DNA-encoded chemistry: enabling the deeper sampling of chemical space

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

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Accurate whole human genome sequencing using reversible terminator chemistry

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How to improve R&D productivity: the pharmaceutical industry's grand challenge

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Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries

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Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

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Protocols for the Design of Kinase‐focused Compound Libraries

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DNA-Encoded Library Technology (DELT) After a Quarter Century

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NeuralDock: Rapid and Conformation-Agnostic Docking of Small Molecules

Sha, C. M., Wang, J., & Dokholyan, N. V. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.867241 · Cited by 9

Targeting fusion oncoproteins in childhood cancers: challenges and future opportunities for developing therapeutics

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Transcriptionally Conditional Recurrent Neural Network for De Novo Drug Design

Matsukiyo, Y., Tengeiji, A., Li, C., & Yamanishi, Y. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c00531 · Cited by 10

DNA-compatible one-pot synthesis of multi-substituted dihydrofuran via pyridinium ylide-mediated cyclization

Fang, X., Ning, X., Li, Y., Zhang, G., Fan, X., & Li, Y. (2025) · Organic & Biomolecular Chemistry · doi:10.1039/d4ob02089h · Cited by 9

Discovery and Optimization of LAG-3-Targeted Small Molecules via DNA-Encoded Chemical Library (DEL) Screening for Cancer Immunotherapy

Abdel‐Rahman, S. A., Calvo‐Barreiro, L., García-Vázquez, N., Nada, H., & Gabr, M. T. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00995 · Cited by 9

High‐Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15‐Specific Protease mUSP18

Kooij, R., Pol, V., Gan, J., van Doodewaerd, B. R., Sapmaz, A., Alonso, M. C., Fritz, G., Knobeloch, K., & Geurink, P. P. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202510941 · Cited by 10

What Happens in Successful Optimizations? A Survey of 2018–2024 Literature

Leeson, P. D. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03171 · Cited by 12

In vivo Pooled Screening: A Scalable Tool to Study the Complexity of Aging and Age-Related Disease

Jensen, M. B., & Marblestone, A. H. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.714926 · Cited by 9

Building Natural Product Libraries Using Quantitative Clade-Based and Chemical Clustering Strategies

Anderson, V. M., Wendt, K. L., Najar, F. Z., McCall, L., & Cichewicz, R. H. (2021) · mSystems · doi:10.1128/msystems.00644-21 · Cited by 9

Complex DNA Architectonics─Self-Assembly of Amphiphilic Oligonucleotides into Ribbons, Vesicles, and Asterosomes

Rothenbühler, S., Iacovache, I., Langenegger, S. M., Zuber, B., & Häner, R. (2022) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.2c00077 · Cited by 9

DNA-Compatible Suzuki-Miyaura Cross-Coupling Reaction of Aryl Iodides With (Hetero)Aryl Boronic Acids for DNA-Encoded Libraries

Siripuram, V. K., Sunkari, Y. K., Nguyen, T.-L., & Flajolet, M. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.894603 · Cited by 9

Essential Paralogous Proteins as Potential Antibiotic Multitargets in Escherichia coli

Hardy, C. D. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02043-22 · Cited by 9

Incorporation of viridicatin alkaloid-like scaffolds into DNA-encoded chemical libraries

Fang, X., Liao, H., Fan, X., Wang, Y., Wang, H., Zhang, G., Fang, W., Li, Y., & Li, Y. (2023) · Organic & Biomolecular Chemistry · doi:10.1039/d2ob02278h · Cited by 9

Discovering Cell‐Targeting Ligands and Cell‐Surface Receptors by Selection of DNA‐Encoded Chemical Libraries against Cancer Cells without Predefined Targets

Gui, Y., Hou, R., Huang, Y., Zhou, Y., Liu, S., Meng, L., Li, Y., Lam, F. S., Ding, R., Cao, Y. W., et al. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202421172 · Cited by 9

Development of DNA-compatible hydroxycarbonylation reactions using chloroform as a source of carbon monoxide

Liu, W., Huang, W., Lin, Q., Tsai, M., Zhang, R., Fan, L., Scott, J. D., Liu, G., & Wan, J. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116118 · Cited by 9

