Telomerase beyond telomeres

Telomeres shorten during ageing of human fibroblasts

Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · see citing works

Mammalian Telomeres End in a Large Duplex Loop

Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., & de Lange, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80760-6 · Cited by 2,447 · see citing works

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · see citing works

Switching and Signaling at the Telomere

Blackburn, E. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00492-5 · Cited by 2,097 · see citing works

Telomere reduction in human colorectal carcinoma and with ageing

Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650 · see citing works

Essential role of mouse telomerase in highly proliferative organs

Lee, H.-W., Blasco, M. A., Gottlieb, G. J., Horner, J. W., Greider, C. W., & DePinho, R. A. (1998) · Nature · doi:10.1038/33345 · Cited by 1,270 · cited 1× · see citing works

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

Hemann, M. T., Strong, M. A., Hao, L.-Y., & Greider, C. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00504-9 · Cited by 1,219 · see citing works

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

Chin, L., Artandi, S. E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80762-x · Cited by 979 · cited 1× · see citing works

Protection of mammalian telomeres

de Lange, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205080 · Cited by 942 · see citing works

Structure and variability of human chromosome ends.

de Lange, T., Shiue, L., Myers, R. M., Cox, D. R., Naylor, S. L., Killery, A. M., & Varmus, H. E. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.2.518 · Cited by 848 · see citing works

Senescence Induced by Altered Telomere State, Not Telomere Loss

Karlseder, J., Smogorzewska, A., & de Lange, T. (2002) · Science · doi:10.1126/science.1069523 · Cited by 796 · see citing works

Control of Human Telomere Length by TRF1 and TRF2

Smogorzewska, A., van Steensel, B., Bianchi, A., Oelmann, S., Schaefer, M. R., Schnapp, G., & de Lange, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1659-1668.2000 · Cited by 768 · see citing works

Telomerase in the human organism

Collins, K., & Mitchell, J. R. (2002) · Oncogene · doi:10.1038/sj.onc.1205083 · Cited by 600 · see citing works

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

Herrera, E., Samper, E., Martín‐Caballero, J., Flores, J. M., Lee, H., & Blasco, M. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.2950 · Cited by 471 · cited 1× · see citing works

A highly selective telomerase inhibitor limiting human cancer cell proliferation

Damm, K., Hemmann, U., Garin‐Chesa, P., Hauel, N., Kauffmann, I., Priepke, H., Niestroj, C., Daiber, C., Enenkel, B., Guilliard, B., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6958 · Cited by 422 · see citing works

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

Zhu, J., Wang, H., Bishop, J. M., & Blackburn, E. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3723 · Cited by 381 · see citing works

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes

González‐Suárez, E., Samper, E., Ramírez, A., Flores, J. M., Martín‐Caballero, J., Jorcano, J. L., & Blasco, M. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2619 · Cited by 372 · see citing works

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis

González-Suárez, E., Samper, E., Flores, J. M., & Blasco, M. A. (2000) · Nature Genetics · doi:10.1038/79089 · Cited by 347 · see citing works

Runaway telomere elongation caused by telomerase RNA gene mutations

McEachern, M. J., & Blackburn, E. H. (1995) · Nature · doi:10.1038/376403a0 · Cited by 336 · see citing works

Constitutive telomerase expression promotes mammary carcinomas in aging mice

Artandi, S. E., Alson, S., Tietze, M. K., Sharpless, N. E., Ye, S., Greenberg, R. A., Castrillon, D. H., Horner, J. W., Weiler, S. R., Carrasco, R. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112515399 · Cited by 317 · see citing works

New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

Chan, S. W.-L., & Blackburn, E. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205082 · Cited by 304 · see citing works

Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

Oh, H., Taffet, G. E., Youker, K. A., Entman, M. L., Overbeek, P. A., Michael, L. H., & Schneider, M. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191169098 · Cited by 289 · see citing works

Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis

Blasco, M. A., Rizen, M., Greider, C. W., & Hanahan, D. (1996) · Nature Genetics · doi:10.1038/ng0296-200 · Cited by 284 · see citing works

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc−/− mice with short telomeres

