Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

Scott, Duncan E., Bayly, Andrew R., Abell, Chris, Skidmore, John·2016·Nature Reviews Drug Discovery

DOI 10.1038/nrd.2016.29

Cited by (1,001)

Items 201–300 of 1,001

Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs
Suwei Zhu, Shuoran Li, Helena Escuin-Ordinas, Robert Dimatteo, Weixian Xi, Antoni Ribas, Tatiana Segura · 2018 · Journal of Controlled Release
Modulating Protein–Protein Interactions with Visible‐Light‐Responsive Peptide Backbone Photoswitches
Lea Albert, Alberto Peñalver, Nemanja Djoković, Laura Werel, Malte Hoffarth, Dušan Ružić, Jing Xu, Lars‐Oliver Essen, Katarina M. Nikolic, Yali Dou et al. · 2019 · ChemBioChem
Microscale Thermophoresis as a Tool to Study Protein Interactions and Their Implication in Human Diseases
Romain Magnez, Christian Bailly, Xavier Thuru · 2022 · International Journal of Molecular Sciences
Peroxisome disruption alters lipid metabolism and potentiates antitumor response with MAPK-targeted therapy in melanoma
Fan Huang, Feiyang Cai, Michael S. Dahabieh, Kshemaka Gunawardena, Ali Talebi, Jonas Dehairs, Farah El-Turk, Jae Yeon Park, Mengqi Li, Christophe Gonçalves et al. · 2023 · Journal of Clinical Investigation
Bioactive cell penetrating peptides and proteins in cancer: a bright future ahead
Toni Jauset, Marie-Ève Beaulieu · 2019 · Current Opinion in Pharmacology
A story of peptides, lipophilicity and chromatography – back and forth in time
Vanessa Erckes, Christian Steuer · 2022 · RSC Medicinal Chemistry
Scanning Protein Surfaces with DNA‐Encoded Libraries
Verena B. K. Kunig, Marco Potowski, Mateja Klika Škopić, Andreas Brunschweiger · 2020 · ChemMedChem
Targeting protein-protein interaction interfaces in COVID-19 drug discovery
Chung‐ke Chang, Shanmeng Lin, Roshan Satange, Shih‐Chao Lin, Sin-Cih Sun, Hung‐Yi Wu, Kylene Kehn‐Hall, Ming‐Hon Hou · 2021 · Computational and Structural Biotechnology Journal
Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development
Meenakshi Bose, Gabriela Farias Quipildor, Michelle E. Ehrlich, Stephen R. Salton · 2022 · Cells
A general-purpose Nanohybrid fabricated by Polymeric Au(I)-peptide precursor to wake the function of Peptide Therapeutics
Jin Yan, Fanpu Ji, Siqi Yan, Weiming You, Fang Ma, Fanni Li, Yinong Huang, Wenjia Liu, Wangxiao He · 2020 · Theranostics
Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction
Fabio Begnini, Stefan Geschwindner, Patrik Johansson, Lisa Wissler, Richard J. Lewis, Emma Danelius, Andreas Luttens, Pierre G. Matricon, Jens Carlsson, Stijn Lenders et al. · 2022 · Journal of Medicinal Chemistry
Advancements and challenges in mRNA and ribonucleoprotein-based therapies: From delivery systems to clinical applications
Zohre Eftekhari, Horieh Zohrabi, Akbar Oghalaie, Tahereh Ebrahimi, Fatemeh Sadat Shariati, Mahdi Behdani, Fatemeh Kazemi‐Lomedasht · 2024 · Molecular Therapy — Nucleic Acids
A Survey on Computational Methods in Drug Discovery for Neurodegenerative Diseases
Caterina Vicidomini, Francesco Fontanella, Tiziana D’Alessandro, Giovanni Nicola Roviello · 2024 · Biomolecules
Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases
Qi Li, Shuaishuai Xing, Ying Chen, Qinghong Liao, Qihang Li, Yang Liu, Siyu He, Feng Feng, Yao Chen, Jie Zhang et al. · 2019 · European Journal of Medicinal Chemistry
Modulating Protein–Protein Interactions by Cyclic and Macrocyclic Peptides. Prominent Strategies and Examples
Rosario González‐Muñiz, M. Ángeles Bonache, M. Jesús Pérez de Vega · 2021 · Molecules
TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer
María Paz Saldías, Diego Maureira, Octavio Orellana‐Serradell, Ian Silva, Boris J. Lavanderos, Pablo Cruz, Camila Torres, Mónica Cáceres, Oscar Cerda · 2021 · Frontiers in Oncology
Antibody-Mediated Small Molecule Detection Using Programmable DNA-Switches
Marianna Rossetti, Rudy Ippodrino, Bruna Marini, Giuseppe Palleschi, Alessandro Porchetta · 2018 · Analytical Chemistry
LuTHy: a double‐readout bioluminescence‐based two‐hybrid technology for quantitative mapping of protein–protein interactions in mammalian cells
Philipp Trepte, Sabrina Kruse, Simona Kostova, Sheila Hoffmann, Alexander Buntru, Anne Tempelmeier, Christopher Secker, Lisa Diez, Aline Schulz, Konrad Klockmeier et al. · 2018 · Molecular Systems Biology
Targeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions
Antoine Mousson, Émilie Sick, Philippe Carl, Denis Dujardin, Jan De Mey, Philippe Rondé · 2018 · Cancers
Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
Wei-Wei Kung, Sarath Ramachandran, Nikolai Makukhin, Elvira Bruno, Alessio Ciulli · 2019 · Nature Communications
Towards the quantum-enabled technologies for development of drugs or delivery systems
Parichehr Hassanzadeh · 2020 · Journal of Controlled Release
Computational methods-guided design of modulators targeting protein-protein interactions (PPIs)
Yuran Qiu, Xinyi Li, Xinheng He, Jun Pu, Jian Zhang, Shaoyong Lu · 2020 · European Journal of Medicinal Chemistry
Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer
Clare F. Malone, Neekesh V. Dharia, Guillaume Kugener, Alexandra B. Forman, Michael V. Rothberg, Mai Abdusamad, Alfredo E. Gonzalez, Miljan Kuljanin, Amanda L. Robichaud, Amy Saur Conway et al. · 2021 · Cancer Discovery
Targeting SOST using a small-molecule compound retards breast cancer bone metastasis
Lisha Sun, Yixiao Zhang, Guanglei Chen, Yaoting Ji, Qingtian Ma, Xinbo Qiao, Sijin Wu, Lin Mei Zhou, Jiawen Bu, Xudong Zhu et al. · 2022 · Molecular Cancer
What Makes a Good Protein–Protein Interaction Stabilizer: Analysis and Application of the Dual-Binding Mechanism
Shuyu Chen, Martin Zacharias · 2023 · ACS Central Science
Fabricating higher-order functional DNA origami structures to reveal biological processes at multiple scales
Yihao Zhou, Jinyi Dong, Qiangbin Wang · 2023 · NPG Asia Materials
From Concepts to Inhibitors: A Blueprint for Targeting Protein–Protein Interactions
Seong Ho Hong, Thu Trang Nguyễn, Joseph F. Ongkingco, Alex Nazzaro, Paramjit S. Arora · 2025 · Chemical Reviews
Plasmon-Mediated Surface Engineering of Silver Nanowires for Surface-Enhanced Raman Scattering
Gang Lü, Haifeng Yuan, Liang Su, Bart Kenens, Yasuhiko Fujita, Maha Chamtouri, Maria Pszona, Eduard Fron, Jacek W. Waluk, Johan Hofkens et al. · 2017 · The Journal of Physical Chemistry Letters