Expanding the scope of native chemical ligation – templated small molecule drug synthesis via benzanilide formation

Houska, R., Stutz, M. B., & Seitz, O. (2021) · Chemical Science · doi:10.1039/d1sc00513h · Cited by 9

Opportunities for Expanding Encoded Chemical Diversification and Improving Hit Enrichment in mRNA‐Displayed Peptide Libraries

Melsen, P. R. A., Yoshisada, R., & Jongkees, S. A. K. (2022) · ChemBioChem · doi:10.1002/cbic.202100685 · Cited by 9

Switchable DNA‐Encoded Chemical Library: Interconversion between Double‐ and Single‐Stranded DNA Formats

Zhao, G., Fan, X., Li, Y., Zhang, G., & Li, Y. (2022) · ChemBioChem · doi:10.1002/cbic.202200025 · Cited by 9

RNA-templated chemical synthesis of proapoptotic L- and d-peptides

Chang, L.-H., & Seitz, O. (2022) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2022.116786 · Cited by 9

Using a PCR‐Based Method To Analyze and Model Large, Heterogeneous Populations of DNA

Andrade, H., Thomas, A. K., Lin, W., Reddavide, F. V., & Zhang, Y. (2019) · ChemBioChem · doi:10.1002/cbic.201900603 · Cited by 9

Oxoammonium Salt-Mediated On-DNA Alcohol Oxidation for DEL Synthesis

Chheda, P. R., Simmons, N., & Shi, Z. (2024) · Organic Letters · doi:10.1021/acs.orglett.4c02474 · Cited by 8

DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors

Carney, S. M., Grosse, S., Yin, Y., Tran, M. T., Kalin, J. H., Jacoby, E., Fung, A. D., Simmons, N., Xie, X., Bhaumik, A., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02906 · Cited by 8

Lysosome-Targeting Chimeras: Design, Mechanisms, and Degradation of “Rogue” Proteins

Rehman, M. U., Wu, X., Chen, Q., Liu, Z., & Long, S. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.109249 · Cited by 8

Analysis of DNA-Encoded Library Screening Data: Selection of Molecules for Synthesis

Satz, A. L., & Cui, W. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2545-3_23 · Cited by 8

DNA‐Encoded Libraries: Towards Harnessing their Full Power with Darwinian Evolution

Dockerill, M., & Winssinger, N. (2022) · Angewandte Chemie · doi:10.1002/ange.202215542 · Cited by 9

Synthesis and Structural Characterization of Macrocyclic α-ABpeptoids and Their DNA-Encoded Library

Lee, S., Kwon, H., Jee, E.-K., Kim, J., Lee, K., Kim, J., Ko, N., Lee, E., & Lim, H. (2024) · Organic Letters · doi:10.1021/acs.orglett.3c04387 · Cited by 8

A carbohydrate-derived trifunctional scaffold for DNA-encoded libraries

Estévez, A. M., Gruber, F., Satz, A. L., Martin, R. E., & Wessel, H. P. (2017) · Tetrahedron Asymmetry · doi:10.1016/j.tetasy.2017.04.007 · Cited by 8

Augmenting Chemical Space with DNA-encoded Library Technology and Machine Learning

Guasch, L., Reutlinger, M., Stoffler, D., & Wichert, M. (2021) · CHIMIA International Journal for Chemistry · doi:10.2533/chimia.2021.105 · Cited by 8

A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles

Qi, J., Liu, S., Seydimemet, M., Wang, X., & Lu, X. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00427 · Cited by 8

DNA-Programmed Lipid Nanoreactors for Synthesis of Carbohydrate Mimetics by Fusion of Aqueous Sub-attoliter Compartments

Tian, X., Risgaard, N. A., Löffler, P. M. G., & Vogel, S. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c04093 · Cited by 8

Industrial medicinal chemistry insights: neuroscience hit generation at Janssen

Tresadern, G., Rombouts, F. J. R., Oehlrich, D., Macdonald, G. J., & Trabanco, A. A. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.05.013 · Cited by 8

Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition

Mimasu, S., Yamagishi, H., Kubo, S., Kiyohara, M., Matsuda, T., Yahata, T., Thomson, H. A., Hupp, C. D., Liu, J. X., Okuda, T., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-01666-5 · Cited by 9

gem‐Difluoromethylene Alkyne‐Enabled Diverse C−H Functionalization and Application to the on‐DNA Synthesis of Difluorinated Isocoumarins

Gao, H., Lin, S., Zhang, S., Chen, W., Liu, X., Yang, G., Lerner, R. A., Xu, H., Zhou, Z., & Yi, W. (2020) · Angewandte Chemie · doi:10.1002/ange.202013052 · Cited by 8

A fluorogenic native chemical ligation for assessing the role of distance in peptide-templated peptide ligation

Petszulat, H., & Seitz, O. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.08.007 · Cited by 8

Recent Advances of Microfluidics Technologies in the Field of Medicinal Chemistry

Ürge, L., Alcázar, J., Huck, L., & Dormán, G. (2017) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2017.09.001 · Cited by 8

Insights of affinity-based probes for target identification in drug discovery

Wang, H., Liu, L., Zhang, Z., Li, C., Wang, K., Gao, J., Hu, Q., Wang, W., & Li, H. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117711 · Cited by 7

A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications

Stacey, P., Lithgow, H., Lewell, X. Q., Konopacka, A., Besley, S., Green, G., Whatling, R., Law, R. P., Röth, S., Sapkota, G. P., et al. (2021) · SLAS DISCOVERY · doi:10.1177/24725552211017517 · Cited by 7

Small Molecule Modulator of the mTORC2 Pathway Discovered from a DEL Library Designed to Bind to Pleckstrin Homology Domains

Gonse, A., Gajić, J., Daguer, J., Barluenga, S., Loewith, R., & Winssinger, N. (2024) · ACS Chemical Biology · doi:10.1021/acschembio.4c00597 · Cited by 9

Detection of protein targets with a single binding epitope using DNA-templated photo-crosslinking and strand displacement

Huang, Y., Zheng, W., & Li, X. (2018) · Analytical Biochemistry · doi:10.1016/j.ab.2018.01.010 · Cited by 7

Protein-protein interactions: a structural view of inhibition strategies and the IL-23/IL-17 axis

Allen, S. J., & Lumb, K. J. (2020) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.12.006 · Cited by 7

DNA-encoded focused indazole library synthesis by a palladium-mediated C N(sp2) cross-coupling reaction between DNA-linked (hetero)aryl halides and aromatic nitrogen heterocycles

Yang, J., Xia, S., Liu, J., Yu, Z., Mei, L., Lu, W., Chen, Y., Chen, S., Wang, X., & Lu, X. (2022) · Tetrahedron Letters · doi:10.1016/j.tetlet.2022.153732 · Cited by 7

Chemically Programmable and Switchable CAR‐T Therapy

Qi, J., Tsuji, K., Hymel, D., Burke, T. R., Hudecek, M., Rader, C. M., & Peng, H. (2020) · Angewandte Chemie · doi:10.1002/ange.202005432 · Cited by 7

Improvements in micelle promoted DNA-encoded library synthesis by surfactant optimisation

Odger, J. A., Anderson, M. J., Carton, T. P., Nguyen, B. N., Foote, K. M., & Waring, M. J. (2025) · Organic & Biomolecular Chemistry · doi:10.1039/d5ob00864f · Cited by 6

Diboron Reagents in Modern Reduction Chemistry: A Versatile Tool for Reduction of Various Functional Groups

Gavit, A. V., Darandale, N. R., Surange, S. B., & Sawant, D. N. (2025) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.70066 · Cited by 6

Toward generalizable predictive models for DNA-encoded libraries

Poongavanam, V., Turunen, S. P., Sandberg, K., Yngve, U., & Wannberg, J. (2026) · Drug Discovery Today · doi:10.1016/j.drudis.2026.104629 · Cited by 6

On drug discovery against infectious diseases and academic medicinal chemistry contributions

Janin, Y. L. (2022) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.18.141 · Cited by 6

Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Al-Amin, R. A., Johansson, L., Abdurakhmanov, E., Landegren, N., Löf, L., Arngården, L., Blokzijl, A., Svensson, R., Hammond, M., Lönn, P., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac842 · Cited by 6

Exploring Chemical Spaces in the Billion Range: Is Docking a Computational Alternative to DNA-Encoded Libraries?

