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Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
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Protein-protein interactions (PPIs) are of pivotal importance in the regulation of biological systems and are consequently implicated in the development of disease states. Recent work has begun to show that, with the right tools, certain classes of PPI can yield to the efforts of medicinal chemists to develop inhibitors, and the first PPI inhibitors have reached clinical development. In this Review, we describe the research leading to these breakthroughs and highlight the existence of groups of structurally related PPIs within the PPI target class. For each of these groups, we use examples of successful discovery efforts to illustrate the research strategies that have proved most useful.
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“The inhibition of PPIs has arguably received more attention in the past and has proved to be challenging but still feasible.2,3”
From Chasing molecular glue degraders: screening approaches (2022) · cites this paper as [2]
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Metadata
- Authors
- Scott, D. E., Bayly, A. R., Abell, C., & Skidmore, J.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Abell, Chris
- Skidmore, John
- Venue
- Nature Reviews Drug Discovery
- Published
- 2016-04-11
- Volume
- 15
- Issue
- 8
- Pages
- 533-550
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2329592726
- Cited by
- 1,137
- References
- 172
- Citations by year
- 2026: 101 · 2025: 121 · 2024: 120 · 2023: 115 · 2022: 117 · 2021: 128 · 2020: 120 · 2019: 106 · 2018: 107 · 2017: 83 · 2016: 16
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Keywords
- protein-protein interaction, PPI inhibitors, small molecule drug discovery, drug target identification, structure-based drug design
- MeSH terms
- Animals, Humans, Models, Molecular, Proteins, Protein Structure, Tertiary, Computational Biology, Protein Interaction Domains and Motifs, Small Molecule Libraries, Drug Discovery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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