Samper, E., Flores, J. M., & Blasco, M. A. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve174 · Cited by 263 · cited 1× · see citing works

Strand-Specific Postreplicative Processing of Mammalian Telomeres

Bailey, S. M., Cornforth, M. N., Kurimasa, A., Chen, D. J., & Goodwin, E. H. (2001) · Science · doi:10.1126/science.1062560 · Cited by 257 · see citing works

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo

Liu, Y., Snow, B. E., Hande, M. P., Yeung, D., Erdmann, N. J., Wakeham, A., Itie, A., Siderovski, D. P., Lansdorp, P. M., Robinson, M. O., et al. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00805-8 · Cited by 244 · see citing works

Short Telomeres Result in Organismal Hypersensitivity to Ionizing Radiation in Mammals

Goytisolo, F. A., Samper, E., Martín‐Caballero, J., Finnon, P., Herrera, E., Flores, J. M., Bouffler, S. D., & Blasco, M. A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.11.1625 · Cited by 223 · see citing works

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

Espejel, S., Franco, S., Rodríguez, S., Bouffler, S. D., Cigudosa, J. C., & Blasco, M. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.9.2207 · Cited by 215 · see citing works

G-quadruplexes as therapeutic targets

Neidle, S., & Read, M. A. (2000) · Biopolymers · doi:10.1002/1097-0282(2000)56:3 · Cited by 206 · see citing works

Targeting Assay To Study the cis Functions of Human Telomeric Proteins: Evidence for Inhibition of Telomerase by TRF1 and for Activation of Telomere Degradation by TRF2

Ancelin, K., Brunori, M., Bauwens, S., Koering, C.-E., Brun, C., Ricoul, M., Pommier, J., Sabatier, L., & Gilson, É. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3474-3487.2002 · Cited by 204 · see citing works

Clinical utility of telomerase in cancer

Hiyama, E., & Hiyama, K. (2002) · Oncogene · doi:10.1038/sj.onc.1205070 · Cited by 202 · see citing works

The Catalytic Subunit of Telomerase Protects Neurons Against Amyloid β‐Peptide‐Induced Apoptosis

Zhu, H., Fu, W., & Mattson, M. P. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750117.x · Cited by 175 · see citing works

Telomerase Activation in Mouse Mammary Tumors: Lack of Detectable Telomere Shortening and Evidence for Regulation of Telomerase RNA with Cell Proliferation

Broccoli, D., Godley, L. A., Donehower, L. A., Varmus, H. E., & de Lange, T. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3765 · Cited by 157 · see citing works

Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor β growth inhibition in p16 INK4A (−) human mammary epithelial cells

Stampfer, M. R., Garbe, J. C., Levine, G. A., Lichtsteiner, S., Vasserot, A. P., & Yaswen, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071483998 · Cited by 133 · see citing works

Presence of telomeric G‐strand tails in the telomerase catalytic subunit TERT knockout mice

Yuan, X., Ishibashi, S., Hatakeyama, S., Saito, M., Nakayama, J., Nikaido, R., Haruyama, T., Watanabe, Y., Iwata, H., Iida, M., et al. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00284.x · Cited by 105 · see citing works

Telomerase inhibition, oligonucleotides, and clinical trials

Corey, D. R. (2002) · Oncogene · doi:10.1038/sj.onc.1205063 · Cited by 97 · see citing works

Cooperation between p53 Mutation and High Telomerase Transgenic Expression in Spontaneous Cancer Development

González‐Suárez, E., Flores, J. M., & Blasco, M. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.20.7291-7301.2002 · Cited by 94 · see citing works

Many ways to telomere dysfunction: in vivo studies using mouse models

Goytisolo, F. A., & Blasco, M. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205085 · Cited by 94 · see citing works

Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway

Xiang, H., Wang, J., Mao, Y., Liu, M., Reddy, V. N., & Li, D. W. (2002) · Oncogene · doi:10.1038/sj.onc.1205455 · Cited by 86 · see citing works

Telomerase protects developing neurons against DNA damage-induced cell death

Lu, C., Fu, W., & Mattson, M. P. (2001) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00237-1 · Cited by 64 · see citing works

Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective

Mattson, M. P. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00221-4 · Cited by 62 · see citing works

Telomerase RNA Template Mutations Reveal Sequence-Specific Requirements for the Activation and Repression of Telomerase Action at Telomeres

Prescott, J. C., & Blackburn, E. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2941-2948.2000 · Cited by 50 · see citing works

Cooperation of hTERT, SV40 T Antigen and Oncogenic Ras in Tumorigenesis: A Cell Transplantation Model Using Bovine Adrenocortical Cells

Thomas, M., Suwa, T., Yang, L., Zhao, L., Hawks, C. L., & Hornsby, P. J. (2002) · Neoplasia · doi:10.1038/sj.neo.7900262 · Cited by 32 · see citing works

Telomeres and human disease: ageing, cancer and beyond

Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,690 · see citing works

Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure

Urbanek, K., Torella, D., Sheikh, F. H., Angelis, A. D., Nurzyńska, D., Silvestri, F., Beltrami, C. A., Bussani, R., Beltrami, A. P., Quaini, F., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500169102 · Cited by 617 · see citing works

Telomeres and telomerase

Chan, S. R. W. L., & Blackburn, E. H. (2004) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2003.1370 · Cited by 595 · see citing works

Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway

Bao, S., Ouyang, G., Bai, X., Huang, Z., Ma, C., Liu, M., Shao, R., Anderson, R. M., Rich, J. N., & Wang, X.-F. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00081-9 · Cited by 561 · see citing works

Cardiac Stem Cell and Myocyte Aging, Heart Failure, and Insulin-Like Growth Factor-1 Overexpression

Torella, D., Rota, M., Nurzyńska, D., Musso, E., Monsen, A., Shiraishi, I., Zias, E. A., Walsh, K., Rosenzweig, A., Sussman, M. A., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000117306.10142.50 · Cited by 538 · see citing works

Chronic Oxidative Stress Compromises Telomere Integrity and Accelerates the Onset of Senescence in Human Endothelial Cells

Kurz, D. J., Decary, S., Hong, Y., Trivier, E., Akhmedov, A., & Erusalimsky, J. D. (2004) · Journal of Cell Science · doi:10.1242/jcs.01097 · Cited by 499 · see citing works

Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior

Flores, I., Cayuela, M. L., & Blasco, M. A. (2005) · Science · doi:10.1126/science.1115025 · Cited by 448 · see citing works

Telomerase modulates expression of growth-controlling genes and enhances cell proliferation

Smith, L. L., Coller, H. A., & Roberts, J. M. (2003) · Nature Cell Biology · doi:10.1038/ncb985 · Cited by 438 · see citing works

Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative Senescence of Endothelial Cells

Haendeler, J., Hoffmann, J., Diehl, J. F., Vasa‐Nicotera, M., Spyridopoulos, I., Zeiher, A. M., & Dimmeler, S. (2004) · Circulation Research · doi:10.1161/01.res.0000121104.05977.f3 · Cited by 382 · see citing works

Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation

Leri, A., Franco, S., Zacheo, A., Barlucchi, L., Chimenti, S., Limana, F., Nadal‐Ginard, B., Kajstura, J., Anversa, P., & Blasco, M. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg013 · Cited by 313 · see citing works

Telomere maintenance and disease

Wong, J. M. Y., & Collins, K. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14369-3 · Cited by 313 · see citing works

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

Akbar, A. N., Henson, S. M., & Lanna, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.09.002 · Cited by 285 · see citing works

The biogenesis and regulation of telomerase holoenzymes

Collins, K. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1961 · Cited by 282 · see citing works

Hydrogen Peroxide Triggers Nuclear Export of Telomerase Reverse Transcriptase via Src Kinase Family-Dependent Phosphorylation of Tyrosine 707

Haendeler, J., Hoffmann, J. U. R., Brandes, R. P., Zeiher, A. M., & Dimmeler, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4598-4610.2003 · Cited by 266 · see citing works

TERT promoter mutations in cancer development

Heidenreich, B., Rachakonda, P. S., Hemminki, K., & Kumar, R. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.11.005 · Cited by 238 · see citing works

Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.