Interaction Energetics and Druggability of the Protein–Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2)
Mengqi Zhong, A.J. Lynch, Samantha N. Muellers, Stefan Jehle, Lingqi Luo, David R. Hall, Reina Iwase, James P. Carolan, Megan E. Egbert, Amanda Wakefield et al. · 2019 · Biochemistry
Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein
Afsaneh Sadremomtaz, Zayana M. Al-Dahmani, Angel Jonathan Ruiz-Moreno, Alessandra Monti, Chao Wang, Taha Azad, John Cameron Bell, Nunzianna Doti, Marco Antonio Velasco-Velázquez, Debora de Jong et al. · 2021 · Journal of Medicinal Chemistry
High-throughput screen for inhibitors of protein–protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex
Isabelle R. Taylor, Bryan M. Dunyak, Tomoko Komiyama, Hao Shao, Ran Xu, Victoria A. Assimon, Chakrapani Kalyanaraman, Jennifer N. Rauch, Matthew P. Jacobson, Erik R. P. Zuiderweg et al. · 2018 · Journal of Biological Chemistry
The role of the gap junction perinexus in cardiac conduction: Potential as a novel anti-arrhythmic drug target
Daniel T. Hoagland, Webster L. Santos, Steven Poelzing, Robert G. Gourdie · 2018 · Progress in Biophysics and Molecular Biology
A tetrameric protein scaffold as a nano-carrier of antitumor peptides for cancer therapy
Bohan Ma, F. Niu, Xiaoyan Qu, Wangxiao He, Chao Feng, Simeng Wang, Zhenlin Ouyang, Jin Yan, Yurong Wen, Dan Xu et al. · 2019 · Biomaterials
Guest Binding Drives Host Redistribution in Libraries of CoII4L4 Cages
Marion Kieffer, Rana A. Bilbeisi, John D. Thoburn, Jack Kay Clegg, Jonathan R. Nitschke · 2020 · Angewandte Chemie International Edition
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides
Charoenpattarapreeda, Jiraborrirak, Tan, Yaw Sing, Iegre, Jessica, Walsh, Stephen J., Fowler, Elaine, Eapen, Rohan S., Wu, Yuteng, Sore, Hannah F., Verma, Chandra S., Itzhaki, Laura et al. · 2019 · Chemical Communications
A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities
Jianfeng Lou, Yuhang Lu, Jing Cheng, Feilong Zhou, Ziqin Yan, Daizhou Zhang, Xiangjing Meng, Yujun Zhao · 2022 · European Journal of Medicinal Chemistry
Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display
Sijie Wang, Franco F. Faucher, Matilde Bertolini, Heeyoung Kim, Bingchen Yu, Li Cao, Katharina Röltgen, Scott Lovell, Varun R. Shanker, Scott Dexter Boyd et al. · 2025 · Journal of the American Chemical Society
Exploiting β‐Amino Acid Enolates in Direct Catalytic Diastereo‐ and Enantioselective C−C Bond‐Forming Reactions
Jin‐Sheng Yu, Hidetoshi Noda, Masakatsu Shibasaki · 2018 · Chemistry - A European Journal
Macrocyclization of an all- d linear α-helical peptide imparts cellular permeability
Srinivasaraghavan Kannan, Pietro G. A. Aronica, Simon Ng, Dawn Thean Gek Lian, Yuri Frosi, Sharon Min Qi Chee, Shimin Jiang, Tsz Ying Yuen, Ahmad Sadruddin, Hung Yi Kristal Kaan et al. · 2020 · Chemical Science
Fluorescence Anisotropy-Based Tethering for Discovery of Protein–Protein Interaction Stabilizers
Eline Sijbesma, Bente A. Somsen, Galen P. Miley, Iris A. Leijten-van de Gevel, Luc Brunsveld, Michelle R. Arkin, Christian Ottmann · 2020 · ACS Chemical Biology
Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin
Simone Brixius‐Anderko, Emily E. Scott · 2021 · Journal of Biological Chemistry
