Cited by 111Ultrasound and Hyperthermia ApplicationsPhotoacoustic and Ultrasonic ImagingCardiac Imaging and Diagnostics

Molecular imaging of cardiovascular disease with contrast-enhanced ultrasonography

Lindner, Jonathan R.·2009·Nature Reviews Cardiology

Abstract

Techniques for noninvasive imaging of specific disease-related molecular changes are being developed to enhance diagnosis and therapeutic decision making in the clinical setting, and to facilitate research efforts. Molecular imaging with contrast-enhanced ultrasonography relies on the detection of the acoustic signal produced by microbubble or nanoparticle agents that are targeted to sites of disease. This Review describes the basis for ultrasound molecular imaging, the unique features of contrast agent behavior or detector performance in relation to clinical or research needs, and the progress that has been made to date in imaging key events in cardiovascular medicine, such as atherosclerosis, postischemic inflammation, angiogenesis, transplant rejection and thrombus formation.

Integrity signals

Registry

Crossref · 10.1038/nrcardio.2009.77

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Echogenicity for effective ultrasound-mediated imaging favours probes larger than nanoparticles, including microbubbles and liposomes 500-800 nm in size.

    “The echogenicity for effective ultrasound-mediated imaging favours the use of probes that are larger than nanoparticles, including microbubbles and larger liposomes that are 500–800 nm in size155.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lindner, J. R.
Affiliations
Oregon Health & Science University (US)
Corresponding author
Lindner, Jonathan R.
Venue
Nature Reviews Cardiology
Published
2009-06-09
Volume
6
Issue
7
Pages
475-481
ISSN
  • 1759-5002 (ISSN-L)
  • 1759-5010
OpenAlex
W2092160452
Cited by
111
References
40
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 9 · 2014: 8 · 2013: 9 · 2012: 9
FWCI
1.10
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords
molecular imaging, contrast-enhanced ultrasound, targeted ultrasound contrast agents, microbubbles, nanoparticle contrast agents, atherosclerosis, post-ischemic inflammation, angiogenesis, graft rejection, thrombus formation, non-invasive imaging
MeSH terms
Animals, Cardiovascular Diseases, Contrast Media, Humans, Inflammation, Neovascularization, Pathologic, Predictive Value of Tests, Thrombosis, Ultrasonography, Interventional, Neovascularization, Physiologic, Microbubbles, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review