Cited by 729Thyroid Disorders and TreatmentsHormonal and reproductive studiesThyroid and Parathyroid Surgery

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Thyroid hormones and cardiovascular disease

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Jabbar, Avais, Pingitore, Alessandro, Pearce, Simon H. S., Zaman, Azfar, Iervasi, Giorgio, Razvi, Salman·2017·Nature Reviews Cardiology

DOI 10.1038/nrcardio.2016.174

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Abstract

Myocardial and vascular endothelial tissues have receptors for thyroid hormones and are sensitive to changes in the concentrations of circulating thyroid hormones. The importance of thyroid hormones in maintaining cardiovascular homeostasis can be deduced from clinical and experimental data showing that even subtle changes in thyroid hormone concentrations - such as those observed in subclinical hypothyroidism or hyperthyroidism, and low triiodothyronine syndrome - adversely influence the cardiovascular system. Some potential mechanisms linking the two conditions are dyslipidaemia, endothelial dysfunction, blood pressure changes, and direct effects of thyroid hormones on the myocardium. Several interventional trials showed that treatment of subclinical thyroid diseases improves cardiovascular risk factors, which implies potential benefits for reducing cardiovascular events. Over the past 2 decades, accumulating evidence supports the association between abnormal thyroid function at the time of an acute myocardial infarction (MI) and subsequent adverse cardiovascular outcomes. Furthermore, experimental studies showed that thyroid hormones can have an important therapeutic role in reducing infarct size and improving myocardial function after acute MI. In this Review, we summarize the literature on thyroid function in cardiovascular diseases, both as a risk factor as well as in the setting of cardiovascular diseases such as heart failure or acute MI, and outline the effect of thyroid hormone replacement therapy for reducing the risk of cardiovascular disease.

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Authors: Jabbar, A., Pingitore, A., Pearce, S. H. S., Zaman, A., Iervasi, G., & Razvi, S.
Affiliations: Freeman Hospital (GB)
Istituto di Fisiologia Clinica (IT)
Royal Victoria Infirmary (GB)
Gateshead Health NHS Foundation Trust (GB)
Corresponding author: Razvi, Salman
ORCID: Pingitore, Alessandro
Pearce, Simon H. S.
Zaman, Azfar
Iervasi, Giorgio
Razvi, Salman
Venue: Nature Reviews Cardiology
Publisher: Springer Science and Business Media LLC
Published: 2016-11-04
Volume: 14
Issue: 1
Pages: 39-55
ISSN: 1759-5002 (ISSN-L)
1759-5010
DOI: 10.1038/nrcardio.2016.174
OpenAlex: W2548036931
Cited by: 729
References: 253
Citations by year: 2026: 65 · 2025: 78 · 2024: 89 · 2023: 95 · 2022: 107 · 2021: 87 · 2020: 88 · 2019: 47 · 2018: 42 · 2017: 25
FWCI: 5.53
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Cardiology (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: National Institute for Health and Care Research (PB-PG-0610-22139, CDF-2012-05-231)
Medical Research Council (G0500783)
NIHR Academy
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords: thyroid hormones, cardiovascular disease, heart failure, acute myocardial infarction, subclinical hypothyroidism, hyperthyroidism, low triiodothyronine syndrome, thyroid hormone receptor, endothelial dysfunction, dyslipidemia, blood pressure, thyroid hormone replacement, cardiovascular risk factors, infarct size
MeSH terms: Cardiovascular Diseases, Cardiovascular System, Humans, Hyperthyroidism, Hypothyroidism, Thyroid Hormones, Hormone Replacement Therapy

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