Cited by 218Microbial metabolism and enzyme functionGut microbiota and healthFolate and B Vitamins Research

Formate metabolism in health and disease

Open access
Pietzke, Matthias, Meiser, Johannes, Vazquez, Alexei·2020·Molecular Metabolism

Abstract

BACKGROUND: Formate is a one-carbon molecule at the crossroad between cellular and whole body metabolism, between host and microbiome metabolism, and between nutrition and toxicology. This centrality confers formate with a key role in human physiology and disease that is currently unappreciated. SCOPE OF REVIEW: Here we review the scientific literature on formate metabolism, highlighting cellular pathways, whole body metabolism, and interactions with the diet and the gut microbiome. We will discuss the relevance of formate metabolism in the context of embryonic development, cancer, obesity, immunometabolism, and neurodegeneration. MAJOR CONCLUSIONS: We will conclude with an outlook of some open questions bringing formate metabolism into the spotlight.

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Crossref · 10.1016/j.molmet.2019.05.012

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Research works printed but not linked: 3

  1. [1]Stumper R. L'acide formique Bulletin – Societe des Naturalistes Luxembourgeois 31 1921 174 187
  2. [39]Voet D. Voet J.G. Biochemistry 4th ed 2011 John Wiley & Sons, Inc. Hoboken, N.J.
  3. [161]Spiller G.A. Caffeine 1998 CRC Press Boca Raton, Fla

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Authors
Pietzke, M., Meiser, J., & Vazquez, A.
Affiliations
  • Cancer Research UK Scotland Institute (GB)
  • Luxembourg Institute of Health (LU)
Venue
Molecular Metabolism
Publisher
Elsevier BV
Published
2020-03
Volume
33
Pages
23-37
ISSN
2212-8778 (ISSN-L)
OpenAlex
W2965191969
Cited by
218
References
159
Citations by year
2026: 29 · 2025: 44 · 2024: 43 · 2023: 28 · 2022: 30 · 2021: 28 · 2020: 15 · 2017: 1
FWCI
1.61
Type
journal article
Language
en
Open access
Locations
  • Molecular Metabolism (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Fonds National de la Recherche Luxembourg (A18/BM/11809970)
  • Cancer Research UK (C596/A21140)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
Keywords
formate metabolism, one-carbon metabolism, gut microbiota, diet, embryonic development, cancer, obesity, immunometabolism, neurodegeneration, cellular metabolism, host-microbiome interactions
MeSH terms
Gastrointestinal Microbiome, Diet, Female, Formates, Humans, Obesity, Host-Pathogen Interactions

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