The present and the future of motif-mediated protein–protein interactions
Moon‐Hyeong Seo, Philip M. Kim · 2018 · Current Opinion in Structural Biology
Allosteric Modulators of Protein–Protein Interactions (PPIs)
Duan Ni, Na Liu, Chunquan Sheng · 2019 · Advances in experimental medicine and biology
Modulators of protein–protein interactions as antimicrobial agents
Rashi Kahan, Dennis J. Worm, Guilherme V. Castro, Simon Ng, Anna Barnard · 2021 · RSC Chemical Biology
Oxidation of Innate Immune Checkpoint CD47 on Cancer Cells with Non-Thermal Plasma
Abraham G. Lin, Jamoliddin Razzokov, Hanne Verswyvel, Angela Privat‐Maldonado, Joey De Backer, Maksudbek Yusupov, Edgar Cardenas De La Hoz, Peter Ponsaerts, Evelien Smits, Annemie Bogaerts · 2021 · Cancers
An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB—Utilizing a Reversible Covalent Tethering Approach
M. Wolter, Dario Valenti, Peter J. Cossar, Stanimira Hristeva, Laura M. Levy, Thorsten Genski, Torsten Hoffmann, Luc Brunsveld, Dimitrios Tzalis, Christian Ottmann · 2021 · Journal of Medicinal Chemistry
Quantitative FRET (qFRET) Technology for the Determination of Protein–Protein Interaction Affinity in Solution
Jiayu Liao, Vipul Madahar, Runrui Dang, Ling Jiang · 2021 · Molecules
Blocker-SELEX: a structure-guided strategy for developing inhibitory aptamers disrupting undruggable transcription factor interactions
Tongqing Li, Xueying Liu, Haifeng Qian, Sheyu Zhang, Yu Hou, Yuchao Zhang, Guoyan Luo, Xun Zhu, Yanxin Tao, Mengyang Fan et al. · 2024 · Nature Communications
Protein–protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics
Laura Carro · 2018 · Beilstein Journal of Organic Chemistry
Affinity Selections of DNA‐Encoded Chemical Libraries on Carbonic Anhydrase IX‐Expressing Tumor Cells Reveal a Dependence on Ligand Valence
Sebastian Oehler, Marco Catalano, Ilario Scapozza, Martina Bigatti, Gabriele Bassi, Nicholas Favalli, Michael R. Mortensen, Florent Samain, Jörg Scheuermann, Dario Neri · 2021 · Chemistry - A European Journal
Genetically encoding latent bioreactive amino acids and the development of covalent protein drugs
Nanxi Wang, Lei Wang · 2021 · Current Opinion in Chemical Biology
Disruption of protein function by pathogenic mutations: common and uncommon mechanisms
Mikko Taipale · 2018 · Biochemistry and Cell Biology
Component stabilizing mechanism of membrane-separated hydrolysates on frozen surimi
Yueying Zhai, Wanqi Peng, Wei Luo, Jinhong Wu, Yongle Liu, Faxiang Wang, Xianghong Li, Jian Yu, Shaoyun Wang · 2023 · Food Chemistry
Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening
Ke‐Jia Wu, Pui-Man Lei, Hao Liu, Chun Wu, Chung‐Hang Leung, Dik‐Lung Ma · 2019 · Molecules
Covalent Targeting of Ras G12C by Rationally Designed Peptidomimetics
Daniel Y. Yoo, Andrew D. Hauser, Stephen T. Joy, Dafna Bar‐Sagi, Paramjit S. Arora · 2020 · ACS Chemical Biology
Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury
Le Zhang, Lijuan Xu, Haihu Chen, Wannian Zhang, Chengguo Xing, Zhuo Qu, Jian‐Qiang Yu, Chunlin Zhuang · 2021 · European Journal of Medicinal Chemistry
Recent progress in nanomedicine-mediated cytosolic delivery
