DNA-encoded chemistry: enabling the deeper sampling of chemical space

Goodnow, Robert A., Dumelin, Christoph E., Keefe, Anthony D.·2017·Nature Reviews Drug Discovery

DOI 10.1038/nrd.2016.213

Cited by (644)

Items 601–644 of 644

Synthesis of Large PNA-Encoded Chemical Libraries via Mismatch-Resistant PNA/DNA Hybridization
J H Park, Jungyeon Kim, Chang Deok Seo, Hee Myeong Wang, Yeongju Lee, Hyun‐Suk Lim · 2026 · Organic Letters
A tailored CoA ligase-N-acyltransferase cascade for on-DNA amide bond formation gives access to broad substrate scope
Daniela Schaub, Alice Lessing, Fabian Meyer, Peter Stockinger, Miquel Estévez‐Gay, Michael Eichenberger, Gerlis von Haugwitz, Andreas Gloger, Jörg Scheuermann, Rebecca Buller · 2026 · Zürcher Hochschule für Angewandte Wissenschaften digital collection (Zurich University of Applied Sciences)
Interpretable Prediction of Ligand–Protein Binding without Protein Structural Information
Ananthan Sadagopan, Anurag Sodhi, William J. Gibson · 2026 · Journal of Medicinal Chemistry
PhenoDEL: A Novel Screening Strategy Based on Intracellular Protein Degradation Activity
Yuichi Onda, Yukio Ochi, Toshihiro Araki, Miho Kageoka, Shuzo Takeda, Kazunori Yamada, Takehiko Ueda, Ken Ohno, M. Tanaka, Daiki Sakai et al. · 2026 · ACS Chemical Biology
DNA-encoded libraries through a machine learning lens: challenges and opportunities
Malkeet Singh Bahia, Yifan Jiang, Arthur Gonse, Robert A. Batey, Michał Koziarski · 2026 · Digital Discovery
A mild three-component on-DNA reaction for accessing pyrazole-centred chemical space in DNA-encoded libraries
Masaki Koshimizu, Masashi Suzuki, Saori Miya, Hiroyuki Miyachi · 2026 · Organic Chemistry Frontiers
Trends and Future Directions in Organic Chemistry for Drug Discovery
Paweł Kozyra, Maciej Masłyk · 2026 · Chemistry - A European Journal
DEL-Ranking framework for ranking-aware denoising of DNA-encoded library screens for improved affinity prediction
Hanqun Cao, Mutian He, Ning Ma, Chang‐Yu Hsieh, Xiaojun Yao, César de la Fuente‐Núñez, Chunbin Gu, Pheng Ann Heng · 2026 · Cell Reports Physical Science
Impact of Primer and Template Designs on PCR and NGS Performance in Single‐Stranded DNA‐Encoded Library Screening at Different Inputs
Maria Heinke, Mosè Fabbri, Jörg Scheuermann, Samuele Cazzamalli, Nicholas Favalli, Dario Neri, Sara Puglioli · 2026 · Chemistry - A European Journal
Systematic Evaluation of Washing Conditions to Preserve Low Affinity Binders in DEL Selections
Mosè Fabbri, Lorenzo Campari, Sara Puglioli, Laura Alvigini, Francesca Migliorini, Samuele Cazzamalli, Dario Neri, Nicholas Favalli · 2026 · Bioconjugate Chemistry
In vivo fate-guided design of efficient delivery systems for PROTACs: From molecular rationales to clinical progress
Wei Zhang, Shiyuan Li, Yao Yao, Yuling Mao, WenJun Jiang, Shuai Li · 2026 · Pharmacological Research
Multicomponent reactions for DNA ‐encoded library construction: Scaffold diversity and reaction engineering strategies
Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim · 2026 · Bulletin of the Korean Chemical Society
The 20 th EFMC Short Course on Medicinal Chemistry Dedicated to Atypical Approaches Focusing on Protein Targets
Rebecca F. Deprez-Poulain, Anna K. H. Hirsch, Laura H. Heitman, Martin Missbach, Minh Thao Tran, Alessio Ciulli, Sereina Riniker, Tanja Poljak · 2026 · ChemMedChem
Divergent Synthetic Strategy for the 2- and 4-Position Diversification of Pyrrolo[2,3-d]pyrimidines for DNA-Encoded Libraries
Hee Myeong Wang, Jungyeon Kim, Hyun‐Suk Lim · 2026 · Synthesis
BindingDB Entry 50013495: Dual Bcl-X
BindingDB · 2022 · UC San Diego
BindingDB Entry 50021451: Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen.
BindingDB · 2025 · UC San Diego