Mihalovits, L. M., Szalai, T. V., Bajusz, D., & Keserű, G. M. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c00803 · Cited by 6

Reversible Covalent Headpiece Enables Interconversion between Double‐ and Single‐Stranded DNA‐Encoded Chemical Libraries

Zhao, G., Zhong, S., Zhang, G., Li, Y., & Li, Y. (2021) · Angewandte Chemie · doi:10.1002/ange.202115157 · Cited by 6

DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathway

Proj, M., Bozovičar, K., Hrast, M., Frlan, R., & Gobec, S. (2022) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2022.128915 · Cited by 8

Design Considerations in Constructing and Screening DNA-Encoded Libraries

Zhang, Y., & Franzini, R. M. (2022) · Topics in medicinal chemistry · doi:10.1007/7355_2022_147 · Cited by 7

Liposomal Permeation Assay for Droplet-Scale Pharmacokinetic Screening

Hu, J., Chan, A. I., Adaligil, E., Kekessie, I., Takahashi, M., Song, A., Cunningham, C. N., & Paegel, B. M. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00138 · Cited by 6

DNA-Compatible Cyanomethylation of (Hetero)aryl Halides or Triflates under a Tandem Reaction for DNA-Encoded Library Synthesis

Zhang, J., Wang, L., Ji, Q., & Liu, F. (2023) · Organic Letters · doi:10.1021/acs.orglett.3c02850 · Cited by 6

Ruthenium-Mediated [2 + 2 + 2] Cyclization: A Route to Forge Indane and Isoindoline Core and Its Application in DNA-Encoded Library Technology

Suo, Y., Xu, M., Sun, M., Lu, W., Wang, X., & Lu, X. (2022) · Organic Letters · doi:10.1021/acs.orglett.2c03759 · Cited by 6

TAF1D promotes proliferation by transcriptionally activating G2 /M phase‐related genes in MYCN ‐amplified neuroblastoma

Zhang, X., Zhan, S., Guan, X., Zhang, Y., Lu, J., Yu, Y., Jin, Y., Yang, Y., Chu, P., Hong, E., et al. (2023) · Cancer Science · doi:10.1111/cas.15815 · Cited by 6

DNA Encoded Glycan Libraries as a next-generation tool for the study of glycan-protein interactionsPreprint

Kondengaden, S. M., Zhang, J., Zhang, H., Parameswaran, A., Kondengadan, S. M., Pawar, S., Puthengot, A., Sunderraman, R., Song, J. K., Polizzi, S. J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.30.017012 · Cited by 6

Photoinduced Site-Selective Alkylation Enabling Synthesis of C-3-Alkylated Quinoxalinone on DNA

Kim, K. S., Ra, J., Babu, M. H., Jang, E., Kang, S., Yoo, M., Bui, T. T. M., Moon, K., & Sim, J. (2025) · Organic Letters · doi:10.1021/acs.orglett.5c01236 · Cited by 5

DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site

Frey, A. F., Schwan, M., Weldert, A. C., Kadenbach, V., Kopp, J., Nidoieva, Z., Zimmermann, R. A., Gleue, L., Zimmer, C., Jörg, M., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113300 · Cited by 5

Toward the Chemoenzymatic Synthesis of DNA-Encoded Libraries

Schaub, D., Lessing, A., von Haugwitz, G., Meyer, F., Scheuermann, J., & Buller, R. (2026) · ACS Central Science · doi:10.1021/acscentsci.5c01516 · Cited by 5

Ugi-Type Reaction Enables Access to Fused Imidazole Derivatives for DNA-Encoded Library Technology

Guo, H., Li, Z., Wang, G., Zhang, B., Wang, M., Liu, L., Satz, A. L., Su, W., Kuai, L., & Zhang, Q. (2026) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5c00655 · Cited by 5