Hangyu Son, Jeongsu Shin, Joonhyuck Park · 2023 · RSC Advances
Citrullination modulation stabilizes HIF-1α to promote tumour progression
Rui Chen, Zhiyuan Lin, Shengqi Shen, Chuxu Zhu, Kai Yan, Caixia Suo, Rui Liu, Haoran Wei, Li Gao, Kaixiang Fan et al. · 2024 · Nature Communications
Invasive fungal infections in the immunocompromised host: Mechanistic insights in an era of changing immunotherapeutics
Christopher P. Eades, Darius P. H. Armstrong-James · 2018 · Medical Mycology
Peptide-assisted Intracellular Delivery of Biomacromolecules
Shiroh Futaki, Jan Vincent V. Arafiles, H. Hirose · 2020 · Chemistry Letters
Serotonin Alters the Phase Equilibrium of a Ternary Mixture of Phospholipids and Cholesterol
Oskar Engberg, Anna Maria Bochicchio, Astrid F. Brandner, Ankur Gupta, Simli Dey, Rainer A. Böckmann, Sudipta Maiti, Daniel Huster · 2020 · Frontiers in Physiology
High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics
Jeffrey R. Simard, Linda Lee, Ellen F. Vieux, Reina Improgo, Trang N. Tieu, Andrew J. Phillips, Stewart L. Fisher, Roy M. Pollock, Eunice Y. Park · 2021 · SLAS DISCOVERY
Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1)
Patricia Santofimia‐Castaño, Bruno Rizzuti, Olga Abián, Adrián Velázquez‐Campoy, Juan Iovanna, José L. Neira · 2018 · Biochimica et Biophysica Acta (BBA) - General Subjects
Methods for Discovering and Targeting Druggable Protein-Protein Interfaces and Their Application to Repurposing
E. Sıla Özdemir, Farideh Halakou, Ruth Nussinov, Attila Gürsoy, Özlem Keskin · 2018 · Methods in molecular biology
Checks and Balances in Bacterial Cell Division
Tanneke den Blaauwen, Joen Luirink · 2019 · mBio
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Matthias Barone, Matthias Müller, Slim Chiha, Jiang Ren, Dominik Albat, Arne Soicke, Stephan Dohmen, Marco Tobias Klein, Judith Bruns, Maarten van Dinther et al. · 2020 · Proceedings of the National Academy of Sciences
Research progress of biosensors for detection of SARS-CoV-2 variants based on ACE2
Hongshuai Wei, Congcong Zhang, Xin Du, Zhenguo Zhang · 2022 · Talanta
De Novo Modular Development of a Foldameric Protein–Protein Interaction Inhibitor for Separate Hot Spots: A Dynamic Covalent Assembly Approach
Éva Bartus, Zsófia Hegedüs, Edit Wéber, Brigitta Csipak, Gerda Szakonyi, Tamás A. Martinek · 2017 · ChemistryOpen
Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation ofERGsuper-enhancer in erythroleukemia cells
Ryusuke Yamamoto, Masahiro Kawahara, Shinji Ito, Junko Satoh, Goichi Tatsumi, Masakatsu Hishizawa, Takayoshi Suzuki, Akira Andoh · 2018 · Oncotarget
Docking-based identification of small-molecule binding sites at protein-protein interfaces
Mireia Rosell, Juan Fernández‐Recio · 2020 · Computational and Structural Biotechnology Journal
Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake
Aline D. de Araujo, Junxian Lim, Kai‐Chen Wu, Huy N. Hoang, Huy T. Nguyen, David P. Fairlie · 2022 · RSC Chemical Biology
A 3D structural SARS-CoV-2–human interactome to explore genetic and drug perturbations
Wierbowski, Shayne D., Liang, Siqi, Liu, Yuan, Chen, You, Gupta, Shagun, Andre, Nicole M., Lipkin, Steven M., Whittaker, Gary R., Yu, Haiyuan · 2021 · Nature Methods