BindingDB Entry 7945: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library.
BindingDB · 2017 · UC San Diego
BindingDB Entry 50020161: Advances of bioorthogonal coupling reactions in drug development.
BindingDB · 2024 · UC San Diego
BindingDB Entry 50019229: Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening.
BindingDB · 2024 · UC San Diego
BindingDB Entry 50020773: Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein-Ligand Interactions and High Selectivity.
BindingDB · 2024 · UC San Diego
BindingDB Entry 50015780: DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathway.
BindingDB · 2023 · UC San Diego
BindingDB Entry 50010503: DNA-Encoded Library Screening as Core Platform Technology in Drug Discovery: Its Synthetic Method Development and Applications in DEL Synthesis.
BindingDB · 2021 · UC San Diego
BindingDB Entry 50017969: Diversity-oriented synthesis as a tool to expand the chemical space of DNA-encoded libraries.
BindingDB · 2023 · UC San Diego
BindingDB Entry 50002351: Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations.
BindingDB · 2020 · UC San Diego
BindingDB Entry 50012993: TBA
BindingDB · 2022 · UC San Diego
BindingDB Entry 50008584: New Modalities, Technologies, and Partnerships in Probe and Lead Generation: Enabling a Mode-of-Action Centric Paradigm.
BindingDB · 2021 · UC San Diego
BindingDB Entry 50012743: Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding.
BindingDB · 2022 · UC San Diego
BindingDB Entry 50017424: Specific Inhibitor of Placental Alkaline Phosphatase Isolated from a DNA-Encoded Chemical Library Targets Tumor of the Female Reproductive Tract.
BindingDB · 2023 · UC San Diego
BindingDB Entry 50021085: Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches.
BindingDB · 2025 · UC San Diego
BindingDB Entry 50023341: From DNA-Encoded Library Screening to AM-9747: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy.
BindingDB · 2026 · UC San Diego
BindingDB Entry 50014995: Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.
BindingDB · 2023 · UC San Diego
BindingDB Entry 50023326: DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.
BindingDB · 2026 · UC San Diego
BindingDB Entry 50014216: DNA-Encoded Library Hit Confirmation: Bridging the Gap Between On-DNA and Off-DNA Chemistry.
BindingDB · 2022 · UC San Diego
BindingDB Entry 50012437: Discovery of 2,4-1
BindingDB · 2022 · UC San Diego
BindingDB Entry 50012042: Integrating DNA-encoded chemical libraries with virtual combinatorial library screening: Optimizing a PARP10 inhibitor.
BindingDB · 2022 · UC San Diego
BindingDB Entry 50020199: PepScaf: Harnessing Machine Learning with In Vitro Selection toward De Novo Macrocyclic Peptides against IL-17C/IL-17RE Interaction.
BindingDB · 2024 · UC San Diego
BindingDB Entry 50014447: Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS).
BindingDB · 2022 · UC San Diego
BindingDB Entry 50019342: Privileged heterocycles for DNA-encoded library design and hit-to-lead optimization.
BindingDB · 2024 · UC San Diego
BindingDB Entry 50019644: The Science and Art of Structure-Based Virtual Screening.
BindingDB · 2024 · UC San Diego
BindingDB Entry 50014476: Identification of isoform/domain-selective fragments from the selection of DNA-encoded dynamic library.
BindingDB · 2022 · UC San Diego
BindingDB Entry 50008478: Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives.
BindingDB · 2021 · UC San Diego
BindingDB Entry 50010546: Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry.
BindingDB · 2021 · UC San Diego
BindingDB Entry 50013640: Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry.
BindingDB · 2022 · UC San Diego
BindingDB Entry 9728: DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M
BindingDB · 2021 · UC San Diego