Cited by 4,032Cell death mechanisms and regulationCancer-related Molecular PathwaysUbiquitin and proteasome pathways

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The Bcl2 family: regulators of the cellular life-or-death switch

Cory, Suzanne, Adams, Jerry M.·2002·Nature Reviews Cancer

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Abstract

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed by proteases called caspases. The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches.

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Cory, S., Vaux, D. L., Strasser, A., Harris, A. W. & Adams, J. M. Insights from Bcl2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation. Cancer Res. 59, S1685–S1692 (1999).
Lassus, P., Opitz-Araya, X. & Lazebnik, Y. Caspase-2 is required for stress-induced apoptosis and acts prior to mitochondrial permeabilization. Science (in the press).In certain cell lines, stress stimuli are shown to activate caspase-2 upstream of mitochondrial disruption. Together with other recent findings by Marsden et al . (see text), this work argues strongly that Bcl2 function extends beyond guarding mitochondrial integrity and is likely to involve direct regulation of the activation of several initiator caspases.

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Authors: Cory, S., & Adams, J. M.
Affiliations: The Royal Melbourne Hospital (AU)
ORCID: Cory, Suzanne
Adams, Jerry M.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2002-09-01
Volume: 2
Issue: 9
Pages: 647-656
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc883
OpenAlex: W2087877138
Cited by: 4,032
References: 155
Citations by year: 2026: 118 · 2025: 111 · 2024: 115 · 2023: 115 · 2022: 132 · 2021: 143 · 2020: 133 · 2019: 155 · 2018: 171 · 2017: 174 · 2016: 189 · 2015: 165 · 2014: 194 · 2013: 214 · 2012: 188
FWCI: 12.89
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Funders: Leukemia and Lymphoma Society
National Institutes of Health
National Health and Medical Research Council
National Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: Bcl-2 family proteins, apoptosis, caspase activation, anti-apoptotic proteins, pro-apoptotic proteins, life-or-death decisions, cancer therapy, tissue homeostasis
MeSH terms: Animals, Humans, Models, Molecular, Neoplasms, Protein Conformation, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Caspases

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The Bcl2 family: regulators of the cellular life-or-death switch

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