Harada, H., Nakagawa, H., Oyama, K., Takaoka, M., Andl, C. D., Jacobmeier, B., von Werder, A., Enders, G. H., Opitz, O. G., & Rustgi, A. K. (2003) · PubMed · Cited by 197 · see citing works

Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism

Phatak, P., Cookson, J. C., Dai, F., Smith, V., Gartenhaus, R. B., Stevens, M. F. G., & Burger, A. M. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603691 · Cited by 192 · see citing works

Role of nuclear glutathione as a key regulator of cell proliferation

Pallardó, F. V., Marković, J., García‐Giménez, J. L., & Viña, J. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.01.001 · Cited by 191 · see citing works

Alternative lengthening of telomeres, telomerase, and cancer

Reddel, R. R. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00702-4 · Cited by 191 · see citing works

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

Laud, P. R., Multani, A. S., Bailey, S. M., Wu, L., Ma, J., Kingsley, C., Lebel, M., Pathak, S., DePinho, R. A., & Chang, S. (2005) · Genes & Development · doi:10.1101/gad.1321305 · Cited by 190 · see citing works

The fetal programming of telomere biology hypothesis: an update

Entringer, S., de Punder, K., Buß, C., & Wadhwa, P. D. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0151 · Cited by 189 · see citing works

Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells

Cao, Y., Bryan, T. M., & Reddel, R. R. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00815.x · Cited by 180 · see citing works

Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis

Ferrón, S. R., Marqués-Torrejón, M. Á., Mira, H., Flores, I., Taylor, K., Blasco, M. A., & Fariñas, I. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3836-09.2009 · Cited by 179 · see citing works

Breast Cancer Survival Is Associated with Telomere Length in Peripheral Blood Cells

Svenson, U., Nordfjäll, K., Stegmayr, B., Manjer, J., Nilsson, P. M., Tavelin, B., Henriksson, R., Lenner, P., & Roos, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6497 · Cited by 179 · see citing works

Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis

Shankar, S., Ganapathy, S., Chen, Q., & Srivastava, R. K. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-16 · Cited by 157 · see citing works

Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532

Eldaly, H., Kull, M., Zimmermann, S., Pantić, M., Waller, C. F., & Martens, U. M. (2004) · Blood · doi:10.1182/blood-2003-12-4322 · Cited by 156 · see citing works

Overexpression of Telomerase Confers Growth Advantage, Stress Resistance, and Enhanced Differentiation of ESCs Toward the Hematopoietic Lineage

Armstrong, L., Saretzki, G., Peters, H., Wappler, I., Evans, J., Hole, N., von Zglinicki, T., & Lako, M. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0269 · Cited by 153 · see citing works

Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells

Ferrón, S., Mira, H., Franco, S., Cano-Jaimez, M., Bellmunt, E., Ramírez, C., Fariñas, I., & Blasco, M. A. (2004) · Development · doi:10.1242/dev.01215 · Cited by 152 · see citing works

Telomere maintenance and cancer ? look, no telomerase

Neumann, A. A., & Reddel, R. R. (2002) · Nature reviews. Cancer · doi:10.1038/nrc929 · Cited by 148 · see citing works

Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging

Blasco, M. A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600598 · Cited by 147 · see citing works

Effects of arsenic on telomerase and telomeres in relation to cell proliferation and apoptosis in human keratinocytes and leukemia cells in vitro

Zhang, T.-C. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg141 · Cited by 142 · see citing works

Telomere Shortening Occurs in Subsets of Normal Breast Epithelium as well as in Situ and Invasive Carcinoma

Meeker, A. K., Hicks, J. L., Gabrielson, E., Strauss, W. M., De Marzo, A. M., & Argani, P. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63180-x · Cited by 140 · see citing works

The diagnosis and treatment of dyskeratosis congenita: a review

Feldstein, J. T., & Garcia, S. F. (2014) · Journal of Blood Medicine · doi:10.2147/jbm.s47437 · Cited by 140 · see citing works

Telomere Maintenance Mechanisms in Liposarcomas: Association with Histologic Subtypes and Disease Progression