DNA-Compatible Strecker Reaction for the Synthesis of α-Aminonitriles

Ryzhikh, D., Cho, G., Lee, J., Song, M., & Hwang, G. T. (2026) · Organic Letters · doi:10.1021/acs.orglett.6c00840 · Cited by 5

The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives

Hua, S., Moon, J., & Lee, T. (2025) · Molecules · doi:10.3390/molecules30020430 · Cited by 5

CoLiNN: A Tool for Fast Chemical Space Visualization of Combinatorial Libraries Without Enumeration

Pikalyova, R., Akhmetshin, T. N., Horvath, D., & Varnek, A. A. (2025) · Molecular Informatics · doi:10.1002/minf.202400263 · Cited by 5

Discovery of a novel CD39 inhibitor by DNA-encoded library screening

Wang, S., Zhao, J., Nakai, T., Chen, S., Duan, Y., Li, R., Song, C., & Yao, Y. (2025) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2025.130294 · Cited by 5

Structural Modifications for Biological Activity Enhancements in Thiosemicarbazone Scaffolds and Their Metal Complexes

Khan, T., Raza, S., Hashmi, K., Ahmad, M. I., & Khan, A. R. (2025) · Synlett · doi:10.1055/a-2649-7544 · Cited by 5

The DNA Word Design Problem: A New Constraint Model and New Results

Codish, M., Frank, M., & Lagoon, V. (2017) · International Joint Conference on Artificial Intelligence · doi:10.24963/ijcai.2017/82 · Cited by 5

Heterocyclization vs Coupling Reactions: A DNA-Encoded Libraries Case

Oksiuta, O., Pashenko, A. E., Smaliy, R. V., Volochnyuk, D. M., & Ryabukhin, S. V. (2023) · Journal of organic and pharmaceutical chemistry · doi:10.24959/ophcj.23.275133 · Cited by 5

Design of bifunctional molecules to accelerate post-translational modifications: achievements and challenges

Wang, Y., He, Y., You, Q., & Wang, L. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.104194 · Cited by 5

DNA-Encoded Macrocyclic Peptide Library

Zhu, Z., Shaginian, A., Grady, L. C., Davie, C. P., Lind, K. E., Pal, S., Thansandote, P., & Simpson, G. L. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9504-2_12 · Cited by 5

DEL+ML paradigm for actionable hit discovery – a cross DEL and cross ML model assessment.Preprint

Iqbal, S., Jiang, W., Hansen, E., Aristotelous, T., Liu, S., Reidenbach, A. G., Raffier, C., Leed, A., Chen, C., Chung, L., et al. (2024) · ChemRxiv · doi:10.26434/chemrxiv-2024-2xrx4 · Cited by 5

Simple and High-Throughput Fluorescence Assay Method for DNA Damage Analysis in Single-Stranded DNA-Encoded Library Synthesis

Kim, G. A., Kang, S., Win, M. N., & Han, M. S. (2025) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5c00219 · Cited by 2

In Situ Click Chemistry Screen Facilitated by an On‐Nanoparticle DNA‐Encoded Library Identifies Highly Selective and Potent Peptoid Ligands for a Phosphatase

Kim, M., Kim, J., Wang, H. M., Kim, H. M., Ahn, D., Lee, J., Son, C. Y., Chung, S. J., Shin, M. H., & Lim, H. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202511606 · Cited by 4

Efficient Computational Framework for Target-Specific Active Peptide Discovery: A Case Study on IL-17C Targeting Cyclic Peptides

Wu, Z., Wu, Y., Zhu, C., Wu, X., Zhai, S., Wang, X., Su, Z., & Duan, H. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.3c01385 · Cited by 5

Engineering protein fragments via evolutionary and protein–protein interaction algorithms: de novo design of peptide inhibitors for FOF1‐ATP synthase

Ruiz‐Blanco, Y. B., Ávila‐Barrientos, L. P., Hernández‐García, E., Antunes, A., Agüero-Chapin, G., & García‐Hernández, E. (2020) · FEBS Letters · doi:10.1002/1873-3468.13988 · Cited by 4

