The DOI matches its Crossref record; 254 of the 254 references it cites were found in a registry or an index.
Thyroid hormones and cardiovascular disease
Open accessAbstract
Myocardial and vascular endothelial tissues have receptors for thyroid hormones and are sensitive to changes in the concentrations of circulating thyroid hormones. The importance of thyroid hormones in maintaining cardiovascular homeostasis can be deduced from clinical and experimental data showing that even subtle changes in thyroid hormone concentrations - such as those observed in subclinical hypothyroidism or hyperthyroidism, and low triiodothyronine syndrome - adversely influence the cardiovascular system. Some potential mechanisms linking the two conditions are dyslipidaemia, endothelial dysfunction, blood pressure changes, and direct effects of thyroid hormones on the myocardium. Several interventional trials showed that treatment of subclinical thyroid diseases improves cardiovascular risk factors, which implies potential benefits for reducing cardiovascular events. Over the past 2 decades, accumulating evidence supports the association between abnormal thyroid function at the time of an acute myocardial infarction (MI) and subsequent adverse cardiovascular outcomes. Furthermore, experimental studies showed that thyroid hormones can have an important therapeutic role in reducing infarct size and improving myocardial function after acute MI. In this Review, we summarize the literature on thyroid function in cardiovascular diseases, both as a risk factor as well as in the setting of cardiovascular diseases such as heart failure or acute MI, and outline the effect of thyroid hormone replacement therapy for reducing the risk of cardiovascular disease.
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“In the context of HF, THs have a cardioprotective role through multifaceted direct or indirect actions at the level of the myocytes, the interstitium, and the vasculature (Figure 2) (6).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [6]
In the citing paper
“Although a reduction in oxygen consumption by lowering TH levels during acute ischemia could be considered beneficial, the net effect of lower TH levels in the heart may still be detrimental because of its important role in postischemic LV remodeling, maintaining CV function and mitochondrial integrity (6).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [6]
In the citing paper
“Patients with severe hyperthyroidism may have coronary vasospasm leading to chest pain at rest or myocardial ischemia(6,70,71,79).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [6]
In the citing paper
“excess increases cardiac output by affecting stroke volume and heart rate(6,71).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [6]
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Metadata
- Authors
- Jabbar, A., Pingitore, A., Pearce, S. H. S., Zaman, A., Iervasi, G., & Razvi, S.
- Affiliations
- Freeman Hospital (GB)
- Istituto di Fisiologia Clinica (IT)
- Royal Victoria Infirmary (GB)
- Gateshead Health NHS Foundation Trust (GB)
- Corresponding author
- Razvi, Salman
- Venue
- Nature Reviews Cardiology
- Published
- 2016-11-04
- Volume
- 14
- Issue
- 1
- Pages
- 39-55
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W2548036931
- Cited by
- 729
- References
- 253
- Citations by year
- 2026: 65 · 2025: 78 · 2024: 89 · 2023: 95 · 2022: 107 · 2021: 87 · 2020: 88 · 2019: 47 · 2018: 42 · 2017: 25
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- National Institute for Health and Care Research (PB-PG-0610-22139, CDF-2012-05-231)
- Medical Research Council (G0500783)
- NIHR Academy
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- thyroid hormones, cardiovascular disease, heart failure, acute myocardial infarction, subclinical hypothyroidism, hyperthyroidism, low triiodothyronine syndrome, thyroid hormone receptor, endothelial dysfunction, dyslipidemia, blood pressure, thyroid hormone replacement, cardiovascular risk factors, infarct size
- MeSH terms
- Cardiovascular Diseases, Cardiovascular System, Humans, Hyperthyroidism, Hypothyroidism, Thyroid Hormones, Hormone Replacement Therapy
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