Selective fluorescent labeling of cellular proteins and its biological applications
Joo Hee Choi, Sooin Kim, On‐Yu Kang, Seong Yun Choi, Ji Young Hyun, Hyun Soo Lee, Injae Shin · 2024 · Chemical Society Reviews
Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium
Yumiko Mizukoshi, Koh Takeuchi, Yuji Tokunaga, Hitomi Matsuo, Misaki Imai, Miwa Fujisaki, Hajime Kamoshida, Takeshi Takizawa, Hiroyuki Hanzawa, Ichio Shimada · 2020 · Science Advances
Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
Annika Meiners, Sandra Bäcker, Inesa Hadrović, Christian Heid, Christine Beuck, Yasser B. Ruiz‐Blanco, Joel Mieres‐Pérez, Marius Pörschke, Jean‐Noël Grad, Cecilia Vallet et al. · 2021 · Nature Communications
Abrogating the Interaction Between p53 and Mortalin (Grp75/HSPA9/mtHsp70) for Cancer Therapy: The Story so far
Ahmed Elwakeel · 2022 · Frontiers in Cell and Developmental Biology
Review: Precision Medicine Approaches for Genetic Cardiomyopathy: Targeting Phospholamban R14del
Frederik Ernst Deiman, Nils Bömer, Peter van der Meer, Niels Grote Beverborg · 2022 · Current Heart Failure Reports
Drug discovery by targeting the protein–protein interactions involved in autophagy
Honggang Xiang, Mi Zhou, Yan Li, Lu Zhou, Renxiao Wang · 2023 · Acta Pharmaceutica Sinica B
PocketAnchor: Learning structure-based pocket representations for protein-ligand interaction prediction
Shuya Li, Tingzhong Tian, Ziting Zhang, Ziheng Zou, Dan Yang Zhao, Jianyang Zeng · 2023 · Cell Systems
Small-Molecule Inhibitors of the CD40–CD40L Costimulatory Protein–Protein Interaction
Jinshui Chen, Yun Gyu Song, Damir Bojadzic, Alejandro Tamayo, Ana Marie Landin, Bonnie B. Blomberg, Péter Buchwald · 2017 · Journal of Medicinal Chemistry
Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target
G. M. Watson, Ketav Kulkarni, Jianrong Sang, Xiuquan Ma, Menachem J. Gunzburg, Patrick Perlmutter, Matthew C. J. Wilce, Matthew C. J. Wilce · 2017 · Journal of Medicinal Chemistry
Protein-Protein Interactions and Aggregation Inhibitors in Alzheimer’s Disease
Ganeshpurkar, Ankit, Swetha, Rayala, Kumar, Devendra, Gangaram, Gore P., Singh, Ravi, Gutti, Gopichand, Jana, Srabanti, Kumar, Dileep, Kumar, Ashok, Singh, Sushil K. · 2019 · Current Topics in Medicinal Chemistry
Total Synthesis of Strempeliopidine and Non-Natural Stereoisomers through a Convergent Petasis Borono–Mannich Reaction
Alexander W. Rand, Kevin J. Gonzalez, Christopher E. Reimann, Scott C. Virgil, Brian M. Stoltz · 2023 · Journal of the American Chemical Society
Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5–MEP50 Complex
Adrian Krzyzanowski, Raphael Gasper, Hélène Adihou, Peter ‘t Hart, Herbert Waldmann · 2021 · ChemBioChem
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme–ubiquitin complex
Daniel J. St‐Cyr, Derek F. J. Ceccarelli, Stephen M. Orlicky, Almer M. van der Sloot, Xiaojing Tang, Susan Kelso, Susan Moore, Clint A. James, Ganna Posternak, Jasmin Coulombe‐Huntington et al. · 2021 · Science Advances
Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies
Dezső Módos, Krishna C. Bulusu, Dávid Fazekas, János Kubisch, Johanne Brooks, István Marczell, Péter Márton Szabó, Tibor Vellai, Péter Csermely, Katalin Lenti et al. · 2017 · npj Systems Biology and Applications
Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies
Christina Schiza, Dimitrios Korbakis, Efstratia Panteleli, Keith Allen Jarvi, Andrei P. Drabovich, Eleftherios P. Diamandis · 2018 · Molecular & Cellular Proteomics
Screening-based approaches to identify small molecules that inhibit protein–protein interactions
Choi, Sehee, Choi, Kang-Yell · 2017 · Expert Opinion on Drug Discovery
Concise Synthesis of Tetrazole Macrocycle
Eman M. M. Abdelraheem, Michel P. de Haan, Pravin Patil, Katarzyna Kurpiewska, Justyna Kalinowska‐Tłuścik, Shabnam Shaabani, Alexander S. S. Dömling · 2017 · Organic Letters
Prediction of Hot Regions in PPIs Based on Improved Local Community Structure Detecting
Xiaoli Lin, Xiaolong Zhang · 2018 · IEEE Transactions on Computational Biology and Bioinformatics
Reversible Interacting-Particle Reaction Dynamics
Christoph Fröhner, Frank Noé · 2018 · The Journal of Physical Chemistry B
Proteomimetics of Natural Regulators of JAK–STAT Pathway: Novel Therapeutic Perspectives
Sara La Manna, Ilaria De Benedictis, Daniela Marasco · 2022 · Frontiers in Molecular Biosciences
High-Throughput Screening of Stapled Helical Peptides in Drug Discovery
Yiwei Zhang, Jiabei Guo, Jiongjia Cheng, Zhenghua Zhang, Fenghua Kang, Xiaoxing Wu, Qian Chu · 2022 · Journal of Medicinal Chemistry
Transformer Performance for Chemical Reactions: Analysis of Different Predictive and Evaluation Scenarios
Fernando Jaume-Santero, Alban Bornet, Alain Valery, Nona Naderi, David Vicente Alvarez, Dimitrios Proios, Anthony Yazdani, Colin Bournez, Thomas C. Fessard, Douglas Teodoro · 2023 · Journal of Chemical Information and Modeling
Sensitive CRISPR-Cas12a-Assisted Immunoassay for Small Molecule Detection in Homogeneous Solution
Fengxi Zhu, Qiang Zhao · 2023 · Analytical Chemistry
A gated graph transformer for protein complex structure quality assessment and its performance in CASP15
Xiao Chen, Alex Morehead, Jian Liu, Jianlin Cheng · 2023 · Bioinformatics
Rational design and structure–activity relationship studies of quercetin–amino acid hybrids targeting the anti-apoptotic protein Bcl-xL
Tahsin F. Kellici, Μaria V. Chatziathanasiadou, Min‐Sung Lee, Nisar Sayyad, Elena G. Geromichalou, Eirinaios I. Vrettos, Antonis D. Tsiailanis, Seung‐Wook Chi, George D. Geromichalos, Thomas Mavromoustakos et al. · 2017 · Organic & Biomolecular Chemistry
Potent Inhibitors of Mycobacterium tuberculosis Growth Identified by Using in-Cell NMR-based Screening
Christopher M. DeMott, Roxie C. Girardin, Jacqueline Cobbert, Sergey Reverdatto, David S. Burz, Kathleen A. McDonough, Alexander G. Shekhtman · 2018 · ACS Chemical Biology
CORUM in 2024: protein complexes as drug targets
Ralph Steinkamp, George Tsitsiridis, Barbara Brauner, Corinna Montrone, Gisela Fobo, Goar Frishman, Sorin I. Avram, Tudor Ionel Oprea, Andreas Ruepp · 2024 · Nucleic Acids Research
Drug resistance: origins, evolution and characterization of genomic clones and the tumor ecosystem to optimize precise individualized therapy
Ioannis D Kyrochristos, Dimosthenis E. Ziogas, Dimitrios H Roukos · 2019 · Drug Discovery Today