Microarrays and NGS for Drug Discovery

Pop, L., Zănoagă, O., Chiroi, P. A., Nutu, A. M., Korban, S. S., Stefan, D. C., Irimie, A., & Berindan‐Neagoe, I. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96657 · Cited by 4

Subnanomolar Detection of Oligonucleotides through Templated Fluorogenic Reaction in Hydrogels: Controlling Diffusion to Improve Sensitivity

Sulaiman, D. A., Chang, J. Y. H., & Ladame, S. (2017) · Angewandte Chemie · doi:10.1002/ange.201701356 · Cited by 4

Computational complexity and pragmatic solutions for flexible tile based DNA self-assembly

Almodóvar, L., Ellis-Monaghan, J. A., Harsy, A., Johnson, C., & Sorrells, J. (2024) · Natural Computing · doi:10.1007/s11047-024-09998-x · Cited by 4

The Discovery of Peptide Macrocycle Rescuers of Pathogenic Protein Misfolding and Aggregation by Integrating SICLOPPS Technology and Ultrahigh-Throughput Screening in Bacteria

Delivoria, D. C., & Σκρέτας, Γ. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1689-5_12 · Cited by 4

Discovery of a first-in-class SLIT2 binder disrupting the SLIT2/ROBO1 axis via DNA-encoded library (DEL) screening

Yuan, S., Abdel‐Rahman, S. A., García-Vázquez, N., Nada, H., Calvo‐Barreiro, L., Kuncewicz, K., & Gabr, M. T. (2025) · RSC Medicinal Chemistry · doi:10.1039/d5md00555h · Cited by 3

Nanopore Discrimination of Protein–Small-Molecule Drug Complexes at Near-Atomic Resolution

Jo, J., Kim, J., Hwang, S., Jeong, K., & Chi, S. (2026) · ACS Nano · doi:10.1021/acsnano.5c22458 · Cited by 3

Harnessing the Catalytic Promiscuity of Hydrolases to Promote the Three‐Component Reactions on DNA

Yu, T., Ma, J., Su, X., Tang, J., He, Y., Chen, X., & Wu, L. (2026) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.70499 · Cited by 3

sp3‐Rich Heterocycle Synthesis on DNA: Application to DNA‐Encoded Library Production

Gruber, F., McDonagh, A. W., Rose, V. E., Hunter, J. H., Guasch, L., Martin, R. E., Geigle, S. N., & Britton, R. (2024) · Angewandte Chemie · doi:10.1002/ange.202319836 · Cited by 3

Recent Development of DNA‐based Biohybrid Systems Driven by Light

Pastorel, Z., Zanzi, J., Canac, Y., Baslé, O., & Smietana, M. (2024) · European Journal of Organic Chemistry · doi:10.1002/ejoc.202401297 · Cited by 3

DNA-templated synthesis optimization

Hansen, B. N., Larsen, K. S., Merkle, D., & Mihalchuk, A. (2018) · Natural Computing · doi:10.1007/s11047-018-9697-7 · Cited by 3

Multiplexed Enzyme Activity-Based Probe Display via Hybridization

Cavett, V. J., & Paegel, B. M. (2020) · ACS Combinatorial Science · doi:10.1021/acscombsci.0c00116 · Cited by 3

Isolation of a Natural Killer Group 2D Small‐Molecule Ligand from DNA‐Encoded Chemical Libraries

Plaza, S. D., Galbiati, A., Migliorini, F., Comacchio, C., Oehler, S., Prati, L., Scheuermann, J., Cazzamalli, S., Neri, D., Bassi, G., et al. (2022) · ChemMedChem · doi:10.1002/cmdc.202200350 · Cited by 3

Using cancer proteomics data to identify gene candidates for therapeutic targeting

Monsivais, D., Parks, S. E., Chandrashekar, D. S., Varambally, S., & Creighton, C. J. (2023) · Oncotarget · doi:10.18632/oncotarget.28420 · Cited by 4

Bioinspired Selenium‐Nitrogen Exchange (SeNEx) Click Chemistry Suitable for Nanomole‐Scale Medicinal Chemistry and Bioconjugation

