The DOI matches its Crossref record; 153 of the 155 references it cites were found in a registry or an index.
The Bcl2 family: regulators of the cellular life-or-death switch
Abstract
Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed by proteases called caspases. The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches.
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“This family consists of anti-apoptotic and pro-apoptotic proteins that act synergistically as apoptotic switches, ultimately determining the cell’s fate.358–360”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [359]
Citations
Cites
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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
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Self-citationPrevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
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2 of the 155 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Cory, S., Vaux, D. L., Strasser, A., Harris, A. W. & Adams, J. M. Insights from Bcl2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation. Cancer Res. 59, S1685–S1692 (1999).
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Yu, H., Liang, X., Chen, P., Wu, X., Zheng, Y., Luo, L., Qin, Y., Long, X., & Xue, M. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.10.033 · Cited by 60
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Hoffman-Luca, C. G., Ziazadeh, D., McEachern, D., Zhao, Y., Sun, W., Debussche, L., & Wang, S. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2506 · Cited by 52
Exercise, Autophagy, and Apoptosis
Mooren, F. C., & Krüger, K. (2015) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2015.07.023 · Cited by 50
Expression of C‐IAP1, C‐IAP2 and SURVIVIN discriminates different types of lymphoid malignancies
de Graaf, A. O., Han van Krieken, J., Tönnissen, E., Wissink, W., van de Locht, L., Overes, I., Dolstra, H., de Witte, T., van der Reijden, B. A., & Jansen, J. H. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05690.x · Cited by 42
Olatunji, O. J., Chen, H., & Zhou, Y. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.07.013 · Cited by 38
Protective effects of 20‐hydroxyecdysone on CoCl2‐induced cell injury in PC12 cells
Hu, J., Zhao, T. Z., Chu, W. H., Luo, C. X., Tang, W. H., Yi, L., & Feng, H. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22877 · Cited by 26
Metadata
- Authors
- Cory, S., & Adams, J. M.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Venue
- Nature Reviews Cancer
- Published
- 2002-09-01
- Volume
- 2
- Issue
- 9
- Pages
- 647-656
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2087877138
- Cited by
- 4,032
- References
- 155
- Citations by year
- 2026: 118 · 2025: 111 · 2024: 115 · 2023: 115 · 2022: 132 · 2021: 143 · 2020: 133 · 2019: 155 · 2018: 171 · 2017: 174 · 2016: 189 · 2015: 165 · 2014: 194 · 2013: 214 · 2012: 188
- FWCI
- 12.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Leukemia and Lymphoma Society
- National Institutes of Health
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- Bcl-2 family proteins, apoptosis, caspase activation, anti-apoptotic proteins, pro-apoptotic proteins, life-or-death decisions, cancer therapy, tissue homeostasis
- MeSH terms
- Animals, Humans, Models, Molecular, Neoplasms, Protein Conformation, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Caspases
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