Costa, A., Daidone, M. G., Daprai, L., Villa, R., Cantù, S., Pilotti, S., Mariani, L., Gronchi, A., Henson, J. D., Reddel, R. R., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0273 · Cited by 138 · see citing works

Biology of Osteogenic Sarcoma

Wang, L. L. (2005) · The Cancer Journal · doi:10.1097/00130404-200507000-00005 · Cited by 126 · see citing works

A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis

Trapp, S., Parcells, M. S., Kamil, J. P., Schumacher, D., Tischer, B. K., Kumar, P. M., Nair, V., & Osterrieder, N. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052240 · Cited by 125 · see citing works

Hormones and growth factors regulate telomerase activity in ageing and cancer

Bayne, S., & Liu, J. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.05.009 · Cited by 123 · see citing works

Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status

Grabowski, P., Hultdin, M., Karlsson, K., Tobin, G., Åleskog, A., Thunberg, U., Laurell, A., Sundström, C., Rosenquist, R., & Roos, G. (2005) · Blood · doi:10.1182/blood-2004-11-4394 · Cited by 116 · see citing works

Telomerase inhibition as cancer therapy

Saretzki, G. C. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00708-5 · Cited by 114 · see citing works

Telomerase activity in the subventricular zone of adult mice

Caporaso, G. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00103-9 · Cited by 111 · see citing works

Marek’s disease virus: lytic replication, oncogenesis and control

Jarosinski, K. W., Tischer, B. K., Trapp, S., & Osterrieder, N. (2006) · Expert Review of Vaccines · doi:10.1586/14760584.5.6.761 · Cited by 110 · see citing works

Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice

González-Suárez, E., Geserick, C., Flores, J. M., & Blasco, M. A. (2005) · Oncogene · doi:10.1038/sj.onc.1208413 · Cited by 109 · see citing works

Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice

Liu, T., Chung, M. J., Ullenbruch, M. R., Yu, H., Jin, H., Hu, B., Choi, Y. Y., Ishikawa, F., & Phan, S. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32369 · Cited by 105 · see citing works

Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress

Rubio, M. Á., Davalos, A. R., & Campisi, J. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.004 · Cited by 105 · see citing works

Mammalian telomeres and telomerase: why they matter for cancer and aging

Blasco, M. A. (2003) · European Journal of Cell Biology · doi:10.1078/0171-9335-00335 · Cited by 104 · see citing works

Telomere Shortening Occurs Early During Breast Tumorigenesis: A Cause of Chromosome Destabilization Underlying Malignant Transformation?

Meeker, A. K., & Argani, P. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000048775.04140.92 · Cited by 100 · see citing works

Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer

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Pharmacodynamics of the G-Quadruplex-Stabilizing Telomerase Inhibitor 3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in Vitro: Activity in Human Tumor Cells Correlates with Telomere Length and Can Be Enhanced, or Antagonized, with Cytotoxic Agents

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Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma

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IFN-α Inhibits Telomerase in Human CD8+ T Cells by Both hTERT Downregulation and Induction of p38 MAPK Signaling

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Genetic Analysis of Myc and Telomerase Interactions In Vivo

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Telomerase as an Important Target of Androgen Signaling Blockade for Prostate Cancer Treatment

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Structures of telomerase subunits provide functional insights

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Oxidative stress causes telomere damage in Fanconi anaemia cells – a possible predisposition for malignant transformation

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hTERT Extends Proliferative Lifespan and Prevents Oxidative Stress-Induced Apoptosis in Human Lens Epithelial Cells

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The telomerase cycle: normal and pathological aspects

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Krüppel-Like Factor 9 Loss-of-Expression in Human Endometrial Carcinoma Links Altered Expression of Growth-Regulatory Genes with Aberrant Proliferative Response to Estrogen1

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Human Telomerase Reverse Transcriptase Immortalizes Bovine Lens Epithelial Cells and Suppresses Differentiation through Regulation of the ERK Signaling Pathway

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Telomere Dynamics and Homeostasis in a Transmissible Cancer

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Telomerase inhibition reduces cell growth

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Telomerase as a Growth-Promoting Factor

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New Functions for Telomerase

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