Hou, W., Zhang, Y., Huang, F., Chen, W., Gu, Y., Wang, Y., Pang, J., Dong, H., Pan, K., Zhang, S., et al. (2024) · Angewandte Chemie · doi:10.1002/ange.202318534 · Cited by 3

Optimization of Reaction Conditions for On‐DNA Synthesis of Ureas, Thioureas, and Sulfonamides

Migliorini, F., Ciamarone, A., Neri, D., Cazzamalli, S., & Favalli, N. (2024) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.202400556 · Cited by 3

Small molecule interleukin (IL) 17A/A antagonists and antibodies blocking both IL17A/A and IL17A/F demonstrate equivalent degrees of efficacy in preclinical models of skin and joint inflammation

Goedken, E. R., Su, Z., Lipovsky, A. I., Kannan, A., Chu, K. L., Ciura, S., Foley, S. E., Frank, K. E., Goess, C., Gopalakrishnan, S. M., et al. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103525 · Cited by 3

Redirecting cytotoxic T cells with chemically programmed antibodies

Qi, J., & Rader, C. M. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115834 · Cited by 3

On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries

Stanway‐Gordon, H. A., Graham, J. S., & Waring, M. J. (2021) · Angewandte Chemie · doi:10.1002/ange.202111927 · Cited by 3

CELLULAR TARGET ENGAGEMENT ASSAYS FOR SMALL-MOLECULE DRUG DISCOVERY

Delwig, A., Ishisoko, N., & Blake, R. A. (2022) · Medicinal chemistry reviews · doi:10.1021/mc-2022-vol57.ch17 · Cited by 3

Recent Advances in Chemistry Technologies and Applications to Medicinal Chemistry

Bogdan, A. R., Gesmundo, N. J., Webster, M. P., Wang, Y., & Vasudevan, A. (2021) · Wiley eBooks · doi:10.1002/0471266949.bmc293 · Cited by 3

Single-molecule Dynamic In-Solution Inhibition Assay: A Method for Full Kinetic Profiling of Drug Candidate Binding to GPCRs in Native MembranesPreprint

Kaminski, T., Zhdanov, V. P., & Höök, F. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.16.460640 · Cited by 3

Orthogonal DNA barcodes enable the high-throughput screening of sequence-defined polymersPreprint

de Rochambeau, D., Hirka, S., Saliba, D., Anderson, S., Toader, V., Dore, M. D., Rizzuto, F. J., McKeague, M., & Sleiman, H. F. (2022) · ChemRxiv · doi:10.26434/chemrxiv-2022-zms0g · Cited by 3

Peptide barcodes meet drug discovery

Haap, W. J. (2023) · Science · doi:10.1126/science.adg7484 · Cited by 3

PhenoDEL as a Novel Screening Strategy Based on Intracellular Protein Degradation ActivityPreprint

Onda, Y., Ochi, Y., Araki, T., Kageoka, M., Takeda, S., Yamada, K. D., Ueda, T., Ohno, K., Tanaka, M., Sakai, D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.26.690606 · Cited by 3

DNA‐Encoded Chemical Libraries

Dumelin, C. E., Scheuermann, J., Melkko, S., & Neri, D. (2006) · QSAR & Combinatorial Science · doi:10.1002/qsar.200640104 · Cited by 9

DNA ‐encoded chemical libraries – achievements and remaining challenges

Favalli, N., Bassi, G., Scheuermann, J., & Neri, D. (2018) · FEBS Letters · doi:10.1002/1873-3468.13068 · Cited by 174

Enabling Technologies for Organic Synthesis: DNA-Encoded Libraries

Carden, S., & Chai, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-96025-0.00062-4

DNA-encoded chemical libraries: foundations and applications in lead discovery

Zimmermann, G., & Neri, D. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.07.013 · Cited by 124

Chemical composition of DNA-encoded libraries, past present and future

Dickson, P., & Kodadek, T. J. (2019) · Organic & Biomolecular Chemistry · doi:10.1039/c9ob00581a · Cited by 101