033590, R01AG033590, P30AG017265)
- National Cancer Institute (CA 109298, CA177909, P50CA098258, U54CA151668, R01CA177909, CA083639, CA-104825, R01CA109298, CA140933, R01CA116778, R01CA104825, CA151668, CA-116778, R01CA140933, P50CA083639, CA098258, P30CA016672)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- sympathetic nervous system, tumor microenvironment, peripheral autonomic nervous system, beta-adrenergic signaling, physiological stress, metastasis, macrophage infiltration, tumor inflammation, angiogenesis, epithelial-mesenchymal transition, tumor invasion, antitumor immunity, hematologic cancer, cancer stem cells, hematopoietic differentiation
- MeSH terms
- Cell Differentiation, Humans, Neoplasms, Neovascularization, Pathologic, Sympathetic Nervous System, Gene Expression Regulation, Neoplastic, Epithelial-Mesenchymal Transition, Tumor Microenvironment
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