Molecular imaging of cardiovascular disease with contrast-enhanced ultrasonography
Abstract
Techniques for noninvasive imaging of specific disease-related molecular changes are being developed to enhance diagnosis and therapeutic decision making in the clinical setting, and to facilitate research efforts. Molecular imaging with contrast-enhanced ultrasonography relies on the detection of the acoustic signal produced by microbubble or nanoparticle agents that are targeted to sites of disease. This Review describes the basis for ultrasound molecular imaging, the unique features of contrast agent behavior or detector performance in relation to clinical or research needs, and the progress that has been made to date in imaging key events in cardiovascular medicine, such as atherosclerosis, postischemic inflammation, angiogenesis, transplant rejection and thrombus formation.
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Echogenicity for effective ultrasound-mediated imaging favours probes larger than nanoparticles, including microbubbles and liposomes 500-800 nm in size.
“The echogenicity for effective ultrasound-mediated imaging favours the use of probes that are larger than nanoparticles, including microbubbles and larger liposomes that are 500–800 nm in size155.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [155]
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- Authors
- Lindner, J. R.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Lindner, Jonathan R.
- ORCID
- Lindner, Jonathan R.
- Venue
- Nature Reviews Cardiology
- Published
- 2009-06-09
- Volume
- 6
- Issue
- 7
- Pages
- 475-481
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W2092160452
- Cited by
- 111
- References
- 40
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 9 · 2014: 8 · 2013: 9 · 2012: 9
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- molecular imaging, contrast-enhanced ultrasound, targeted ultrasound contrast agents, microbubbles, nanoparticle contrast agents, atherosclerosis, post-ischemic inflammation, angiogenesis, graft rejection, thrombus formation, non-invasive imaging
- MeSH terms
- Animals, Cardiovascular Diseases, Contrast Media, Humans, Inflammation, Neovascularization, Pathologic, Predictive Value of Tests, Thrombosis, Ultrasonography, Interventional, Neovascularization, Physiologic, Microbubbles, Nanoparticles
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